PharmaCoNets of Ximelagatran (SPCN: 45.58 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ximelagatranhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Ximelagatranhsa00310Lysine degradation2.86E-022Q96KQ7, Q02809EHMT2, PLOD1More
Ximelagatranhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Ximelagatranhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Ximelagatranhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Ximelagatranhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Ximelagatranhsa03020RNA polymerase9.80E-052Q9GZM3, P52435POLR2J2, POLR2JMore
Ximelagatranhsa03040Spliceosome4.73E-026Q14562, O43143, P52298, Q13595, Q07955, Q13243DHX8, DHX15, NCBP2, TRA2A, SFRS1, SFRS5More
Ximelagatranhsa03050Proteasome3.05E-021P55036PSMD4More
Ximelagatranhsa03060Protein export1.90E-022Q15070, O76094OXA1L, SRP72More
Ximelagatranhsa04015Rap1 signaling pathway2.05E-034P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Ximelagatranhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Ximelagatranhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Ximelagatranhsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Ximelagatranhsa04071Sphingolipid signaling pathway5.85E-038P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Ximelagatranhsa04080Neuroactive ligand-receptor interaction2.76E-026Q15722, P21453, O00398, P25116, P21462, Q16581LTB4R, S1PR1, P2RY10, F2R, FPR1, C3AR1More
Ximelagatranhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Ximelagatranhsa04145Phagosome8.42E-036Q15080, P14598, Q13509, P68371, Q13488, O60603NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2More
Ximelagatranhsa04217Necroptosis2.64E-0310P01375, P01568, P48023, Q13489, Q13546, Q14765, Q6FI13, Q99878, P10415, O43633TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC18; H2AC19, H2AC14, BCL2, CHMP2AMore
Ximelagatranhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Ximelagatranhsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Ximelagatranhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Ximelagatranhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Ximelagatranhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Ximelagatranhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Ximelagatranhsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Ximelagatranhsa04610Complement and coagulation cascades9.44E-044P25116, P00734, P0C0L4, P10909F2R, F2, C4A, CLUMore
Ximelagatranhsa04611Platelet activation7.40E-065P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Ximelagatranhsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Ximelagatranhsa04613Neutrophil extracellular trap formation4.51E-0316P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Ximelagatranhsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Ximelagatranhsa04623Cytosolic DNA-sensing pathway2.86E-022P01568, Q13546IFNA21, RIPK1More
Ximelagatranhsa04650Natural killer cell mediated cytotoxicity2.95E-027P06239, P20963, Q13241, P26718, O14931, P26717, P26715LCK, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Ximelagatranhsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Ximelagatranhsa04658Th1 and Th2 cell differentiation1.78E-0411Q04759, P07766, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3More
Ximelagatranhsa04660T cell receptor signaling pathway1.44E-0413P01375, Q9UDY8, Q04759, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Ximelagatranhsa04666Fc gamma R-mediated phagocytosis1.88E-024P23528, O14494, P14598, P17252CFL1, PLPP1, NCF1, PRKCAMore
Ximelagatranhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Ximelagatranhsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Ximelagatranhsa04720Long-term potentiation5.06E-034P17252, Q16566, P0DP23, Q14643PRKCA, CAMK4, CALM1, ITPR1More
Ximelagatranhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Ximelagatranhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Ximelagatranhsa04725Cholinergic synapse2.72E-035Q14643, P17252, P62873, Q16566, P10415ITPR1, PRKCA, GNB1, CAMK4, BCL2More
Ximelagatranhsa04726Serotonergic synapse4.49E-024Q14643, P17252, P62873, P33260ITPR1, PRKCA, GNB1, CYP2C18More
Ximelagatranhsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Ximelagatranhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Ximelagatranhsa04912GnRH signaling pathway3.89E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Ximelagatranhsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Ximelagatranhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Ximelagatranhsa04925Aldosterone synthesis and secretion1.29E-024Q14643, P0DP23, P17252, Q16566ITPR1, CALM1, PRKCA, CAMK4More
Ximelagatranhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Ximelagatranhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Ximelagatranhsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Ximelagatranhsa05016Huntington disease1.07E-023Q9GZM3, P52435, P55036POLR2J2, POLR2J, PSMD4More
Ximelagatranhsa05020Prion disease3.99E-026O14521, Q14643, Q13509, P68371, P14598, Q15080SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4More
Ximelagatranhsa05022Pathways of neurodegeneration - multiple diseases4.11E-028Q14643, Q13509, P68371, P10415, O14521, Q13561, P17252, P0DP23ITPR1, TUBB3, TUBB2C, BCL2, SDHD, DCTN2, PRKCA, CALM1More
Ximelagatranhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Ximelagatranhsa05132Salmonella infection1.11E-028Q9UJU2, Q13546, Q13489, P10415, O60603, Q13561, Q13509, P68371LEF1, RIPK1, BIRC3, BCL2, TLR2, DCTN2, TUBB3, TUBB2CMore
Ximelagatranhsa05133Pertussis2.02E-034P0DP23, P23528, P09871, P0C0L4CALM1, CFL1, C1S, C4AMore
Ximelagatranhsa05140Leishmaniasis1.87E-027P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Ximelagatranhsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Ximelagatranhsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Ximelagatranhsa05152Tuberculosis4.18E-037Q13488, P0DP23, P48382, O60603, P10415, P01568, Q9UDY8TCIRG1, CALM1, RFX5, TLR2, BCL2, IFNA21, MALT1More
Ximelagatranhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Ximelagatranhsa05163Human cytomegalovirus infection4.73E-026P62873, Q14643, P0DP23, P17252, Q13546, P01568GNB1, ITPR1, CALM1, PRKCA, RIPK1, IFNA21More
Ximelagatranhsa05170Human immunodeficiency virus 1 infection1.16E-0310P62873, P0DP23, P17252, Q13546, Q14643, P01568, O60603, P23528, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, RIPK1, ITPR1, IFNA21, TLR2, CFL1, BCL2, AP1M2More
Ximelagatranhsa05202Transcriptional misregulation in cancer3.00E-0213P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Ximelagatranhsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Ximelagatranhsa05310Asthma1.25E-034P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Ximelagatranhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Ximelagatranhsa05321Inflammatory bowel disease3.16E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Ximelagatranhsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Ximelagatranhsa05332Graft-versus-host disease4.38E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Ximelagatranhsa05340Primary immunodeficiency3.73E-022P11912, P16871CD79A, IL7RMore
Ximelagatranhsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Ximelagatranhsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Ximelagatran (SDC: 4.10)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00734F2ProthrombinReported10.09630.7070.49771.9598
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P13612ITGA4Integrin alphaNone4Predicted00.11650.23860.68621.2217
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
Q13489BIRC3Baculoviral IAP repeatNonecontaining protein 3Predicted00.33620.04930.84721.114
Q14790CASP8CaspaseNone8Predicted10.150.055811.1867
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)