PharmaCoNets of Glimepiride (SPCN: 1.45 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Glimepiridehsa00071Fatty acid degradation2.52E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Glimepiridehsa00500Starch and sucrose metabolism1.07E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Glimepiridehsa00630Glyoxylate and dicarboxylate metabolism4.12E-032P40925, P15104MDH1, GLULMore
Glimepiridehsa00730Thiamine metabolism8.96E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Glimepiridehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Glimepiridehsa00770Pantothenate and CoA biosynthesis2.27E-022O95498, O95497VNN2, VNN1More
Glimepiridehsa00970Aminoacyl-tRNA biosynthesis2.77E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Glimepiridehsa01100Metabolic pathways3.52E-0223P05089, O95455, P21953, P32320, P11766, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q9UNP4, P37837, P32321, Q9BPW9, Q9UHY7, P43490, P46976, P06737ARG1, TGDS, BCKDHB, CDA, ADH5, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, ST3GAL5, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, GYG1, PYGLMore
Glimepiridehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Glimepiridehsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Glimepiridehsa04150mTOR signaling pathway2.23E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Glimepiridehsa04380Osteoclast differentiation4.80E-024P06239, P42338, P14778, Q8N149LCK, PIK3CB, IL1R1, LILRA2More
Glimepiridehsa04621NOD-like receptor signaling pathway1.93E-028Q16539, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Glimepiridehsa04657IL-17 signaling pathway1.03E-026O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Glimepiridehsa04659Th17 cell differentiation4.12E-024P06239, P14784, P14778, P07766LCK, IL2RB, IL1R1, CD3EMore
Glimepiridehsa04662B cell receptor signaling pathway7.25E-034P49841, P42338, P21854, Q8N149GSK3B, PIK3CB, CD72, LILRA2More
Glimepiridehsa04730Long-term depression3.52E-021Q14344GNA13More
Glimepiridehsa04750Inflammatory mediator regulation of TRP channels3.72E-023P14778, P42338, P24723IL1R1, PIK3CB, PRKCHMore
Glimepiridehsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Glimepiridehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Glimepiridehsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Glimepiridehsa05120Epithelial cell signaling in Helicobacter pylori infection2.27E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Glimepiridehsa05140Leishmaniasis2.47E-025P13612, O75015, P01375, P49006, Q16539ITGA4, FCGR3B, TNF, MARCKSL1, MAPK14More
Glimepiridehsa05146Amoebiasis4.20E-025P09341, P14778, P27930, P01375, P05089CXCL1, IL1R1, IL1R2, TNF, ARG1More
Glimepiridehsa05163Human cytomegalovirus infection3.28E-027P01375, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Glimepiridehsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Glimepiridehsa05418Fluid shear stress and atherosclerosis2.43E-037Q16539, P42338, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Glimepiride (SDC: 0.57)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Reported00.00420.2820.12740.6935
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)