PharmaCoNets of Tiagabine (SPCN: 5.37 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tiagabinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Tiagabinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Tiagabinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Tiagabinehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Tiagabinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Tiagabinehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Tiagabinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Tiagabinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Tiagabinehsa04610Complement and coagulation cascades6.23E-061P0C0L4C4AMore
Tiagabinehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Tiagabinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Tiagabinehsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Tiagabinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Tiagabinehsa04966Collecting duct acid secretion1.38E-032P02730, P00918SLC4A1, CA2More
Tiagabinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Tiagabinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Tiagabinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Tiagabinehsa05133Pertussis4.24E-031P0C0L4C4AMore
Tiagabinehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Tiagabinehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Tiagabinehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Tiagabinehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Tiagabinehsa05412Arrhythmogenic right ventricular cardiomyopathy5.12E-033Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Tiagabinehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Tiagabinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Tiagabine (SDC: 2.51)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Reported10.08890.52020.10471.1894
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
SLC6A1P30531IC5049
SLC6A1P30531IC5070
SLC6A1P30531IC50280
SLC6A1P30531Ki16.98
SLC6A1P30531Ki48