PharmaCoNets of Umeclidinium (SPCN: 19.92 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Umeclidiniumhsa00040Pentose and glucuronate interconversions3.01E-021P15121AKR1B1More
Umeclidiniumhsa00190Oxidative phosphorylation8.33E-044Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Umeclidiniumhsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Umeclidiniumhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Umeclidiniumhsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Umeclidiniumhsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Umeclidiniumhsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Umeclidiniumhsa00790Folate biosynthesis3.01E-021P15121AKR1B1More
Umeclidiniumhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Umeclidiniumhsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Umeclidiniumhsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Umeclidiniumhsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Umeclidiniumhsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Umeclidiniumhsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Umeclidiniumhsa03050Proteasome1.21E-021P28074PSMB5More
Umeclidiniumhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Umeclidiniumhsa04064NF-kappa B signaling pathway2.35E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Umeclidiniumhsa04130SNARE interactions in vesicular transport1.52E-021P23763VAMP1More
Umeclidiniumhsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Umeclidiniumhsa04142Lysosome2.45E-039Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Umeclidiniumhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Umeclidiniumhsa04145Phagosome2.07E-028P60709, Q15075, Q15080, P14598, Q13509, Q13488, Q99437, P25774ACTB, EEA1, NCF4, NCF1, TUBB3, TCIRG1, ATP6V0B, CTSSMore
Umeclidiniumhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Umeclidiniumhsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Umeclidiniumhsa04217Necroptosis3.73E-022P42229, Q9BTM1STAT5A, H2AFJMore
Umeclidiniumhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Umeclidiniumhsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Umeclidiniumhsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Umeclidiniumhsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Umeclidiniumhsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Umeclidiniumhsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Umeclidiniumhsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Umeclidiniumhsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Umeclidiniumhsa04932Non-alcoholic fatty liver disease1.39E-026O43521, O75460, P01584, P13073, P12074, O95298BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2More
Umeclidiniumhsa04970Salivary secretion4.78E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Umeclidiniumhsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Umeclidiniumhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Umeclidiniumhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Umeclidiniumhsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Umeclidiniumhsa05110Vibrio cholerae infection6.26E-045Q13488, Q99437, P17252, P19174, P60709TCIRG1, ATP6V0B, PRKCA, PLCG1, ACTBMore
Umeclidiniumhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Umeclidiniumhsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Umeclidiniumhsa05140Leishmaniasis4.75E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Umeclidiniumhsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Umeclidiniumhsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Umeclidiniumhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Umeclidiniumhsa05163Human cytomegalovirus infection3.31E-027P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RAMore
Umeclidiniumhsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Umeclidiniumhsa05223Non-small cell lung cancer3.99E-024P17252, O43524, P19174, O75293PRKCA, FOXO3, PLCG1, GADD45BMore
Umeclidiniumhsa05231Choline metabolism in cancer3.99E-024P19174, P23743, O14494, P17252PLCG1, DGKA, PLPP1, PRKCAMore
Umeclidiniumhsa05415Diabetic cardiomyopathy3.94E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Umeclidinium (SDC: 3.72)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P42229STAT5ASignal transducer and activator of transcription 5APredicted10.21190.01190.78460.9144
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)