PharmaCoNets of Lamivudine (SPCN: 8.90 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lamivudinehsa00190Oxidative phosphorylation3.20E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Lamivudinehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Lamivudinehsa03020RNA polymerase3.22E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Lamivudinehsa03040Spliceosome1.64E-0311Q14562, O43143, O14776, O75940, P52298, P09651, O75494, Q07955, Q13243, O95777, P61326DHX8, DHX15, TCERG1, SMNDC1, NCBP2, HNRNPA1, FUSIP1, SFRS1, SFRS5, LSM8, MAGOHMore
Lamivudinehsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Lamivudinehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Lamivudinehsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Lamivudinehsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Lamivudinehsa04217Necroptosis8.73E-067P07900, P15104, P05141, P01584, P0C0S5, Q13557, Q9H444HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Lamivudinehsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Lamivudinehsa04668TNF signaling pathway2.91E-023P18848, P01584, P20333ATF4, IL1B, TNFRSF1BMore
Lamivudinehsa04744Phototransduction2.59E-022P62873, P0DP23GNB1, CALM1More
Lamivudinehsa04932Non-alcoholic fatty liver disease5.73E-056O43521, P18848, O75460, P01584, P13073, O15239BCL2L11, ATF4, ERN1, IL1B, COX4I1, NDUFA1More
Lamivudinehsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Lamivudinehsa05012Parkinson disease2.77E-037O15239, P13073, P05141, O75460, P18848, P0DP24, Q13557NDUFA1, COX4I1, SLC25A5, ERN1, ATF4, CALM2, CAMK2DMore
Lamivudinehsa05016Huntington disease4.33E-037O15239, P13073, P24928, P30876, P62487, P05141, O75460NDUFA1, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1More
Lamivudinehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Lamivudinehsa05022Pathways of neurodegeneration - multiple diseases2.20E-039O15239, P13073, O75460, P18848, P05141, P20333, P01584, P0DP24, Q13557NDUFA1, COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2, CAMK2DMore
Lamivudinehsa05132Salmonella infection2.35E-0312P25963, P08238, Q13489, P10415, P04406, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P49754NFKBIA, HSP90AB1, BIRC3, BCL2, GAPDH, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, VPS41More
Lamivudinehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Lamivudinehsa05140Leishmaniasis2.25E-026P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Lamivudinehsa05152Tuberculosis4.32E-039Q13488, Q15075, P0DP23, P42224, P25208, O60603, P10415, P01568, Q9UDY8TCIRG1, EEA1, CALM1, STAT1, NFYB, TLR2, BCL2, IFNA21, MALT1More
Lamivudinehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Lamivudinehsa05168Herpes simplex virus 1 infection7.93E-0417O60603, P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, P52738, O75820, P10415TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF140, ZNF189, BCL2More
Lamivudinehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Lamivudinehsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore

Community members of Lamivudine (SDC: 1.86)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P27707DCKDeoxycytidine kinasePredicted00.05740.06140.16530.3169
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)