PharmaCoNets of Udenafil (SPCN: 96.42 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Udenafilhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Udenafilhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Udenafilhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Udenafilhsa00500Starch and sucrose metabolism1.91E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Udenafilhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Udenafilhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Udenafilhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Udenafilhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Udenafilhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Udenafilhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Udenafilhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Udenafilhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Udenafilhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Udenafilhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Udenafilhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Udenafilhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Udenafilhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Udenafilhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Udenafilhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Udenafilhsa01524Platinum drug resistance4.94E-022P78417, P52701GSTO1, MSH6More
Udenafilhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Udenafilhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Udenafilhsa03013RNA transport1.21E-0718O14980, P52298, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, EIF4B, TACC3More
Udenafilhsa03040Spliceosome4.52E-039Q14562, O60508, P08579, Q15427, P38159, P61978, Q01130, P11142, O43447DHX8, CDC40, SNRPB2, SF3B4, RBMX, HNRPK, SFRS2, HSPA8, PPIHMore
Udenafilhsa03050Proteasome4.83E-021P55036PSMD4More
Udenafilhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Udenafilhsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Udenafilhsa04020Calcium signaling pathway2.18E-058Q96DU7, P21796, P45880, Q13557, P21860, P30679, P51828, P23634ITPKC, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, ADCY7, ATP2B4More
Udenafilhsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Udenafilhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Udenafilhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Udenafilhsa04064NF-kappa B signaling pathway1.90E-0312O00463, P14778, P19174, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, P19875, Q06643TRAF5, IL1R1, PLCG1, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTBMore
Udenafilhsa04071Sphingolipid signaling pathway1.87E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Udenafilhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Udenafilhsa04114Oocyte meiosis2.05E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Udenafilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Udenafilhsa04130SNARE interactions in vesicular transport1.27E-021O15155BET1More
Udenafilhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Udenafilhsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Udenafilhsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Udenafilhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Udenafilhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Udenafilhsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Udenafilhsa04310Wnt signaling pathway5.60E-033P30279, Q13485, O43318CCND2, SMAD4, MAP3K7More
Udenafilhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Udenafilhsa04370VEGF signaling pathway1.29E-023P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Udenafilhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Udenafilhsa04520Adherens junction3.91E-022Q13485, O43318SMAD4, MAP3K7More
Udenafilhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Udenafilhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Udenafilhsa04613Neutrophil extracellular trap formation6.68E-0417O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Udenafilhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Udenafilhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Udenafilhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Udenafilhsa04657IL-17 signaling pathway3.26E-048O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNFMore
Udenafilhsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Udenafilhsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Udenafilhsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Udenafilhsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Udenafilhsa04664Fc epsilon RI signaling pathway2.20E-036P01375, Q16539, P42338, Q9UQC2, P07948, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5More
Udenafilhsa04668TNF signaling pathway2.47E-038P01375, O00463, Q16539, Q99941, P01584, P20749, P14780, O95429TNF, TRAF5, MAPK14, CREBL1, IL1B, BCL3, MMP9, BAG4More
Udenafilhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Udenafilhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Udenafilhsa04725Cholinergic synapse4.10E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Udenafilhsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Udenafilhsa04750Inflammatory mediator regulation of TRP channels7.62E-048P14778, P01584, P51828, Q13557, P19174, P42338, P24723, Q04759IL1R1, IL1B, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQMore
Udenafilhsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Udenafilhsa04914Progesterone-mediated oocyte maturation2.66E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Udenafilhsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Udenafilhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Udenafilhsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Udenafilhsa04926Relaxin signaling pathway8.02E-046P42338, P63218, P50151, P49767, P30679, P49407PIK3CB, GNG5, GNG10, VEGFC, GNA15, ARRB1More
Udenafilhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Udenafilhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Udenafilhsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Udenafilhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Udenafilhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Udenafilhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Udenafilhsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Udenafilhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Udenafilhsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Udenafilhsa05017Spinocerebellar ataxia2.16E-022Q8TB72, P21796PUM2, VDAC1More
Udenafilhsa05020Prion disease1.81E-027P01584, P46531, P11142, P05496, P12074, P45880, Q99941IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1More
Udenafilhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Udenafilhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Udenafilhsa05133Pertussis4.20E-021P0C0L4C4AMore
Udenafilhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Udenafilhsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Udenafilhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Udenafilhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Udenafilhsa05146Amoebiasis5.70E-059P09341, P19875, P14778, P27930, O60603, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, TLR2, PIK3CB, ITGAM, ARG1, ACTN1More
Udenafilhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Udenafilhsa05163Human cytomegalovirus infection3.04E-038P01375, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463TNF, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Udenafilhsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Udenafilhsa05200Pathways in cancer1.44E-025Q13485, P52701, P30279, P63218, P78417SMAD4, MSH6, CCND2, GNG5, GSTO1More
Udenafilhsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Udenafilhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Udenafilhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Udenafilhsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Udenafilhsa05210Colorectal cancer4.94E-022Q13485, P52701SMAD4, MSH6More
Udenafilhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Udenafilhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Udenafilhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.15E-0311P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4More
Udenafilhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Udenafilhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Udenafilhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Udenafilhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Udenafilhsa05418Fluid shear stress and atherosclerosis1.26E-048Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Udenafil (SDC: 7.13)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q86W56PARGPoly(ADPNoneribose) glycohydrolasePredicted00.03580.044100.106
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)