PharmaCoNets of Oxymetholone (SPCN: 79.95 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Oxymetholonehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Oxymetholonehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Oxymetholonehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Oxymetholonehsa00071Fatty acid degradation3.77E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Oxymetholonehsa00190Oxidative phosphorylation4.36E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Oxymetholonehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Oxymetholonehsa00500Starch and sucrose metabolism1.00E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Oxymetholonehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Oxymetholonehsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Oxymetholonehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Oxymetholonehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Oxymetholonehsa00970Aminoacyl-tRNA biosynthesis9.32E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Oxymetholonehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Oxymetholonehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Oxymetholonehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Oxymetholonehsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Oxymetholonehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Oxymetholonehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Oxymetholonehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Oxymetholonehsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Oxymetholonehsa03430Mismatch repair4.38E-021P20585MSH3More
Oxymetholonehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Oxymetholonehsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Oxymetholonehsa04015Rap1 signaling pathway5.18E-043P08069, P06213, O00522IGF1R, INSR, KRIT1More
Oxymetholonehsa04024cAMP signaling pathway4.25E-037P63092, P42338, P26678, P0DP23, P61586, Q13370, Q13009GNAS, PIK3CB, PLN, CALM1, RHOA, PDE3B, TIAM1More
Oxymetholonehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Oxymetholonehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Oxymetholonehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Oxymetholonehsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Oxymetholonehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Oxymetholonehsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Oxymetholonehsa04080Neuroactive ligand-receptor interaction3.70E-027P08311, P48058, Q15722, Q9H228, P43657, P21730, P35318CTSG, GRIA4, LTB4R, EDG8, P2RY5, C5AR1, ADMMore
Oxymetholonehsa04114Oocyte meiosis3.19E-035P51812, Q02750, P16298, Q17RY0, P08069RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Oxymetholonehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Oxymetholonehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Oxymetholonehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Oxymetholonehsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Oxymetholonehsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Oxymetholonehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Oxymetholonehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Oxymetholonehsa04211Longevity regulating pathway1.34E-034Q12778, P08069, Q9UEF7, Q96KQ7FOXO1, IGF1R, KL, EHMT2More
Oxymetholonehsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Oxymetholonehsa04217Necroptosis1.85E-037P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14More
Oxymetholonehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Oxymetholonehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Oxymetholonehsa04360Axon guidance7.48E-045P20827, O95631, P42338, P23528, Q06124EFNA1, NTN1, PIK3CB, CFL1, PTPN11More
Oxymetholonehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Oxymetholonehsa04510Focal adhesion8.84E-034O14986, P61586, Q16363, P08069PIP5K1B, RHOA, LAMA4, IGF1RMore
Oxymetholonehsa04520Adherens junction1.65E-054P08069, P19784, P67870, P61586IGF1R, CSNK2A2, CSNK2B, RHOAMore
Oxymetholonehsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Oxymetholonehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Oxymetholonehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Oxymetholonehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Oxymetholonehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Oxymetholonehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Oxymetholonehsa04640Hematopoietic cell lineage1.13E-028P13612, P14778, P27930, P15144, P07766, P09693, P01732, P01730ITGA4, IL1R1, IL1R2, ANPEP, CD3E, CD3G, CD8A, CD4More
Oxymetholonehsa04650Natural killer cell mediated cytotoxicity9.90E-0512P16298, P50591, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715PPP3CB, TNFSF10, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Oxymetholonehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Oxymetholonehsa04658Th1 and Th2 cell differentiation1.27E-049Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21More
Oxymetholonehsa04659Th17 cell differentiation3.25E-0514Q04759, Q16539, P01730, P06239, P42224, P14784, P14778, P40189, Q9UL17, P23771, P08238, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, STAT1, IL2RB, IL1R1, IL6ST, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247More
Oxymetholonehsa04660T cell receptor signaling pathway6.29E-0410Q04759, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841PRKCQ, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Oxymetholonehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Oxymetholonehsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Oxymetholonehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Oxymetholonehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Oxymetholonehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Oxymetholonehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Oxymetholonehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Oxymetholonehsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Oxymetholonehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Oxymetholonehsa04730Long-term depression1.16E-021P08069IGF1RMore
Oxymetholonehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Oxymetholonehsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Oxymetholonehsa04914Progesterone-mediated oocyte maturation9.67E-047P08069, Q17RY0, P42338, Q13370, P08238, P51812, Q02750IGF1R, CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1More
Oxymetholonehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Oxymetholonehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Oxymetholonehsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Oxymetholonehsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Oxymetholonehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Oxymetholonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Oxymetholonehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Oxymetholonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Oxymetholonehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Oxymetholonehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Oxymetholonehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Oxymetholonehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Oxymetholonehsa05032Morphine addiction2.47E-033P62873, P48169, P63092GNB1, GABRA4, GNASMore
Oxymetholonehsa05120Epithelial cell signaling in Helicobacter pylori infection3.76E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Oxymetholonehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Oxymetholonehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Oxymetholonehsa05135Yersinia infection1.52E-026P13612, P06239, Q16539, P49841, P01730, P01732ITGA4, LCK, MAPK14, GSK3B, CD4, CD8AMore
Oxymetholonehsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Oxymetholonehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Oxymetholonehsa05146Amoebiasis2.10E-026P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Oxymetholonehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Oxymetholonehsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Oxymetholonehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Oxymetholonehsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Oxymetholonehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Oxymetholonehsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Oxymetholonehsa05202Transcriptional misregulation in cancer2.82E-021P08069IGF1RMore
Oxymetholonehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Oxymetholonehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Oxymetholonehsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Oxymetholonehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Oxymetholonehsa05214Glioma1.88E-034P08069, P0DP23, P42338, O75293IGF1R, CALM1, PIK3CB, GADD45BMore
Oxymetholonehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Oxymetholonehsa05218Melanoma6.63E-031P08069IGF1RMore
Oxymetholonehsa05224Breast cancer1.49E-021P08069IGF1RMore
Oxymetholonehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Oxymetholonehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Oxymetholonehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Oxymetholonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.79E-037P07766, P20963, P09693, P06239, Q04759, Q16539, P01730CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4More
Oxymetholonehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Oxymetholonehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Oxymetholonehsa05340Primary immunodeficiency3.76E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Oxymetholonehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore
Oxymetholonehsa05418Fluid shear stress and atherosclerosis3.73E-024P42338, P14598, P0DP23, P08238PIK3CB, NCF1, CALM1, HSP90AB1More

Community members of Oxymetholone (SDC: 5.63)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Predicted00.32530.5650.15791.4506
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
O43451MGAMMaltaseNoneglucoamylasePredicted10.19540.16780.1910.6242
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)