PharmaCoNets of Rosoxacin (SPCN: 249.01 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rosoxacinhsa00030Pentose phosphate pathway1.03E-034P06744, P60891, P52209, P37837GPI, PRPS1, PGD, TALDO1More
Rosoxacinhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Rosoxacinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Rosoxacinhsa00190Oxidative phosphorylation3.56E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Rosoxacinhsa00220Arginine biosynthesis2.25E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Rosoxacinhsa00230Purine metabolism1.73E-034P31350, P21589, P20839, Q02153RRM2, NT5E, IMPDH1, GUCY1B3More
Rosoxacinhsa00240Pyrimidine metabolism6.80E-075P31350, P21589, P32320, P04183, P04818RRM2, NT5E, CDA, TK1, TYMSMore
Rosoxacinhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Rosoxacinhsa00310Lysine degradation4.57E-022Q96KQ7, Q02809EHMT2, PLOD1More
Rosoxacinhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Rosoxacinhsa00500Starch and sucrose metabolism1.91E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Rosoxacinhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Rosoxacinhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Rosoxacinhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Rosoxacinhsa00562Inositol phosphate metabolism2.00E-024P27987, P19174, P42338, Q02252ITPKB, PLCG1, PIK3CB, ALDH6A1More
Rosoxacinhsa00565Ether lipid metabolism3.00E-031Q8N661TMEM86BMore
Rosoxacinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Rosoxacinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Rosoxacinhsa00600Sphingolipid metabolism2.68E-022P07602, Q13510PSAP, ASAH1More
Rosoxacinhsa00630Glyoxylate and dicarboxylate metabolism6.40E-073P40925, P40926, P15104MDH1, MDH2, GLULMore
Rosoxacinhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Rosoxacinhsa00670One carbon pool by folate3.15E-022O95954, Q99707FTCD, MTRMore
Rosoxacinhsa00730Thiamine metabolism1.38E-053Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Rosoxacinhsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Rosoxacinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Rosoxacinhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Rosoxacinhsa00830Retinol metabolism4.55E-021P00325ADH1BMore
Rosoxacinhsa00860Porphyrin and chlorophyll metabolism3.15E-022P36551, P30043CPOX, BLVRBMore
Rosoxacinhsa00910Nitrogen metabolism2.93E-022P22748, P49448CA4, GLUD2More
Rosoxacinhsa00920Sulfur metabolism4.01E-041Q16762TSTMore
Rosoxacinhsa00970Aminoacyl-tRNA biosynthesis6.41E-054O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Rosoxacinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Rosoxacinhsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Rosoxacinhsa00983Drug metabolism - other enzymes5.40E-076P04183, P32320, P31350, P05164, Q16772, P09211TK1, CDA, RRM2, MPO, GSTA3, GSTP1More
Rosoxacinhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Rosoxacinhsa01100Metabolic pathways3.55E-0334Q9NR34, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6MAN1C1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1More
Rosoxacinhsa01200Carbon metabolism7.69E-033P06744, P37837, P40926GPI, TALDO1, MDH2More
Rosoxacinhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Rosoxacinhsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Rosoxacinhsa01523Antifolate resistance2.19E-076P41439, P41440, Q92820, P04818, P01375, P18054FOLR3, SLC19A1, GGH, TYMS, TNF, ALOX12More
Rosoxacinhsa01524Platinum drug resistance4.95E-046O15392, Q16772, P09211, P78417, P11388, P52701BIRC5, GSTA3, GSTP1, GSTO1, TOP2A, MSH6More
Rosoxacinhsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Rosoxacinhsa03010Ribosome7.34E-036P62753, P62829, P62888, P61927, P61513, P36578RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4More
Rosoxacinhsa03013RNA transport1.16E-0824P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, TACC3, EIF2B1, FMR1, FXR1More
Rosoxacinhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Rosoxacinhsa03020RNA polymerase4.09E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Rosoxacinhsa03030DNA replication5.00E-021P27694RPA1More
Rosoxacinhsa03040Spliceosome3.61E-1319Q14562, O43143, O60508, P17844, P08579, Q15427, P26368, P51991, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, HNRPA3, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Rosoxacinhsa03050Proteasome4.83E-021P55036PSMD4More
Rosoxacinhsa03060Protein export1.13E-032P37108, Q15005SRP14, SPCS2More
Rosoxacinhsa03320PPAR signaling pathway4.55E-022O00767, Q02318SCD, CYP27A1More
Rosoxacinhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Rosoxacinhsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Rosoxacinhsa04012ErbB signaling pathway8.75E-068P21860, P16333, P17252, Q13557, P19174, O14944, P42338, P01106ERBB3, NCK1, PRKCA, CAMK2D, PLCG1, EREG, PIK3CB, MYCMore
Rosoxacinhsa04014Ras signaling pathway1.30E-0816P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P17252, P14921, Q7LDG7, Q15283, P61586, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, RASGRP2, RASA2, RHOA, CALM1, GNB1, GNG5, GNG10, PLCG1More
Rosoxacinhsa04015Rap1 signaling pathway4.08E-0612P20827, Q9NRA1, P49767, P08069, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P0DP23, P17252, P19174EFNA1, PDGFC, VEGFC, IGF1R, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, CALM1, PRKCA, PLCG1More
Rosoxacinhsa04020Calcium signaling pathway2.42E-0717P27987, Q96DU7, Q08828, P21796, P45880, Q13557, P17252, P21860, P30679, O15399, P19174, P0DP23, P05141, P51828, P23634, Q9NRA1, P49767ITPKB, ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, PRKCA, ERBB3, GNA15, GRIN2D, PLCG1, CALM1, SLC25A5, ADCY7, ATP2B4, PDGFC, VEGFCMore
Rosoxacinhsa04022cGMP-PKG signaling pathway6.39E-049Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP23CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM1More
Rosoxacinhsa04024cAMP signaling pathway6.55E-049Q08828, P51828, P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1More
Rosoxacinhsa04060Cytokine-cytokine receptor interaction5.39E-0310P27930, P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, IL10RA, IL21R, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Rosoxacinhsa04061Viral protein interaction with cytokine and cytokine receptor4.51E-0813Q8NHW4, P09341, P19875, P25024, P02775, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P09603, P01375CCL4L2, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNFMore
Rosoxacinhsa04062Chemokine signaling pathway9.82E-0923P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P22694, P42224, P25963, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, PRKACB, STAT1, NFKBIA, GSK3B, PIK3R5More
Rosoxacinhsa04064NF-kappa B signaling pathway1.42E-1525P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, P67870, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Rosoxacinhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Rosoxacinhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Rosoxacinhsa04070Phosphatidylinositol signaling system5.33E-079P19174, P0DP23, P42338, O14986, P23743, Q16760, P48426, P27987, P17252PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKB, PRKCAMore
Rosoxacinhsa04071Sphingolipid signaling pathway7.33E-0610P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Rosoxacinhsa04072Phospholipase D signaling pathway1.51E-0516P31751, P42338, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q14344, Q8WYR1, Q15438, Q08828, P51828, P23743, Q16760, Q9NRA1AKT2, PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNA13, PIK3R5, PSCD1, ADCY1, ADCY7, DGKA, DGKD, PDGFCMore
Rosoxacinhsa04080Neuroactive ligand-receptor interaction1.35E-0510P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, ADRB2, ADMMore
Rosoxacinhsa04110Cell cycle2.16E-068P06493, O60566, O75293, P30304, P33981, P42773, P01106, Q13547CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Rosoxacinhsa04114Oocyte meiosis1.78E-0410P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Rosoxacinhsa04115p53 signaling pathway6.07E-057P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2More
Rosoxacinhsa04120Ubiquitin mediated proteolysis1.28E-058Q9UBT2, Q14145, Q13042, P62837, Q15751, O95071, Q14669, P0CG47SAE2, KEAP1, CDC16, UBE2D2, HERC1, UBR5, TRIP12, UBBMore
Rosoxacinhsa04122Sulfur relay system4.01E-041Q16762TSTMore
Rosoxacinhsa04136Autophagy - other3.53E-021O94817ATG12More
Rosoxacinhsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Rosoxacinhsa04140Autophagy - animal2.65E-0413P08069, Q9Y4H2, P31751, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, AKT2, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Rosoxacinhsa04141Protein processing in endoplasmic reticulum2.94E-048P18848, Q15437, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31ATF4, SEC23B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Rosoxacinhsa04142Lysosome2.01E-036P22304, P38571, Q13510, Q9UJJ9, P07602, P49279IDS, LIPA, ASAH1, GNPTG, PSAP, SLC11A1More
Rosoxacinhsa04144Endocytosis6.92E-047P0DMV8, Q9H444, O75351, P62491, Q8WU79, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SMAP1L, GIT2, SNX12More
Rosoxacinhsa04145Phagosome3.01E-0710Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Rosoxacinhsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Rosoxacinhsa04151PI3K-Akt signaling pathway2.59E-0729P62753, P42338, P43657, P01106, O43521, P27348, P20827, Q9NRA1, P49767, Q13362, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, P22105, P14784, P23458, P01568, Q99941, P18848, P17252, O00141, Q6ZUJ8, P30281RPS6, PIK3CB, P2RY5, MYC, BCL2L11, YWHAQ, EFNA1, PDGFC, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TNXB, IL2RB, JAK1, IFNA21, CREBL1, ATF4, PRKCA, SGK, PIK3AP1, CCND3More
Rosoxacinhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Rosoxacinhsa04210Apoptosis1.54E-0311Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1More
Rosoxacinhsa04211Longevity regulating pathway3.68E-046P31751, P08069, Q08828, P51828, Q99941, P18848AKT2, IGF1R, ADCY1, ADCY7, CREBL1, ATF4More
Rosoxacinhsa04213Longevity regulating pathway - multiple species7.65E-069P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Rosoxacinhsa04217Necroptosis3.97E-0515P01375, P01568, P48023, Q13489, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P01584, Q6FI13, Q99878, Q9H444, O43633TNF, IFNA21, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, IL1B, H2AC18; H2AC19, H2AC14, CHMP4B, CHMP2AMore
Rosoxacinhsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Rosoxacinhsa04261Adrenergic signaling in cardiomyocytes3.74E-0610Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557, P23634ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D, ATP2B4More
Rosoxacinhsa04270Vascular smooth muscle contraction2.59E-048P24723, Q04759, Q14643, P0DP23, Q08828, P22694, P35579, P35318PRKCH, PRKCQ, ITPR1, CALM1, ADCY1, PRKACB, MYH9, ADMMore
Rosoxacinhsa04310Wnt signaling pathway5.60E-033P30279, Q13485, O43318CCND2, SMAD4, MAP3K7More
Rosoxacinhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Rosoxacinhsa04340Hedgehog signaling pathway2.62E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Rosoxacinhsa04360Axon guidance2.88E-068P16333, P20827, O95631, P17252, P42338, P07332, P23528, P19174NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, CFL1, PLCG1More
Rosoxacinhsa04370VEGF signaling pathway1.04E-046P19174, P16298, P42338, P17252, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1More
Rosoxacinhsa04371Apelin signaling pathway1.14E-0513P62873, P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Rosoxacinhsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Rosoxacinhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Rosoxacinhsa04510Focal adhesion2.69E-0310P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P08069, P49767ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, IGF1R, VEGFCMore
Rosoxacinhsa04512ECM-receptor interaction2.00E-022P07359, P08514GP1BA, ITGA2BMore
Rosoxacinhsa04514Cell adhesion molecules7.16E-054P23229, P16109, P30511, O00501ITGA6, SELP, HLA-F, CLDN5More
Rosoxacinhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Rosoxacinhsa04530Tight junction2.74E-046Q8TEU7, P16989, P56750, O00501, Q14247, P24844RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9More
Rosoxacinhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Rosoxacinhsa04610Complement and coagulation cascades3.71E-082P00734, P0C0L4F2, C4AMore
Rosoxacinhsa04611Platelet activation1.53E-056Q9Y490, P08514, Q15746, Q08828, Q8WYR1, P07359TLN1, ITGA2B, MYLK, ADCY1, PIK3R5, GP1BAMore
Rosoxacinhsa04612Antigen processing and presentation4.25E-089P13765, P48382, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Rosoxacinhsa04613Neutrophil extracellular trap formation5.96E-0830P42338, P19174, P17252, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q99878, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PIK3CB, PLCG1, PRKCA, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Rosoxacinhsa04620Toll-like receptor signaling pathway4.12E-047P01568, P01584, P31751, P42224, P25963, P42338, Q8NHW4IFNA21, IL1B, AKT2, STAT1, NFKBIA, PIK3CB, CCL4L2More
Rosoxacinhsa04621NOD-like receptor signaling pathway7.89E-0820P01584, P07900, Q16539, Q14643, P23458, P21796, P25963, Q9H3M7, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, P29728, Q05823, P01375, P09341, P49913, P12838IL1B, HSP90AA1, MAPK14, ITPR1, JAK1, VDAC1, NFKBIA, TXNIP, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Rosoxacinhsa04623Cytosolic DNA-sensing pathway9.72E-085P01584, P01568, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2More
Rosoxacinhsa04625C-type lectin receptor signaling pathway7.57E-0511Q9ULY5, P01584, Q9NQC7, P42224, P20749, P25963, P01375, P42338, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, STAT1, BCL3, NFKBIA, TNF, PIK3CB, AKT2, CALM1, MAPK14More
Rosoxacinhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Rosoxacinhsa04640Hematopoietic cell lineage7.53E-0816P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1More
Rosoxacinhsa04650Natural killer cell mediated cytotoxicity2.59E-1517P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Rosoxacinhsa04657IL-17 signaling pathway1.18E-069P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Rosoxacinhsa04658Th1 and Th2 cell differentiation5.84E-2416P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Rosoxacinhsa04659Th17 cell differentiation1.15E-1620P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Rosoxacinhsa04660T cell receptor signaling pathway7.52E-1619P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Rosoxacinhsa04662B cell receptor signaling pathway5.25E-046P25963, P42338, P60033, P07948, P21854, Q8N149NFKBIA, PIK3CB, CD81, LYN, CD72, LILRA2More
Rosoxacinhsa04664Fc epsilon RI signaling pathway8.84E-079P01375, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P09917, P20292TNF, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, ALOX5, ALOX5APMore
Rosoxacinhsa04666Fc gamma R-mediated phagocytosis4.81E-068P07948, P42338, P19174, P23528, P06396, O14494, P14598, P17252LYN, PIK3CB, PLCG1, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Rosoxacinhsa04668TNF signaling pathway2.41E-0411P01375, O00463, Q13489, Q16539, P25963, Q99941, P01584, P20749, Q13077, P14780, O95429TNF, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, IL1B, BCL3, TRAF1, MMP9, BAG4More
Rosoxacinhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Rosoxacinhsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Rosoxacinhsa04710Circadian rhythm1.14E-031O15516CLOCKMore
Rosoxacinhsa04713Circadian entrainment1.64E-048O15399, P0DP23, P17252, P62873, P63218, P50151, Q08828, P51828GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, ADCY1, ADCY7More
Rosoxacinhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Rosoxacinhsa04720Long-term potentiation1.71E-036P16298, P0DP23, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Rosoxacinhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Rosoxacinhsa04723Retrograde endocannabinoid signaling9.74E-037Q14643, P48169, P62873, P63218, P50151, P22694, Q16539ITPR1, GABRA4, GNB1, GNG5, GNG10, PRKACB, MAPK14More
Rosoxacinhsa04724Glutamatergic synapse6.21E-046O15399, P17252, P62873, P63218, P50151, P15104GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLULMore
Rosoxacinhsa04725Cholinergic synapse1.62E-0510Q08828, P51828, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P31751ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, AKT2More
Rosoxacinhsa04726Serotonergic synapse2.54E-025P17252, P62873, P50151, P33260, P09917PRKCA, GNB1, GNG10, CYP2C18, ALOX5More
Rosoxacinhsa04727GABAergic synapse1.70E-046P62873, P63218, P50151, P48169, P15104, P17252GNB1, GNG5, GNG10, GABRA4, GLUL, PRKCAMore
Rosoxacinhsa04728Dopaminergic synapse1.01E-037P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Rosoxacinhsa04730Long-term depression3.01E-032Q14344, P08069GNA13, IGF1RMore
Rosoxacinhsa04742Taste transduction4.80E-021P48169GABRA4More
Rosoxacinhsa04744Phototransduction6.54E-062P62873, P0DP23GNB1, CALM1More
Rosoxacinhsa04750Inflammatory mediator regulation of TRP channels2.47E-0713P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM1More
Rosoxacinhsa04810Regulation of actin cytoskeleton4.14E-037P12814, Q13009, P42338, P23229, P11215, Q14344, Q9NRA1ACTN1, TIAM1, PIK3CB, ITGA6, ITGAM, GNA13, PDGFCMore
Rosoxacinhsa04911Insulin secretion1.68E-065Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Rosoxacinhsa04912GnRH signaling pathway5.32E-056Q08828, P51828, P18848, Q13557, Q9Y6R4, P0DP23ADCY1, ADCY7, ATF4, CAMK2D, MAP3K4, CALM1More
Rosoxacinhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Rosoxacinhsa04914Progesterone-mediated oocyte maturation1.22E-059P08069, Q17RY0, P42338, Q13370, Q9UJX4, P30304, P08238, P51812, Q02750IGF1R, CPEB4, PIK3CB, PDE3B, ANAPC5, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Rosoxacinhsa04915Estrogen signaling pathway2.12E-0810Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Rosoxacinhsa04916Melanogenesis3.48E-036P0DP23, Q9UJU2, Q08828, P51828, P17252, P04628CALM1, LEF1, ADCY1, ADCY7, PRKCA, WNT1More
Rosoxacinhsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Rosoxacinhsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Rosoxacinhsa04921Oxytocin signaling pathway3.84E-034Q15746, Q08828, Q96RR4, Q8WYR1MYLK, ADCY1, CAMKK2, PIK3R5More
Rosoxacinhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Rosoxacinhsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Rosoxacinhsa04924Renin secretion8.07E-065P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Rosoxacinhsa04925Aldosterone synthesis and secretion8.33E-077Q99941, P18848, Q08828, P51828, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2D, ATP2B4More
Rosoxacinhsa04926Relaxin signaling pathway6.94E-0713P31751, P25963, P42338, P62873, P63218, P50151, Q99941, P18848, P49767, Q08828, P51828, P17252, P30679AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, PRKCA, GNA15More
Rosoxacinhsa04927Cortisol synthesis and secretion1.76E-044Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Rosoxacinhsa04928Parathyroid hormone synthesis, secretion and action3.09E-037Q14643, P51828, P22694, P23771, Q99941, P18848, P10415ITPR1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2More
Rosoxacinhsa04932Non-alcoholic fatty liver disease2.72E-0612P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Rosoxacinhsa04933AGE-RAGE signaling pathway in diabetic complications2.76E-037P84022, Q13485, P42224, P42338, P49767, P17252, P19174SMAD3, SMAD4, STAT1, PIK3CB, VEGFC, PRKCA, PLCG1More
Rosoxacinhsa04934Cushing syndrome2.24E-066Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Rosoxacinhsa04935Growth hormone synthesis, secretion and action1.32E-035Q08828, P51828, Q99941, P18848, P31751ADCY1, ADCY7, CREBL1, ATF4, AKT2More
Rosoxacinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Rosoxacinhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Rosoxacinhsa04960Aldosterone-regulated sodium reabsorption4.40E-021O00141SGKMore
Rosoxacinhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Rosoxacinhsa04964Proximal tubule bicarbonate reclamation2.08E-043P22748, P00918, P49448CA4, CA2, GLUD2More
Rosoxacinhsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Rosoxacinhsa04970Salivary secretion1.27E-048P07550, Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMPMore
Rosoxacinhsa04971Gastric acid secretion9.27E-055Q08828, P51828, P15311, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM1, CAMK2DMore
Rosoxacinhsa04972Pancreatic secretion4.73E-022Q08828, P62491ADCY1, RAB11AMore
Rosoxacinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Rosoxacinhsa04976Bile secretion1.59E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Rosoxacinhsa05010Alzheimer disease3.26E-0518Q92542, O15239, O95298, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P18848, O15169, P67870, P31751, P05141, P45880, P28070NCSTN, NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, ATF4, AXIN1, CSNK2B, AKT2, SLC25A5, VDAC2, PSMB4More
Rosoxacinhsa05012Parkinson disease4.01E-026P21796, P60604, P19174, P0DP23, Q71U36, Q13509VDAC1, UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3More
Rosoxacinhsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Rosoxacinhsa05017Spinocerebellar ataxia1.71E-036O75460, Q8TB72, P31751, P28070, P05141, P21796ERN1, PUM2, AKT2, PSMB4, SLC25A5, VDAC1More
Rosoxacinhsa05020Prion disease1.81E-027P01584, P46531, P11142, P05496, P12074, P45880, Q99941IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1More
Rosoxacinhsa05022Pathways of neurodegeneration - multiple diseases3.46E-0311O95298, Q06055, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, O15020, P0DP23, P28070NDUFC2, ATP5G2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, SPTBN2, CALM1, PSMB4More
Rosoxacinhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Rosoxacinhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Rosoxacinhsa05032Morphine addiction1.38E-057P62873, P63218, P50151, Q13370, P48169, P17252, P43250GNB1, GNG5, GNG10, PDE3B, GABRA4, PRKCA, GRK6More
Rosoxacinhsa05033Nicotine addiction2.43E-021P48169GABRA4More
Rosoxacinhsa05034Alcoholism9.92E-0510Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rosoxacinhsa05110Vibrio cholerae infection3.15E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Rosoxacinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.00E-057Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Rosoxacinhsa05131Shigellosis3.62E-0318P01375, P25963, O00463, P14778, Q16539, Q04759, Q9UDY8, P61088, Q9NQL2, Q9H1Y0, P12814, Q14643, Q12778, P49841, Q13315, P10415, P21796, Q96A32TNF, NFKBIA, TRAF5, IL1R1, MAPK14, PRKCQ, MALT1, UBE2N, RRAGD, ATG5, ACTN1, ITPR1, FOXO1, GSK3B, ATM, BCL2, VDAC1, MYLPFMore
Rosoxacinhsa05132Salmonella infection2.98E-0418P51617, P25963, P01375, P08238, Q9UJU2, P01106, P42338, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, MYC, PIK3CB, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Rosoxacinhsa05133Pertussis2.60E-042P0DP23, P0C0L4CALM1, C4AMore
Rosoxacinhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Rosoxacinhsa05140Leishmaniasis6.70E-0511P13612, O75015, P14598, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4More
Rosoxacinhsa05143African trypanosomiasis1.11E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Rosoxacinhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Rosoxacinhsa05145Toxoplasmosis1.79E-0414P51617, P25963, P01375, P10415, Q13489, P23458, P42224, P13765, P09917, Q8WYR1, Q13751, P0DMV8, P11142, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, JAK1, STAT1, HLA-DOB, ALOX5, PIK3R5, LAMB3, HSPA1A, HSPA8, TLR2More
Rosoxacinhsa05146Amoebiasis4.59E-1112P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Rosoxacinhsa05150Staphylococcus aureus infection9.05E-057P0C0L4, P13646, Q14532, P16109, P59665, P59666, P49913C4A, KRT13, KRT32, SELP, DEFA1; DEFA1B, DEFA3, CAMPMore
Rosoxacinhsa05152Tuberculosis4.02E-0511Q13488, P0DP23, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1More
Rosoxacinhsa05160Hepatitis C1.52E-037P60033, O00501, P29728, P49841, P01375, P48023, P01106CD81, CLDN5, OAS2, GSK3B, TNF, FASLG, MYCMore
Rosoxacinhsa05161Hepatitis B2.41E-0311P17252, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765PRKCA, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4More
Rosoxacinhsa05162Measles1.13E-039P01568, P25963, P23458, P42224, P14784, P07766, P42338, P0DMV8, P11142IFNA21, NFKBIA, JAK1, STAT1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8More
Rosoxacinhsa05163Human cytomegalovirus infection1.14E-1230P31751, P42338, P01375, P30511, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P01106, P14778, P01584, P61073, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, PIK3CB, TNF, HLA-F, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, MYC, IL1R1, IL1B, CXCR4, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Rosoxacinhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Rosoxacinhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Rosoxacinhsa05167Kaposi sarcoma-associated herpesvirus infection9.52E-0816P01568, P42224, P25963, P42338, P40189, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CALM1, UBBMore
Rosoxacinhsa05168Herpes simplex virus 1 infection9.55E-0617P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Rosoxacinhsa05169Epstein-Barr virus infection1.66E-0419P13765, P01106, Q13547, O00463, P25963, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P01375, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, TNF, OAS2, CD3E, CD3G, CD247More
Rosoxacinhsa05170Human immunodeficiency virus 1 infection2.29E-1028P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P07766, P10415, Q13619, Q93034, Q9Y6Q5, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, CD3E, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Rosoxacinhsa05171Coronavirus disease - COVID-194.35E-0314P01584, P25963, P42224, P01568, P62753, P36578, P62888, P61927, P61513, P62829, P40189, P42338, P19174, P17252IL1B, NFKBIA, STAT1, IFNA21, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23, IL6ST, PIK3CB, PLCG1, PRKCAMore
Rosoxacinhsa05200Pathways in cancer1.02E-0932Q13751, P42338, P08238, P42224, P25963, P19174, P01106, P17252, P43246, P84022, Q13485, P52701, Q13547, P10826, P14923, P30279, P30281, Q13489, P49767, P14921, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, PRKCA, MSH2, SMAD3, SMAD4, MSH6, HDAC1, RARB, JUP, CCND2, CCND3, BIRC3, VEGFC, ETS1, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Rosoxacinhsa05202Transcriptional misregulation in cancer9.81E-1221Q12778, Q15532, Q13315, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522FOXO1, SS18, ATM, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Rosoxacinhsa05203Viral carcinogenesis2.99E-0617Q12933, Q99941, P18848, P42229, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P12814, P25963, P61978, P62807, Q93079, O60814TRAF2, CREBL1, ATF4, STAT5A, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, HNRPK, HIST1H2BC, H2BC9, H2BC12More
Rosoxacinhsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Rosoxacinhsa05205Proteoglycans in cancer4.93E-0311Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P08069, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63More
Rosoxacinhsa05206MicroRNAs in cancer4.00E-0413P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P20827, P19174CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, EFNA1, PLCG1More
Rosoxacinhsa05210Colorectal cancer4.94E-022Q13485, P52701SMAD4, MSH6More
Rosoxacinhsa05212Pancreatic cancer1.45E-048P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Rosoxacinhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Rosoxacinhsa05214Glioma8.26E-076P08069, P0DP23, P17252, P42338, P19174, O75293IGF1R, CALM1, PRKCA, PIK3CB, PLCG1, GADD45BMore
Rosoxacinhsa05215Prostate cancer1.33E-021P08069IGF1RMore
Rosoxacinhsa05218Melanoma2.77E-034P08069, Q9NRA1, P42338, O75293IGF1R, PDGFC, PIK3CB, GADD45BMore
Rosoxacinhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Rosoxacinhsa05220Chronic myeloid leukemia1.15E-037Q13547, P01106, Q13485, P25963, P84022, P42338, O75293HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Rosoxacinhsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Rosoxacinhsa05222Small cell lung cancer9.25E-0410P10826, P42338, Q13751, Q13489, P10415, P25963, Q13077, O00463, P24522, O75293RARB, PIK3CB, LAMB3, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45BMore
Rosoxacinhsa05223Non-small cell lung cancer5.61E-046P17252, P42338, P19174, P10826, Q9HC35, O75293PRKCA, PIK3CB, PLCG1, RARB, EML4, GADD45BMore
Rosoxacinhsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Rosoxacinhsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Rosoxacinhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Rosoxacinhsa05231Choline metabolism in cancer5.22E-0710P31751, P42338, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986, P17252AKT2, PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PRKCAMore
Rosoxacinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer6.89E-1115P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Rosoxacinhsa05310Asthma9.09E-083P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Rosoxacinhsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Rosoxacinhsa05321Inflammatory bowel disease6.29E-127O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Rosoxacinhsa05322Systemic lupus erythematosus2.03E-0715O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Rosoxacinhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Rosoxacinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Rosoxacinhsa05332Graft-versus-host disease1.03E-106P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Rosoxacinhsa05340Primary immunodeficiency4.24E-023P01730, P07766, P06239CD4, CD3E, LCKMore
Rosoxacinhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Rosoxacinhsa05414Dilated cardiomyopathy2.60E-033P54284, P09493, P26678CACNB3, TPM1, PLNMore
Rosoxacinhsa05418Fluid shear stress and atherosclerosis1.56E-0512Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Rosoxacin (SDC: 9.60)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P42892ECE1EndothelinNoneconverting enzyme 1Predicted00.48530.092200.4269
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
P61586RHOATransforming protein RhoAPredicted00.35410.068911.3149
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P04183TK1Thymidine kinase, cytosolicPredicted00.27170.16370.16530.6286
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P16109SELPPNoneselectinPredicted10.15230.07220.57330.7938
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
Q16875PFKFB36NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3Predicted10.04620.08860.23420.4345
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
P10619CTSALysosomal protective proteinPredicted00.12260.15310.19010.5575
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)