PharmaCoNets of Framycetin (SPCN: 11.38 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Framycetinhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Framycetinhsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Framycetinhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Framycetinhsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Framycetinhsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Framycetinhsa03008Ribosome biogenesis in eukaryotes4.42E-023Q9NYH9, P78345, Q9BVP2UTP6, RPP38, GNL3More
Framycetinhsa03013RNA transport2.29E-0413O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Framycetinhsa03020RNA polymerase4.40E-022P24928, P62487POLR2A, POLR2GMore
Framycetinhsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Framycetinhsa04060Cytokine-cytokine receptor interaction1.74E-027Q9UHF4, P16871, Q9UBD3, P47992, P02775, P32248, P51684IL20RA, IL7R, XCL2, XCL1, PPBP, CCR7, CCR6More
Framycetinhsa04061Viral protein interaction with cytokine and cytokine receptor7.74E-046P51684, P32248, P02775, P47992, Q9UBD3, Q9UHF4CCR6, CCR7, PPBP, XCL1, XCL2, IL20RAMore
Framycetinhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Framycetinhsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Framycetinhsa04066HIF-1 signaling pathway3.40E-023Q09472, P07195, P10415EP300, LDHB, BCL2More
Framycetinhsa04068FoxO signaling pathway3.52E-021Q96BR1SGK3More
Framycetinhsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Framycetinhsa04071Sphingolipid signaling pathway1.90E-038P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Framycetinhsa04110Cell cycle2.06E-026Q9UJX4, O60566, Q09472, P24522, P04637, P49918ANAPC5, BUB1B, EP300, GADD45A, TP53, CDKN1CMore
Framycetinhsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Framycetinhsa04210Apoptosis2.44E-0410P04637, P10415, O75460, P24522, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643TP53, BCL2, ERN1, GADD45A, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1More
Framycetinhsa04217Necroptosis5.66E-035P15104, P05141, P01584, P0C0S5, Q9H444GLUL, SLC25A5, IL1B, H2AFZ, CHMP4BMore
Framycetinhsa04261Adrenergic signaling in cardiomyocytes3.44E-025Q16537, P0DP23, P17252, P10415, P20020PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Framycetinhsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Framycetinhsa04613Neutrophil extracellular trap formation1.68E-029P17252, O60603, P08246, Q92769, Q6FI13, P33778, P14598, Q15080, P21462PRKCA, TLR2, ELA2, HDAC2, H2AC18; H2AC19, H2BC3, NCF1, NCF4, FPR1More
Framycetinhsa04650Natural killer cell mediated cytotoxicity7.01E-0510P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Framycetinhsa04660T cell receptor signaling pathway1.49E-0310P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Framycetinhsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Framycetinhsa04668TNF signaling pathway2.91E-023P18848, P01584, P20333ATF4, IL1B, TNFRSF1BMore
Framycetinhsa04720Long-term potentiation4.42E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Framycetinhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Framycetinhsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Framycetinhsa04925Aldosterone synthesis and secretion1.54E-024Q14643, P0DP23, P17252, P20020ITPR1, CALM1, PRKCA, ATP2B1More
Framycetinhsa04932Non-alcoholic fatty liver disease2.05E-035O43521, P18848, O75460, P01584, P13073BCL2L11, ATF4, ERN1, IL1B, COX4I1More
Framycetinhsa04966Collecting duct acid secretion3.15E-022P02730, Q9Y666SLC4A1, SLC12A7More
Framycetinhsa04970Salivary secretion1.00E-024Q14643, P20020, P17252, P0DP23ITPR1, ATP2B1, PRKCA, CALM1More
Framycetinhsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Framycetinhsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Framycetinhsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Framycetinhsa05016Huntington disease4.87E-025P13073, P24928, P62487, P05141, O75460COX4I1, POLR2A, POLR2G, SLC25A5, ERN1More
Framycetinhsa05022Pathways of neurodegeneration - multiple diseases1.98E-027P13073, O75460, P18848, P05141, P20333, P01584, P0DP24COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2More
Framycetinhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Framycetinhsa05132Salmonella infection1.02E-0310P51617, Q9UJU2, Q13546, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509IRAK1, LEF1, RIPK1, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3More
Framycetinhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Framycetinhsa05140Leishmaniasis1.56E-025P14598, O60603, P49006, P51617, Q15080NCF1, TLR2, MARCKSL1, IRAK1, NCF4More
Framycetinhsa05144Malaria1.64E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Framycetinhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Framycetinhsa05169Epstein-Barr virus infection2.15E-0310P13765, Q92769, P04637, Q13546, P10415, P24522, O60603, P29728, P51617, P09693HLA-DOB, HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, OAS2, IRAK1, CD3GMore
Framycetinhsa05170Human immunodeficiency virus 1 infection6.54E-039P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Framycetinhsa05200Pathways in cancer4.87E-029P04637, Q9UJU2, Q09472, P14923, P10415, Q13077, O95267, P24522, P16871TP53, LEF1, EP300, JUP, BCL2, TRAF1, RASGRP1, GADD45A, IL7RMore
Framycetinhsa05202Transcriptional misregulation in cancer1.98E-027Q15532, P14923, Q13077, O15550, P04637, Q9C0K0, P24522SS18, JUP, TRAF1, UTX, TP53, BCL11B, GADD45AMore
Framycetinhsa05210Colorectal cancer2.41E-024P10415, P04637, Q9UJU2, P24522BCL2, TP53, LEF1, GADD45AMore
Framycetinhsa05213Endometrial cancer1.91E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Framycetinhsa05214Glioma1.00E-024P0DP23, P17252, P04637, P24522CALM1, PRKCA, TP53, GADD45AMore
Framycetinhsa05215Prostate cancer1.94E-024P10415, Q9UJU2, Q09472, P04637BCL2, LEF1, EP300, TP53More
Framycetinhsa05216Thyroid cancer2.42E-043Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Framycetinhsa05217Basal cell carcinoma1.56E-033Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Framycetinhsa05222Small cell lung cancer1.94E-024P10415, Q13077, P04637, P24522BCL2, TRAF1, TP53, GADD45AMore
Framycetinhsa05224Breast cancer4.32E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Framycetinhsa05226Gastric cancer8.86E-035Q9UJU2, P04637, P24522, P14923, P10415LEF1, TP53, GADD45A, JUP, BCL2More
Framycetinhsa05230Central carbon metabolism in cancer4.04E-022P07195, P04637LDHB, TP53More
Framycetinhsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Framycetin (SDC: 1.29)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P61073CXCR4CNoneXNoneC chemokine receptor type 4Reported10.28230.40180.6481.5927
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P32248CCR7CNoneC chemokine receptor type 7Predicted10.13910.04610.33040.4922
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P32302CXCR5CNoneXNoneC chemokine receptor type 5Predicted00.24550.04590.33040.545
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)