PharmaCoNets of Sofosbuvir (SPCN: 14.65 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Sofosbuvirhsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Sofosbuvirhsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Sofosbuvirhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Sofosbuvirhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Sofosbuvirhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Sofosbuvirhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Sofosbuvirhsa01522Endocrine resistance4.55E-025P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Sofosbuvirhsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Sofosbuvirhsa04064NF-kappa B signaling pathway9.28E-0310P10415, Q13489, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P24522BCL2, BIRC3, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, GADD45AMore
Sofosbuvirhsa04071Sphingolipid signaling pathway8.09E-048P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Sofosbuvirhsa04080Neuroactive ligand-receptor interaction4.72E-028P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1More
Sofosbuvirhsa04110Cell cycle2.34E-023P06493, O60566, P33981CDK1, BUB1B, TTKMore
Sofosbuvirhsa04115p53 signaling pathway3.34E-022P31350, P06493RRM2, CDK1More
Sofosbuvirhsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Sofosbuvirhsa04145Phagosome1.08E-028O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOBMore
Sofosbuvirhsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Sofosbuvirhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Sofosbuvirhsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Sofosbuvirhsa04613Neutrophil extracellular trap formation8.10E-0520P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Sofosbuvirhsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Sofosbuvirhsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Sofosbuvirhsa04658Th1 and Th2 cell differentiation1.12E-028Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Sofosbuvirhsa04660T cell receptor signaling pathway3.76E-0311P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Sofosbuvirhsa04666Fc gamma R-mediated phagocytosis3.08E-025O75015, P06396, O14494, P14598, P17252FCGR3B, GSN, PLPP1, NCF1, PRKCAMore
Sofosbuvirhsa04940Type I diabetes mellitus4.18E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Sofosbuvirhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Sofosbuvirhsa05140Leishmaniasis4.75E-049P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4More
Sofosbuvirhsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Sofosbuvirhsa05150Staphylococcus aureus infection1.65E-026P21730, P21462, O75015, P13765, Q16581, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMPMore
Sofosbuvirhsa05152Tuberculosis8.54E-039O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Sofosbuvirhsa05202Transcriptional misregulation in cancer2.28E-0317Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Sofosbuvirhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Sofosbuvirhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Sofosbuvirhsa05310Asthma9.08E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Sofosbuvirhsa05321Inflammatory bowel disease9.03E-056O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Sofosbuvirhsa05322Systemic lupus erythematosus1.24E-0413O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Sofosbuvirhsa05332Graft-versus-host disease1.64E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More

Community members of Sofosbuvir (SDC: 2.66)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)