PharmaCoNets of Tryptophan (SPCN: 11.74 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tryptophanhsa00030Pentose phosphate pathway3.33E-032P60891, P37837PRPS1, TALDO1More
Tryptophanhsa00240Pyrimidine metabolism3.59E-032P31350, P04818RRM2, TYMSMore
Tryptophanhsa00250Alanine, aspartate and glutamate metabolism1.22E-022Q96RQ9, P15104IL4I1, GLULMore
Tryptophanhsa00270Cysteine and methionine metabolism3.39E-022Q96RQ9, P40926IL4I1, MDH2More
Tryptophanhsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Tryptophanhsa00561Glycerolipid metabolism7.46E-043Q8NEB5, P14550, Q86XP1PPAPDC1B, AKR1A1, DGKHMore
Tryptophanhsa00565Ether lipid metabolism3.78E-032Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Tryptophanhsa00670One carbon pool by folate4.14E-021P04818TYMSMore
Tryptophanhsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Tryptophanhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Tryptophanhsa00900Terpenoid backbone biosynthesis1.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Tryptophanhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Tryptophanhsa01100Metabolic pathways2.24E-0213Q9Y234, Q6ZQY3, Q02153, P20839, Q9Y6K0, Q86XP1, P14550, Q9UHK6, Q86VZ5, Q9BVK2, P37837, Q99437, Q9NVH6LIPT1, GADL1, GUCY1B3, IMPDH1, CEPT1, DGKH, AKR1A1, AMACR, SGMS1, ALG8, TALDO1, ATP6V0B, TMLHEMore
Tryptophanhsa01230Biosynthesis of amino acids4.31E-022P60891, P37837PRPS1, TALDO1More
Tryptophanhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Tryptophanhsa03460Fanconi anemia pathway4.83E-022Q9BXW9, P07992FANCD2, ERCC1More
Tryptophanhsa04020Calcium signaling pathway2.41E-025Q96DU7, Q13557, P21860, P26678, P63092ITPKC, CAMK2D, ERBB3, PLN, GNASMore
Tryptophanhsa04115p53 signaling pathway1.69E-022P31350, P06493RRM2, CDK1More
Tryptophanhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Tryptophanhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Tryptophanhsa04330Notch signaling pathway1.12E-023Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Tryptophanhsa04622RIG-I-like receptor signaling pathway3.39E-022Q12933, P10145TRAF2, IL8More
Tryptophanhsa04650Natural killer cell mediated cytotoxicity4.40E-026P78314, P06239, O60880, P20963, P26718, O75015SH3BP2, LCK, SH2D1A, CD247, KLRK1, FCGR3BMore
Tryptophanhsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Tryptophanhsa04659Th17 cell differentiation7.42E-037Q16539, P06239, P13765, P14778, Q9UL17, P09693, P20963MAPK14, LCK, HLA-DOB, IL1R1, TBX21, CD3G, CD247More
Tryptophanhsa04713Circadian entrainment1.75E-024Q13557, Q02153, P61952, P63092CAMK2D, GUCY1B3, GNG11, GNASMore
Tryptophanhsa04721Synaptic vesicle cycle4.83E-022Q99437, P43005ATP6V0B, SLC1A1More
Tryptophanhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Tryptophanhsa04728Dopaminergic synapse2.41E-025P63092, P61952, Q99941, Q13557, O15516GNAS, GNG11, CREBL1, CAMK2D, CLOCKMore
Tryptophanhsa04911Insulin secretion4.88E-023P63092, Q99941, Q13557GNAS, CREBL1, CAMK2DMore
Tryptophanhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Tryptophanhsa04934Cushing syndrome1.75E-024Q99941, P63092, O15169, Q13557CREBL1, GNAS, AXIN1, CAMK2DMore
Tryptophanhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Tryptophanhsa04977Vitamin digestion and absorption3.43E-021P41440SLC19A1More
Tryptophanhsa05031Amphetamine addiction4.88E-023Q13557, P63092, Q99941CAMK2D, GNAS, CREBL1More
Tryptophanhsa05120Epithelial cell signaling in Helicobacter pylori infection4.83E-022Q99437, P10145ATP6V0B, IL8More
Tryptophanhsa05143African trypanosomiasis1.22E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Tryptophanhsa05144Malaria6.70E-047P60033, P69905, P68871, O60603, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, THBS4, IL8, KLRK1More
Tryptophanhsa05152Tuberculosis3.52E-022Q15075, Q13651EEA1, IL10RAMore
Tryptophanhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Tryptophanhsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Tryptophanhsa05202Transcriptional misregulation in cancer3.02E-024Q92570, O94812, P58340, P10145NR4A3, BAIAP3, MLF1, IL8More
Tryptophanhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.03E-025P20963, P09693, P06239, O60603, Q16539CD247, CD3G, LCK, TLR2, MAPK14More
Tryptophanhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Tryptophanhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Tryptophan (SDC: 2.73)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
Q06609RAD51DNA repair protein RAD51 homolog 1Predicted00.10220.09540.27250.5144
Q6PL18ATAD2ATPase family AAA domainNonecontaining protein 2Predicted00.19630.051200.2006
Q92830KAT2AHistone acetyltransferase KAT2APredicted00.0510.01790.48070.5421
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P38919EIF4A3Eukaryotic initiation factor 4ANoneIIIPredicted00.36460.03340.48860.7378
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)