PharmaCoNets of Pimozide (SPCN: 288.32 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pimozidehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Pimozidehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Pimozidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Pimozidehsa00071Fatty acid degradation3.65E-034O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Pimozidehsa00190Oxidative phosphorylation2.65E-063Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Pimozidehsa00220Arginine biosynthesis4.97E-042P15104, P49448GLUL, GLUD2More
Pimozidehsa00230Purine metabolism1.71E-037Q13370, P21589, P36959, P20839, Q02153, Q13956, P27707PDE3B, NT5E, GMPR, IMPDH1, GUCY1B3, PDE6H, DCKMore
Pimozidehsa00240Pyrimidine metabolism3.42E-033P21589, P32320, P27707NT5E, CDA, DCKMore
Pimozidehsa00250Alanine, aspartate and glutamate metabolism1.20E-032P49448, P15104GLUD2, GLULMore
Pimozidehsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Pimozidehsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Pimozidehsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Pimozidehsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Pimozidehsa00500Starch and sucrose metabolism1.89E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Pimozidehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Pimozidehsa00520Amino sugar and nucleotide sugar metabolism1.59E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Pimozidehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Pimozidehsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin4.77E-021Q7LGA3HS2ST1More
Pimozidehsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Pimozidehsa00565Ether lipid metabolism3.00E-031Q8N661TMEM86BMore
Pimozidehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Pimozidehsa00591Linoleic acid metabolism1.29E-031P11712CYP2C9More
Pimozidehsa00600Sphingolipid metabolism8.72E-034Q9BX95, O14494, P06280, P15289SGPP1, PLPP1, GLA, ARSAMore
Pimozidehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Pimozidehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Pimozidehsa00630Glyoxylate and dicarboxylate metabolism6.37E-052P40925, P15104MDH1, GLULMore
Pimozidehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Pimozidehsa00670One carbon pool by folate9.96E-043O95954, P04818, Q99707FTCD, TYMS, MTRMore
Pimozidehsa00730Thiamine metabolism5.65E-052P05186, P24666ALPL, ACP1More
Pimozidehsa00760Nicotinate and nicotinamide metabolism9.09E-031P21589NT5EMore
Pimozidehsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Pimozidehsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Pimozidehsa00910Nitrogen metabolism1.20E-032P15104, P49448GLUL, GLUD2More
Pimozidehsa00920Sulfur metabolism3.01E-021O95571ETHE1More
Pimozidehsa00970Aminoacyl-tRNA biosynthesis3.63E-074O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Pimozidehsa00980Metabolism of xenobiotics by cytochrome P4508.40E-043P78417, P28332, P11712GSTO1, ADH6, CYP2C9More
Pimozidehsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Pimozidehsa00983Drug metabolism - other enzymes1.18E-045P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Pimozidehsa01100Metabolic pathways5.77E-0345Q9NR34, Q9Y234, P05089, Q99707, P29218, P11310, P27707, P32320, Q13370, P36959, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P30043, P05186, P24666, Q02252, O60701, O14772, O95954, Q9HCC0, P33121, Q02318, P04406, P57054, Q9UNP4, O15466, Q9BX95, P09960, P32321, Q9P2R7, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q13488, Q16718, Q02809MAN1C1, LIPT1, ARG1, MTR, IMPA1, ACADM, DCK, CDA, PDE3B, GMPR, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRB, ALPL, ACP1, ALDH6A1, UGDH, FPGT, FTCD, MCCC2, ACSL1, CYP27A1, GAPDH, PIGP, ST3GAL5, ST8SIA5, SGPP1, LTA4H, DCTD, SUCLA2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, TCIRG1, NDUFA5, PLOD1More
Pimozidehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Pimozidehsa012102-Oxocarboxylic acid metabolism6.96E-041P50213IDH3AMore
Pimozidehsa01230Biosynthesis of amino acids1.16E-034P51854, P60891, P15104, P37837TKTL1, PRPS1, GLUL, TALDO1More
Pimozidehsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Pimozidehsa01522Endocrine resistance4.22E-035P22694, P04049, P08069, P10415, Q13323PRKACB, RAF1, IGF1R, BCL2, BIKMore
Pimozidehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Pimozidehsa01524Platinum drug resistance4.45E-024P10415, Q13489, P78417, P43246BCL2, BIRC3, GSTO1, MSH2More
Pimozidehsa02010ABC transporters1.99E-044P45844, P08183, Q8IZY2, Q99758ABCG1, ABCB1, ABCA7, ABCA3More
Pimozidehsa03008Ribosome biogenesis in eukaryotes1.46E-024Q9NYH9, P78345, Q9BVP2, Q9GZY0UTP6, RPP38, GNL3, NXF2; NXF2BMore
Pimozidehsa03013RNA transport1.41E-0621P62826, P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, Q9GZY0, P37198, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q9Y6A5, Q53GS7RAN, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, NXF2; NXF2B, NUP62, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, TACC3, GLE1More
Pimozidehsa03015mRNA surveillance pathway1.09E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Pimozidehsa03020RNA polymerase4.40E-022P24928, P62487POLR2A, POLR2GMore
Pimozidehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Pimozidehsa03040Spliceosome5.91E-1626Q14562, O43143, O60508, P17844, O14776, P08579, Q15427, P26368, O75940, P52298, P38159, P09651, P61978, Q15365, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O95777, O43447, O75643, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SF3B4, U2AF2, SMNDC1, NCBP2, RBMX, HNRNPA1, HNRPK, PCBP1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, LSM8, PPIH, ASCC3L1, MAGOHMore
Pimozidehsa03050Proteasome4.01E-054P43686, P62195, P28070, P40306PSMC4, PSMC5, PSMB4, PSMB10More
Pimozidehsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Pimozidehsa03320PPAR signaling pathway2.18E-022O00767, Q02318SCD, CYP27A1More
Pimozidehsa03430Mismatch repair4.38E-021P20585MSH3More
Pimozidehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Pimozidehsa03460Fanconi anemia pathway4.00E-044Q9NPI8, O94782, O60673, Q9UNA4FANCF, USP1, REV3L, POLIMore
Pimozidehsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Pimozidehsa04012ErbB signaling pathway6.03E-047P21860, P16333, Q13557, P19174, O14944, P01106, P04049ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC, RAF1More
Pimozidehsa04014Ras signaling pathway6.20E-0515P04049, P31751, P42338, P20827, P49767, P08069, Q13009, P17252, Q15311, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, PRKCA, RALBP1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Pimozidehsa04015Rap1 signaling pathway8.85E-0617P04049, P20827, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, Q08828, P51828, P42338, P31751, P0DP23, P17252, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PRKCA, PLCG1More
Pimozidehsa04020Calcium signaling pathway6.53E-0914P27987, Q96DU7, Q08828, P45880, Q13557, P17252, P21860, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767ITPKB, ITPKC, ADCY1, VDAC2, CAMK2D, PRKCA, ERBB3, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFCMore
Pimozidehsa04022cGMP-PKG signaling pathway1.03E-039P04049, Q99941, P18848, P23634, Q8WYR1, P51828, P05141, P45880, P0DP24RAF1, CREBL1, ATF4, ATP2B4, PIK3R5, ADCY7, SLC25A5, VDAC2, CALM2More
Pimozidehsa04024cAMP signaling pathway1.25E-0310Q08828, P51828, P31751, P0DP23, P23634, P04049, Q13557, Q13370, O15399, Q13009ADCY1, ADCY7, AKT2, CALM1, ATP2B4, RAF1, CAMK2D, PDE3B, GRIN2D, TIAM1More
Pimozidehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Pimozidehsa04062Chemokine signaling pathway4.48E-0728P51684, P25024, P25025, P09341, P19875, Q8NHW4, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q08828, P51828, Q7LDG7, Q13009, P14598, P42224, P31751, P04049, P49841, Q8WYR1CCR6, CXCR1, CXCR2, CXCL1, CXCL2, CCL4L2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, ADCY1, ADCY7, RASGRP2, TIAM1, NCF1, STAT1, AKT2, RAF1, GSK3B, PIK3R5More
Pimozidehsa04064NF-kappa B signaling pathway1.00E-0925P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, O75293, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, GADD45B, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Pimozidehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Pimozidehsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Pimozidehsa04070Phosphatidylinositol signaling system7.01E-069P19174, P0DP23, Q14643, P23743, Q86XP1, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, DGKA, DGKH, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Pimozidehsa04071Sphingolipid signaling pathway2.29E-0714P04049, P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2, P01042RAF1, PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2, KNG1More
Pimozidehsa04072Phospholipase D signaling pathway1.52E-0313P04049, P31751, P42338, P43657, P25024, P25025, P19174, P17252, Q15438, Q08828, P51828, P23743, P00734RAF1, AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PRKCA, PSCD1, ADCY1, ADCY7, DGKA, F2More
Pimozidehsa04080Neuroactive ligand-receptor interaction2.95E-048P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Pimozidehsa04110Cell cycle4.61E-048Q9UBD5, P06493, Q14683, O75293, P30304, P33981, P42773, P01106ORC3, CDK1, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Pimozidehsa04114Oocyte meiosis4.41E-036Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Pimozidehsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Pimozidehsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Pimozidehsa04140Autophagy - animal1.37E-0311P08069, P31751, P04049, Q7L523, Q96RR4, O75460, P22694, Q14643, P10415, Q96GC9, Q8TEV9IGF1R, AKT2, RAF1, RRAGA, CAMKK2, ERN1, PRKACB, ITPR1, BCL2, TMEM49, SMCR8More
Pimozidehsa04141Protein processing in endoplasmic reticulum2.01E-038P07384, O95487, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816CAPN1, SEC24B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2More
Pimozidehsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Pimozidehsa04144Endocytosis8.55E-0415Q13191, P11142, Q9H444, O43633, O75351, Q9NZZ3, P25024, P43250, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7CBLB, HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, CXCR1, GRK6, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Pimozidehsa04145Phagosome1.96E-1014P60709, P63261, Q15075, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, O60603, P35443, P13765, P25774ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSSMore
Pimozidehsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Pimozidehsa04151PI3K-Akt signaling pathway8.96E-0733P62753, P42338, P43657, P25116, O43521, P27348, P09603, P20827, P49767, Q9GZP0, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, O60603, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, O00141, Q6ZUJ8, P30281RPS6, PIK3CB, P2RY5, F2R, BCL2L11, YWHAQ, CSF1, EFNA1, VEGFC, PDGFD, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, TLR2, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, SGK, PIK3AP1, CCND3More
Pimozidehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Pimozidehsa04210Apoptosis2.75E-0511O76075, P07384, P01375, Q9NR28, O75460, Q16548, O43521, P18848, P60709, P63261, P04049DFFB, CAPN1, TNF, DIABLO, ERN1, BCL2A1, BCL2L11, ATF4, ACTB, ACTG1, RAF1More
Pimozidehsa04211Longevity regulating pathway1.34E-034Q12778, P08069, Q9UEF7, Q96KQ7FOXO1, IGF1R, KL, EHMT2More
Pimozidehsa04213Longevity regulating pathway - multiple species1.17E-025P42338, P08069, Q9Y4H2, P11142, Q13547PIK3CB, IGF1R, IRS2, HSPA8, HDAC1More
Pimozidehsa04217Necroptosis3.59E-1323P01375, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351, Q08752TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B, PPIDMore
Pimozidehsa04218Cellular senescence8.08E-035P01106, P04049, O75293, P30304, P06493MYC, RAF1, GADD45B, CDC25A, CDK1More
Pimozidehsa04260Cardiac muscle contraction4.02E-022P09493, P14927TPM1, UQCRBMore
Pimozidehsa04261Adrenergic signaling in cardiomyocytes6.52E-0914P09493, P07550, Q08828, P51828, P22694, P31751, Q99941, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Pimozidehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Pimozidehsa04330Notch signaling pathway2.46E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Pimozidehsa04340Hedgehog signaling pathway1.36E-044P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Pimozidehsa04360Axon guidance3.31E-0612P61073, P16333, P20827, O95631, P17252, Q13557, P42338, P07332, P23528, P04049, P19174, Q06124CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, PIK3CB, FES, CFL1, RAF1, PLCG1, PTPN11More
Pimozidehsa04370VEGF signaling pathway9.75E-044P16298, Q05397, Q02750, P04049PPP3CB, PTK2, MAP2K1, RAF1More
Pimozidehsa04371Apelin signaling pathway5.57E-0414P62873, P63218, P50151, Q8WYR1, P31751, P04049, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Pimozidehsa04380Osteoclast differentiation3.26E-0414Q9NQC7, Q9UQC2, Q16539, P23458, P42224, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P14598, P78324CYLD, GAB2, MAPK14, JAK1, STAT1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, NCF1, SIRPAMore
Pimozidehsa04390Hippo signaling pathway2.63E-033P60709, P63261, O15105ACTB, ACTG1, SMAD7More
Pimozidehsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Pimozidehsa04510Focal adhesion3.91E-039P16144, O75369, Q15942, P17252, Q13489, P10415, P04049, P08069, P49767ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, RAF1, IGF1R, VEGFCMore
Pimozidehsa04512ECM-receptor interaction9.21E-034Q16787, Q13751, P13612, O15335LAMA3, LAMB3, ITGA4, CHADMore
Pimozidehsa04520Adherens junction6.59E-043P08069, P60709, P63261IGF1R, ACTB, ACTG1More
Pimozidehsa04530Tight junction5.12E-068P60709, P63261, P16989, P56750, Q9Y478, Q92974, Q14247, P60660ACTB, ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTN, MYL6More
Pimozidehsa04540Gap junction5.12E-068P17252, P22694, Q13509, P68371, Q08828, P51828, P04049, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, ADCY1, ADCY7, RAF1, ITPR1More
Pimozidehsa04550Signaling pathways regulating pluripotency of stem cells3.80E-042P04049, P08069RAF1, IGF1RMore
Pimozidehsa04610Complement and coagulation cascades1.01E-041P0C0L4C4AMore
Pimozidehsa04611Platelet activation2.61E-022P60709, P63261ACTB, ACTG1More
Pimozidehsa04612Antigen processing and presentation7.40E-079P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Pimozidehsa04613Neutrophil extracellular trap formation2.91E-0926P17252, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, P63261, O43315, Q16539PRKCA, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Pimozidehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Pimozidehsa04620Toll-like receptor signaling pathway2.13E-036P51617, Q13546, P01568, P31751, P42224, Q8NHW4IRAK1, RIPK1, IFNA21, AKT2, STAT1, CCL4L2More
Pimozidehsa04621NOD-like receptor signaling pathway6.48E-0419P01584, P08238, Q16539, Q14643, P23458, P42224, P01568, Q9H3M7, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P09341, P12838IL1B, HSP90AB1, MAPK14, ITPR1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CXCL1, DEFA4More
Pimozidehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Pimozidehsa04623Cytosolic DNA-sensing pathway7.83E-043P01568, Q13546, Q8NHW4IFNA21, RIPK1, CCL4L2More
Pimozidehsa04625C-type lectin receptor signaling pathway2.72E-0410Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Pimozidehsa04630JAK-STAT signaling pathway1.77E-039P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P04049, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1, IFNA21More
Pimozidehsa04640Hematopoietic cell lineage2.61E-0617P13612, P08514, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584ITGA4, ITGA2B, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1BMore
Pimozidehsa04650Natural killer cell mediated cytotoxicity9.83E-1215P19174, P01375, P78314, P06239, O60880, P20963, P42338, P04049, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Pimozidehsa04657IL-17 signaling pathway5.40E-079O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Pimozidehsa04658Th1 and Th2 cell differentiation3.60E-0914Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Pimozidehsa04659Th17 cell differentiation1.81E-0817Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Pimozidehsa04660T cell receptor signaling pathway4.46E-1116P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Pimozidehsa04662B cell receptor signaling pathway2.60E-078P25963, P42338, P20023, P60033, P07948, P21854, Q8N149, P04049NFKBIA, PIK3CB, CR2, CD81, LYN, CD72, LILRA2, RAF1More
Pimozidehsa04664Fc epsilon RI signaling pathway3.61E-045P42338, P07948, P19174, P04049, P09917PIK3CB, LYN, PLCG1, RAF1, ALOX5More
Pimozidehsa04666Fc gamma R-mediated phagocytosis1.08E-0410P08575, P19174, P04049, P23528, P49006, P06396, O14494, Q9UQC2, P14598, P17252PTPRC, PLCG1, RAF1, CFL1, MARCKSL1, GSN, PLPP1, GAB2, NCF1, PRKCAMore
Pimozidehsa04668TNF signaling pathway3.53E-048P01375, Q99941, P18848, P19875, P01584, P14780, P20333, O95429TNF, CREBL1, ATF4, CXCL2, IL1B, MMP9, TNFRSF1B, BAG4More
Pimozidehsa04670Leukocyte transendothelial migration4.07E-022P60709, P63261ACTB, ACTG1More
Pimozidehsa04672Intestinal immune network for IgA production1.24E-043P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Pimozidehsa04713Circadian entrainment4.66E-068O15399, P0DP23, Q13557, P17252, P62873, Q14643, Q08828, P51828GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, ITPR1, ADCY1, ADCY7More
Pimozidehsa04714Thermogenesis1.62E-069Q16539, P15336, P60709, P63261, P33121, Q9Y478, Q16718, O14521, P36542MAPK14, ATF2, ACTB, ACTG1, ACSL1, PRKAB1, NDUFA5, SDHD, ATP5C1More
Pimozidehsa04720Long-term potentiation2.39E-0511P17252, Q13557, P16298, P0DP23, P51812, P18848, O15399, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, RPS6KA3, ATF4, GRIN2D, ADCY1, MAP2K1, RAF1, ITPR1More
Pimozidehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Pimozidehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Pimozidehsa04724Glutamatergic synapse3.32E-079P48058, O15399, Q08828, P51828, P17252, P62873, P63218, P50151, P15104GRIA4, GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, GLULMore
Pimozidehsa04725Cholinergic synapse3.72E-0713Q08828, P51828, P22694, Q14643, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Pimozidehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Pimozidehsa04727GABAergic synapse2.06E-058Q08828, P51828, P62873, P63218, P50151, P15104, P46459, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, GLUL, NSF, PRKCAMore
Pimozidehsa04728Dopaminergic synapse2.76E-0311Q14643, P17252, P14416, P62873, P63218, P50151, P49841, Q16539, P49407, Q13362, P0DP23ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, GSK3B, MAPK14, ARRB1, PPP2R5C, CALM1More
Pimozidehsa04730Long-term depression2.64E-034Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Pimozidehsa04740Olfactory transduction5.88E-034P62873, Q9H255, Q13557, P0DP23GNB1, OR51E2, CAMK2D, CALM1More
Pimozidehsa04742Taste transduction1.01E-021P30939HTR1FMore
Pimozidehsa04744Phototransduction6.98E-092P62873, P0DP23GNB1, CALM1More
Pimozidehsa04750Inflammatory mediator regulation of TRP channels8.91E-0916P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P17252, P24723, Q04759, P0DP23, P0DP24, P01042IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCA, PRKCH, PRKCQ, CALM1, CALM2, KNG1More
Pimozidehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Pimozidehsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Pimozidehsa04911Insulin secretion1.82E-036Q08828, P51828, P17252, Q99941, P18848, Q13557ADCY1, ADCY7, PRKCA, CREBL1, ATF4, CAMK2DMore
Pimozidehsa04912GnRH signaling pathway6.57E-0512P17252, Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1More
Pimozidehsa04913Ovarian steroidogenesis5.64E-054P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Pimozidehsa04914Progesterone-mediated oocyte maturation3.79E-0412P08069, Q17RY0, Q08828, P51828, P31751, Q13370, Q9UJX4, Q9Y6D9, P08238, P51812, Q02750, P04049IGF1R, CPEB4, ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Pimozidehsa04915Estrogen signaling pathway3.98E-0412P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P08238, P11142, P0DP23, Q15788, P10415RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2More
Pimozidehsa04916Melanogenesis1.79E-025P0DP23, Q9UJU2, P17252, P04628, P04049CALM1, LEF1, PRKCA, WNT1, RAF1More
Pimozidehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Pimozidehsa04919Thyroid hormone signaling pathway6.15E-057P49841, P04049, P22694, P60709, P63261, O60244, Q9NVC6GSK3B, RAF1, PRKACB, ACTB, ACTG1, MED14, MED17More
Pimozidehsa04920Adipocytokine signaling pathway5.67E-036Q06124, P33121, Q9Y478, Q04759, Q9Y4H2, P01375PTPN11, ACSL1, PRKAB1, PRKCQ, IRS2, TNFMore
Pimozidehsa04921Oxytocin signaling pathway1.43E-044P04049, P60660, P60709, P63261RAF1, MYL6, ACTB, ACTG1More
Pimozidehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Pimozidehsa04923Regulation of lipolysis in adipocytes2.75E-048Q08828, P51828, P07550, P06213, Q13370, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PDE3B, PIK3CB, IRS2, AKT2More
Pimozidehsa04924Renin secretion6.00E-065P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Pimozidehsa04925Aldosterone synthesis and secretion1.87E-058Q99941, P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4More
Pimozidehsa04926Relaxin signaling pathway1.17E-0410P42338, P63218, P50151, P18848, P22694, P49767, P14780, P04049, P30679, P49407PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, RAF1, GNA15, ARRB1More
Pimozidehsa04927Cortisol synthesis and secretion1.27E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Pimozidehsa04928Parathyroid hormone synthesis, secretion and action2.75E-035Q14643, P22694, P23771, P04049, P10415ITPR1, PRKACB, GATA3, RAF1, BCL2More
Pimozidehsa04929GnRH secretion3.50E-033P42338, P49407, P04049PIK3CB, ARRB1, RAF1More
Pimozidehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Pimozidehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Pimozidehsa04932Non-alcoholic fatty liver disease1.52E-0510P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, Q16718, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA5, SDHDMore
Pimozidehsa04933AGE-RAGE signaling pathway in diabetic complications1.05E-0811P84022, Q13485, P01584, P42224, P10415, P31751, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, IL1B, STAT1, BCL2, AKT2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Pimozidehsa04934Cushing syndrome5.32E-047Q14643, Q99941, P51828, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1More
Pimozidehsa04935Growth hormone synthesis, secretion and action1.77E-027P19174, Q08828, P51828, P04049, P17252, P31751, P42224PLCG1, ADCY1, ADCY7, RAF1, PRKCA, AKT2, STAT1More
Pimozidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pimozidehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Pimozidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Pimozidehsa04966Collecting duct acid secretion2.07E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Pimozidehsa04970Salivary secretion6.63E-069P07550, Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM1, CAMPMore
Pimozidehsa04971Gastric acid secretion6.13E-045P51828, P15311, P60709, P63261, Q13557ADCY7, VIL2, ACTB, ACTG1, CAMK2DMore
Pimozidehsa04972Pancreatic secretion1.41E-047Q14643, P20020, P23634, P17252, Q08828, P51828, P62491ITPR1, ATP2B1, ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Pimozidehsa04973Carbohydrate digestion and absorption4.61E-033P13866, O43451, P42338SLC5A1, MGAM, PIK3CBMore
Pimozidehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Pimozidehsa04976Bile secretion3.62E-044O43315, P22694, P08183, P13866AQP9, PRKACB, ABCB1, SLC5A1More
Pimozidehsa05010Alzheimer disease3.09E-0526Q92542, Q16718, O14521, P05496, P13073, P12074, Q14643, O15399, Q9NZJ5, O75460, P0DP23, P0DP24, Q13564, P01584, P18848, Q71U36, Q13509, P68371, O15169, P09603, P05141, P21796, P45880, Q08752, P17861, P62195NCSTN, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, GRIN2D, EIF2AK3, ERN1, CALM1, CALM2, APPBP1, IL1B, ATF4, TUBA1A, TUBB3, TUBB2C, AXIN1, CSF1, SLC25A5, VDAC1, VDAC2, PPID, XBP1, PSMC5More
Pimozidehsa05012Parkinson disease1.46E-0313Q16718, O14521, P13073, P05141, O75460, P18848, P17861, P62195, Q14643, P0DP23, P0DP24, Q13509, P68371NDUFA5, SDHD, COX4I1, SLC25A5, ERN1, ATF4, XBP1, PSMC5, ITPR1, CALM1, CALM2, TUBB3, TUBB2CMore
Pimozidehsa05014Amyotrophic lateral sclerosis1.52E-046P36542, P17861, P62195, Q53GS7, P60709, P63261ATP5C1, XBP1, PSMC5, GLE1, ACTB, ACTG1More
Pimozidehsa05016Huntington disease4.87E-025P13073, P24928, P62487, P05141, O75460COX4I1, POLR2A, POLR2G, SLC25A5, ERN1More
Pimozidehsa05017Spinocerebellar ataxia7.02E-0513P17252, Q92915, O75460, Q8TB72, O15399, P42338, P31751, P17861, P28070, P43686, P62195, O00232, P21796PRKCA, FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, XBP1, PSMB4, PSMC4, PSMC5, PSMD12, VDAC1More
Pimozidehsa05020Prion disease9.54E-0618P01584, P46531, P11142, Q16718, O14521, P05496, P12074, Q92736, Q14643, P45880, O60282, Q13509, P68371, P49841, Q99941, P14598, Q15080, Q16539IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, RYR2, ITPR1, VDAC2, KIF5C, TUBB3, TUBB2C, GSK3B, CREBL1, NCF1, NCF4, MAPK14More
Pimozidehsa05022Pathways of neurodegeneration - multiple diseases4.04E-0623Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, P13073, Q06055, O75460, P18848, P17861, Q13561, P05141, P17252, P20333, Q16539, P01584, Q08752, O15020, P0DP23, P0DP24, P62195ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, COX4I1, ATP5G2, ERN1, ATF4, XBP1, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, IL1B, PPID, SPTBN2, CALM1, CALM2, PSMC5More
Pimozidehsa05031Amphetamine addiction3.62E-037O15399, P0DP23, Q13557, P22694, P18848, P17252, Q13547GRIN2D, CALM1, CAMK2D, PRKACB, ATF4, PRKCA, HDAC1More
Pimozidehsa05032Morphine addiction1.94E-039Q08828, P51828, P62873, P63218, P50151, Q13370, Q07343, P17252, P43250ADCY1, ADCY7, GNB1, GNG5, GNG10, PDE3B, PDE4B, PRKCA, GRK6More
Pimozidehsa05034Alcoholism4.61E-055P04049, Q93077, P62807, O60814, P68431RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pimozidehsa05100Bacterial invasion of epithelial cells1.72E-035Q14141, P60709, P63261, Q05397, Q96JJ3SEPT6, ACTB, ACTG1, PTK2, ELMO2More
Pimozidehsa05110Vibrio cholerae infection2.30E-056Q13488, Q99437, P17252, P19174, P60709, P63261TCIRG1, ATP6V0B, PRKCA, PLCG1, ACTB, ACTG1More
Pimozidehsa05120Epithelial cell signaling in Helicobacter pylori infection1.84E-057Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Pimozidehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Pimozidehsa05131Shigellosis3.00E-0416P68431, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q14247, Q96JJ3, P60709, P63261, Q05397, Q14643, Q12778, P07384, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, RRAGD, UBB, SEPT6, CTTN, ELMO2, ACTB, ACTG1, PTK2, ITPR1, FOXO1, CAPN1, ATM, BCL2, PPIDMore
Pimozidehsa05132Salmonella infection4.36E-0921P51617, P01584, P08238, P04049, Q9UJU2, P63261, Q96RF0, O00471, Q13546, Q13489, P10415, P08575, O75369, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, HSP90AB1, RAF1, LEF1, ACTG1, SNAG1, EXOC5, RIPK1, BIRC3, BCL2, PTPRC, FLNB, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C, VPS41, RAB9BMore
Pimozidehsa05133Pertussis6.00E-056P0DP23, P01584, P23528, P09871, P0C0L4, P51617CALM1, IL1B, CFL1, C1S, C4A, IRAK1More
Pimozidehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Pimozidehsa05135Yersinia infection5.31E-038P60709, P63261, Q16513, P13612, P06239, Q16539, P01375, P49841ACTB, ACTG1, PKN2, ITGA4, LCK, MAPK14, TNF, GSK3BMore
Pimozidehsa05140Leishmaniasis1.83E-1014P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4More
Pimozidehsa05143African trypanosomiasis1.93E-047P01375, P01584, P69905, P68871, P48023, P17252, P01042TNF, IL1B, HBA2, HBB, FASLG, PRKCA, KNG1More
Pimozidehsa05144Malaria8.07E-088P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Pimozidehsa05145Toxoplasmosis2.35E-0611P51617, P10415, Q13489, P23458, P42224, P13765, P31751, P11142, O60603, P29965, Q13651IRAK1, BCL2, BIRC3, JAK1, STAT1, HLA-DOB, AKT2, HSPA8, TLR2, CD40LG, IL10RAMore
Pimozidehsa05146Amoebiasis1.05E-0814P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Pimozidehsa05150Staphylococcus aureus infection1.91E-024Q14532, P59665, P59666, P49913KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Pimozidehsa05152Tuberculosis3.00E-0513P04049, Q13488, Q99437, P0DP23, P42224, P48382, O60603, P10415, P13765, P25774, P01568, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, CALM1, STAT1, RFX5, TLR2, BCL2, HLA-DOB, CTSS, IFNA21, MALT1, IRAK1More
Pimozidehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Pimozidehsa05161Hepatitis B2.85E-0511P17252, P04049, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, RAF1, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Pimozidehsa05162Measles1.74E-0410P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2More
Pimozidehsa05163Human cytomegalovirus infection3.46E-0525P31751, P04049, P01375, P62873, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P61769, P01568AKT2, RAF1, TNF, GNB1, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, B2M, IFNA21More
Pimozidehsa05164Influenza A8.97E-044P48551, P04049, P60709, P63261IFNAR2, RAF1, ACTB, ACTG1More
Pimozidehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Pimozidehsa05167Kaposi sarcoma-associated herpesvirus infection1.48E-027P01568, P42224, P62873, Q14643, P04049, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, RAF1, CALM1, LEF1More
Pimozidehsa05168Herpes simplex virus 1 infection4.23E-0624P25963, P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q9Y2A4, Q13398, P51522, Q6P280, P17038, Q03923, P52738, O75820, Q9UDV6, P10415, Q14232NFKBIA, IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF443, ZNF211, ZNF83, ZNF529, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2, EIF2B1More
Pimozidehsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Pimozidehsa05170Human immunodeficiency virus 1 infection8.22E-1022P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, P61073, Q05397, P17252, O00463, P61769, Q14643, P01568, P51617, O60603, Q13315, P19174, P23528, P10415, Q93034, Q9Y6Q5AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, CXCR4, PTK2, PRKCA, TRAF5, B2M, ITPR1, IFNA21, IRAK1, TLR2, ATM, PLCG1, CFL1, BCL2, CUL5, AP1M2More
Pimozidehsa05200Pathways in cancer5.45E-1141Q13751, P42338, P23458, P08238, P42224, P19174, Q15311, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P31751, P43657, P25116, Q08828, P51828, P62873, P63218, P50151, Q14344, Q7LDG7, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042LAMB3, PIK3CB, JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, AKT2, P2RY5, F2R, ADCY1, ADCY7, GNB1, GNG5, GNG10, GNA13, RASGRP2, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Pimozidehsa05202Transcriptional misregulation in cancer1.79E-0924Q12778, Q15532, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Pimozidehsa05203Viral carcinogenesis2.93E-033Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Pimozidehsa05204Chemical carcinogenesis2.59E-044P00325, P78417, P11712, P33260ADH1B, GSTO1, CYP2C9, CYP2C18More
Pimozidehsa05205Proteoglycans in cancer2.34E-0517Q13009, Q12955, Q14643, O75369, P63261, P04049, P04637, P14780, P17252, O60603, P01375, P08069, P23588, P04628, Q13635, P22694, P08962TIAM1, ANK3, ITPR1, FLNB, ACTG1, RAF1, TP53, MMP9, PRKCA, TLR2, TNF, IGF1R, EIF4B, WNT1, PTCH1, PRKACB, CD63More
Pimozidehsa05206MicroRNAs in cancer7.37E-057P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Pimozidehsa05210Colorectal cancer1.66E-021P04049RAF1More
Pimozidehsa05211Renal cell carcinoma1.43E-033Q06124, Q99814, P04049PTPN11, EPAS1, RAF1More
Pimozidehsa05212Pancreatic cancer1.50E-049P42338, P31751, P04049, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Pimozidehsa05213Endometrial cancer9.95E-031P04049RAF1More
Pimozidehsa05214Glioma7.94E-078P08069, P0DP23, Q13557, P17252, P04049, P31751, P19174, O75293IGF1R, CALM1, CAMK2D, PRKCA, RAF1, AKT2, PLCG1, GADD45BMore
Pimozidehsa05215Prostate cancer1.65E-042P08069, P04049IGF1R, RAF1More
Pimozidehsa05216Thyroid cancer3.35E-035P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Pimozidehsa05217Basal cell carcinoma1.39E-035Q13635, P49841, Q9UJU2, P04637, P24522PTCH1, GSK3B, LEF1, TP53, GADD45AMore
Pimozidehsa05218Melanoma3.85E-052P08069, P04049IGF1R, RAF1More
Pimozidehsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Pimozidehsa05220Chronic myeloid leukemia3.00E-036Q13547, Q13485, P84022, P42338, P04049, O75293HDAC1, SMAD4, SMAD3, PIK3CB, RAF1, GADD45BMore
Pimozidehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Pimozidehsa05222Small cell lung cancer4.78E-021Q16787LAMA3More
Pimozidehsa05223Non-small cell lung cancer1.52E-047P17252, O43524, P19174, P10826, P04049, Q9HC35, O75293PRKCA, FOXO3, PLCG1, RARB, RAF1, EML4, GADD45BMore
Pimozidehsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Pimozidehsa05225Hepatocellular carcinoma1.50E-044P04049, P08069, P60709, P63261RAF1, IGF1R, ACTB, ACTG1More
Pimozidehsa05226Gastric cancer8.29E-031P04049RAF1More
Pimozidehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Pimozidehsa05231Choline metabolism in cancer8.00E-047P04049, Q9Y259, P19174, P23743, P49619, O14494, P17252RAF1, CHKB, PLCG1, DGKA, DGKG, PLPP1, PRKCAMore
Pimozidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.39E-0614P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Pimozidehsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Pimozidehsa05320Autoimmune thyroid disease2.92E-054P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Pimozidehsa05321Inflammatory bowel disease1.06E-077O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Pimozidehsa05322Systemic lupus erythematosus4.90E-0710P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pimozidehsa05323Rheumatoid arthritis1.22E-035P13765, Q13488, P10747, P09341, O60603HLA-DOB, TCIRG1, CD28, CXCL1, TLR2More
Pimozidehsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Pimozidehsa05332Graft-versus-host disease1.15E-055P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Pimozidehsa05340Primary immunodeficiency8.85E-054P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Pimozidehsa05410Hypertrophic cardiomyopathy1.18E-034P26012, P09493, P60709, P63261ITGB8, TPM1, ACTB, ACTG1More
Pimozidehsa05412Arrhythmogenic right ventricular cardiomyopathy1.58E-045P54284, P15924, P26012, P60709, P63261CACNB3, DSP, ITGB8, ACTB, ACTG1More
Pimozidehsa05414Dilated cardiomyopathy1.73E-022P60709, P63261ACTB, ACTG1More
Pimozidehsa05415Diabetic cardiomyopathy2.36E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Pimozidehsa05416Viral myocarditis2.25E-035P13765, P29965, P10747, P60709, P63261HLA-DOB, CD40LG, CD28, ACTB, ACTG1More
Pimozidehsa05418Fluid shear stress and atherosclerosis8.97E-0615Q16539, P14598, P78417, P10599, P14780, P01375, P60709, P63261, P04637, P10415, P14778, P27930, P0DP23, P08238, Q92974MAPK14, NCF1, GSTO1, TXN, MMP9, TNF, ACTB, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, HSP90AB1, ARHGEF2More

Community members of Pimozide (SDC: 9.76)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P0DP23CALM1CalmodulinNone1Reported00.45520.147911.5235
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
P17861XBP1XNoneboxNonebinding protein 1Predicted00.29140.06510.46080.7367
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
P40306PSMB10Proteasome subunit beta typeNone10Predicted00.26880.0510.01830.2548
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
Q99527GPER1GNoneprotein coupled estrogen receptor 1Predicted00.02490.12940.21380.485
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
O75381PEX14Peroxisomal membrane protein PEX14Predicted00.19070.09950.10970.4039
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P60660MYL6Myosin light polypeptide 6Predicted00.55950.06870.21750.6346
P24844MYL9Myosin regulatory light polypeptide 9Predicted00.00640.0630.60260.7318
P14649MYL6BMyosin light chain 6BPredicted00.04770.06530.21750.3719
P05976MYL1Myosin light chain 1/3, skeletal muscle isoformPredicted00.25810.061900.2528
O15182CETN3CentrinNone3Predicted00.18720.059400.2123
Q96A32MYLPFMyosin regulatory light chain 2, skeletal muscle isoformPredicted00.01350.04730.54120.6425
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416Ki0.39
DRD2P14416Ki0.5
DRD2P14416Ki0.6