PharmaCoNets

PharmaCoNets of Oxytetracycline (S_PCN: 30.53 )

Oxytetracycline regulated-network (S_DN: 9.54)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Oxytetracycline

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Oxytetracycline

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Oxytetracycline

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Oxytetracycline

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Oxytetracycline

hsa01522

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Oxytetracycline

hsa01524

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Oxytetracycline

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Oxytetracycline

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Oxytetracycline

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Oxytetracycline

hsa04012

ErbB signaling pathway

3.15E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Oxytetracycline

hsa04015

Rap1 signaling pathway

4.78E-02

P09603, Q9GZP0, P11215, Q86WV1, P19174

CSF1, PDGFD, ITGAM, SKAP1, PLCG1

Oxytetracycline

hsa04064

NF-kappa B signaling pathway

9.28E-03

P10415, Q13489, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P24522

BCL2, BIRC3, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, GADD45A

Oxytetracycline

hsa04071

Sphingolipid signaling pathway

4.78E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Oxytetracycline

hsa04080

Neuroactive ligand-receptor interaction

4.72E-02

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Oxytetracycline

hsa04140

Autophagy - animal

4.20E-03

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Oxytetracycline

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Oxytetracycline

hsa04145

Phagosome

1.08E-02

O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOB

Oxytetracycline

hsa04151

PI3K-Akt signaling pathway

1.27E-02

P43657, P01106, P09603, Q9GZP0, P63218, P50151, P13612, Q13751, P14784

P2RY5, MYC, CSF1, PDGFD, GNG5, GNG10, ITGA4, LAMB3, IL2RB

Oxytetracycline

hsa04217

Necroptosis

4.42E-04

P07900, P15104, P05141, P01584, P0C0S5, Q13557

HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D

Oxytetracycline

hsa04340

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Oxytetracycline

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Oxytetracycline

hsa04612

Antigen processing and presentation

1.94E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Oxytetracycline

hsa04613

Neutrophil extracellular trap formation

1.59E-05

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Oxytetracycline

hsa04621

NOD-like receptor signaling pathway

2.62E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Oxytetracycline

hsa04640

Hematopoietic cell lineage

4.59E-03

P13612, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P09603

ITGA4, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, CSF1

Oxytetracycline

hsa04657

IL-17 signaling pathway

2.59E-03

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Oxytetracycline

hsa04658

Th1 and Th2 cell differentiation

2.06E-05

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43250	GRK6	G protein-coupled receptor kinase 6	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.787
P43250	GRK6	G protein-coupled receptor kinase 6	P06239	LCK	Tyrosine-protein kinase Lck	-0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.815
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q9UM07	PADI4	Protein-arginine deiminase type-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.905
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UL17	TBX21	T-box transcription factor TBX21	-0.788
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
Q9UM07	PADI4	Protein-arginine deiminase type-4	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43250	GRK6	G protein-coupled receptor kinase 6	Q13761	RUNX3	Runt-related transcription factor 3	-0.828

Oxytetracycline

hsa04660

T cell receptor signaling pathway

4.04E-05

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01375	TNF	Tumor necrosis factor	0.788
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q04759	PRKCQ	Protein kinase C theta type	-0.91
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q9UM07	PADI4	Protein-arginine deiminase type-4	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.799
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.828
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q9UM07	PADI4	Protein-arginine deiminase type-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.793
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
Q9UM07	PADI4	Protein-arginine deiminase type-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.839
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Oxytetracycline

hsa04664

Fc epsilon RI signaling pathway

3.15E-02

P07948, P19174, P09917

LYN, PLCG1, ALOX5

Oxytetracycline

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Oxytetracycline

hsa04672

Intestinal immune network for IgA production

1.66E-02

P10747, P13765, P13612

CD28, HLA-DOB, ITGA4

Oxytetracycline

hsa04924

Renin secretion

3.64E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Oxytetracycline

hsa04927

Cortisol synthesis and secretion

1.66E-02

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Oxytetracycline

hsa04932

Non-alcoholic fatty liver disease

9.70E-03

P18848, P01584, P13073, O15239

ATF4, IL1B, COX4I1, NDUFA1

Oxytetracycline

hsa04940

Type I diabetes mellitus

2.91E-03

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Oxytetracycline

hsa04970

Salivary secretion

4.92E-02

P07550, P22694, Q14643, P49913

ADRB2, PRKACB, ITPR1, CAMP

Oxytetracycline

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Oxytetracycline

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Oxytetracycline

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Oxytetracycline

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Oxytetracycline

hsa05032

Morphine addiction

1.27E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Oxytetracycline

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Oxytetracycline

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Oxytetracycline

hsa05140

Leishmaniasis

4.75E-04

P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4

Oxytetracycline

hsa05144

Malaria

4.92E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Oxytetracycline

hsa05146

Amoebiasis

1.70E-03

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Oxytetracycline

hsa05150

Staphylococcus aureus infection

1.65E-02

P21730, P21462, O75015, P13765, Q16581, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP

Oxytetracycline

hsa05152

Tuberculosis

8.54E-03

O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Oxytetracycline

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Oxytetracycline

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Oxytetracycline

hsa05202

Transcriptional misregulation in cancer

2.97E-04

Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Oxytetracycline

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Oxytetracycline

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Oxytetracycline

hsa05310

Asthma

2.84E-05

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Oxytetracycline

hsa05321

Inflammatory bowel disease

3.13E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Oxytetracycline

hsa05322

Systemic lupus erythematosus

1.24E-04

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB