PharmaCoNets

PharmaCoNets of Nicardipine (S_PCN: 58.78 )

Nicardipine regulated-network (S_DN: 20.99)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Nicardipine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Nicardipine

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Nicardipine

hsa00230

Purine metabolism

4.60E-02

Q13370, P36959, Q13956, P27707

PDE3B, GMPR, PDE6H, DCK

Nicardipine

hsa00240

Pyrimidine metabolism

4.50E-02

P32320, P27707

CDA, DCK

Nicardipine

hsa00500

Starch and sucrose metabolism

1.67E-02

O43451, P06737

MGAM, PYGL

Nicardipine

hsa00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

4.77E-02

Q7LGA3

HS2ST1

Nicardipine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Nicardipine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Nicardipine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

1.34E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Nicardipine

hsa00630

Glyoxylate and dicarboxylate metabolism

1.32E-02

P40925, P15104

MDH1, GLUL

Nicardipine

hsa00670

One carbon pool by folate

3.99E-02

O95954, Q99707

FTCD, MTR

Nicardipine

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Nicardipine

hsa00920

Sulfur metabolism

3.01E-02

O95571

ETHE1

Nicardipine

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Nicardipine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Nicardipine

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Nicardipine

hsa01100

Metabolic pathways

3.95E-02

Q9Y234, Q99707, P29218, P11310, P27707, Q13370, P36959, Q13956, P30043, Q02252, O60701, O14772, O95954, Q02318, P04406, O15466, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809

LIPT1, MTR, IMPA1, ACADM, DCK, PDE3B, GMPR, PDE6H, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, CYP27A1, GAPDH, ST8SIA5, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1

Nicardipine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Nicardipine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Nicardipine

hsa01524

Platinum drug resistance

4.45E-02

P10415, Q13489, P78417, P43246

BCL2, BIRC3, GSTO1, MSH2

Nicardipine

hsa02010

ABC transporters

4.89E-02

Q99758

ABCA3

Nicardipine

hsa03013

RNA transport

4.79E-02

P62826, P63279

RAN, UBE2I

Nicardipine

hsa03015

mRNA surveillance pathway

3.62E-02

O43148, P61326, P52298

RNMT, MAGOH, NCBP2

Nicardipine

hsa03040

Spliceosome

3.00E-10

Q14562, O43143, O60508, P17844, O14776, P08579, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, O75643, P61326

DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, ASCC3L1, MAGOH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.803
P0DP25	CALM3	Calmodulin-3	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP24	CALM2	Calmodulin-2	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.942
P0DP23	CALM1	Calmodulin-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.869
P0DP25	CALM3	Calmodulin-3	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP24	CALM2	Calmodulin-2	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.963
P0DP23	CALM1	Calmodulin-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O60508	CDC40	Pre-mRNA-processing factor 17	0.827
P0DP25	CALM3	Calmodulin-3	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP24	CALM2	Calmodulin-2	O60508	CDC40	Pre-mRNA-processing factor 17	0.828
P0DP24	CALM2	Calmodulin-2	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.734
O15182	CETN3	Centrin-3	O14776	TCERG1	Transcription elongation regulator 1	0.758
P0DP23	CALM1	Calmodulin-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.778
P0DP25	CALM3	Calmodulin-3	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
P0DP24	CALM2	Calmodulin-2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.781
O15182	CETN3	Centrin-3	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.859
O15182	CETN3	Centrin-3	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.701
O15182	CETN3	Centrin-3	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.757
P0DP24	CALM2	Calmodulin-2	Q15365	PCBP1	Poly(rC)-binding protein 1	0.75
O15182	CETN3	Centrin-3	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.85
P0DP23	CALM1	Calmodulin-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P0DP25	CALM3	Calmodulin-3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP24	CALM2	Calmodulin-2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP23	CALM1	Calmodulin-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P0DP25	CALM3	Calmodulin-3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP24	CALM2	Calmodulin-2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP23	CALM1	Calmodulin-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P0DP25	CALM3	Calmodulin-3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP24	CALM2	Calmodulin-2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP23	CALM1	Calmodulin-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P0DP25	CALM3	Calmodulin-3	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP24	CALM2	Calmodulin-2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
O15182	CETN3	Centrin-3	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	0.723
P0DP23	CALM1	Calmodulin-1	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.786
P0DP25	CALM3	Calmodulin-3	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P0DP24	CALM2	Calmodulin-2	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	0.78
O15182	CETN3	Centrin-3	P61326	MAGOH	Protein mago nashi homolog	0.811

Nicardipine

hsa03050

Proteasome

2.51E-03

P55036, P43686, P28070

PSMD4, PSMC4, PSMB4

Nicardipine

hsa03320

PPAR signaling pathway

2.18E-02

O00767, Q02318

SCD, CYP27A1

Nicardipine

hsa03460

Fanconi anemia pathway

3.70E-03

Q9NPI8, O60673, Q9UNA4

FANCF, REV3L, POLI

Nicardipine

hsa04012

ErbB signaling pathway

1.34E-02

P16333, P19174, P42338, P01106

NCK1, PLCG1, PIK3CB, MYC

Nicardipine

hsa04014

Ras signaling pathway

8.64E-06

P31751, P42338, P20827, Q9NRA1, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P63218, P50151, P19174

AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P20827	EFNA1	Ephrin-A1	-0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P0DP25	CALM3	Calmodulin-3	P20827	EFNA1	Ephrin-A1	-0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P0DP25	CALM3	Calmodulin-3	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.788
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	Q15311	RALBP1	RalA-binding protein 1	0.858
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744

Nicardipine

hsa04015

Rap1 signaling pathway

1.43E-04

P20827, Q9NRA1, P49767, P11215, Q13009, Q08828, P51828, P42338, P31751, P0DP23, P17252, P19174

EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PRKCA, PLCG1

Nicardipine

hsa04020

Calcium signaling pathway

9.51E-08

P27987, Q08828, P21796, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, Q9NRA1, P49767

ITPKB, ADCY1, VDAC1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, PDGFC, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.891
P0DP25	CALM3	Calmodulin-3	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP24	CALM2	Calmodulin-2	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.701
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP25	CALM3	Calmodulin-3	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP24	CALM2	Calmodulin-2	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.764
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP25	CALM3	Calmodulin-3	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP24	CALM2	Calmodulin-2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84

Nicardipine

hsa04024

cAMP signaling pathway

3.01E-03

Q08828, P51828, P31751, P0DP23, P23634, Q13557, Q13370, O15399, Q13009

ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK2D, PDE3B, GRIN2D, TIAM1

Nicardipine

hsa04062

Chemokine signaling pathway

5.66E-05

P51684, Q8NHW4, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08828, P51828, Q13009, P14598, P42224, P31751, P25963

CCR6, CCL4L2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P51684	CCR6	C-C chemokine receptor type 6	-0.734
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P0DP23	CALM1	Calmodulin-1	P14598	NCF1	Neutrophil cytosol factor 1	0.854
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711

Nicardipine

hsa04064

NF-kappa B signaling pathway

2.28E-04

P10415, Q13489, P51617, P01584, P29965, P19174, O75293, Q8NHW4, Q9NQC7

BCL2, BIRC3, IRAK1, IL1B, CD40LG, PLCG1, GADD45B, CCL4L2, CYLD

Nicardipine

hsa04070

Phosphatidylinositol signaling system

2.08E-05

P19174, P0DP23, P42338, P23743, P48426, P27987, P17252

PLCG1, CALM1, PIK3CB, DGKA, PIP4K2A, ITPKB, PRKCA

Nicardipine

hsa04071

Sphingolipid signaling pathway

1.21E-04

P17252, P21453, Q9H228, P01375, Q13510, Q13362, P10415, Q9UQC2, P01042

PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, BCL2, GAB2, KNG1

Nicardipine

hsa04072

Phospholipase D signaling pathway

2.78E-03

P31751, P42338, P19174, P17252, Q14344, Q15438, Q08828, P51828, P23743, Q9NRA1, P00734

AKT2, PIK3CB, PLCG1, PRKCA, GNA13, PSCD1, ADCY1, ADCY7, DGKA, PDGFC, F2

Nicardipine

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Nicardipine

hsa04140

Autophagy - animal

2.58E-02

P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9

AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8

Nicardipine

hsa04144

Endocytosis

8.99E-03

P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7

HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6

Nicardipine

hsa04145

Phagosome

5.56E-03

P60709, P63261, Q15075, Q15080, P14598, Q13509, Q13488, O60603

ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TCIRG1, TLR2

Nicardipine

hsa04151

PI3K-Akt signaling pathway

1.33E-04

P42338, P01106, O43521, P27348, P20827, Q9NRA1, P49767, Q13362, P08238, P62873, P63218, P50151, P16144, O15335, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8

PIK3CB, MYC, BCL2L11, YWHAQ, EFNA1, PDGFC, VEGFC, PPP2R5C, HSP90AB1, GNB1, GNG5, GNG10, ITGB4, CHAD, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P0DP24	CALM2	Calmodulin-2	O43521	BCL2L11	Bcl-2-like protein 11	0.75
P0DP24	CALM2	Calmodulin-2	P27348	YWHAQ	14-3-3 protein theta	0.777
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P0DP24	CALM2	Calmodulin-2	P20827	EFNA1	Ephrin-A1	-0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.765
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P0DP24	CALM2	Calmodulin-2	P16144	ITGB4	Integrin beta-4	-0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O15335	CHAD	Chondroadherin	-0.704
P60660	MYL6	Myosin light polypeptide 6	P48551	IFNAR2	Interferon alpha/beta receptor 2	0.746
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P0DP24	CALM2	Calmodulin-2	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P60660	MYL6	Myosin light polypeptide 6	P15336	ATF2	Cyclic AMP-dependent transcription factor ATF-2	0.729
P0DP24	CALM2	Calmodulin-2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P60660	MYL6	Myosin light polypeptide 6	Q16513	PKN2	Serine/threonine-protein kinase N2	-0.748
P0DP24	CALM2	Calmodulin-2	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.859

Nicardipine

hsa04210

Apoptosis

7.52E-04

O76075, P07384, P01375, Q9NR28, Q16548, P60709, P63261

DFFB, CAPN1, TNF, DIABLO, BCL2A1, ACTB, ACTG1

Nicardipine

hsa04217

Necroptosis

3.39E-08

P01568, P23458, Q13489, Q9NQC7, P42224, P08238, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351

IFNA21, JAK1, BIRC3, CYLD, STAT1, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.883
P0DP24	CALM2	Calmodulin-2	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.778
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	P0C0S5	H2AFZ	Histone H2A.Z	0.749
P0DP23	CALM1	Calmodulin-1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP25	CALM3	Calmodulin-3	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP24	CALM2	Calmodulin-2	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.81
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.73
P0DP24	CALM2	Calmodulin-2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.713
P0DP23	CALM1	Calmodulin-1	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP25	CALM3	Calmodulin-3	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP24	CALM2	Calmodulin-2	O43633	CHMP2A	Charged multivesicular body protein 2a	0.842
P0DP23	CALM1	Calmodulin-1	Q9NZZ3	CHMP5	Charged multivesicular body protein 5	0.713
P0DP24	CALM2	Calmodulin-2	Q9NZZ3	CHMP5	Charged multivesicular body protein 5	0.763
P0DP23	CALM1	Calmodulin-1	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.784

Nicardipine

hsa04261

Adrenergic signaling in cardiomyocytes

4.46E-07

P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634

TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P09493	TPM1	Tropomyosin alpha-1 chain	-0.749
P0DP25	CALM3	Calmodulin-3	P09493	TPM1	Tropomyosin alpha-1 chain	-0.749
P0DP24	CALM2	Calmodulin-2	P09493	TPM1	Tropomyosin alpha-1 chain	-0.749
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP24	CALM2	Calmodulin-2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P07550	ADRB2	Beta-2 adrenergic receptor	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	-0.704
P0DP23	CALM1	Calmodulin-1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.736
P0DP24	CALM2	Calmodulin-2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.765
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP25	CALM3	Calmodulin-3	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793
P0DP24	CALM2	Calmodulin-2	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.793

Nicardipine

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Nicardipine

hsa04360

Axon guidance

9.40E-05

P61073, P16333, P20827, O95631, P17252, Q13557, P42338, P23528, P19174

CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, PIK3CB, CFL1, PLCG1

Nicardipine

hsa04371

Apelin signaling pathway

3.57E-04

P62873, P63218, P50151, P31751, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P0DP23

GNB1, GNG5, GNG10, AKT2, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, CALM1

Nicardipine

hsa04380

Osteoclast differentiation

4.18E-02

Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598

CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1

Nicardipine

hsa04390

Hippo signaling pathway

2.80E-02

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa04510

Focal adhesion

3.76E-02

P16144, O75369, Q15942, P17252, Q13489, P10415, P49767

ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, VEGFC

Nicardipine

hsa04520

Adherens junction

1.58E-02

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa04530

Tight junction

6.83E-04

P60709, P63261, P16989, P56750, Q14247, P60660

ACTB, ACTG1, CSDA, CLDN17, CTTN, MYL6

Nicardipine

hsa04540

Gap junction

4.08E-02

P17252, Q13509, P68371, Q08828, P51828

PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7

Nicardipine

hsa04610

Complement and coagulation cascades

4.69E-03

P0C0L4

C4A

Nicardipine

hsa04611

Platelet activation

2.61E-02

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Nicardipine

hsa04613

Neutrophil extracellular trap formation

2.06E-03

P42338, P19174, P11215, Q13547, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598

PIK3CB, PLCG1, ITGAM, HDAC1, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1

Nicardipine

hsa04620

Toll-like receptor signaling pathway

1.41E-03

P51617, P01568, P31751, P42224, P25963, P42338, Q8NHW4

IRAK1, IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, CCL4L2

Nicardipine

hsa04621

NOD-like receptor signaling pathway

3.16E-02

P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415

IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2

Nicardipine

hsa04623

Cytosolic DNA-sensing pathway

3.89E-03

P01568, P25963, Q8NHW4

IFNA21, NFKBIA, CCL4L2

Nicardipine

hsa04625

C-type lectin receptor signaling pathway

2.17E-02

Q9ULY5, P42224, P25963, P42338, P0DP23

CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1

Nicardipine

hsa04630

JAK-STAT signaling pathway

1.16E-02

P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568

AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21

Nicardipine

hsa04640

Hematopoietic cell lineage

2.82E-03

P08514, P21926, P07766, P09564

ITGA2B, CD9, CD3E, CD7

Nicardipine

hsa04650

Natural killer cell mediated cytotoxicity

5.05E-04

P01375, P20963, Q13241, P26718, P26717, Q14953, P26715

TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Nicardipine

hsa04657

IL-17 signaling pathway

2.10E-03

P49841, P19875, P14780, P80188, P01375

GSK3B, CXCL2, MMP9, LCN2, TNF

Nicardipine

hsa04658

Th1 and Th2 cell differentiation

8.74E-03

P25963, P07766, P19174, P42224, P14784, Q13761

NFKBIA, CD3E, PLCG1, STAT1, IL2RB, RUNX3

Nicardipine

hsa04659

Th17 cell differentiation

2.61E-02

P25963, P19174, P42224, P14784, P08238, P07766

NFKBIA, PLCG1, STAT1, IL2RB, HSP90AB1, CD3E

Nicardipine

hsa04662

B cell receptor signaling pathway

1.46E-03

P25963, P42338, P20023, P07948, P21854, Q8N149

NFKBIA, PIK3CB, CR2, LYN, CD72, LILRA2

Nicardipine

hsa04664

Fc epsilon RI signaling pathway

1.34E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Nicardipine

hsa04666

Fc gamma R-mediated phagocytosis

2.54E-03

P07948, P08575, P42338, P19174, P23528, Q9UQC2, P14598, P17252

LYN, PTPRC, PIK3CB, PLCG1, CFL1, GAB2, NCF1, PRKCA

Nicardipine

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Nicardipine

hsa04670

Leukocyte transendothelial migration

4.07E-02

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa04713

Circadian entrainment

6.79E-06

O15399, P0DP23, Q13557, P17252, P62873, P63218, P50151, Q08828, P51828

GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, GNG5, GNG10, ADCY1, ADCY7

Nicardipine

hsa04714

Thermogenesis

3.64E-04

P15336, P60709, P63261, P36542

ATF2, ACTB, ACTG1, ATP5C1

Nicardipine

hsa04720

Long-term potentiation

3.26E-03

P17252, Q13557, P0DP23, P18848, O15399, Q08828

PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1

Nicardipine

hsa04724

Glutamatergic synapse

5.04E-04

P48058, O15399, Q08828, P51828, P17252, P62873, P63218, P50151, P15104

GRIA4, GRIN2D, ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, GLUL

Nicardipine

hsa04725

Cholinergic synapse

3.93E-05

Q08828, P51828, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P31751, P10415

ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, AKT2, BCL2

Nicardipine

hsa04727

GABAergic synapse

1.47E-03

Q08828, P51828, P62873, P63218, P50151, P15104, P46459, P17252

ADCY1, ADCY7, GNB1, GNG5, GNG10, GLUL, NSF, PRKCA

Nicardipine

hsa04740

Olfactory transduction

5.88E-03

P62873, Q9H255, Q13557, P0DP23

GNB1, OR51E2, CAMK2D, CALM1

Nicardipine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Nicardipine

hsa04744

Phototransduction

2.37E-07

P62873, P0DP23

GNB1, CALM1

Nicardipine

hsa04750

Inflammatory mediator regulation of TRP channels

5.49E-06

P01584, Q08828, P51828, Q13557, P19174, P42338, P17252, P24723, P0DP23, P01042

IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCA, PRKCH, CALM1, KNG1

Nicardipine

hsa04810

Regulation of actin cytoskeleton

2.61E-02

P12814, Q13009, P42338, P11215, Q14344, Q9NRA1

ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFC

Nicardipine

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Nicardipine

hsa04911

Insulin secretion

3.47E-02

Q08828, P17252, P18848, Q13557

ADCY1, PRKCA, ATF4, CAMK2D

Nicardipine

hsa04912

GnRH signaling pathway

2.85E-02

P17252, Q08828, P18848, Q13557, P0DP23

PRKCA, ADCY1, ATF4, CAMK2D, CALM1

Nicardipine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Nicardipine

hsa04914

Progesterone-mediated oocyte maturation

3.76E-03

Q08828, P51828, P42338, P31751, Q13370, Q9UJX4, P30304, P08238

ADCY1, ADCY7, PIK3CB, AKT2, PDE3B, ANAPC5, CDC25A, HSP90AB1

Nicardipine

hsa04915

Estrogen signaling pathway

3.28E-03

P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415

ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2

Nicardipine

hsa04919

Thyroid hormone signaling pathway

5.60E-04

P49841, P22694, P60709, P63261, O60244, Q9NVC6

GSK3B, PRKACB, ACTB, ACTG1, MED14, MED17

Nicardipine

hsa04921

Oxytocin signaling pathway

1.77E-03

P60660, P60709, P63261

MYL6, ACTB, ACTG1

Nicardipine

hsa04923

Regulation of lipolysis in adipocytes

2.12E-02

Q08828, P51828, Q13370, P31751

ADCY1, ADCY7, PDE3B, AKT2

Nicardipine

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Nicardipine

hsa04925

Aldosterone synthesis and secretion

6.45E-04

P18848, Q08828, P51828, P0DP23, P17252, Q13557, P23634

ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, ATP2B4

Nicardipine

hsa04926

Relaxin signaling pathway

6.11E-04

P25963, P42338, P62873, P63218, P50151, P18848, P22694, P49767, P14780, P30679

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15

Nicardipine

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Nicardipine

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Nicardipine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.04E-06

Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174

SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1

Nicardipine

hsa04935

Growth hormone synthesis, secretion and action

3.93E-02

P19174, Q08828, P51828, P17252, P31751, P42224

PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1

Nicardipine

hsa04970

Salivary secretion

9.40E-05

P07550, Q08828, P51828, P22694, P23634, P17252, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, ATP2B4, PRKCA, CALM1, CAMP

Nicardipine

hsa04971

Gastric acid secretion

1.02E-02

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa04972

Pancreatic secretion

1.92E-03

P23634, P17252, Q08828, P51828, P62491

ATP2B4, PRKCA, ADCY1, ADCY7, RAB11A

Nicardipine

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Nicardipine

hsa05012

Parkinson disease

4.01E-02

P21796, P60604, P19174, P0DP23, Q71U36, Q13509

VDAC1, UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3

Nicardipine

hsa05014

Amyotrophic lateral sclerosis

2.98E-02

P36542, P60709, P63261

ATP5C1, ACTB, ACTG1

Nicardipine

hsa05017

Spinocerebellar ataxia

3.80E-03

P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232

PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12

Nicardipine

hsa05031

Amphetamine addiction

3.62E-03

O15399, P0DP23, Q13557, P22694, P18848, P17252, Q13547

GRIN2D, CALM1, CAMK2D, PRKACB, ATF4, PRKCA, HDAC1

Nicardipine

hsa05032

Morphine addiction

1.07E-03

Q08828, P51828, P62873, P63218, P50151, Q13370, P17252, P43250

ADCY1, ADCY7, GNB1, GNG5, GNG10, PDE3B, PRKCA, GRK6

Nicardipine

hsa05034

Alcoholism

9.92E-05

Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431

HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Nicardipine

hsa05100

Bacterial invasion of epithelial cells

1.02E-02

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa05110

Vibrio cholerae infection

3.95E-03

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa05131

Shigellosis

1.91E-02

P60709, P63261, P07384

ACTB, ACTG1, CAPN1

Nicardipine

hsa05132

Salmonella infection

4.00E-05

P51617, P01584, P25963, P08238, P01106, P42338, Q96RF0, Q13489, P10415, P08575, O75369, Q13561, Q71U36, Q13509, P68371, P49754, Q9NP90

IRAK1, IL1B, NFKBIA, HSP90AB1, MYC, PIK3CB, SNAG1, BIRC3, BCL2, PTPRC, FLNB, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41, RAB9B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP24	CALM2	Calmodulin-2	Q96RF0	SNAG1	Sorting nexin-18	0.703
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	0.716
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
P0DP25	CALM3	Calmodulin-3	O75369	FLNB	Filamin-B	0.874
P0DP24	CALM2	Calmodulin-2	O75369	FLNB	Filamin-B	0.874
P0DP25	CALM3	Calmodulin-3	Q13561	DCTN2	Dynactin subunit 2	0.739
P0DP24	CALM2	Calmodulin-2	Q13561	DCTN2	Dynactin subunit 2	0.739
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P0DP25	CALM3	Calmodulin-3	Q13509	TUBB3	Tubulin beta-3 chain	0.892
P0DP24	CALM2	Calmodulin-2	Q13509	TUBB3	Tubulin beta-3 chain	0.892
P0DP25	CALM3	Calmodulin-3	P68371	TUBB2C	Tubulin beta-4B chain	0.742
P0DP24	CALM2	Calmodulin-2	P68371	TUBB2C	Tubulin beta-4B chain	0.742
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807
P0DP25	CALM3	Calmodulin-3	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.723
P0DP24	CALM2	Calmodulin-2	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.723
P0DP24	CALM2	Calmodulin-2	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.791

Nicardipine

hsa05133

Pertussis

3.94E-04

P0DP23, P01584, P23528, P09871, P51617

CALM1, IL1B, CFL1, C1S, IRAK1

Nicardipine

hsa05135

Yersinia infection

3.88E-03

P60709, P63261, Q16513

ACTB, ACTG1, PKN2

Nicardipine

hsa05140

Leishmaniasis

2.58E-02

P14598, O60603, P25963, P29350, Q15080

NCF1, TLR2, NFKBIA, PTPN6, NCF4

Nicardipine

hsa05143

African trypanosomiasis

3.87E-02

P01584, P17252, P01042

IL1B, PRKCA, KNG1

Nicardipine

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Nicardipine

hsa05145

Toxoplasmosis

5.28E-05

P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651

IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RA

Nicardipine

hsa05146

Amoebiasis

2.41E-02

P19875, P01375, P30679, P22694

CXCL2, TNF, GNA15, PRKACB

Nicardipine

hsa05150

Staphylococcus aureus infection

4.36E-02

P0C0L4, P13646

C4A, KRT13

Nicardipine

hsa05161

Hepatitis B

1.31E-04

P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617

PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1

Nicardipine

hsa05162

Measles

1.12E-05

P51617, P01568, P25963, P23458, P42224, P14784, P07766, P42338, P31751, P11142, P01584, Q9NP90, P10415

IRAK1, IFNA21, NFKBIA, JAK1, STAT1, IL2RB, CD3E, PIK3CB, AKT2, HSPA8, IL1B, RAB9B, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P0DP25	CALM3	Calmodulin-3	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP24	CALM2	Calmodulin-2	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P0DP25	CALM3	Calmodulin-3	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP24	CALM2	Calmodulin-2	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.804
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	Q9NP90	RAB9B	Ras-related protein Rab-9B	0.791
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772

Nicardipine

hsa05163

Human cytomegalovirus infection

1.68E-05

P31751, P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P01106, P01584, P61073, P17252, Q13651, P18848, P30101, P61769, P01568

AKT2, PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, MYC, IL1B, CXCR4, PRKCA, IL10RA, ATF4, PDIA3, B2M, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.729
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.701
P0DP24	CALM2	Calmodulin-2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.708
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852

Nicardipine

hsa05164

Influenza A

7.10E-03

P48551, P60709, P63261

IFNAR2, ACTB, ACTG1

Nicardipine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

7.49E-05

P01568, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P07948, P01106, P0DP23

IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, LYN, MYC, CALM1

Nicardipine

hsa05168

Herpes simplex virus 1 infection

4.10E-06

P25963, P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P30101, P61769, P31751, P42338, Q13398, Q6P280, Q03923, O75820, Q9UDV6, P10415, Q14232

NFKBIA, IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, PDIA3, B2M, AKT2, PIK3CB, ZNF211, ZNF529, ZNF85, ZNF189, ZNF212, BCL2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01584	IL1B	Interleukin-1 beta	0.72
P0DP23	CALM1	Calmodulin-1	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.743
P0DP24	CALM2	Calmodulin-2	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.772
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP23	CALM1	Calmodulin-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P0DP25	CALM3	Calmodulin-3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP24	CALM2	Calmodulin-2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.914
P0DP23	CALM1	Calmodulin-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P0DP25	CALM3	Calmodulin-3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP24	CALM2	Calmodulin-2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.841
P0DP23	CALM1	Calmodulin-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P0DP25	CALM3	Calmodulin-3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP24	CALM2	Calmodulin-2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.784
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	Q13398	ZNF211	Zinc finger protein 211	0.898
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13398	ZNF211	Zinc finger protein 211	0.891
P0DP25	CALM3	Calmodulin-3	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP24	CALM2	Calmodulin-2	Q13398	ZNF211	Zinc finger protein 211	0.898
P0DP23	CALM1	Calmodulin-1	Q6P280	ZNF529	Zinc finger protein 529	0.767
P0DP23	CALM1	Calmodulin-1	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP25	CALM3	Calmodulin-3	Q03923	ZNF85	Zinc finger protein 85	-0.818
P0DP24	CALM2	Calmodulin-2	Q03923	ZNF85	Zinc finger protein 85	-0.818
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75820	ZNF189	Zinc finger protein 189	-0.749
P0DP23	CALM1	Calmodulin-1	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP25	CALM3	Calmodulin-3	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP24	CALM2	Calmodulin-2	Q9UDV6	ZNF212	Zinc finger protein 212	0.759
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.797

Nicardipine

hsa05169

Epstein-Barr virus infection

1.08E-03

P01106, Q13547, P25963, P42338, P07948, P30101, Q13761, O75293, P42224, P01568, P07766

MYC, HDAC1, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, STAT1, IFNA21, CD3E

Nicardipine

hsa05170

Human immunodeficiency virus 1 infection

6.31E-07

P31751, P42338, P62873, P63218, P50151, P0DP23, P61073, P17252, P30101, P61769, P01568, P51617, P25963, P19174, P23528, P07766, P10415, Q9Y6Q5

AKT2, PIK3CB, GNB1, GNG5, GNG10, CALM1, CXCR4, PRKCA, PDIA3, B2M, IFNA21, IRAK1, NFKBIA, PLCG1, CFL1, CD3E, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P0DP24	CALM2	Calmodulin-2	P61769	B2M	Beta-2-microglobulin	0.787
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP25	CALM3	Calmodulin-3	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P0DP24	CALM2	Calmodulin-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	P23528	CFL1	Cofilin-1	-0.832
P0DP25	CALM3	Calmodulin-3	P23528	CFL1	Cofilin-1	-0.832
P0DP24	CALM2	Calmodulin-2	P23528	CFL1	Cofilin-1	-0.832
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742
P0DP25	CALM3	Calmodulin-3	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742
P0DP24	CALM2	Calmodulin-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.742

Nicardipine

hsa05200

Pathways in cancer

3.46E-11

P42338, P23458, P08238, P42224, P25963, P19174, Q15311, P01106, P17252, P43246, Q13485, Q13547, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P63218, P50151, Q14344, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042

PIK3CB, JAK1, HSP90AB1, STAT1, NFKBIA, PLCG1, RALBP1, MYC, PRKCA, MSH2, SMAD4, HDAC1, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, GNG5, GNG10, GNA13, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.822
P0DP24	CALM2	Calmodulin-2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.738
P0DP23	CALM1	Calmodulin-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P0DP25	CALM3	Calmodulin-3	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP24	CALM2	Calmodulin-2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.775
P0DP23	CALM1	Calmodulin-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P0DP25	CALM3	Calmodulin-3	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P0DP24	CALM2	Calmodulin-2	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	Q15311	RALBP1	RalA-binding protein 1	0.858
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP23	CALM1	Calmodulin-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43246	MSH2	DNA mismatch repair protein Msh2	0.887
P0DP25	CALM3	Calmodulin-3	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP24	CALM2	Calmodulin-2	P43246	MSH2	DNA mismatch repair protein Msh2	0.944
P0DP23	CALM1	Calmodulin-1	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP25	CALM3	Calmodulin-3	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P0DP24	CALM2	Calmodulin-2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.777
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P0DP23	CALM1	Calmodulin-1	P14923	JUP	Junction plakoglobin	-0.852
P0DP25	CALM3	Calmodulin-3	P14923	JUP	Junction plakoglobin	-0.852
P0DP24	CALM2	Calmodulin-2	P14923	JUP	Junction plakoglobin	-0.852
P0DP23	CALM1	Calmodulin-1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP25	CALM3	Calmodulin-3	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP24	CALM2	Calmodulin-2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.772
P0DP23	CALM1	Calmodulin-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP25	CALM3	Calmodulin-3	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP24	CALM2	Calmodulin-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.8
P0DP23	CALM1	Calmodulin-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P0DP25	CALM3	Calmodulin-3	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP24	CALM2	Calmodulin-2	P49767	VEGFC	Vascular endothelial growth factor C	-0.84
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	Q08828	ADCY1	Adenylate cyclase type 1	0.725
P0DP24	CALM2	Calmodulin-2	Q08828	ADCY1	Adenylate cyclase type 1	0.711
P0DP23	CALM1	Calmodulin-1	P51828	ADCY7	Adenylate cyclase type 7	0.719
P0DP23	CALM1	Calmodulin-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P0DP25	CALM3	Calmodulin-3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P0DP24	CALM2	Calmodulin-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P0DP24	CALM2	Calmodulin-2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.759
P0DP23	CALM1	Calmodulin-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP25	CALM3	Calmodulin-3	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP24	CALM2	Calmodulin-2	P78417	GSTO1	Glutathione S-transferase omega-1	-0.804
P0DP23	CALM1	Calmodulin-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P0DP25	CALM3	Calmodulin-3	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	Q15788	NCOA1	Nuclear receptor coactivator 1	0.731
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP24	CALM2	Calmodulin-2	O43521	BCL2L11	Bcl-2-like protein 11	0.75
P0DP23	CALM1	Calmodulin-1	P01568	IFNA21	Interferon alpha-21	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P0DP25	CALM3	Calmodulin-3	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP24	CALM2	Calmodulin-2	P01568	IFNA21	Interferon alpha-21	-0.852
P0DP23	CALM1	Calmodulin-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P0DP25	CALM3	Calmodulin-3	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP24	CALM2	Calmodulin-2	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.801
P0DP23	CALM1	Calmodulin-1	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.718
P0DP23	CALM1	Calmodulin-1	P00734	F2	Prothrombin	-0.738
P0DP23	CALM1	Calmodulin-1	P01042	KNG1	Kininogen-1	-0.71
P0DP25	CALM3	Calmodulin-3	P01042	KNG1	Kininogen-1	-0.71
P0DP24	CALM2	Calmodulin-2	P01042	KNG1	Kininogen-1	-0.71

Nicardipine

hsa05203

Viral carcinogenesis

6.72E-04

P42338, P06746, P07948, P29083, Q13547, Q15283, P12814, P25963, P62807, Q93079, O60814

PIK3CB, POLB, LYN, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, HIST1H2BC, H2BC9, H2BC12

Nicardipine

hsa05204

Chemical carcinogenesis

2.59E-04

P00325, P78417, P11712, P33260

ADH1B, GSTO1, CYP2C9, CYP2C18

Nicardipine

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Nicardipine

hsa05206

MicroRNAs in cancer

5.40E-03

P30304, P09493, P15311, P01106, P42338, Q13547, P63279, P20827, P19174

CDC25A, TPM1, VIL2, MYC, PIK3CB, HDAC1, UBE2I, EFNA1, PLCG1

Nicardipine

hsa05212

Pancreatic cancer

5.55E-03

P31751, Q15311, P23458, P42224, Q13485, O75293

AKT2, RALBP1, JAK1, STAT1, SMAD4, GADD45B

Nicardipine

hsa05214

Glioma

9.93E-08

P09619, P0DP23, Q13557, P17252, Q02750, P42338, P31751, P19174, O75293

PDGFRB, CALM1, CAMK2D, PRKCA, MAP2K1, PIK3CB, AKT2, PLCG1, GADD45B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P54284	CACNB3	Voltage-dependent L-type calcium channel subunit beta-3	P09619	PDGFRB	Platelet-derived growth factor receptor beta	0.882
P0DP23	CALM1	Calmodulin-1	P0DP23	CALM1	Calmodulin-1	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P0DP25	CALM3	Calmodulin-3	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	P0DP23	CALM1	Calmodulin-1	1
P0DP24	CALM2	Calmodulin-2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.786
P0DP23	CALM1	Calmodulin-1	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP25	CALM3	Calmodulin-3	P17252	PRKCA	Protein kinase C alpha type	-0.776
P0DP24	CALM2	Calmodulin-2	P17252	PRKCA	Protein kinase C alpha type	-0.776
P54284	CACNB3	Voltage-dependent L-type calcium channel subunit beta-3	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	-0.796
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P0DP23	CALM1	Calmodulin-1	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.761
P0DP23	CALM1	Calmodulin-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P0DP25	CALM3	Calmodulin-3	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP24	CALM2	Calmodulin-2	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.744
P0DP23	CALM1	Calmodulin-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P0DP25	CALM3	Calmodulin-3	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853
P0DP24	CALM2	Calmodulin-2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.853

Nicardipine

hsa05218

Melanoma

7.97E-04

P09619, Q9NRA1, P42338, Q02750, O75293

PDGFRB, PDGFC, PIK3CB, MAP2K1, GADD45B

Nicardipine

hsa05220

Chronic myeloid leukemia

2.17E-02

Q13547, P01106, P25963, P42338, O75293

HDAC1, MYC, NFKBIA, PIK3CB, GADD45B

Nicardipine

hsa05225

Hepatocellular carcinoma

4.07E-02

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa05230

Central carbon metabolism in cancer

4.10E-02

P09619, Q02750

PDGFRB, MAP2K1

Nicardipine

hsa05231

Choline metabolism in cancer

2.92E-03

P42338, Q9NRA1, Q9Y259, P19174, P23743

PIK3CB, PDGFC, CHKB, PLCG1, DGKA

Nicardipine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.71E-02

P25963, P42338, P19174, P07766, P42224

NFKBIA, PIK3CB, PLCG1, CD3E, STAT1

Nicardipine

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Nicardipine

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Nicardipine

hsa05332

Graft-versus-host disease

8.79E-03

P01375, P26715, Q13241

TNF, KLRC1, KLRD1

Nicardipine

hsa05340

Primary immunodeficiency

2.68E-02

P11912, P07766

CD79A, CD3E

Nicardipine

hsa05410

Hypertrophic cardiomyopathy

1.02E-02

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

8.96E-03

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa05414

Dilated cardiomyopathy

1.73E-02

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa05416

Viral myocarditis

8.96E-03

P60709, P63261

ACTB, ACTG1

Nicardipine

hsa05418

Fluid shear stress and atherosclerosis

3.64E-03

P14598, P78417, P60709, P63261, P10415, P0DP23, P08238, Q92974

NCF1, GSTO1, ACTB, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2

Community members of Nicardipine (S_DC: 2.80)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CALM1

CalmodulinNone1

Reported

0.4552

0.1479

1.5235

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P40925

MDH1

Malate dehydrogenase, cytoplasmic

Predicted

0.3566

0.2746

0.2426

0.97

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P54284

CACNB3

VoltageNonedependent LNonetype calcium channel subunit betaNone3

Predicted

0.1026

0.1539

0.3291

0.6881

P0DP25

CALM3

CalmodulinNone3

Predicted

0.5661

0.1479

0.5789

P0DP24

CALM2

CalmodulinNone2

Predicted

0.4376

0.1479

0.5147

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P60660

MYL6

Myosin light polypeptide 6

Predicted

0.5595

0.0687

0.2175

0.6346

P24844

MYL9

Myosin regulatory light polypeptide 9

Predicted

0.0064

0.063

0.6026

0.7318

P14649

MYL6B

Myosin light chain 6B

Predicted

0.0477

0.0653

0.2175

0.3719

P05976

MYL1

Myosin light chain 1/3, skeletal muscle isoform

Predicted

0.2581

0.0619

0.2528

O15182

CETN3

CentrinNone3

Predicted

0.1872

0.0594

0.2123

Q96A32

MYLPF

Myosin regulatory light chain 2, skeletal muscle isoform

Predicted

0.0135

0.0473

0.5412

0.6425

PharmaCoNets of Nicardipine (SPCN: 58.78 )

Nicardipine regulated-network (SDN: 20.99)

Community members of Nicardipine (SDC: 2.80)

PharmaCoNets of Nicardipine (S_PCN: 58.78 )

Nicardipine regulated-network (S_DN: 20.99)

Community members of Nicardipine (S_DC: 2.80)