PharmaCoNets of Stiripentol (SPCN: 10.03 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Stiripentolhsa00030Pentose phosphate pathway2.27E-022P60891, P37837PRPS1, TALDO1More
Stiripentolhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Stiripentolhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Stiripentolhsa03050Proteasome1.40E-021P55036PSMD4More
Stiripentolhsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Stiripentolhsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Stiripentolhsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Stiripentolhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Stiripentolhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Stiripentolhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Stiripentolhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Stiripentolhsa04612Antigen processing and presentation2.21E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Stiripentolhsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Stiripentolhsa04640Hematopoietic cell lineage1.58E-026P13612, P20023, P11836, P09693, P01732, P13765ITGA4, CR2, MS4A1, CD3G, CD8A, HLA-DOBMore
Stiripentolhsa04650Natural killer cell mediated cytotoxicity1.28E-026P20963, Q13241, P26718, O14931, P26717, P26715CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Stiripentolhsa04658Th1 and Th2 cell differentiation1.36E-025P20963, P09693, P23771, Q9UL17, P13765CD247, CD3G, GATA3, TBX21, HLA-DOBMore
Stiripentolhsa04659Th17 cell differentiation3.36E-025P13765, Q9UL17, P23771, P09693, P20963HLA-DOB, TBX21, GATA3, CD3G, CD247More
Stiripentolhsa04660T cell receptor signaling pathway1.58E-026O95267, Q08881, P20963, P09693, P01732, Q13191RASGRP1, ITK, CD247, CD3G, CD8A, CBLBMore
Stiripentolhsa04672Intestinal immune network for IgA production4.27E-022P13765, P13612HLA-DOB, ITGA4More
Stiripentolhsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Stiripentolhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Stiripentolhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Stiripentolhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Stiripentolhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Stiripentolhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Stiripentolhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Stiripentolhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Stiripentolhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Stiripentolhsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Stiripentolhsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Stiripentolhsa05169Epstein-Barr virus infection3.10E-027P20023, P13765, Q92769, O00463, P24522, P09693, P20963CR2, HLA-DOB, HDAC2, TRAF5, GADD45A, CD3G, CD247More
Stiripentolhsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Stiripentolhsa05217Basal cell carcinoma2.83E-023Q13635, Q9UJU2, P24522PTCH1, LEF1, GADD45AMore
Stiripentolhsa05321Inflammatory bowel disease3.98E-023P13765, Q9UL17, P23771HLA-DOB, TBX21, GATA3More
Stiripentolhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Stiripentolhsa05332Graft-versus-host disease1.62E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More

Community members of Stiripentol (SDC: 2.11)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P07195LDHBLNonelactate dehydrogenase B chainReported00.01670.17490.2310.5892
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)