PharmaCoNets of Ivabradine (SPCN: 45.28 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ivabradinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Ivabradinehsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Ivabradinehsa00500Starch and sucrose metabolism1.36E-033O43451, P35573, P06737MGAM, AGL, PYGLMore
Ivabradinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Ivabradinehsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Ivabradinehsa00630Glyoxylate and dicarboxylate metabolism4.46E-032P40925, P15104MDH1, GLULMore
Ivabradinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Ivabradinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Ivabradinehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Ivabradinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Ivabradinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Ivabradinehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Ivabradinehsa03040Spliceosome3.31E-0914Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Ivabradinehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Ivabradinehsa04014Ras signaling pathway1.13E-0410P42338, P20827, P49767, P08069, Q13009, Q7LDG7, P0DP23, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, CALM1, GNG5, GNG10, PLCG1More
Ivabradinehsa04015Rap1 signaling pathway5.95E-039P20827, P49767, P08069, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Ivabradinehsa04020Calcium signaling pathway5.15E-058P27987, P21796, Q16566, P30679, O15399, P0DP23, P23634, P49767ITPKB, VDAC1, CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Ivabradinehsa04024cAMP signaling pathway1.49E-025P42338, P0DP23, P23634, Q16566, O15399PIK3CB, CALM1, ATP2B4, CAMK4, GRIN2DMore
Ivabradinehsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Ivabradinehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Ivabradinehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Ivabradinehsa04070Phosphatidylinositol signaling system1.49E-035P0DP23, P42338, Q96PE3, Q13572, P27987CALM1, PIK3CB, INPP4A, ITPK1, ITPKBMore
Ivabradinehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Ivabradinehsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Ivabradinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Ivabradinehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Ivabradinehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Ivabradinehsa04151PI3K-Akt signaling pathway1.89E-0312P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Ivabradinehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Ivabradinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Ivabradinehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Ivabradinehsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Ivabradinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Ivabradinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Ivabradinehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Ivabradinehsa04371Apelin signaling pathway2.63E-049P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Ivabradinehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Ivabradinehsa04520Adherens junction8.29E-031P08069IGF1RMore
Ivabradinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Ivabradinehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Ivabradinehsa04659Th17 cell differentiation1.70E-027P19174, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Ivabradinehsa04662B cell receptor signaling pathway9.03E-055P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Ivabradinehsa04664Fc epsilon RI signaling pathway8.33E-054P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Ivabradinehsa04666Fc gamma R-mediated phagocytosis4.10E-023P07948, P42338, P23528LYN, PIK3CB, CFL1More
Ivabradinehsa04713Circadian entrainment8.43E-034O15399, P0DP23, P63218, P50151GRIN2D, CALM1, GNG5, GNG10More
Ivabradinehsa04720Long-term potentiation1.63E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Ivabradinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Ivabradinehsa04724Glutamatergic synapse3.15E-035O15399, P43003, P63218, P50151, P15104GRIN2D, SLC1A3, GNG5, GNG10, GLULMore
Ivabradinehsa04725Cholinergic synapse5.94E-034P63218, P50151, Q16566, P42338GNG5, GNG10, CAMK4, PIK3CBMore
Ivabradinehsa04726Serotonergic synapse1.52E-024P63218, P50151, P33260, P09917GNG5, GNG10, CYP2C18, ALOX5More
Ivabradinehsa04728Dopaminergic synapse4.47E-024P63218, P50151, P0DP23, O00327GNG5, GNG10, CALM1, ARNTLMore
Ivabradinehsa04730Long-term depression1.16E-021P08069IGF1RMore
Ivabradinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Ivabradinehsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Ivabradinehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Ivabradinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Ivabradinehsa04925Aldosterone synthesis and secretion3.14E-023P0DP23, Q16566, P23634CALM1, CAMK4, ATP2B4More
Ivabradinehsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P30679PIK3CB, GNG5, GNG10, VEGFC, GNA15More
Ivabradinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Ivabradinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Ivabradinehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Ivabradinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Ivabradinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Ivabradinehsa05017Spinocerebellar ataxia5.94E-034Q8TB72, O15399, P42338, P21796PUM2, GRIN2D, PIK3CB, VDAC1More
Ivabradinehsa05034Alcoholism3.62E-025O15399, Q16566, P0DP23, P63218, P50151GRIN2D, CAMK4, CALM1, GNG5, GNG10More
Ivabradinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Ivabradinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Ivabradinehsa05163Human cytomegalovirus infection4.19E-025P42338, P63218, P50151, P0DP23, P30101PIK3CB, GNG5, GNG10, CALM1, PDIA3More
Ivabradinehsa05167Kaposi sarcoma-associated herpesvirus infection4.19E-025P42338, P63218, P50151, P07948, P0DP23PIK3CB, GNG5, GNG10, LYN, CALM1More
Ivabradinehsa05170Human immunodeficiency virus 1 infection3.27E-026P42338, P63218, P50151, P0DP23, P30101, P23528PIK3CB, GNG5, GNG10, CALM1, PDIA3, CFL1More
Ivabradinehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Ivabradinehsa05202Transcriptional misregulation in cancer2.82E-021P08069IGF1RMore
Ivabradinehsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Ivabradinehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Ivabradinehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Ivabradinehsa05214Glioma2.82E-034P08069, P0DP23, Q16566, P42338IGF1R, CALM1, CAMK4, PIK3CBMore
Ivabradinehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Ivabradinehsa05218Melanoma6.63E-031P08069IGF1RMore
Ivabradinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Ivabradinehsa05224Breast cancer1.49E-021P08069IGF1RMore
Ivabradinehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Ivabradinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Ivabradinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Ivabradine (SDC: 4.33)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
O15399GRIN2DGlutamate receptor ionotropic, NMDA 2DPredicted00.10350.15650.64481.0095
P35610SOAT1Sterol ONoneacyltransferase 1Predicted10.38550.29360.01650.7964
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)