PharmaCoNets of Thalidomide (SPCN: 35.34 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Thalidomidehsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Thalidomidehsa00531Glycosaminoglycan degradation1.05E-032P15586, P34059GNS, GALNSMore
Thalidomidehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate3.30E-021Q9Y2C2USTMore
Thalidomidehsa00562Inositol phosphate metabolism4.28E-022Q14642, P19174INPP5A, PLCG1More
Thalidomidehsa00564Glycerophospholipid metabolism2.62E-022P23743, Q3LIE5DGKA, ADPRMMore
Thalidomidehsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Thalidomidehsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Thalidomidehsa00983Drug metabolism - other enzymes1.32E-045P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Thalidomidehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Thalidomidehsa01522Endocrine resistance4.07E-045P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Thalidomidehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Thalidomidehsa03050Proteasome4.83E-021P55036PSMD4More
Thalidomidehsa03060Protein export3.56E-022P37108, Q15005SRP14, SPCS2More
Thalidomidehsa04012ErbB signaling pathway4.28E-022Q13191, P19174CBLB, PLCG1More
Thalidomidehsa04020Calcium signaling pathway7.93E-036Q08828, Q13557, P61073, P0DP24, P05141, P51828ADCY1, CAMK2D, CXCR4, CALM2, SLC25A5, ADCY7More
Thalidomidehsa04022cGMP-PKG signaling pathway1.87E-026Q99941, P18848, Q08828, P51828, P05141, P0DP24CREBL1, ATF4, ADCY1, ADCY7, SLC25A5, CALM2More
Thalidomidehsa04061Viral protein interaction with cytokine and cytokine receptor1.91E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Thalidomidehsa04064NF-kappa B signaling pathway1.47E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Thalidomidehsa04071Sphingolipid signaling pathway1.70E-035Q9H228, P01375, Q13362, Q9BX95, P10415EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Thalidomidehsa04114Oocyte meiosis4.36E-025Q13557, P0DP24, Q08828, P51828, P27348CAMK2D, CALM2, ADCY1, ADCY7, YWHAQMore
Thalidomidehsa04137Mitophagy - animal3.55E-044Q96CV9, Q9H1Y0, P18848, O43524OPTN, ATG5, ATF4, FOXO3More
Thalidomidehsa04141Protein processing in endoplasmic reticulum3.68E-023P60604, P08238, Q9H173UBE2G2, HSP90AB1, SIL1More
Thalidomidehsa04142Lysosome1.67E-034P43234, P15586, P34059, P49281CTSO, GNS, GALNS, SLC11A2More
Thalidomidehsa04146Peroxisome4.38E-034O43933, O96011, P56589, P33121PEX1, PEX11B, PEX3, ACSL1More
Thalidomidehsa04210Apoptosis1.43E-024P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Thalidomidehsa04211Longevity regulating pathway4.98E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Thalidomidehsa04213Longevity regulating pathway - multiple species8.73E-033Q9Y4H2, P11142, Q13547IRS2, HSPA8, HDAC1More
Thalidomidehsa04216Ferroptosis1.45E-022P04637, P49281TP53, SLC11A2More
Thalidomidehsa04217Necroptosis5.85E-037P23458, Q9NQC7, P05141, P01584, P0C0S5, Q13557, Q9H444JAK1, CYLD, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Thalidomidehsa04261Adrenergic signaling in cardiomyocytes1.44E-026Q08828, P51828, Q99941, P18848, P0DP24, Q13557ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2DMore
Thalidomidehsa04340Hedgehog signaling pathway2.62E-022O43791, P30279SPOP, CCND2More
Thalidomidehsa04371Apelin signaling pathway2.77E-023P62873, Q13370, Q9UM47GNB1, PDE3B, NOTCH3More
Thalidomidehsa04380Osteoclast differentiation4.98E-024Q9NQC7, Q9UQC2, P23458, P01584CYLD, GAB2, JAK1, IL1BMore
Thalidomidehsa04612Antigen processing and presentation6.19E-038P48382, P26715, P26717, Q13241, O43908, P01732, P11142, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HSPA8, TNFMore
Thalidomidehsa04613Neutrophil extracellular trap formation1.32E-0616P19174, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P62807, Q15080, P20160, P08311, P49913, O75015, P21730, P21462PLCG1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2BC, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1More
Thalidomidehsa04621NOD-like receptor signaling pathway2.14E-0410Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Thalidomidehsa04623Cytosolic DNA-sensing pathway1.20E-022P01584, Q8NHW4IL1B, CCL4L2More
Thalidomidehsa04650Natural killer cell mediated cytotoxicity1.25E-028P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Thalidomidehsa04657IL-17 signaling pathway2.90E-034P25963, P08238, P04141, P06702NFKBIA, HSP90AB1, CSF2, S100A9More
Thalidomidehsa04658Th1 and Th2 cell differentiation2.37E-023P25963, P42224, Q9UM47NFKBIA, STAT1, NOTCH3More
Thalidomidehsa04659Th17 cell differentiation4.18E-023P25963, P42224, P08238NFKBIA, STAT1, HSP90AB1More
Thalidomidehsa04713Circadian entrainment1.91E-024P0DP24, Q13557, Q08828, P51828CALM2, CAMK2D, ADCY1, ADCY7More
Thalidomidehsa04720Long-term potentiation1.91E-024Q13557, P0DP24, P18848, Q08828CAMK2D, CALM2, ATF4, ADCY1More
Thalidomidehsa04725Cholinergic synapse3.77E-024Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Thalidomidehsa04728Dopaminergic synapse2.67E-025Q99941, P18848, Q13557, P0DP24, O15516CREBL1, ATF4, CAMK2D, CALM2, CLOCKMore
Thalidomidehsa04750Inflammatory mediator regulation of TRP channels4.47E-035P01584, Q08828, P51828, Q13557, P0DP24IL1B, ADCY1, ADCY7, CAMK2D, CALM2More
Thalidomidehsa04910Insulin signaling pathway1.67E-023Q14642, Q13191, Q9Y4H2INPP5A, CBLB, IRS2More
Thalidomidehsa04911Insulin secretion7.16E-045Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Thalidomidehsa04912GnRH signaling pathway6.99E-035Q08828, P51828, P18848, Q13557, P0DP24ADCY1, ADCY7, ATF4, CAMK2D, CALM2More
Thalidomidehsa04916Melanogenesis7.61E-034Q13557, P0DP24, Q08828, P51828CAMK2D, CALM2, ADCY1, ADCY7More
Thalidomidehsa04918Thyroid hormone synthesis4.47E-035Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Thalidomidehsa04925Aldosterone synthesis and secretion5.21E-046Q99941, P18848, Q08828, P51828, P0DP24, Q13557CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2DMore
Thalidomidehsa04927Cortisol synthesis and secretion4.16E-034Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Thalidomidehsa04928Parathyroid hormone synthesis, secretion and action3.77E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Thalidomidehsa04932Non-alcoholic fatty liver disease3.45E-025P18848, O75460, P01584, P12074, O15239ATF4, ERN1, IL1B, COX6A1, NDUFA1More
Thalidomidehsa04934Cushing syndrome2.60E-046Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Thalidomidehsa04935Growth hormone synthesis, secretion and action4.98E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Thalidomidehsa04970Salivary secretion3.54E-023Q08828, P51828, P0DP24ADCY1, ADCY7, CALM2More
Thalidomidehsa04971Gastric acid secretion7.16E-045Q08828, P51828, P15311, P0DP24, Q13557ADCY1, ADCY7, VIL2, CALM2, CAMK2DMore
Thalidomidehsa05010Alzheimer disease3.73E-0311O15239, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P28070, P43686NDUFA1, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, PSMB4, PSMC4More
Thalidomidehsa05012Parkinson disease7.90E-039O15239, P12074, P05141, O75460, P18848, P28070, P43686, P0DP24, Q13557NDUFA1, COX6A1, SLC25A5, ERN1, ATF4, PSMB4, PSMC4, CALM2, CAMK2DMore
Thalidomidehsa05016Huntington disease3.54E-028O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4More
Thalidomidehsa05020Prion disease2.86E-029P01584, P46531, O15239, P12074, P18848, P05141, P28070, P43686, Q99941IL1B, NOTCH1, NDUFA1, COX6A1, ATF4, SLC25A5, PSMB4, PSMC4, CREBL1More
Thalidomidehsa05022Pathways of neurodegeneration - multiple diseases1.74E-0313O15239, P12074, Q8TEV9, O75460, P18848, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686NDUFA1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4More
Thalidomidehsa05030Cocaine addiction3.54E-023Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Thalidomidehsa05031Amphetamine addiction7.61E-034P0DP24, Q13557, Q99941, P18848CALM2, CAMK2D, CREBL1, ATF4More
Thalidomidehsa05131Shigellosis3.32E-039P01375, O00463, Q04759, Q9UDY8, Q9H1Y0, P20810, O43524, P10415, Q96A32TNF, TRAF5, PRKCQ, MALT1, ATG5, CAST, FOXO3, BCL2, MYLPFMore
Thalidomidehsa05134Legionellosis3.60E-033P11215, P11142, P19875ITGAM, HSPA8, CXCL2More
Thalidomidehsa05140Leishmaniasis1.67E-023P42224, P25963, P29350STAT1, NFKBIA, PTPN6More
Thalidomidehsa05144Malaria8.11E-055P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Thalidomidehsa05150Staphylococcus aureus infection3.52E-067P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Thalidomidehsa05152Tuberculosis7.83E-047O75015, P48382, O60603, P01375, P10415, P49913, Q9UDY8FCGR3B, RFX5, TLR2, TNF, BCL2, CAMP, MALT1More
Thalidomidehsa05163Human cytomegalovirus infection2.62E-0410P0DP24, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, Q13651, Q99941, P18848CALM2, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4More
Thalidomidehsa05167Kaposi sarcoma-associated herpesvirus infection1.63E-024P42224, P25963, P62873, P04141STAT1, NFKBIA, GNB1, CSF2More
Thalidomidehsa05171Coronavirus disease - COVID-191.24E-024P25963, P42224, P46777, P04141NFKBIA, STAT1, RPL5, CSF2More
Thalidomidehsa05200Pathways in cancer4.79E-026P08238, P42224, P25963, P20585, P62873, Q9UM47HSP90AB1, STAT1, NFKBIA, MSH3, GNB1, NOTCH3More
Thalidomidehsa05203Viral carcinogenesis1.13E-036Q12933, P42229, P30279, Q13547, Q15283, P62807TRAF2, STAT5A, CCND2, HDAC1, RASA2, HIST1H2BCMore
Thalidomidehsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Thalidomidehsa05206MicroRNAs in cancer1.63E-024P30279, Q9Y4H2, Q13547, P19174CCND2, IRS2, HDAC1, PLCG1More
Thalidomidehsa05211Renal cell carcinoma9.88E-032Q06124, Q99814PTPN11, EPAS1More
Thalidomidehsa05212Pancreatic cancer3.28E-022P04637, P24522TP53, GADD45AMore
Thalidomidehsa05213Endometrial cancer3.28E-022P04637, P24522TP53, GADD45AMore
Thalidomidehsa05214Glioma3.28E-022P04637, P24522TP53, GADD45AMore
Thalidomidehsa05215Prostate cancer2.00E-023P25963, Q9NRA1, P08238NFKBIA, PDGFC, HSP90AB1More
Thalidomidehsa05216Thyroid cancer1.45E-022P04637, P24522TP53, GADD45AMore
Thalidomidehsa05217Basal cell carcinoma2.60E-022P04637, P24522TP53, GADD45AMore
Thalidomidehsa05218Melanoma1.45E-022P04637, P24522TP53, GADD45AMore
Thalidomidehsa05220Chronic myeloid leukemia1.12E-023Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Thalidomidehsa05223Non-small cell lung cancer4.01E-022P04637, P24522TP53, GADD45AMore
Thalidomidehsa05225Hepatocellular carcinoma4.54E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Thalidomidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.37E-023P25963, P29350, P42224NFKBIA, PTPN6, STAT1More

Community members of Thalidomide (SDC: 2.83)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q96SW2CRBNProtein cereblonReported00.2490.042700.2099
P01375TNFTumor necrosis factorReported10.18650.55112.1953
P02763ORM1AlphaNone1Noneacid glycoprotein 1Reported10.05530.057900.1435
P19652ORM2AlphaNone1Noneacid glycoprotein 2Reported10.09380.057900.1628
P01584IL1BInterleukinNone1 betaPredicted10.2060.137611.3782
P04141CSF2GranulocyteNonemacrophage colonyNonestimulating factorPredicted10.00020.01260.8810.9063
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
Q99814EPAS1Endothelial PAS domainNonecontaining protein 1Predicted00.23220.0620.24910.4892
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CRBNQ96SW2IC5029900
CRBNQ96SW2Ki22700
TNFP01375IC50>10000