PharmaCoNets of Obeticholic-acid (SPCN: 61.37 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Obeticholic-acidhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Obeticholic-acidhsa00190Oxidative phosphorylation2.21E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Obeticholic-acidhsa00220Arginine biosynthesis1.94E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Obeticholic-acidhsa00250Alanine, aspartate and glutamate metabolism4.32E-022P49448, P15104GLUD2, GLULMore
Obeticholic-acidhsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Obeticholic-acidhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Obeticholic-acidhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Obeticholic-acidhsa00561Glycerolipid metabolism1.37E-034O14494, P51648, P06280, P23743PLPP1, ALDH3A2, GLA, DGKAMore
Obeticholic-acidhsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Obeticholic-acidhsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Obeticholic-acidhsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Obeticholic-acidhsa00630Glyoxylate and dicarboxylate metabolism2.78E-032P40925, P15104MDH1, GLULMore
Obeticholic-acidhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Obeticholic-acidhsa00910Nitrogen metabolism4.32E-022P15104, P49448GLUL, GLUD2More
Obeticholic-acidhsa00980Metabolism of xenobiotics by cytochrome P4504.08E-044Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Obeticholic-acidhsa00982Drug metabolism - cytochrome P4507.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Obeticholic-acidhsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Obeticholic-acidhsa01100Metabolic pathways1.44E-0323P35790, Q16772, P09211, Q9UJ14, P30041, P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P40926, Q7KZN9, P15121, P23743, Q9UHK6, P43034, Q86VZ5, P09917, Q53FZ2, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, MDH2, COX15, AKR1B1, DGKA, AMACR, PAFAH1B1, SGMS1, ALOX5, ACSM3, VKORC1More
Obeticholic-acidhsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Obeticholic-acidhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Obeticholic-acidhsa01521EGFR tyrosine kinase inhibitor resistance7.30E-044Q92529, P19174, P42338, Q9NRA1SHC3, PLCG1, PIK3CB, PDGFCMore
Obeticholic-acidhsa01524Platinum drug resistance3.80E-034O15392, Q16772, P09211, P11388BIRC5, GSTA3, GSTP1, TOP2AMore
Obeticholic-acidhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Obeticholic-acidhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Obeticholic-acidhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Obeticholic-acidhsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Obeticholic-acidhsa03040Spliceosome1.27E-026O43143, P08579, Q13595, Q07955, P84103, P11142DHX15, SNRPB2, TRA2A, SFRS1, SFRS3, HSPA8More
Obeticholic-acidhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Obeticholic-acidhsa04012ErbB signaling pathway9.49E-033Q92529, P19174, P42338SHC3, PLCG1, PIK3CBMore
Obeticholic-acidhsa04014Ras signaling pathway6.70E-0510P42338, Q92529, P20827, Q9NRA1, P49767, Q14644, P0DP23, P63218, P50151, P19174PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, RASA3, CALM1, GNG5, GNG10, PLCG1More
Obeticholic-acidhsa04015Rap1 signaling pathway3.91E-024Q9NRA1, P49767, P42338, P19174PDGFC, VEGFC, PIK3CB, PLCG1More
Obeticholic-acidhsa04020Calcium signaling pathway2.74E-0511P27987, Q16566, P30679, O15399, P19174, P0DP24, P0DP23, P51828, P23634, Q9NRA1, P49767ITPKB, CAMK4, GNA15, GRIN2D, PLCG1, CALM2, CALM1, ADCY7, ATP2B4, PDGFC, VEGFCMore
Obeticholic-acidhsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Obeticholic-acidhsa04062Chemokine signaling pathway2.13E-0411P25024, P25025, P07948, P42338, P19174, Q92529, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Obeticholic-acidhsa04064NF-kappa B signaling pathway2.35E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Obeticholic-acidhsa04070Phosphatidylinositol signaling system3.19E-045P19174, P42338, P23743, Q96PE3, P27987PLCG1, PIK3CB, DGKA, INPP4A, ITPKBMore
Obeticholic-acidhsa04071Sphingolipid signaling pathway2.14E-023Q13510, Q13362, Q9UQC2ASAH1, PPP2R5C, GAB2More
Obeticholic-acidhsa04072Phospholipase D signaling pathway3.21E-0510P42338, Q92529, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1, Q9GZP0PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFC, PDGFDMore
Obeticholic-acidhsa04114Oocyte meiosis8.69E-034P0DP24, P51828, P27348, Q13362CALM2, ADCY7, YWHAQ, PPP2R5CMore
Obeticholic-acidhsa04120Ubiquitin mediated proteolysis2.57E-024Q14145, Q13042, Q93034, Q15751KEAP1, CDC16, CUL5, HERC1More
Obeticholic-acidhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Obeticholic-acidhsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Obeticholic-acidhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Obeticholic-acidhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Obeticholic-acidhsa04145Phagosome3.94E-026P60709, Q15075, Q15080, P14598, Q13509, Q13488ACTB, EEA1, NCF4, NCF1, TUBB3, TCIRG1More
Obeticholic-acidhsa04151PI3K-Akt signaling pathway2.55E-038P42338, Q9NRA1, P49767, P08238, P63218, P50151, O15335, P14784PIK3CB, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, IL2RBMore
Obeticholic-acidhsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Obeticholic-acidhsa04261Adrenergic signaling in cardiomyocytes1.06E-024P51828, Q13362, P0DP24, P23634ADCY7, PPP2R5C, CALM2, ATP2B4More
Obeticholic-acidhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Obeticholic-acidhsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Obeticholic-acidhsa04370VEGF signaling pathway1.56E-022P19174, P42338PLCG1, PIK3CBMore
Obeticholic-acidhsa04371Apelin signaling pathway1.56E-037P63218, P50151, Q13370, Q14344, Q13485, Q16566, P0DP23GNG5, GNG10, PDE3B, GNA13, SMAD4, CAMK4, CALM1More
Obeticholic-acidhsa04380Osteoclast differentiation3.37E-038P09603, P06239, P42338, P14778, O75015, P01375, Q8N149, P78324CSF1, LCK, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2, SIRPAMore
Obeticholic-acidhsa04510Focal adhesion1.55E-025P42338, O15335, Q9NRA1, P49767, Q92529PIK3CB, CHAD, PDGFC, VEGFC, SHC3More
Obeticholic-acidhsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Obeticholic-acidhsa04610Complement and coagulation cascades4.48E-023P01042, P09871, P11215KNG1, C1S, ITGAMMore
Obeticholic-acidhsa04611Platelet activation4.11E-023P42338, Q14344, P07948PIK3CB, GNA13, LYNMore
Obeticholic-acidhsa04612Antigen processing and presentation4.12E-023O43908, P30511, P01375KLRC4, HLA-F, TNFMore
Obeticholic-acidhsa04621NOD-like receptor signaling pathway3.24E-024P52630, P10599, P01375, P12838STAT2, TXN, TNF, DEFA4More
Obeticholic-acidhsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Obeticholic-acidhsa04625C-type lectin receptor signaling pathway2.38E-036Q9ULY5, P52630, P20749, P01375, Q13191, P42338CLEC4E, STAT2, BCL3, TNF, CBLB, PIK3CBMore
Obeticholic-acidhsa04650Natural killer cell mediated cytotoxicity1.79E-027P01375, P06239, O60880, P20963, P42338, P26718, O75015TNF, LCK, SH2D1A, CD247, PIK3CB, KLRK1, FCGR3BMore
Obeticholic-acidhsa04657IL-17 signaling pathway3.06E-023P49841, P80188, P01375GSK3B, LCN2, TNFMore
Obeticholic-acidhsa04658Th1 and Th2 cell differentiation1.01E-024P07766, P19174, P14784, Q13761CD3E, PLCG1, IL2RB, RUNX3More
Obeticholic-acidhsa04659Th17 cell differentiation2.16E-024P19174, P14784, P08238, P07766PLCG1, IL2RB, HSP90AB1, CD3EMore
Obeticholic-acidhsa04660T cell receptor signaling pathway6.23E-038P01375, P42338, Q08881, P07766, P20963, Q13191, P06239, P49841TNF, PIK3CB, ITK, CD3E, CD247, CBLB, LCK, GSK3BMore
Obeticholic-acidhsa04662B cell receptor signaling pathway1.32E-035P49841, P42338, P60033, P07948, Q8N149GSK3B, PIK3CB, CD81, LYN, LILRA2More
Obeticholic-acidhsa04664Fc epsilon RI signaling pathway6.90E-055P01375, P42338, P07948, P19174, P09917TNF, PIK3CB, LYN, PLCG1, ALOX5More
Obeticholic-acidhsa04666Fc gamma R-mediated phagocytosis1.73E-023P07948, P42338, P19174LYN, PIK3CB, PLCG1More
Obeticholic-acidhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Obeticholic-acidhsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Obeticholic-acidhsa04720Long-term potentiation1.79E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Obeticholic-acidhsa04722Neurotrophin signaling pathway4.87E-023P42338, P19174, Q92529PIK3CB, PLCG1, SHC3More
Obeticholic-acidhsa04724Glutamatergic synapse2.04E-035O15399, P63218, P50151, P15104, Q9NSB8GRIN2D, GNG5, GNG10, GLUL, HOMER2More
Obeticholic-acidhsa04725Cholinergic synapse1.73E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Obeticholic-acidhsa04726Serotonergic synapse3.41E-023P63218, P50151, P09917GNG5, GNG10, ALOX5More
Obeticholic-acidhsa04727GABAergic synapse6.57E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Obeticholic-acidhsa04730Long-term depression1.56E-022Q14344, P07948GNA13, LYNMore
Obeticholic-acidhsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Obeticholic-acidhsa04910Insulin signaling pathway4.11E-023Q92529, Q13370, P42338SHC3, PDE3B, PIK3CBMore
Obeticholic-acidhsa04914Progesterone-mediated oocyte maturation2.22E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Obeticholic-acidhsa04915Estrogen signaling pathway3.80E-049Q08828, P51828, P42338, Q92529, P08238, P0DMV8, P11142, P0DP23, Q15788ADCY1, ADCY7, PIK3CB, SHC3, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1More
Obeticholic-acidhsa04920Adipocytokine signaling pathway2.62E-033Q06124, Q9Y478, Q96RR4PTPN11, PRKAB1, CAMKK2More
Obeticholic-acidhsa04923Regulation of lipolysis in adipocytes3.64E-022Q13370, P42338PDE3B, PIK3CBMore
Obeticholic-acidhsa04925Aldosterone synthesis and secretion1.40E-035P51828, P0DP24, P0DP23, Q16566, P23634ADCY7, CALM2, CALM1, CAMK4, ATP2B4More
Obeticholic-acidhsa04926Relaxin signaling pathway1.31E-035P42338, P63218, P50151, P49767, Q92529PIK3CB, GNG5, GNG10, VEGFC, SHC3More
Obeticholic-acidhsa04932Non-alcoholic fatty liver disease1.39E-026O43521, O75460, P01584, P13073, P12074, O95298BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2More
Obeticholic-acidhsa04933AGE-RAGE signaling pathway in diabetic complications4.11E-023P42338, P49767, P19174PIK3CB, VEGFC, PLCG1More
Obeticholic-acidhsa04935Growth hormone synthesis, secretion and action2.78E-023P19174, P42338, Q92529PLCG1, PIK3CB, SHC3More
Obeticholic-acidhsa04940Type I diabetes mellitus1.58E-022P30511, P01375HLA-F, TNFMore
Obeticholic-acidhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Obeticholic-acidhsa04970Salivary secretion6.83E-045Q08828, P51828, P23634, P0DP24, P0DP23ADCY1, ADCY7, ATP2B4, CALM2, CALM1More
Obeticholic-acidhsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Obeticholic-acidhsa04973Carbohydrate digestion and absorption1.57E-022O43451, P42338MGAM, PIK3CBMore
Obeticholic-acidhsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Obeticholic-acidhsa05010Alzheimer disease3.75E-028P01375, Q9NZJ5, Q13564, P49841, Q92837, P09603, P42338, P21796TNF, EIF2AK3, APPBP1, GSK3B, FRAT1, CSF1, PIK3CB, VDAC1More
Obeticholic-acidhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Obeticholic-acidhsa05032Morphine addiction2.22E-023P63218, P50151, Q13370GNG5, GNG10, PDE3BMore
Obeticholic-acidhsa05034Alcoholism1.05E-026O15399, Q16566, P0DP23, P63218, O60814, P68431GRIN2D, CAMK4, CALM1, GNG5, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Obeticholic-acidhsa05100Bacterial invasion of epithelial cells3.64E-022P42338, Q92529PIK3CB, SHC3More
Obeticholic-acidhsa05110Vibrio cholerae infection4.50E-034Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Obeticholic-acidhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Obeticholic-acidhsa05133Pertussis1.70E-034P11215, P0DP23, P23528, P09871ITGAM, CALM1, CFL1, C1SMore
Obeticholic-acidhsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Obeticholic-acidhsa05135Yersinia infection4.00E-025P13612, P06239, P01375, P42338, P49841ITGA4, LCK, TNF, PIK3CB, GSK3BMore
Obeticholic-acidhsa05140Leishmaniasis4.75E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Obeticholic-acidhsa05160Hepatitis C9.27E-034P52630, P60033, P49841, P01375STAT2, CD81, GSK3B, TNFMore
Obeticholic-acidhsa05162Measles5.79E-038P23458, P14784, P07766, P42338, P0DMV8, P11142, P01584, Q9NP90JAK1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8, IL1B, RAB9BMore
Obeticholic-acidhsa05163Human cytomegalovirus infection1.23E-0618P42338, P01375, P30511, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, O00463, P30101PIK3CB, TNF, HLA-F, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, TRAF5, PDIA3More
Obeticholic-acidhsa05165Human papillomavirus infection1.76E-025P49841, P24821, P01375, P52630, P30511GSK3B, TNC, TNF, STAT2, HLA-FMore
Obeticholic-acidhsa05167Kaposi sarcoma-associated herpesvirus infection1.14E-025P42338, P63218, P50151, P19174, P07948PIK3CB, GNG5, GNG10, PLCG1, LYNMore
Obeticholic-acidhsa05169Epstein-Barr virus infection8.75E-0410Q13547, O00463, P42338, P07948, P30511, P30101, Q13761, P01375, P07766, P20963HDAC1, TRAF5, PIK3CB, LYN, HLA-F, PDIA3, RUNX3, TNF, CD3E, CD247More
Obeticholic-acidhsa05170Human immunodeficiency virus 1 infection6.31E-0410P42338, P30511, P63218, P50151, P01375, O00463, P30101, P19174, P07766, P20963PIK3CB, HLA-F, GNG5, GNG10, TNF, TRAF5, PDIA3, PLCG1, CD3E, CD247More
Obeticholic-acidhsa05200Pathways in cancer3.05E-028P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RBMore
Obeticholic-acidhsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Obeticholic-acidhsa05204Chemical carcinogenesis7.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Obeticholic-acidhsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Obeticholic-acidhsa05214Glioma9.49E-033Q92529, P42338, P19174SHC3, PIK3CB, PLCG1More
Obeticholic-acidhsa05215Prostate cancer4.87E-023Q9NRA1, P08238, P42338PDGFC, HSP90AB1, PIK3CBMore
Obeticholic-acidhsa05218Melanoma3.64E-022Q9NRA1, P42338PDGFC, PIK3CBMore
Obeticholic-acidhsa05223Non-small cell lung cancer3.99E-024P17252, O43524, P19174, O75293PRKCA, FOXO3, PLCG1, GADD45BMore
Obeticholic-acidhsa05231Choline metabolism in cancer3.04E-046P42338, Q9NRA1, P19174, P23743, O14494, P17252PIK3CB, PDGFC, PLCG1, DGKA, PLPP1, PRKCAMore
Obeticholic-acidhsa05310Asthma9.71E-032P12724, P01375RNASE3, TNFMore
Obeticholic-acidhsa05330Allograft rejection2.30E-022P30511, P01375HLA-F, TNFMore
Obeticholic-acidhsa05332Graft-versus-host disease3.14E-022P30511, P01375HLA-F, TNFMore
Obeticholic-acidhsa05415Diabetic cardiomyopathy3.94E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore
Obeticholic-acidhsa05418Fluid shear stress and atherosclerosis4.52E-036P42338, Q14145, P10599, P01375, P14778, P27930PIK3CB, KEAP1, TXN, TNF, IL1R1, IL1R2More

Community members of Obeticholic-acid (SDC: 3.82)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)