PharmaCoNets of Tafamidis (SPCN: 137.89 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tafamidishsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Tafamidishsa00190Oxidative phosphorylation1.94E-023Q16718, P36542, O14521NDUFA5, ATP5C1, SDHDMore
Tafamidishsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Tafamidishsa00500Starch and sucrose metabolism2.21E-034O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Tafamidishsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Tafamidishsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Tafamidishsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Tafamidishsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Tafamidishsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Tafamidishsa00920Sulfur metabolism2.29E-021Q16762TSTMore
Tafamidishsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Tafamidishsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Tafamidishsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Tafamidishsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Tafamidishsa01100Metabolic pathways3.55E-0334Q9NR34, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6MAN1C1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1More
Tafamidishsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Tafamidishsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Tafamidishsa01523Antifolate resistance2.24E-023P41439, P41440, P01375FOLR3, SLC19A1, TNFMore
Tafamidishsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Tafamidishsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Tafamidishsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Tafamidishsa03013RNA transport8.62E-0620P62826, O14980, P52298, Q09161, O14893, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, P47813, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Tafamidishsa03020RNA polymerase5.68E-096P30876, P24928, P62487, Q9GZM3, P52435, Q9Y535POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J, POLR3HMore
Tafamidishsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Tafamidishsa03030DNA replication5.00E-021P27694RPA1More
Tafamidishsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Tafamidishsa03050Proteasome4.83E-021P55036PSMD4More
Tafamidishsa03430Mismatch repair4.38E-021P20585MSH3More
Tafamidishsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Tafamidishsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Tafamidishsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Tafamidishsa04015Rap1 signaling pathway5.18E-043P08069, P06213, O00522IGF1R, INSR, KRIT1More
Tafamidishsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Tafamidishsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Tafamidishsa04024cAMP signaling pathway4.63E-037Q08828, P51828, P42338, P31751, P0DP23, Q13370, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, TIAM1More
Tafamidishsa04061Viral protein interaction with cytokine and cytokine receptor4.54E-022Q8NHW4, Q13651CCL4L2, IL10RAMore
Tafamidishsa04064NF-kappa B signaling pathway3.81E-0719P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CYLDMore
Tafamidishsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Tafamidishsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Tafamidishsa04070Phosphatidylinositol signaling system1.28E-036P0DP23, P42338, O14986, Q16760, P48426, P27987CALM1, PIK3CB, PIP5K1B, DGKD, PIP4K2A, ITPKBMore
Tafamidishsa04071Sphingolipid signaling pathway9.39E-037P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Tafamidishsa04072Phospholipase D signaling pathway2.40E-036P31751, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Tafamidishsa04080Neuroactive ligand-receptor interaction1.18E-027P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1More
Tafamidishsa04114Oocyte meiosis4.41E-036P0DP23, Q08828, P51828, Q13362, Q14738, P08069CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Tafamidishsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Tafamidishsa04120Ubiquitin mediated proteolysis4.61E-022Q13042, Q15751CDC16, HERC1More
Tafamidishsa04122Sulfur relay system2.29E-021Q16762TSTMore
Tafamidishsa04140Autophagy - animal4.41E-036P08069, P31751, Q7L523, O75460, Q96GC9, Q8TEV9IGF1R, AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Tafamidishsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Tafamidishsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Tafamidishsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Tafamidishsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Tafamidishsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Tafamidishsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Tafamidishsa04211Longevity regulating pathway5.00E-035P31751, P08069, Q08828, P51828, P18848AKT2, IGF1R, ADCY1, ADCY7, ATF4More
Tafamidishsa04213Longevity regulating pathway - multiple species1.06E-024P31751, P08069, Q08828, P51828AKT2, IGF1R, ADCY1, ADCY7More
Tafamidishsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Tafamidishsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Tafamidishsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Tafamidishsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Tafamidishsa04380Osteoclast differentiation1.88E-024Q9NQC7, P23458, P31751, P01584CYLD, JAK1, AKT2, IL1BMore
Tafamidishsa04510Focal adhesion3.48E-021P08069IGF1RMore
Tafamidishsa04512ECM-receptor interaction2.00E-022P07359, P08514GP1BA, ITGA2BMore
Tafamidishsa04514Cell adhesion molecules1.22E-034P23229, P16109, P30511, O00501ITGA6, SELP, HLA-F, CLDN5More
Tafamidishsa04520Adherens junction8.29E-031P08069IGF1RMore
Tafamidishsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Tafamidishsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Tafamidishsa04611Platelet activation2.25E-044P08514, Q15746, Q8WYR1, P07359ITGA2B, MYLK, PIK3R5, GP1BAMore
Tafamidishsa04613Neutrophil extracellular trap formation1.60E-0417P17252, P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, Q99878, P14598, Q15080, P20160, P08311, P49913, P21730, P08514, P21462, P07359PRKCA, SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H2AC14, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, ITGA2B, FPR1, GP1BAMore
Tafamidishsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Tafamidishsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Tafamidishsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Tafamidishsa04625C-type lectin receptor signaling pathway9.86E-034P01584, Q9NQC7, P31751, P0DP23IL1B, CYLD, AKT2, CALM1More
Tafamidishsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Tafamidishsa04650Natural killer cell mediated cytotoxicity3.82E-026P01375, Q13241, P26718, O75015, P26717, P26715TNF, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Tafamidishsa04657IL-17 signaling pathway3.98E-037P07900, O00463, Q16539, P49841, P09341, P14780, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, IL1BMore
Tafamidishsa04659Th17 cell differentiation4.38E-024P42224, P14784, P40189, P08238STAT1, IL2RB, IL6ST, HSP90AB1More
Tafamidishsa04660T cell receptor signaling pathway4.20E-027P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITKMore
Tafamidishsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Tafamidishsa04668TNF signaling pathway2.59E-027P01375, O00463, Q13489, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9More
Tafamidishsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Tafamidishsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Tafamidishsa04720Long-term potentiation4.54E-023P0DP23, P18848, Q08828CALM1, ATF4, ADCY1More
Tafamidishsa04725Cholinergic synapse1.39E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Tafamidishsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Tafamidishsa04730Long-term depression3.01E-032Q14344, P08069GNA13, IGF1RMore
Tafamidishsa04750Inflammatory mediator regulation of TRP channels9.86E-034P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Tafamidishsa04810Regulation of actin cytoskeleton2.68E-022P23229, Q14344ITGA6, GNA13More
Tafamidishsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Tafamidishsa04912GnRH signaling pathway1.39E-024Q08828, P51828, P18848, P0DP23ADCY1, ADCY7, ATF4, CALM1More
Tafamidishsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Tafamidishsa04914Progesterone-mediated oocyte maturation1.31E-024P08069, P42338, Q13370, P08238IGF1R, PIK3CB, PDE3B, HSP90AB1More
Tafamidishsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Tafamidishsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Tafamidishsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Tafamidishsa04921Oxytocin signaling pathway4.91E-022Q15746, Q8WYR1MYLK, PIK3R5More
Tafamidishsa04923Regulation of lipolysis in adipocytes7.59E-044Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Tafamidishsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Tafamidishsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Tafamidishsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Tafamidishsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Tafamidishsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Tafamidishsa04932Non-alcoholic fatty liver disease2.99E-047P31751, P18848, O75460, P01584, P13073, O15239, O95298AKT2, ATF4, ERN1, IL1B, COX4I1, NDUFA1, NDUFC2More
Tafamidishsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Tafamidishsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Tafamidishsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Tafamidishsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Tafamidishsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Tafamidishsa04970Salivary secretion2.40E-037Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMPMore
Tafamidishsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Tafamidishsa04976Bile secretion1.59E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Tafamidishsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Tafamidishsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Tafamidishsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Tafamidishsa05016Huntington disease6.73E-0612O15239, O95298, P13073, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460, P28070NDUFA1, NDUFC2, COX4I1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1, PSMB4More
Tafamidishsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Tafamidishsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Tafamidishsa05022Pathways of neurodegeneration - multiple diseases1.94E-0312O15239, O95298, P13073, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, Q13557, P28070NDUFA1, NDUFC2, COX4I1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, CAMK2D, PSMB4More
Tafamidishsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Tafamidishsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Tafamidishsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Tafamidishsa05132Salmonella infection2.98E-0211P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3More
Tafamidishsa05133Pertussis4.20E-021P0C0L4C4AMore
Tafamidishsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Tafamidishsa05140Leishmaniasis9.33E-0410O75015, P14598, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4More
Tafamidishsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Tafamidishsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Tafamidishsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Tafamidishsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Tafamidishsa05150Staphylococcus aureus infection3.11E-058P21462, O75015, Q14532, P16109, P59665, P59666, P12838, P49913FPR1, FCGR3B, KRT32, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Tafamidishsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Tafamidishsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Tafamidishsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Tafamidishsa05163Human cytomegalovirus infection5.10E-0618P31751, P30511, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463AKT2, HLA-F, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Tafamidishsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Tafamidishsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Tafamidishsa05168Herpes simplex virus 1 infection1.95E-0314P25963, P42224, Q07955, Q01130, Q13243, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Tafamidishsa05170Human immunodeficiency virus 1 infection1.06E-0313P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2More
Tafamidishsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Tafamidishsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Tafamidishsa05202Transcriptional misregulation in cancer1.51E-0515Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Tafamidishsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Tafamidishsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Tafamidishsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Tafamidishsa05212Pancreatic cancer9.49E-046P42338, P31751, Q15311, P23458, P42224, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, GADD45BMore
Tafamidishsa05214Glioma1.88E-034P08069, P0DP23, P42338, O75293IGF1R, CALM1, PIK3CB, GADD45BMore
Tafamidishsa05215Prostate cancer1.33E-021P08069IGF1RMore
Tafamidishsa05218Melanoma6.63E-031P08069IGF1RMore
Tafamidishsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Tafamidishsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Tafamidishsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Tafamidishsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Tafamidishsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Tafamidishsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Tafamidishsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Tafamidishsa05321Inflammatory bowel disease1.28E-025O60603, P01375, P13765, Q14765, P23771TLR2, TNF, HLA-DOB, STAT4, GATA3More
Tafamidishsa05322Systemic lupus erythematosus4.20E-027P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Tafamidishsa05332Graft-versus-host disease8.50E-045P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Tafamidishsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Tafamidishsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Tafamidishsa05418Fluid shear stress and atherosclerosis2.84E-0310Q16539, P42338, P14598, P10599, P14780, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, NCF1, TXN, MMP9, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Tafamidis (SDC: 6.53)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P16109SELPPNoneselectinPredicted10.15230.07220.57330.7938
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)