PharmaCoNets of Tucatinib (SPCN: 264.83 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tucatinibhsa00030Pentose phosphate pathway2.25E-033P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Tucatinibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Tucatinibhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Tucatinibhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Tucatinibhsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Tucatinibhsa00230Purine metabolism4.93E-021P21589NT5EMore
Tucatinibhsa00240Pyrimidine metabolism1.81E-021P21589NT5EMore
Tucatinibhsa00250Alanine, aspartate and glutamate metabolism8.48E-032Q96RQ9, P15104IL4I1, GLULMore
Tucatinibhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Tucatinibhsa00280Valine, leucine and isoleucine degradation8.48E-032Q96RQ9, P05166IL4I1, PCCBMore
Tucatinibhsa00310Lysine degradation2.71E-034Q9NVH6, Q96KQ7, O15047, P51648TMLHE, EHMT2, SETD1A, ALDH3A2More
Tucatinibhsa00500Starch and sucrose metabolism3.06E-054O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Tucatinibhsa00520Amino sugar and nucleotide sugar metabolism1.04E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Tucatinibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Tucatinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Tucatinibhsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Tucatinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Tucatinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Tucatinibhsa00630Glyoxylate and dicarboxylate metabolism1.62E-054P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Tucatinibhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Tucatinibhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Tucatinibhsa00760Nicotinate and nicotinamide metabolism9.09E-031P21589NT5EMore
Tucatinibhsa00770Pantothenate and CoA biosynthesis1.94E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Tucatinibhsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Tucatinibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Tucatinibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Tucatinibhsa00983Drug metabolism - other enzymes3.32E-023P04183, P32320, P05164TK1, CDA, MPOMore
Tucatinibhsa01100Metabolic pathways3.18E-0340Q9NR34, P05089, Q9UJ14, P15104, Q96DU7, P32320, Q08828, Q02153, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q86XP1, Q96RQ9, Q9HCC0, P33121, Q9UHK6, P57054, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, P05166, P12074, P05496, O15239, O15047, Q9NVH6MAN1C1, ARG1, GGTL3, GLUL, ITPKC, CDA, ADCY1, GUCY1B3, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKH, IL4I1, MCCC2, ACSL1, AMACR, PIGP, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, PCCB, COX6A1, ATP5G1, NDUFA1, SETD1A, TMLHEMore
Tucatinibhsa01230Biosynthesis of amino acids3.21E-024P51854, P60891, P05089, P37837TKTL1, PRPS1, ARG1, TALDO1More
Tucatinibhsa01240Biosynthesis of cofactors2.05E-022P36551, O60701CPOX, UGDHMore
Tucatinibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Tucatinibhsa01522Endocrine resistance4.47E-042P04049, P08069RAF1, IGF1RMore
Tucatinibhsa01523Antifolate resistance1.88E-034P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Tucatinibhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Tucatinibhsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Tucatinibhsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Tucatinibhsa03022Basal transcription factors2.68E-043O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Tucatinibhsa03040Spliceosome7.72E-0613O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1More
Tucatinibhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Tucatinibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Tucatinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Tucatinibhsa03460Fanconi anemia pathway2.71E-021O94782USP1More
Tucatinibhsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Tucatinibhsa04012ErbB signaling pathway6.63E-034P16333, P19174, P01106, P04049NCK1, PLCG1, MYC, RAF1More
Tucatinibhsa04014Ras signaling pathway2.30E-054P04049, P31751, P08069, P0DP23RAF1, AKT2, IGF1R, CALM1More
Tucatinibhsa04015Rap1 signaling pathway3.20E-076P04049, P08069, P06213, O00522, P31751, P0DP23RAF1, IGF1R, INSR, KRIT1, AKT2, CALM1More
Tucatinibhsa04022cGMP-PKG signaling pathway2.62E-043P04049, P31751, P0DP23RAF1, AKT2, CALM1More
Tucatinibhsa04024cAMP signaling pathway1.30E-043P31751, P0DP23, P04049AKT2, CALM1, RAF1More
Tucatinibhsa04060Cytokine-cytokine receptor interaction8.46E-0414P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, P78552, P25024, Q9UBD3, P47992, P09341, P80075, P01730IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CCL8, CD4More
Tucatinibhsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Tucatinibhsa04062Chemokine signaling pathway2.83E-0310P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881, P04049CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITK, RAF1More
Tucatinibhsa04064NF-kappa B signaling pathway9.72E-0616O00463, P14778, P01584, P01375, Q04759, Q13077, Q16548, P07948, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7TRAF5, IL1R1, IL1B, TNF, PRKCQ, TRAF1, BCL2A1, LYN, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLDMore
Tucatinibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Tucatinibhsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Tucatinibhsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Tucatinibhsa04071Sphingolipid signaling pathway2.16E-021P04049RAF1More
Tucatinibhsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Tucatinibhsa04110Cell cycle8.83E-058Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYCMore
Tucatinibhsa04114Oocyte meiosis1.45E-046Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Tucatinibhsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Tucatinibhsa04140Autophagy - animal7.72E-042P08069, P04049IGF1R, RAF1More
Tucatinibhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Tucatinibhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Tucatinibhsa04144Endocytosis1.13E-0314Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5More
Tucatinibhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Tucatinibhsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Tucatinibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Tucatinibhsa04210Apoptosis2.16E-021P04049RAF1More
Tucatinibhsa04211Longevity regulating pathway5.33E-034P08069, P51828, Q99941, P18848IGF1R, ADCY7, CREBL1, ATF4More
Tucatinibhsa04213Longevity regulating pathway - multiple species8.54E-034P08069, Q08828, P51828, P0DMV8IGF1R, ADCY1, ADCY7, HSPA1AMore
Tucatinibhsa04217Necroptosis7.34E-035P01568, Q13546, P07384, Q6FI13, P10415IFNA21, RIPK1, CAPN1, H2AC18; H2AC19, BCL2More
Tucatinibhsa04218Cellular senescence1.43E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Tucatinibhsa04261Adrenergic signaling in cardiomyocytes6.22E-046P51828, P31751, Q99941, P18848, P0DP23, Q13557ADCY7, AKT2, CREBL1, ATF4, CALM1, CAMK2DMore
Tucatinibhsa04270Vascular smooth muscle contraction2.27E-037P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Tucatinibhsa04330Notch signaling pathway6.65E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Tucatinibhsa04360Axon guidance2.49E-021P04049RAF1More
Tucatinibhsa04370VEGF signaling pathway1.94E-065P16298, P31751, Q05397, Q02750, P04049PPP3CB, AKT2, PTK2, MAP2K1, RAF1More
Tucatinibhsa04371Apelin signaling pathway1.43E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Tucatinibhsa04380Osteoclast differentiation2.72E-048Q9NQC7, Q9UQC2, Q16539, P31751, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, AKT2, IL1R1, FCGR3B, TNF, LILRA2More
Tucatinibhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Tucatinibhsa04510Focal adhesion1.18E-032P04049, P08069RAF1, IGF1RMore
Tucatinibhsa04520Adherens junction8.29E-031P08069IGF1RMore
Tucatinibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Tucatinibhsa04540Gap junction1.33E-021P04049RAF1More
Tucatinibhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Tucatinibhsa04610Complement and coagulation cascades1.14E-052P00734, P0C0L4F2, C4AMore
Tucatinibhsa04612Antigen processing and presentation2.28E-049P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Tucatinibhsa04613Neutrophil extracellular trap formation2.09E-048P04049, P04908, Q93077, P62807, O60814, P68431, O43315, Q16539RAF1, H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Tucatinibhsa04620Toll-like receptor signaling pathway4.78E-021P31751AKT2More
Tucatinibhsa04621NOD-like receptor signaling pathway2.32E-0313Q14643, P10599, Q9H1Y0, P43490, O00463, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838ITPR1, TXN, ATG5, PBEF1, TRAF5, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Tucatinibhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Tucatinibhsa04623Cytosolic DNA-sensing pathway2.02E-044P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Tucatinibhsa04625C-type lectin receptor signaling pathway2.59E-058Q9ULY5, P04049, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Tucatinibhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Tucatinibhsa04640Hematopoietic cell lineage5.73E-0612P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Tucatinibhsa04650Natural killer cell mediated cytotoxicity2.24E-0814P16298, P50591, P01375, P06239, O60880, P20963, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Tucatinibhsa04657IL-17 signaling pathway1.88E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Tucatinibhsa04658Th1 and Th2 cell differentiation3.99E-1112Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Tucatinibhsa04659Th17 cell differentiation3.12E-1014Q04759, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Tucatinibhsa04660T cell receptor signaling pathway4.93E-0812P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1More
Tucatinibhsa04662B cell receptor signaling pathway8.03E-046P31751, P42338, P60033, P07948, Q8N149, P04049AKT2, PIK3CB, CD81, LYN, LILRA2, RAF1More
Tucatinibhsa04664Fc epsilon RI signaling pathway1.50E-035P01375, P31751, Q16539, Q9UQC2, P04049TNF, AKT2, MAPK14, GAB2, RAF1More
Tucatinibhsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Tucatinibhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Tucatinibhsa04713Circadian entrainment9.20E-034Q13557, Q02153, P61952, Q08828CAMK2D, GUCY1B3, GNG11, ADCY1More
Tucatinibhsa04714Thermogenesis6.01E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Tucatinibhsa04720Long-term potentiation4.88E-034P16298, P51812, Q02750, P04049PPP3CB, RPS6KA3, MAP2K1, RAF1More
Tucatinibhsa04722Neurotrophin signaling pathway2.58E-065Q05655, P31751, P04049, P52566, P0DP23PRKCD, AKT2, RAF1, ARHGDIB, CALM1More
Tucatinibhsa04724Glutamatergic synapse2.22E-024O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Tucatinibhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Tucatinibhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Tucatinibhsa04727GABAergic synapse1.62E-036Q08828, P63218, P50151, P61952, P15104, Q15111ADCY1, GNG5, GNG10, GNG11, GLUL, PLCL1More
Tucatinibhsa04728Dopaminergic synapse1.96E-035P31751, Q99941, P18848, Q13557, P0DP23AKT2, CREBL1, ATF4, CAMK2D, CALM1More
Tucatinibhsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Tucatinibhsa04740Olfactory transduction2.41E-021P0DP23CALM1More
Tucatinibhsa04744Phototransduction1.81E-021P0DP23CALM1More
Tucatinibhsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Tucatinibhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Tucatinibhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Tucatinibhsa04911Insulin secretion5.41E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Tucatinibhsa04912GnRH signaling pathway3.36E-034P51828, P18848, Q13557, P04049ADCY7, ATF4, CAMK2D, RAF1More
Tucatinibhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Tucatinibhsa04914Progesterone-mediated oocyte maturation5.28E-056P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Tucatinibhsa04915Estrogen signaling pathway1.26E-0511P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Tucatinibhsa04916Melanogenesis1.47E-032P0DP23, P04049CALM1, RAF1More
Tucatinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Tucatinibhsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Tucatinibhsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Tucatinibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Tucatinibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Tucatinibhsa04922Glucagon signaling pathway1.79E-032P31751, P0DP23AKT2, CALM1More
Tucatinibhsa04923Regulation of lipolysis in adipocytes1.84E-032P06213, P31751INSR, AKT2More
Tucatinibhsa04924Renin secretion3.01E-021P0DP23CALM1More
Tucatinibhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Tucatinibhsa04926Relaxin signaling pathway7.01E-034Q99941, P18848, P51828, P04049CREBL1, ATF4, ADCY7, RAF1More
Tucatinibhsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Tucatinibhsa04928Parathyroid hormone synthesis, secretion and action3.95E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Tucatinibhsa04929GnRH secretion1.87E-042P31751, P04049AKT2, RAF1More
Tucatinibhsa04930Type II diabetes mellitus1.48E-032P06213, Q05655INSR, PRKCDMore
Tucatinibhsa04932Non-alcoholic fatty liver disease9.65E-049P49841, O43521, O75460, P01584, P13073, P12074, Q16718, O95298, O14521GSK3B, BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Tucatinibhsa04934Cushing syndrome3.32E-056Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Tucatinibhsa04935Growth hormone synthesis, secretion and action5.33E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Tucatinibhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Tucatinibhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Tucatinibhsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Tucatinibhsa04970Salivary secretion1.11E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Tucatinibhsa04971Gastric acid secretion4.78E-021P0DP23CALM1More
Tucatinibhsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Tucatinibhsa04976Bile secretion3.14E-035O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Tucatinibhsa05010Alzheimer disease9.96E-0411P49768, Q92542, O15239, P05496, P12074, Q00535, P0DP23, Q12933, O15169, P31751, P43686PSEN1, NCSTN, NDUFA1, ATP5G1, COX6A1, CDK5, CALM1, TRAF2, AXIN1, AKT2, PSMC4More
Tucatinibhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Tucatinibhsa05017Spinocerebellar ataxia2.22E-024Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Tucatinibhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Tucatinibhsa05022Pathways of neurodegeneration - multiple diseases1.30E-0519P49841, O15239, Q16718, O14521, P12074, P05496, Q06055, Q12933, Q13561, Q16539, Q00535, O15169, P49768, Q08752, O15020, P0DP23, Q13557, P62987, P43686GSK3B, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G1, ATP5G2, TRAF2, DCTN2, MAPK14, CDK5, AXIN1, PSEN1, PPID, SPTBN2, CALM1, CAMK2D, UBA52, PSMC4More
Tucatinibhsa05030Cocaine addiction6.96E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Tucatinibhsa05031Amphetamine addiction9.24E-044P0DP23, Q13557, Q99941, P18848CALM1, CAMK2D, CREBL1, ATF4More
Tucatinibhsa05034Alcoholism2.78E-045P04049, Q93077, P62807, O60814, P68431RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tucatinibhsa05100Bacterial invasion of epithelial cells2.85E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Tucatinibhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Tucatinibhsa05131Shigellosis2.57E-022Q05655, P07737PRKCD, PFN1More
Tucatinibhsa05132Salmonella infection4.80E-033P04049, P84095, P07737RAF1, RHOG, PFN1More
Tucatinibhsa05133Pertussis2.35E-032P0DP23, P0C0L4CALM1, C4AMore
Tucatinibhsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Tucatinibhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Tucatinibhsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Tucatinibhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Tucatinibhsa05144Malaria3.12E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Tucatinibhsa05146Amoebiasis1.74E-059P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Tucatinibhsa05150Staphylococcus aureus infection1.48E-049P0C0L4, P21730, P21462, O75015, P13646, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, KRT13, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Tucatinibhsa05152Tuberculosis6.23E-043P04049, P0DP23, P31751RAF1, CALM1, AKT2More
Tucatinibhsa05160Hepatitis C4.55E-035P52630, P60033, Q9NZJ5, P04049, P49841STAT2, CD81, EIF2AK3, RAF1, GSK3BMore
Tucatinibhsa05161Hepatitis B5.33E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Tucatinibhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Tucatinibhsa05163Human cytomegalovirus infection1.11E-0417P31751, P04049, P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463AKT2, RAF1, TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5More
Tucatinibhsa05164Influenza A3.65E-021P04049RAF1More
Tucatinibhsa05167Kaposi sarcoma-associated herpesvirus infection2.62E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Tucatinibhsa05169Epstein-Barr virus infection5.59E-0412P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P01375, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, TNF, OAS2, CD3E, CD3G, CD247More
Tucatinibhsa05170Human immunodeficiency virus 1 infection3.77E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Tucatinibhsa05200Pathways in cancer3.07E-022P31751, P0DP23AKT2, CALM1More
Tucatinibhsa05202Transcriptional misregulation in cancer3.47E-0311P14780, P27930, Q15744, Q16548, P08069, P05164, P12838, P08246, Q9C0K0, Q13547, P24522MMP9, IL1R2, CEBPE, BCL2A1, IGF1R, MPO, DEFA4, ELA2, BCL11B, HDAC1, GADD45AMore
Tucatinibhsa05203Viral carcinogenesis2.63E-037Q99941, P18848, P27348, Q15283, P61978, P62807, O60814CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12More
Tucatinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Tucatinibhsa05205Proteoglycans in cancer1.18E-032P04049, P08069RAF1, IGF1RMore
Tucatinibhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Tucatinibhsa05210Colorectal cancer2.55E-033Q9UKG1, P04049, P37173APPL1, RAF1, TGFBR2More
Tucatinibhsa05211Renal cell carcinoma1.29E-032P31751, P04049AKT2, RAF1More
Tucatinibhsa05212Pancreatic cancer1.29E-032P31751, P04049AKT2, RAF1More
Tucatinibhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Tucatinibhsa05214Glioma1.14E-074P08069, P0DP23, P04049, P31751IGF1R, CALM1, RAF1, AKT2More
Tucatinibhsa05215Prostate cancer1.65E-042P08069, P04049IGF1R, RAF1More
Tucatinibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Tucatinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Tucatinibhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Tucatinibhsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Tucatinibhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Tucatinibhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Tucatinibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Tucatinibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Tucatinibhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Tucatinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Tucatinibhsa05231Choline metabolism in cancer4.44E-034P04049, Q9Y259, P19174, P49619RAF1, CHKB, PLCG1, DGKGMore
Tucatinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.29E-0510O95267, P07766, P20963, P09693, P06239, P04049, O60603, Q04759, Q16539, P01730RASGRP1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, PRKCQ, MAPK14, CD4More
Tucatinibhsa05310Asthma8.13E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Tucatinibhsa05321Inflammatory bowel disease2.80E-046P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Tucatinibhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tucatinibhsa05332Graft-versus-host disease6.88E-044P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Tucatinibhsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Tucatinibhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Tucatinibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Tucatinibhsa05415Diabetic cardiomyopathy1.46E-036P30405, Q16718, O14521, Q16539, P49841, P37173PPIF, NDUFA5, SDHD, MAPK14, GSK3B, TGFBR2More
Tucatinibhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Tucatinib (SDC: 9.11)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Reported00.1260.27290.47881.0876
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P04628WNT1ProtoNoneoncogene WntNone1Predicted00.02820.02250.45140.5105
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)