PharmaCoNets

PharmaCoNets of Sulfaphenazole (S_PCN: 178.45 )

Sulfaphenazole regulated-network (S_DN: 24.99)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Sulfaphenazole

hsa00020

Citrate cycle (TCA cycle)

6.05E-03

Q9P2R7, P40925, O14521

SUCLA2, MDH1, SDHD

Sulfaphenazole

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Sulfaphenazole

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Sulfaphenazole

hsa00190

Oxidative phosphorylation

3.20E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Sulfaphenazole

hsa00220

Arginine biosynthesis

4.40E-02

P15104

GLUL

Sulfaphenazole

hsa00310

Lysine degradation

4.57E-02

Q96KQ7, Q02809

EHMT2, PLOD1

Sulfaphenazole

hsa00500

Starch and sucrose metabolism

1.91E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Sulfaphenazole

hsa00531

Glycosaminoglycan degradation

1.05E-03

P15586, P34059

GNS, GALNS

Sulfaphenazole

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

3.30E-02

Q9Y2C2

UST

Sulfaphenazole

hsa00562

Inositol phosphate metabolism

2.00E-02

P27987, P19174, P42338, Q02252

ITPKB, PLCG1, PIK3CB, ALDH6A1

Sulfaphenazole

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Sulfaphenazole

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Sulfaphenazole

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Sulfaphenazole

hsa00630

Glyoxylate and dicarboxylate metabolism

1.03E-04

P40925, P15104

MDH1, GLUL

Sulfaphenazole

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Sulfaphenazole

hsa00730

Thiamine metabolism

1.55E-03

P05186, P24666

ALPL, ACP1

Sulfaphenazole

hsa00740

Riboflavin metabolism

4.77E-02

P30043

BLVRB

Sulfaphenazole

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Sulfaphenazole

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Sulfaphenazole

hsa00970

Aminoacyl-tRNA biosynthesis

7.84E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Sulfaphenazole

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Sulfaphenazole

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Sulfaphenazole

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Sulfaphenazole

hsa01200

Carbon metabolism

8.75E-03

P04406, P40925, O14521, Q9P2R7, Q02252

GAPDH, MDH1, SDHD, SUCLA2, ALDH6A1

Sulfaphenazole

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Sulfaphenazole

hsa01524

Platinum drug resistance

4.78E-02

P31751

AKT2

Sulfaphenazole

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Sulfaphenazole

hsa03010

Ribosome

7.34E-03

P62753, P62829, P62888, P61927, P61513, P36578

RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4

Sulfaphenazole

hsa03013

RNA transport

2.40E-03

P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787

NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1

Sulfaphenazole

hsa03015

mRNA surveillance pathway

6.77E-03

Q9BZI7, O60942, O43148, O94913, P52298, Q53GS7

UPF3B, RNGTT, RNMT, PCF11, NCBP2, GLE1

Sulfaphenazole

hsa03020

RNA polymerase

2.06E-03

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Sulfaphenazole

hsa03022

Basal transcription factors

2.41E-02

Q12962

TAF10

Sulfaphenazole

hsa03040

Spliceosome

1.81E-06

Q14562, O43143, O60508, O14776, P08579, O75940, P52298, P09651, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, O43395, P61326

DHX8, DHX15, CDC40, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, PRPF3, MAGOH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.888
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
P27707	DCK	Deoxycytidine kinase	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.726
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.953
P25963	NFKBIA	NF-kappa-B inhibitor alpha	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.76
P27707	DCK	Deoxycytidine kinase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.816
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.838
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P27707	DCK	Deoxycytidine kinase	O14776	TCERG1	Transcription elongation regulator 1	0.757
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.788
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P25963	NFKBIA	NF-kappa-B inhibitor alpha	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	-0.812
P27707	DCK	Deoxycytidine kinase	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.84
P27707	DCK	Deoxycytidine kinase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.769
P27707	DCK	Deoxycytidine kinase	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.736
P25963	NFKBIA	NF-kappa-B inhibitor alpha	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	-0.809
P27707	DCK	Deoxycytidine kinase	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.824
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
P25963	NFKBIA	NF-kappa-B inhibitor alpha	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.839
P27707	DCK	Deoxycytidine kinase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.804
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
P25963	NFKBIA	NF-kappa-B inhibitor alpha	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.775
P27707	DCK	Deoxycytidine kinase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.757
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.746
P25963	NFKBIA	NF-kappa-B inhibitor alpha	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	-0.891
P27707	DCK	Deoxycytidine kinase	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	0.797
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761
P25963	NFKBIA	NF-kappa-B inhibitor alpha	O43395	PRPF3	U4/U6 small nuclear ribonucleoprotein Prp3	-0.747
P27707	DCK	Deoxycytidine kinase	P61326	MAGOH	Protein mago nashi homolog	0.732

Sulfaphenazole

hsa03060

Protein export

4.97E-03

Q15070, P37108, Q15005

OXA1L, SRP14, SPCS2

Sulfaphenazole

hsa03320

PPAR signaling pathway

3.60E-02

Q13418

ILK

Sulfaphenazole

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Sulfaphenazole

hsa04012

ErbB signaling pathway

2.00E-02

P16333, P17252, P19174, P42338

NCK1, PRKCA, PLCG1, PIK3CB

Sulfaphenazole

hsa04014

Ras signaling pathway

1.48E-04

P31751, P42338, P20827, P49767, Q13009, P17252, P14921, P0DP23, P62873, P50151, P19174

AKT2, PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, ETS1, CALM1, GNB1, GNG10, PLCG1

Sulfaphenazole

hsa04015

Rap1 signaling pathway

1.93E-04

P20827, P49767, P11215, P25116, Q8TEU7, Q13009, P42338, P31751, P0DP23, P08514, P17252, P19174

EFNA1, VEGFC, ITGAM, F2R, RAPGEF6, TIAM1, PIK3CB, AKT2, CALM1, ITGA2B, PRKCA, PLCG1

Sulfaphenazole

hsa04020

Calcium signaling pathway

4.34E-02

P27987, P17252, O15399, P19174, P0DP23, P49767

ITPKB, PRKCA, GRIN2D, PLCG1, CALM1, VEGFC

Sulfaphenazole

hsa04022

cGMP-PKG signaling pathway

5.07E-03

P31751, P0DP23

AKT2, CALM1

Sulfaphenazole

hsa04024

cAMP signaling pathway

4.12E-03

P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009

PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1

Sulfaphenazole

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.28E-02

P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P09603, P01375

CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, CSF1, TNF

Sulfaphenazole

hsa04062

Chemokine signaling pathway

1.07E-03

P25024, P25025, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P22694, P42224, P25963, P49841

CXCR1, CXCR2, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, PRKACB, STAT1, NFKBIA, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.901
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.917
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P47992	XCL1	Lymphotactin	-0.797
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.797
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.713
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.737
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43250	GRK6	G protein-coupled receptor kinase 6	-0.701
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.847
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.792
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14598	NCF1	Neutrophil cytosol factor 1	0.908
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.758
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.794

Sulfaphenazole

hsa04064

NF-kappa B signaling pathway

7.60E-06

P10415, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q9NQC7

BCL2, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16548	BCL2A1	Bcl-2-related protein A1	0.889
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.713
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Sulfaphenazole

hsa04070

Phosphatidylinositol signaling system

3.29E-03

P19174, P0DP23, P42338, P23743, P27987, P17252

PLCG1, CALM1, PIK3CB, DGKA, ITPKB, PRKCA

Sulfaphenazole

hsa04071

Sphingolipid signaling pathway

6.65E-04

P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Sulfaphenazole

hsa04080

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Sulfaphenazole

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Sulfaphenazole

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Sulfaphenazole

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Sulfaphenazole

hsa04140

Autophagy - animal

1.44E-03

Q9Y4H2, Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759

IRS2, RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Sulfaphenazole

hsa04142

Lysosome

8.21E-05

P43234, P06865, P15586, P22304, P34059, P38571, Q13510, P07602, Q9NRA2, P49281, P61916

CTSO, HEXA, GNS, IDS, GALNS, LIPA, ASAH1, PSAP, SLC17A5, SLC11A2, NPC2

Sulfaphenazole

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Sulfaphenazole

hsa04145

Phagosome

3.23E-03

P63261, Q15080, P14598, Q13509, P68371, P05164, O60603, P35443, P13765

ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4, HLA-DOB

Sulfaphenazole

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Sulfaphenazole

hsa04151

PI3K-Akt signaling pathway

1.43E-02

P42338, P20827, P49767, P08238, P62873, P50151, P16144, O15335, Q13751, P14784, P01568, P17252

PIK3CB, EFNA1, VEGFC, HSP90AB1, GNB1, GNG10, ITGB4, CHAD, LAMB3, IL2RB, IFNA21, PRKCA

Sulfaphenazole

hsa04210

Apoptosis

2.35E-03

Q13315, P04637, P10415, O76075, P24522, Q16548, P43234, Q14643, P63261

ATM, TP53, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1, ACTG1

Sulfaphenazole

hsa04213

Longevity regulating pathway - multiple species

2.82E-02

Q08828, P51828, P0DMV8

ADCY1, ADCY7, HSPA1A

Sulfaphenazole

hsa04216

Ferroptosis

1.45E-02

P04637, P49281

TP53, SLC11A2

Sulfaphenazole

hsa04217

Necroptosis

8.72E-07

P01375, P01568, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P08238, P15104, P01584, P07384, Q6FI13, Q99878, P10415, Q9H444, O43633

TNF, IFNA21, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, IL1B, CAPN1, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P33260	CYP2C18	Cytochrome P450 2C18	P01568	IFNA21	Interferon alpha-21	0.86
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
P33260	CYP2C18	Cytochrome P450 2C18	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.752
O00141	SGK	Serine/threonine-protein kinase Sgk1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.749
P33260	CYP2C18	Cytochrome P450 2C18	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.765
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P15104	GLUL	Glutamine synthetase	-0.729
O00141	SGK	Serine/threonine-protein kinase Sgk1	P15104	GLUL	Glutamine synthetase	0.761
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
P33260	CYP2C18	Cytochrome P450 2C18	P07384	CAPN1	Calpain-1 catalytic subunit	-0.819
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.756
P33260	CYP2C18	Cytochrome P450 2C18	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.821
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P33260	CYP2C18	Cytochrome P450 2C18	P10415	BCL2	Apoptosis regulator Bcl-2	0.784
O00141	SGK	Serine/threonine-protein kinase Sgk1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.717
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O43633	CHMP2A	Charged multivesicular body protein 2a	0.894
P33260	CYP2C18	Cytochrome P450 2C18	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.734

Sulfaphenazole

hsa04218

Cellular senescence

3.65E-03

P31751, P0DP23

AKT2, CALM1

Sulfaphenazole

hsa04261

Adrenergic signaling in cardiomyocytes

4.57E-03

P31751, P0DP23

AKT2, CALM1

Sulfaphenazole

hsa04270

Vascular smooth muscle contraction

9.46E-04

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Sulfaphenazole

hsa04340

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Sulfaphenazole

hsa04360

Axon guidance

2.13E-03

P16333, P20827, O95631, P17252, P42338, P23528, P19174

NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, PLCG1

Sulfaphenazole

hsa04370

VEGF signaling pathway

4.06E-03

P19174, P31751, P42338, P17252

PLCG1, AKT2, PIK3CB, PRKCA

Sulfaphenazole

hsa04371

Apelin signaling pathway

3.23E-03

P31751, P0DP23

AKT2, CALM1

Sulfaphenazole

hsa04380

Osteoclast differentiation

2.72E-04

Q9NQC7, Q9UQC2, Q16539, P31751, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, AKT2, IL1R1, FCGR3B, TNF, LILRA2

Sulfaphenazole

hsa04510

Focal adhesion

1.14E-03

P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P10415, P49767, P63261

ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, BCL2, VEGFC, ACTG1

Sulfaphenazole

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Sulfaphenazole

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Sulfaphenazole

hsa04530

Tight junction

2.47E-05

Q8TEU7, P16989, P56750, O00501, Q14247

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN

Sulfaphenazole

hsa04610

Complement and coagulation cascades

1.03E-03

P25116, P09871, P0C0L4

F2R, C1S, C4A

Sulfaphenazole

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Sulfaphenazole

hsa04612

Antigen processing and presentation

5.83E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Sulfaphenazole

hsa04613

Neutrophil extracellular trap formation

1.76E-05

P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P08514, P21462, P07359, O43315, Q16539

SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Sulfaphenazole

hsa04620

Toll-like receptor signaling pathway

4.78E-02

P31751

AKT2

Sulfaphenazole

hsa04621

NOD-like receptor signaling pathway

7.10E-05

P01584, P07900, Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

IL1B, HSP90AA1, MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.763
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	-0.705
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P10599	TXN	Thioredoxin	0.847
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9H1Y0	ATG5	Autophagy protein 5	-0.726
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
O00141	SGK	Serine/threonine-protein kinase Sgk1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.742
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.964
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.72
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09341	CXCL1	Growth-regulated alpha protein	0.859
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P12838	DEFA4	Neutrophil defensin 4	0.842

Sulfaphenazole

hsa04622

RIG-I-like receptor signaling pathway

1.81E-02

Q9NQC7

CYLD

Sulfaphenazole

hsa04623

Cytosolic DNA-sensing pathway

5.86E-05

P01584, P01568, Q13546, P25963, Q8NHW4

IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2

Sulfaphenazole

hsa04625

C-type lectin receptor signaling pathway

2.27E-04

Q9ULY5, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Sulfaphenazole

hsa04640

Hematopoietic cell lineage

1.62E-04

P13612, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603

ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1

Sulfaphenazole

hsa04650

Natural killer cell mediated cytotoxicity

2.72E-05

P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P78314	SH3BP2	SH3 domain-binding protein 2	0.769
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.848
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.931
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.855
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Sulfaphenazole

hsa04657

IL-17 signaling pathway

2.89E-06

P25963, P07900, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, Q9UJX4, P04141, P80188, P01375, P06702, P01584

NFKBIA, HSP90AA1, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, CSF2, LCN2, TNF, S100A9, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25963	NFKBIA	NF-kappa-B inhibitor alpha	P25963	NFKBIA	NF-kappa-B inhibitor alpha	1
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P25963	NFKBIA	NF-kappa-B inhibitor alpha	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.818
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P25963	NFKBIA	NF-kappa-B inhibitor alpha	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.839
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P25963	NFKBIA	NF-kappa-B inhibitor alpha	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.759
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P25963	NFKBIA	NF-kappa-B inhibitor alpha	P06702	S100A9	Protein S100-A9	0.877
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786

Sulfaphenazole

hsa04658

Th1 and Th2 cell differentiation

2.14E-07

Q04759, P07766, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13761	RUNX3	Runt-related transcription factor 3	-0.769

Sulfaphenazole

hsa04659

Th17 cell differentiation

2.91E-05

P25963, Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.927
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Sulfaphenazole

hsa04660

T cell receptor signaling pathway

2.44E-05

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q04759	PRKCQ	Protein kinase C theta type	-0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.824
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.847
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.783
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.858
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.809
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.794

Sulfaphenazole

hsa04662

B cell receptor signaling pathway

1.60E-04

P31751, P42338, P60033, P07948, P21854, Q8N149

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2

Sulfaphenazole

hsa04664

Fc epsilon RI signaling pathway

2.15E-06

P01375, P31751, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P09917, P20292

TNF, AKT2, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, ALOX5, ALOX5AP

Sulfaphenazole

hsa04666

Fc gamma R-mediated phagocytosis

8.08E-03

P42338, P19174, P23528, P14598, P17252

PIK3CB, PLCG1, CFL1, NCF1, PRKCA

Sulfaphenazole

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Sulfaphenazole

hsa04710

Circadian rhythm

4.40E-02

O15516

CLOCK

Sulfaphenazole

hsa04713

Circadian entrainment

1.24E-02

O15399, P0DP23, P17252, P62873, P50151

GRIN2D, CALM1, PRKCA, GNB1, GNG10

Sulfaphenazole

hsa04722

Neurotrophin signaling pathway

1.26E-03

P31751, P49841, O43524, P48023, P0DP23

AKT2, GSK3B, FOXO3, FASLG, CALM1

Sulfaphenazole

hsa04723

Retrograde endocannabinoid signaling

4.40E-02

Q14643, P63218, P50151, P22694, Q16539

ITPR1, GNG5, GNG10, PRKACB, MAPK14

Sulfaphenazole

hsa04724

Glutamatergic synapse

1.44E-04

O15399, P17252, P62873, P63218, P50151, P15104

GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLUL

Sulfaphenazole

hsa04725

Cholinergic synapse

4.49E-03

P17252, P62873, P63218, P50151, P42338

PRKCA, GNB1, GNG5, GNG10, PIK3CB

Sulfaphenazole

hsa04726

Serotonergic synapse

2.54E-02

P17252, P62873, P50151, P33260, P09917

PRKCA, GNB1, GNG10, CYP2C18, ALOX5

Sulfaphenazole

hsa04727

GABAergic synapse

5.11E-04

P62873, P63218, P50151, P15104, P17252

GNB1, GNG5, GNG10, GLUL, PRKCA

Sulfaphenazole

hsa04728

Dopaminergic synapse

3.23E-03

P31751, P0DP23

AKT2, CALM1

Sulfaphenazole

hsa04740

Olfactory transduction

9.46E-04

Q9H255, P0DP23

OR51E2, CALM1

Sulfaphenazole

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Sulfaphenazole

hsa04744

Phototransduction

2.09E-04

P62873, P0DP23

GNB1, CALM1

Sulfaphenazole

hsa04750

Inflammatory mediator regulation of TRP channels

1.83E-03

P14778, P01584, Q08828, P51828, P22694, Q16539, Q14643, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, ITPR1, PRKCH, PRKCQ, CALM1

Sulfaphenazole

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Sulfaphenazole

hsa04910

Insulin signaling pathway

9.82E-04

P0DP23, P31751

CALM1, AKT2

Sulfaphenazole

hsa04914

Progesterone-mediated oocyte maturation

1.24E-02

P42338, Q13370, Q9UJX4, P30304, P08238

PIK3CB, PDE3B, ANAPC5, CDC25A, HSP90AB1

Sulfaphenazole

hsa04915

Estrogen signaling pathway

3.76E-03

Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1

Sulfaphenazole

hsa04916

Melanogenesis

4.78E-02

P0DP23

CALM1

Sulfaphenazole

hsa04917

Prolactin signaling pathway

2.41E-02

P31751

AKT2

Sulfaphenazole

hsa04920

Adipocytokine signaling pathway

4.19E-02

P31751

AKT2

Sulfaphenazole

hsa04922

Glucagon signaling pathway

3.14E-03

P22694, P06737, Q12778, P31751, P0DP23, Q14643

PRKACB, PYGL, FOXO1, AKT2, CALM1, ITPR1

Sulfaphenazole

hsa04923

Regulation of lipolysis in adipocytes

3.01E-02

P31751

AKT2

Sulfaphenazole

hsa04924

Renin secretion

2.12E-03

P22694, P07550, Q14643, P0DP23

PRKACB, ADRB2, ITPR1, CALM1

Sulfaphenazole

hsa04926

Relaxin signaling pathway

3.06E-04

P25963, P42338, P62873, P63218, P50151, P49767, P17252, P49407

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC, PRKCA, ARRB1

Sulfaphenazole

hsa04928

Parathyroid hormone synthesis, secretion and action

4.23E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Sulfaphenazole

hsa04929

GnRH secretion

3.61E-03

P42338, P31751, P49407

PIK3CB, AKT2, ARRB1

Sulfaphenazole

hsa04932

Non-alcoholic fatty liver disease

9.52E-05

P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O15239, O95298

TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2

Sulfaphenazole

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.43E-02

P42224, P42338, P49767, P17252, P19174

STAT1, PIK3CB, VEGFC, PRKCA, PLCG1

Sulfaphenazole

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Sulfaphenazole

hsa04960

Aldosterone-regulated sodium reabsorption

4.40E-02

O00141

SGK

Sulfaphenazole

hsa04962

Vasopressin-regulated water reabsorption

7.22E-03

P52566, P62491

ARHGDIB, RAB11A

Sulfaphenazole

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Sulfaphenazole

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Sulfaphenazole

hsa04970

Salivary secretion

1.11E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Sulfaphenazole

hsa04971

Gastric acid secretion

4.78E-02

P0DP23

CALM1

Sulfaphenazole

hsa04973

Carbohydrate digestion and absorption

2.41E-02

P31751

AKT2

Sulfaphenazole

hsa04976

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Sulfaphenazole

hsa05010

Alzheimer disease

8.59E-04

Q00535, P0DP23, P31751

CDK5, CALM1, AKT2

Sulfaphenazole

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Sulfaphenazole

hsa05022

Pathways of neurodegeneration - multiple diseases

1.81E-02

O15399, Q13509, P68371, P10415, Q13561, P07384, Q00535, P04628, P0DP23

GRIN2D, TUBB3, TUBB2C, BCL2, DCTN2, CAPN1, CDK5, WNT1, CALM1

Sulfaphenazole

hsa05030

Cocaine addiction

4.19E-02

Q00535

CDK5

Sulfaphenazole

hsa05031

Amphetamine addiction

4.78E-02

P0DP23

CALM1

Sulfaphenazole

hsa05032

Morphine addiction

1.24E-02

P62873, P50151, Q13370, P17252, P43250

GNB1, GNG10, PDE3B, PRKCA, GRK6

Sulfaphenazole

hsa05034

Alcoholism

1.96E-04

Q96RR4, Q93077, P62807, O60814, P84243, P68431

CAMKK2, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Sulfaphenazole

hsa05110

Vibrio cholerae infection

3.15E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Sulfaphenazole

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.82E-03

Q16539, P09341, P25024, P25025, P07948

MAPK14, CXCL1, CXCR1, CXCR2, LYN

Sulfaphenazole

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Sulfaphenazole

hsa05131

Shigellosis

3.15E-02

P01375, O00463, P14778, Q16539, Q04759, P61088, Q9NQL2, Q9H1Y0, P12814, Q14643, P49841, P21796

TNF, TRAF5, IL1R1, MAPK14, PRKCQ, UBE2N, RRAGD, ATG5, ACTN1, ITPR1, GSK3B, VDAC1

Sulfaphenazole

hsa05132

Salmonella infection

6.08E-05

P25963, P08238, P63261, Q13546, Q13489, P10415, P04406, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754

NFKBIA, HSP90AB1, ACTG1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41

Sulfaphenazole

hsa05133

Pertussis

1.86E-03

P09871, P0C0L4, Q02556

C1S, C4A, IRF8

Sulfaphenazole

hsa05134

Legionellosis

2.82E-02

P01584, Q9NR31, P0DMV8

IL1B, SAR1A, HSPA1A

Sulfaphenazole

hsa05140

Leishmaniasis

1.65E-03

O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4

Sulfaphenazole

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Sulfaphenazole

hsa05144

Malaria

3.76E-03

P60033, P69905, P68871, P01375, P35443, P26718

CD81, HBA2, HBB, TNF, THBS4, KLRK1

Sulfaphenazole

hsa05145

Toxoplasmosis

3.45E-02

P25963, Q13489, P42224, P09917, Q13751, P11142

NFKBIA, BIRC3, STAT1, ALOX5, LAMB3, HSPA8

Sulfaphenazole

hsa05146

Amoebiasis

1.16E-03

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Sulfaphenazole

hsa05150

Staphylococcus aureus infection

6.29E-05

P21730, P21462, O75015, Q14532, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Sulfaphenazole

hsa05152

Tuberculosis

3.80E-03

Q13488, Q15075, P0DP23, P42224, P25208, O60603, P31751, P10415, P01568, Q9UDY8

TCIRG1, EEA1, CALM1, STAT1, NFYB, TLR2, AKT2, BCL2, IFNA21, MALT1

Sulfaphenazole

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Sulfaphenazole

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Sulfaphenazole

hsa05163

Human cytomegalovirus infection

5.74E-07

P31751, P42338, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, P04637, O00463, P30101, P01568

AKT2, PIK3CB, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.737
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.763
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.758
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.702
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868

Sulfaphenazole

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.63E-04

P01568, P31751, P42224, P25963, P42338, P40189, P62873, P50151, P19174, P0DP23

IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNG10, PLCG1, CALM1

Sulfaphenazole

hsa05168

Herpes simplex virus 1 infection

2.03E-07

Q9UKJ0, Q06124, O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, Q9NR11, Q9HCX3, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415

PILRB, PTPN11, TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P33260	CYP2C18	Cytochrome P450 2C18	Q9UKJ0	PILRB	Paired immunoglobulin-like type 2 receptor beta	-0.762
P33260	CYP2C18	Cytochrome P450 2C18	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	0.742
P27707	DCK	Deoxycytidine kinase	O60603	TLR2	Toll-like receptor 2	-0.781
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.825
P27707	DCK	Deoxycytidine kinase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.89
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P27707	DCK	Deoxycytidine kinase	P01568	IFNA21	Interferon alpha-21	0.798
P33260	CYP2C18	Cytochrome P450 2C18	P01568	IFNA21	Interferon alpha-21	0.86
P27707	DCK	Deoxycytidine kinase	Q05823	RNASEL	2-5A-dependent ribonuclease	-0.752
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P27707	DCK	Deoxycytidine kinase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.7
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.703
P27707	DCK	Deoxycytidine kinase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.804
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.781
P33260	CYP2C18	Cytochrome P450 2C18	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.817
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
P27707	DCK	Deoxycytidine kinase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.757
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
P27707	DCK	Deoxycytidine kinase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.731
P33260	CYP2C18	Cytochrome P450 2C18	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.752
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q9Y2A4	ZNF443	Zinc finger protein 443	0.731
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13398	ZNF211	Zinc finger protein 211	0.956
P27707	DCK	Deoxycytidine kinase	Q13398	ZNF211	Zinc finger protein 211	-0.719
P33260	CYP2C18	Cytochrome P450 2C18	Q13398	ZNF211	Zinc finger protein 211	-0.743
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P51522	ZNF83	Zinc finger protein 83	0.851
P27707	DCK	Deoxycytidine kinase	P51522	ZNF83	Zinc finger protein 83	0.811
P27707	DCK	Deoxycytidine kinase	Q9NR11	ZNF302	Zinc finger protein 302	0.759
P33260	CYP2C18	Cytochrome P450 2C18	Q9NR11	ZNF302	Zinc finger protein 302	0.7
P27707	DCK	Deoxycytidine kinase	Q9HCX3	ZNF304	Zinc finger protein 304	0.737
P27707	DCK	Deoxycytidine kinase	P17097	ZNF7	Zinc finger protein 7	0.8
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P17038	ZNF43	Zinc finger protein 43	0.718
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q03923	ZNF85	Zinc finger protein 85	-0.731
P27707	DCK	Deoxycytidine kinase	Q03923	ZNF85	Zinc finger protein 85	0.731
P33260	CYP2C18	Cytochrome P450 2C18	Q03923	ZNF85	Zinc finger protein 85	0.723
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P52738	ZNF140	Zinc finger protein 140	0.71
P27707	DCK	Deoxycytidine kinase	P52738	ZNF140	Zinc finger protein 140	0.789
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75820	ZNF189	Zinc finger protein 189	-0.756
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	O75820	ZNF189	Zinc finger protein 189	0.768
P27707	DCK	Deoxycytidine kinase	O75820	ZNF189	Zinc finger protein 189	0.801
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q9UDV6	ZNF212	Zinc finger protein 212	0.798
P33260	CYP2C18	Cytochrome P450 2C18	Q9UDV6	ZNF212	Zinc finger protein 212	-0.752
P27707	DCK	Deoxycytidine kinase	P10415	BCL2	Apoptosis regulator Bcl-2	0.781
P33260	CYP2C18	Cytochrome P450 2C18	P10415	BCL2	Apoptosis regulator Bcl-2	0.784

Sulfaphenazole

hsa05169

Epstein-Barr virus infection

3.48E-03

P13765, Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, O75293, P01375, P29728, P07766, P09693, P20963

HLA-DOB, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TNF, OAS2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.748
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13547	HDAC1	Histone deacetylase 1	-0.774
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13547	HDAC1	Histone deacetylase 1	-0.795
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.849
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.713
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13761	RUNX3	Runt-related transcription factor 3	-0.708
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	Q13761	RUNX3	Runt-related transcription factor 3	-0.769
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.805
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.768
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P01375	TNF	Tumor necrosis factor	0.782
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.72
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.77
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.782
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.862

Sulfaphenazole

hsa05170

Human immunodeficiency virus 1 infection

5.56E-04

P31751, P42338, P62873, P50151, P0DP23, P17252, P30101, P01568, P25963, P19174, P23528

AKT2, PIK3CB, GNB1, GNG10, CALM1, PRKCA, PDIA3, IFNA21, NFKBIA, PLCG1, CFL1

Sulfaphenazole

hsa05171

Coronavirus disease - COVID-19

4.35E-03

P01584, P25963, P42224, P01568, P62753, P36578, P62888, P61927, P61513, P62829, P40189, P42338, P19174, P17252

IL1B, NFKBIA, STAT1, IFNA21, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23, IL6ST, PIK3CB, PLCG1, PRKCA

Sulfaphenazole

hsa05200

Pathways in cancer

8.39E-06

Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P10826, P14923, Q13489, P49767, P14921, P31751, P62873, P50151, P78417, O75293, P0DP23, P01568, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, RARB, JUP, BIRC3, VEGFC, ETS1, AKT2, GNB1, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.925
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P10826	RARB	Retinoic acid receptor beta	0.779
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14923	JUP	Junction plakoglobin	-0.716
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.919
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748

Sulfaphenazole

hsa05202

Transcriptional misregulation in cancer

1.40E-03

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, BCL11B, GADD45A

Sulfaphenazole

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Sulfaphenazole

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Sulfaphenazole

hsa05211

Renal cell carcinoma

2.01E-03

Q06124, Q99814, P31751

PTPN11, EPAS1, AKT2

Sulfaphenazole

hsa05212

Pancreatic cancer

4.51E-03

P31751, P04637, P24522

AKT2, TP53, GADD45A

Sulfaphenazole

hsa05213

Endometrial cancer

2.80E-04

Q13418, P31751, P04637, P24522

ILK, AKT2, TP53, GADD45A

Sulfaphenazole

hsa05214

Glioma

6.12E-06

P0DP23, P17252, P42338, P31751, P04637, P19174, P24522, O75293

CALM1, PRKCA, PIK3CB, AKT2, TP53, PLCG1, GADD45A, GADD45B

Sulfaphenazole

hsa05216

Thyroid cancer

1.45E-02

P04637, P24522

TP53, GADD45A

Sulfaphenazole

hsa05217

Basal cell carcinoma

2.60E-02

P04637, P24522

TP53, GADD45A

Sulfaphenazole

hsa05218

Melanoma

1.19E-03

P04637, P31751, P24522

TP53, AKT2, GADD45A

Sulfaphenazole

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Sulfaphenazole

hsa05220

Chronic myeloid leukemia

8.51E-04

Q06124, P04637, P31751, P24522

PTPN11, TP53, AKT2, GADD45A

Sulfaphenazole

hsa05221

Acute myeloid leukemia

4.19E-02

P31751

AKT2

Sulfaphenazole

hsa05222

Small cell lung cancer

1.14E-03

P10826, P31751, P42338, Q13751, Q13489, P25963, O75293

RARB, AKT2, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45B

Sulfaphenazole

hsa05223

Non-small cell lung cancer

3.97E-05

P17252, P31751, P42338, P19174, P10826, P04637, P24522, O75293

PRKCA, AKT2, PIK3CB, PLCG1, RARB, TP53, GADD45A, GADD45B

Sulfaphenazole

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Sulfaphenazole

hsa05225

Hepatocellular carcinoma

4.54E-02

P04637, P24522, P63261

TP53, GADD45A, ACTG1

Sulfaphenazole

hsa05226

Gastric cancer

3.60E-02

P31751

AKT2

Sulfaphenazole

hsa05230

Central carbon metabolism in cancer

4.78E-02

P31751

AKT2

Sulfaphenazole

hsa05231

Choline metabolism in cancer

4.91E-03

P42338, Q9Y259, P19174, P23743, P17252

PIK3CB, CHKB, PLCG1, DGKA, PRKCA

Sulfaphenazole

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.66E-04

O95267, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4

Sulfaphenazole

hsa05310

Asthma

2.48E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Sulfaphenazole

hsa05321

Inflammatory bowel disease

7.47E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Sulfaphenazole

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Sulfaphenazole

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Sulfaphenazole

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Sulfaphenazole

hsa05332

Graft-versus-host disease

4.14E-05

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Sulfaphenazole

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Sulfaphenazole

hsa05418

Fluid shear stress and atherosclerosis

1.27E-05

Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23

MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1

Community members of Sulfaphenazole (S_DC: 7.14)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P33260

CYP2C18

Cytochrome P450 2C18

Predicted

0.0239

0.0756

0.1528

0.316

O00141

SGK

Serine/threonineNoneprotein kinase Sgk1

Predicted

0.2413

0.3037

0.3059

1.034

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

P27707

DCK

Deoxycytidine kinase

Predicted

0.0574

0.0614

0.1653

0.3169

Q9GZR1

SENP6

SentrinNonespecific protease 6

Predicted

0.3844

0.0784

0.349

P01375

TNF

Tumor necrosis factor

Predicted

0.1865

0.551

2.1953

Q99814

EPAS1

Endothelial PAS domainNonecontaining protein 1

Predicted

0.2322

0.062

0.2491

0.4892

P25963

NFKBIA

NFNonekappaNoneB inhibitor alpha

Predicted

0.1048

0.0295

1.1114

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

Q16875

PFKFB3

6NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3

Predicted

0.0462

0.0886

0.2342

0.4345

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

Q13627

DYRK1A

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 1A

Predicted

0.015

0.7082

1.4239

P49759

CLK1

Dual specificity protein kinase CLK1

Predicted

0.2968

0.4546

0.1587

1.2163

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

O95271

TNKS

Poly [ADPNoneribose] polymerase tankyraseNone1

Predicted

0.1017

0.2224

0.4957

Q13418

ILK

IntegrinNonelinked protein kinase

Predicted

0.5885

0.0388

0.394

0.7658

P20292

ALOX5AP

Arachidonate 5NonelipoxygenaseNoneactivating protein

Predicted

0.1303

0.2418

0.0907

0.6395

PharmaCoNets of Sulfaphenazole (SPCN: 178.45 )

Sulfaphenazole regulated-network (SDN: 24.99)

Community members of Sulfaphenazole (SDC: 7.14)

PharmaCoNets of Sulfaphenazole (S_PCN: 178.45 )

Sulfaphenazole regulated-network (S_DN: 24.99)

Community members of Sulfaphenazole (S_DC: 7.14)