PharmaCoNets

PharmaCoNets of Meclizine (S_PCN: 168.86 )

Meclizine regulated-network (S_DN: 22.48)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Meclizine

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Meclizine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Meclizine

hsa00240

Pyrimidine metabolism

4.29E-02

P21589, P04183

NT5E, TK1

Meclizine

hsa00500

Starch and sucrose metabolism

8.89E-07

O43451, P46976, P06737

MGAM, GYG1, PYGL

Meclizine

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Meclizine

hsa00513

Various types of N-glycan biosynthesis

4.96E-02

Q9NR34

MAN1C1

Meclizine

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Meclizine

hsa00564

Glycerophospholipid metabolism

4.29E-02

Q6P1A2, P23743

MBOAT5, DGKA

Meclizine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Meclizine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Meclizine

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Meclizine

hsa00730

Thiamine metabolism

4.16E-06

P05186, P24666

ALPL, ACP1

Meclizine

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Meclizine

hsa00970

Aminoacyl-tRNA biosynthesis

4.54E-04

O95363, P54136, Q15046

FARS2, RARS1, KARS

Meclizine

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Meclizine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Meclizine

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Meclizine

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Meclizine

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Meclizine

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Meclizine

hsa01523

Antifolate resistance

1.43E-03

Q92820, P04818

GGH, TYMS

Meclizine

hsa01524

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Meclizine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Meclizine

hsa03013

RNA transport

8.19E-04

Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042

RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2

Meclizine

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Meclizine

hsa03020

RNA polymerase

5.24E-06

P24928, P62487, Q9GZM3, P52435

POLR2A, POLR2G, POLR2J2, POLR2J

Meclizine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Meclizine

hsa03040

Spliceosome

1.81E-06

O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Meclizine

hsa03060

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Meclizine

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Meclizine

hsa04012

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Meclizine

hsa04014

Ras signaling pathway

1.13E-02

P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Meclizine

hsa04015

Rap1 signaling pathway

5.88E-04

P20827, P49767, P08069, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P17252, P19174

EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PRKCA, PLCG1

Meclizine

hsa04020

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Meclizine

hsa04022

cGMP-PKG signaling pathway

3.25E-03

Q99941, P18848, P23634, Q8WYR1, P51828, P05141, P45880, P0DP24

CREBL1, ATF4, ATP2B4, PIK3R5, ADCY7, SLC25A5, VDAC2, CALM2

Meclizine

hsa04062

Chemokine signaling pathway

1.43E-04

P25024, P25025, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1

CXCR1, CXCR2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Meclizine

hsa04064

NF-kappa B signaling pathway

2.99E-02

O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341

TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1

Meclizine

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Meclizine

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Meclizine

hsa04071

Sphingolipid signaling pathway

4.61E-03

Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Meclizine

hsa04110

Cell cycle

1.97E-05

P06493, O60566, O75293, P30304, P33981, P42773, P01106

CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC

Meclizine

hsa04114

Oocyte meiosis

3.19E-03

P51812, Q02750, P16298, Q17RY0, P08069

RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Meclizine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Meclizine

hsa04140

Autophagy - animal

2.82E-02

P08069

IGF1R

Meclizine

hsa04141

Protein processing in endoplasmic reticulum

3.64E-02

Q99941, O75460, P11142, Q9H3Z4, P07900

CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1

Meclizine

hsa04150

mTOR signaling pathway

7.74E-03

P08069, Q02750, Q9NQL2, P51812

IGF1R, MAP2K1, RRAGD, RPS6KA3

Meclizine

hsa04151

PI3K-Akt signaling pathway

1.67E-03

P62753, P42338, P43657, O43521, P27348, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P18848, O00141, Q6ZUJ8, P30281

RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, ATF4, SGK, PIK3AP1, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Meclizine

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Meclizine

hsa04210

Apoptosis

4.66E-03

O76075, P01375, Q9NR28, O75460, Q16548, O43521, P18848

DFFB, TNF, DIABLO, ERN1, BCL2A1, BCL2L11, ATF4

Meclizine

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Meclizine

hsa04213

Longevity regulating pathway - multiple species

1.66E-02

P08069

IGF1R

Meclizine

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Meclizine

hsa04217

Necroptosis

3.89E-04

P01375, P48023, Q14765, P15104, P05141, P01584, P0C0S5, Q99878, Q9H444

TNF, FASLG, STAT4, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CHMP4B

Meclizine

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Meclizine

hsa04261

Adrenergic signaling in cardiomyocytes

3.98E-02

P51828, Q99941, Q13557, P23634

ADCY7, CREBL1, CAMK2D, ATP2B4

Meclizine

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Meclizine

hsa04340

Hedgehog signaling pathway

4.15E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Meclizine

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Meclizine

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Meclizine

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Meclizine

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Meclizine

hsa04392

Hippo signaling pathway - multiple species

3.01E-02

Q6V0I7

FAT4

Meclizine

hsa04510

Focal adhesion

3.48E-02

P08069

IGF1R

Meclizine

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Meclizine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Meclizine

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Meclizine

hsa04611

Platelet activation

3.39E-02

P25116, P08514, P07359

F2R, ITGA2B, GP1BA

Meclizine

hsa04612

Antigen processing and presentation

2.40E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Meclizine

hsa04613

Neutrophil extracellular trap formation

6.94E-04

O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Meclizine

hsa04621

NOD-like receptor signaling pathway

2.62E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Meclizine

hsa04640

Hematopoietic cell lineage

4.71E-03

P21926, P07766, P01730, P06127, P09564

CD9, CD3E, CD4, CD5, CD7

Meclizine

hsa04650

Natural killer cell mediated cytotoxicity

1.36E-05

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Meclizine

hsa04657

IL-17 signaling pathway

7.74E-04

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Meclizine

hsa04658

Th1 and Th2 cell differentiation

3.62E-04

Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB

Meclizine

hsa04659

Th17 cell differentiation

5.44E-05

P25963, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P14778	IL1R1	Interleukin-1 receptor type 1	0.909
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703

Meclizine

hsa04660

T cell receptor signaling pathway

3.59E-04

P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Meclizine

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Meclizine

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Meclizine

hsa04668

TNF signaling pathway

3.36E-03

Q99941, P18848, P01584, P20333, O95429

CREBL1, ATF4, IL1B, TNFRSF1B, BAG4

Meclizine

hsa04672

Intestinal immune network for IgA production

1.35E-02

P29965, P13765

CD40LG, HLA-DOB

Meclizine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Meclizine

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Meclizine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Meclizine

hsa04728

Dopaminergic synapse

2.82E-02

P14416, P63218, P50151, P49841, Q16539, P49407

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1

Meclizine

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Meclizine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Meclizine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Meclizine

hsa04750

Inflammatory mediator regulation of TRP channels

3.74E-02

P01584, P51828, Q13557

IL1B, ADCY7, CAMK2D

Meclizine

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Meclizine

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Meclizine

hsa04913

Ovarian steroidogenesis

1.16E-02

P08069

IGF1R

Meclizine

hsa04914

Progesterone-mediated oocyte maturation

5.89E-03

P08069, Q17RY0, P51812, Q02750

IGF1R, CPEB4, RPS6KA3, MAP2K1

Meclizine

hsa04915

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Meclizine

hsa04918

Thyroid hormone synthesis

3.16E-02

P17252, P27824

PRKCA, CANX

Meclizine

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Meclizine

hsa04925

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Meclizine

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Meclizine

hsa04932

Non-alcoholic fatty liver disease

1.52E-05

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, Q16718, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA5, SDHD

Meclizine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.11E-03

P84022, Q13485, P10415, P42338, P49767, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1

Meclizine

hsa04934

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Meclizine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Meclizine

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Meclizine

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Meclizine

hsa04976

Bile secretion

1.67E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Meclizine

hsa05010

Alzheimer disease

1.70E-03

Q92542, P05496, P13073, P12074, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880

NCSTN, ATP5G1, COX4I1, COX6A1, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2

Meclizine

hsa05012

Parkinson disease

3.89E-02

P13073, P05141, O75460, P18848, P0DP24

COX4I1, SLC25A5, ERN1, ATF4, CALM2

Meclizine

hsa05016

Huntington disease

1.05E-04

P13073, Q9GZM3, P24928, P62487, P52435, P05141, Q9NYC9, O75460

COX4I1, POLR2J2, POLR2A, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1

Meclizine

hsa05020

Prion disease

1.37E-03

P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539

IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14

Meclizine

hsa05022

Pathways of neurodegeneration - multiple diseases

2.12E-04

P49841, Q16718, O14521, P13073, Q06055, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, O15020, P0DP24

GSK3B, NDUFA5, SDHD, COX4I1, ATP5G2, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, SPTBN2, CALM2

Meclizine

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Meclizine

hsa05100

Bacterial invasion of epithelial cells

4.50E-02

Q92529

SHC3

Meclizine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.85E-03

Q16539, P09341, P25024, P25025, P07948

MAPK14, CXCL1, CXCR1, CXCR2, LYN

Meclizine

hsa05132

Salmonella infection

2.04E-02

P25963, Q13489, P10415, Q9BQS8

NFKBIA, BIRC3, BCL2, FYCO1

Meclizine

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Meclizine

hsa05140

Leishmaniasis

1.46E-03

P13612, O75015, P13765, O60603, P01375, P49006, Q16539, Q15080

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14, NCF4

Meclizine

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Meclizine

hsa05144

Malaria

7.25E-04

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Meclizine

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Meclizine

hsa05146

Amoebiasis

5.02E-03

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Meclizine

hsa05150

Staphylococcus aureus infection

1.91E-02

Q14532, P59665, P59666, P49913

KRT32, DEFA1; DEFA1B, DEFA3, CAMP

Meclizine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Meclizine

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Meclizine

hsa05163

Human cytomegalovirus infection

1.87E-03

P01375, P63218, P50151, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

TNF, GNG5, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Meclizine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Meclizine

hsa05168

Herpes simplex virus 1 infection

4.79E-02

P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820

NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189

Meclizine

hsa05169

Epstein-Barr virus infection

4.41E-02

P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963

HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247

Meclizine

hsa05170

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Meclizine

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Meclizine

hsa05202

Transcriptional misregulation in cancer

1.94E-03

P14780, P27930, Q15744, Q16548, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Meclizine

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Meclizine

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Meclizine

hsa05205

Proteoglycans in cancer

1.15E-02

Q12955, Q14247, P17252, P08069, P08962

ANK3, CTTN, PRKCA, IGF1R, CD63

Meclizine

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Meclizine

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Meclizine

hsa05212

Pancreatic cancer

4.45E-03

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Meclizine

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Meclizine

hsa05214

Glioma

9.95E-03

P08069

IGF1R

Meclizine

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Meclizine

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Meclizine

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Meclizine

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Meclizine

hsa05220

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Meclizine

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Meclizine

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Meclizine

hsa05224

Breast cancer

1.24E-02

P08069, P49841, Q92837, P04637, P24522

IGF1R, GSK3B, FRAT1, TP53, GADD45A

Meclizine

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Meclizine

hsa05226

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Meclizine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.47E-04

O95267, P07766, P20963, P09693, P06239, O60603, Q16539, Q9HC35, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, MAPK14, EML4, CD4

Meclizine

hsa05310

Asthma

1.25E-03

P13765, P29965, P12724, P01375

HLA-DOB, CD40LG, RNASE3, TNF

Meclizine

hsa05320

Autoimmune thyroid disease

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Meclizine

hsa05321

Inflammatory bowel disease

3.16E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Meclizine

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Meclizine

hsa05330

Allograft rejection

1.76E-03

P13765, P29965, P48023, P01375

HLA-DOB, CD40LG, FASLG, TNF

Meclizine

hsa05332

Graft-versus-host disease

4.38E-03

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Meclizine

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Meclizine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

1.82E-02

P14923, P08514, Q9UJU2

JUP, ITGA2B, LEF1

Meclizine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Meclizine

hsa05416

Viral myocarditis

4.29E-02

P13765, P29965

HLA-DOB, CD40LG

Meclizine

hsa05418

Fluid shear stress and atherosclerosis

2.64E-03

Q16539, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Meclizine (S_DC: 7.51)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P25116

F2R

ProteinaseNoneactivated receptor 1

Predicted

0.2038

0.3196

0.5136

1.2547

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

P30530

AXL

TyrosineNoneprotein kinase receptor UFO

Predicted

0.3797

0.5365

0.1637

1.4264

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P05186

ALPL

Alkaline phosphatase, tissueNonenonspecific isozyme

Predicted

0.3064

0.4143

0.1992

1.181

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

Q13627

DYRK1A

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 1A

Predicted

0.015

0.7082

1.4239

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

PharmaCoNets of Meclizine (SPCN: 168.86 )

Meclizine regulated-network (SDN: 22.48)

Community members of Meclizine (SDC: 7.51)

PharmaCoNets of Meclizine (S_PCN: 168.86 )

Meclizine regulated-network (S_DN: 22.48)

Community members of Meclizine (S_DC: 7.51)