PharmaCoNets of Ferrous-fumarate (SPCN: 24.54 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ferrous-fumaratehsa00030Pentose phosphate pathway2.93E-022P60891, P37837PRPS1, TALDO1More
Ferrous-fumaratehsa00052Galactose metabolism2.00E-023P08237, P19367, Q14376PFKM, HK1, GALEMore
Ferrous-fumaratehsa00220Arginine biosynthesis2.93E-022P05089, P49448ARG1, GLUD2More
Ferrous-fumaratehsa00230Purine metabolism3.16E-022P20839, Q16774IMPDH1, GUK1More
Ferrous-fumaratehsa00380Tryptophan metabolism2.05E-052Q16613, P46952AANAT, HAAOMore
Ferrous-fumaratehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate1.24E-031Q9Y2C2USTMore
Ferrous-fumaratehsa00561Glycerolipid metabolism2.51E-022P51648, P23743ALDH3A2, DGKAMore
Ferrous-fumaratehsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Ferrous-fumaratehsa00565Ether lipid metabolism1.25E-022Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Ferrous-fumaratehsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Ferrous-fumaratehsa00630Glyoxylate and dicarboxylate metabolism2.78E-032P40925, P15104MDH1, GLULMore
Ferrous-fumaratehsa00785Lipoic acid metabolism1.84E-052O43766, Q9Y234LIAS, LIPT1More
Ferrous-fumaratehsa00830Retinol metabolism1.10E-032P11766, P00352ADH5, ALDH1A1More
Ferrous-fumaratehsa00860Porphyrin and chlorophyll metabolism6.63E-031Q16595FXNMore
Ferrous-fumaratehsa00970Aminoacyl-tRNA biosynthesis2.65E-021P14868DARSMore
Ferrous-fumaratehsa01100Metabolic pathways1.95E-0337O43766, Q9Y234, P35790, Q16772, P30041, P15104, P51648, P19367, P42338, Q96PE3, P19174, Q14642, P27987, Q13370, P20839, P00918, P40925, Q9Y6K0, Q14376, P48506, P08237, P23743, O95861, P21399, P07101, Q9UHK6, P43034, Q86VZ5, P09917, P48651, Q9H4F1, Q53FZ2, P34059, P35573, Q969G6, P14927, Q13029LIAS, LIPT1, CHKA, GSTA3, PRDX6, GLUL, ALDH3A2, HK1, PIK3CB, INPP4A, PLCG1, INPP5A, ITPKB, PDE3B, IMPDH1, CA2, MDH1, CEPT1, GALE, GCLC, PFKM, DGKA, BPNT1, ACO1, TH, AMACR, PAFAH1B1, SGMS1, ALOX5, PTDSS1, ST6GALNAC4, ACSM3, GALNS, AGL, RFK, UQCRB, PRDM2More
Ferrous-fumaratehsa01200Carbon metabolism2.71E-024P37837, P60891, P11766, P49448TALDO1, PRPS1, ADH5, GLUD2More
Ferrous-fumaratehsa012102-Oxocarboxylic acid metabolism1.51E-022P21399, P50213ACO1, IDH3AMore
Ferrous-fumaratehsa01230Biosynthesis of amino acids3.05E-024P08237, P21399, P50213, P37837PFKM, ACO1, IDH3A, TALDO1More
Ferrous-fumaratehsa01521EGFR tyrosine kinase inhibitor resistance7.30E-044Q92529, P19174, P42338, Q9NRA1SHC3, PLCG1, PIK3CB, PDGFCMore
Ferrous-fumaratehsa01522Endocrine resistance3.67E-025P14780, P22694, Q9UM47, P46527, P10415MMP9, PRKACB, NOTCH3, CDKN1B, BCL2More
Ferrous-fumaratehsa02010ABC transporters2.65E-021P45844ABCG1More
Ferrous-fumaratehsa03013RNA transport3.03E-0312P52298, Q09161, O14893, P61326, P37198, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5, Q06787NCBP2, NCBP1, GEMIN2, MAGOH, NUP62, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FMR1More
Ferrous-fumaratehsa03015mRNA surveillance pathway3.71E-026O43148, Q13362, O94913, Q12996, Q09161, P52298RNMT, PPP2R5C, PCF11, CSTF3, NCBP1, NCBP2More
Ferrous-fumaratehsa04010MAPK signaling pathway1.15E-029Q02750, Q15283, P09619, Q8IZS8, P54284, Q9H2K8, O43283, Q12933, P51812MAP2K1, RASA2, PDGFRB, CACNA2D3, CACNB3, TAOK3, MAP3K13, TRAF2, RPS6KA3More
Ferrous-fumaratehsa04012ErbB signaling pathway9.49E-033Q92529, P19174, P42338SHC3, PLCG1, PIK3CBMore
Ferrous-fumaratehsa04014Ras signaling pathway2.29E-047P42338, Q92529, Q9NRA1, P49767, P63218, P50151, P19174PIK3CB, SHC3, PDGFC, VEGFC, GNG5, GNG10, PLCG1More
Ferrous-fumaratehsa04015Rap1 signaling pathway3.91E-024Q9NRA1, P49767, P42338, P19174PDGFC, VEGFC, PIK3CB, PLCG1More
Ferrous-fumaratehsa04020Calcium signaling pathway2.16E-024P27987, P19174, Q9NRA1, P49767ITPKB, PLCG1, PDGFC, VEGFCMore
Ferrous-fumaratehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Ferrous-fumaratehsa04062Chemokine signaling pathway3.76E-0410P25024, P25025, P09341, P19875, P07948, P42338, P19174, Q92529, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10More
Ferrous-fumaratehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Ferrous-fumaratehsa04070Phosphatidylinositol signaling system3.19E-045P19174, P42338, P23743, Q96PE3, P27987PLCG1, PIK3CB, DGKA, INPP4A, ITPKBMore
Ferrous-fumaratehsa04071Sphingolipid signaling pathway4.14E-024Q16537, Q9BX95, Q16539, P04637PPP2R5E, SGPP1, MAPK14, TP53More
Ferrous-fumaratehsa04072Phospholipase D signaling pathway9.29E-059P42338, Q92529, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFCMore
Ferrous-fumaratehsa04137Mitophagy - animal3.24E-024Q96CV9, Q9H1Y0, P18848, O43524OPTN, ATG5, ATF4, FOXO3More
Ferrous-fumaratehsa04144Endocytosis4.65E-035O75351, P62491, Q14161, O75154, P49418VPS4B, RAB11A, GIT2, RAB11FIP3, AMPHMore
Ferrous-fumaratehsa04151PI3K-Akt signaling pathway2.55E-038P42338, Q9NRA1, P49767, P08238, P63218, P50151, O15335, P14784PIK3CB, PDGFC, VEGFC, HSP90AB1, GNG5, GNG10, CHAD, IL2RBMore
Ferrous-fumaratehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Ferrous-fumaratehsa04216Ferroptosis1.51E-023P04637, Q9H1Y0, P33121TP53, ATG5, ACSL1More
Ferrous-fumaratehsa04260Cardiac muscle contraction1.81E-044Q8IZS8, P54284, P09493, P14927CACNA2D3, CACNB3, TPM1, UQCRBMore
Ferrous-fumaratehsa04370VEGF signaling pathway1.56E-022P19174, P42338PLCG1, PIK3CBMore
Ferrous-fumaratehsa04371Apelin signaling pathway1.24E-024P63218, P50151, Q13370, Q14344GNG5, GNG10, PDE3B, GNA13More
Ferrous-fumaratehsa04510Focal adhesion1.55E-025P42338, O15335, Q9NRA1, P49767, Q92529PIK3CB, CHAD, PDGFC, VEGFC, SHC3More
Ferrous-fumaratehsa04520Adherens junction9.72E-035Q09472, P19784, P61586, P60709, P63261EP300, CSNK2A2, RHOA, ACTB, ACTG1More
Ferrous-fumaratehsa04610Complement and coagulation cascades5.02E-032P00734, P0C0L4F2, C4AMore
Ferrous-fumaratehsa04611Platelet activation4.11E-023P42338, Q14344, P07948PIK3CB, GNA13, LYNMore
Ferrous-fumaratehsa04613Neutrophil extracellular trap formation2.76E-0210O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P49913, O75015, P21462TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, CAMP, FCGR3B, FPR1More
Ferrous-fumaratehsa04621NOD-like receptor signaling pathway7.61E-0310P25963, Q9H1Y0, O00463, P10415, Q05823, P01375, P49913, P59665, P59666, P12838NFKBIA, ATG5, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Ferrous-fumaratehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Ferrous-fumaratehsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Ferrous-fumaratehsa04657IL-17 signaling pathway1.53E-026P25963, O00463, P14780, P80188, P01375, P06702NFKBIA, TRAF5, MMP9, LCN2, TNF, S100A9More
Ferrous-fumaratehsa04658Th1 and Th2 cell differentiation8.18E-068Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Ferrous-fumaratehsa04659Th17 cell differentiation9.15E-059Q04759, P19174, P06239, P14784, P14778, Q9UL17, P08238, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, HSP90AB1, CD3E, CD247More
Ferrous-fumaratehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Ferrous-fumaratehsa04662B cell receptor signaling pathway2.78E-023P42338, P07948, Q8N149PIK3CB, LYN, LILRA2More
Ferrous-fumaratehsa04664Fc epsilon RI signaling pathway7.30E-044P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Ferrous-fumaratehsa04666Fc gamma R-mediated phagocytosis1.73E-023P07948, P42338, P19174LYN, PIK3CB, PLCG1More
Ferrous-fumaratehsa04722Neurotrophin signaling pathway4.87E-023P42338, P19174, Q92529PIK3CB, PLCG1, SHC3More
Ferrous-fumaratehsa04724Glutamatergic synapse1.73E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Ferrous-fumaratehsa04725Cholinergic synapse1.73E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Ferrous-fumaratehsa04726Serotonergic synapse3.41E-023P63218, P50151, P09917GNG5, GNG10, ALOX5More
Ferrous-fumaratehsa04727GABAergic synapse6.57E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Ferrous-fumaratehsa04730Long-term depression1.56E-022Q14344, P07948GNA13, LYNMore
Ferrous-fumaratehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Ferrous-fumaratehsa04810Regulation of actin cytoskeleton2.84E-027P00734, P61586, Q02750, P23229, P26012, P60709, P63261F2, RHOA, MAP2K1, ITGA6, ITGB8, ACTB, ACTG1More
Ferrous-fumaratehsa04910Insulin signaling pathway4.11E-023Q92529, Q13370, P42338SHC3, PDE3B, PIK3CBMore
Ferrous-fumaratehsa04914Progesterone-mediated oocyte maturation2.22E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Ferrous-fumaratehsa04915Estrogen signaling pathway4.76E-034P42338, Q92529, P08238, P11142PIK3CB, SHC3, HSP90AB1, HSPA8More
Ferrous-fumaratehsa04919Thyroid hormone signaling pathway2.73E-037Q02750, P26678, P60709, P63261, Q09472, P08237, P01106MAP2K1, PLN, ACTB, ACTG1, EP300, PFKM, MYCMore
Ferrous-fumaratehsa04921Oxytocin signaling pathway1.22E-026Q02750, P60660, P60709, P63261, P61586, P54284MAP2K1, MYL6, ACTB, ACTG1, RHOA, CACNB3More
Ferrous-fumaratehsa04923Regulation of lipolysis in adipocytes1.88E-034P07550, Q13370, P42338, Q9Y4H2ADRB2, PDE3B, PIK3CB, IRS2More
Ferrous-fumaratehsa04926Relaxin signaling pathway1.31E-035P42338, P63218, P50151, P49767, Q92529PIK3CB, GNG5, GNG10, VEGFC, SHC3More
Ferrous-fumaratehsa04931Insulin resistance3.18E-043Q9Y4H2, P36956, Q13133IRS2, SREBF1, NR1H3More
Ferrous-fumaratehsa04932Non-alcoholic fatty liver disease4.74E-043Q9Y4H2, P36956, Q13133IRS2, SREBF1, NR1H3More
Ferrous-fumaratehsa04933AGE-RAGE signaling pathway in diabetic complications4.11E-023P42338, P49767, P19174PIK3CB, VEGFC, PLCG1More
Ferrous-fumaratehsa04935Growth hormone synthesis, secretion and action2.78E-023P19174, P42338, Q92529PLCG1, PIK3CB, SHC3More
Ferrous-fumaratehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Ferrous-fumaratehsa04966Collecting duct acid secretion3.44E-022P02730, P00918SLC4A1, CA2More
Ferrous-fumaratehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Ferrous-fumaratehsa05032Morphine addiction2.22E-023P63218, P50151, Q13370GNG5, GNG10, PDE3BMore
Ferrous-fumaratehsa05100Bacterial invasion of epithelial cells3.64E-022P42338, Q92529PIK3CB, SHC3More
Ferrous-fumaratehsa05120Epithelial cell signaling in Helicobacter pylori infection1.00E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Ferrous-fumaratehsa05130Pathogenic Escherichia coli infection1.31E-028P61586, P19338, Q13885, P60709, P63261, Q12933, P00734, O95487RHOA, NCL, TUBB2A, ACTB, ACTG1, TRAF2, F2, SEC24BMore
Ferrous-fumaratehsa05133Pertussis1.96E-023P10145, P23528, P0C0L4IL8, CFL1, C4AMore
Ferrous-fumaratehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Ferrous-fumaratehsa05135Yersinia infection9.76E-037P60709, P63261, P61586, Q16513, P51812, Q12933, Q02750ACTB, ACTG1, RHOA, PKN2, RPS6KA3, TRAF2, MAP2K1More
Ferrous-fumaratehsa05140Leishmaniasis1.98E-0410P13612, O75015, P14598, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Ferrous-fumaratehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Ferrous-fumaratehsa05150Staphylococcus aureus infection3.71E-026P21462, O75015, P59665, P59666, P12838, P49913FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Ferrous-fumaratehsa05152Tuberculosis3.04E-029Q13488, O75015, P48382, P25208, O60603, P01375, P10415, P49913, Q9UDY8TCIRG1, FCGR3B, RFX5, NFYB, TLR2, TNF, BCL2, CAMP, MALT1More
Ferrous-fumaratehsa05162Measles3.91E-024P14784, P07766, P42338, P11142IL2RB, CD3E, PIK3CB, HSPA8More
Ferrous-fumaratehsa05163Human cytomegalovirus infection1.14E-025P42338, P63218, P50151, Q14344, P30101PIK3CB, GNG5, GNG10, GNA13, PDIA3More
Ferrous-fumaratehsa05164Influenza A8.79E-038Q09472, P48551, P29728, O15131, Q02750, P60709, P63261, Q9BUJ2EP300, IFNAR2, OAS2, KPNA5, MAP2K1, ACTB, ACTG1, HNRPUL1More
Ferrous-fumaratehsa05167Kaposi sarcoma-associated herpesvirus infection1.14E-025P42338, P63218, P50151, P19174, P07948PIK3CB, GNG5, GNG10, PLCG1, LYNMore
Ferrous-fumaratehsa05169Epstein-Barr virus infection3.34E-025P42338, P07948, P30101, Q13761, P07766PIK3CB, LYN, PDIA3, RUNX3, CD3EMore
Ferrous-fumaratehsa05170Human immunodeficiency virus 1 infection7.03E-036P42338, P63218, P50151, P30101, P19174, P07766PIK3CB, GNG5, GNG10, PDIA3, PLCG1, CD3EMore
Ferrous-fumaratehsa05200Pathways in cancer3.05E-028P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RBMore
Ferrous-fumaratehsa05202Transcriptional misregulation in cancer8.78E-0310Q13315, P14780, P46527, P35226, O60583, P05164, P59665, P59666, P12838, P08246ATM, MMP9, CDKN1B, BMI1, CCNT2, MPO, DEFA1; DEFA1B, DEFA3, DEFA4, ELA2More
Ferrous-fumaratehsa05203Viral carcinogenesis2.61E-033Q12834, P62807, Q16778CDC20, HIST1H2BC, HIST2H2BEMore
Ferrous-fumaratehsa05214Glioma9.49E-033Q92529, P42338, P19174SHC3, PIK3CB, PLCG1More
Ferrous-fumaratehsa05215Prostate cancer4.87E-023Q9NRA1, P08238, P42338PDGFC, HSP90AB1, PIK3CBMore
Ferrous-fumaratehsa05218Melanoma3.64E-022Q9NRA1, P42338PDGFC, PIK3CBMore
Ferrous-fumaratehsa05219Bladder cancer2.72E-022P14780, P04637MMP9, TP53More
Ferrous-fumaratehsa05230Central carbon metabolism in cancer1.09E-035P01106, P09619, Q02750, P19367, P08237MYC, PDGFRB, MAP2K1, HK1, PFKMMore
Ferrous-fumaratehsa05231Choline metabolism in cancer1.83E-048Q02750, P42338, P09619, Q9NRA1, O15245, P35790, P19174, P23743MAP2K1, PIK3CB, PDGFRB, PDGFC, SLC22A1, CHKA, PLCG1, DGKAMore
Ferrous-fumaratehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Ferrous-fumaratehsa05322Systemic lupus erythematosus3.83E-032P62807, Q16778HIST1H2BC, HIST2H2BEMore
Ferrous-fumaratehsa05410Hypertrophic cardiomyopathy1.48E-069Q8IZS8, P54284, P23229, P13612, P26012, P09493, Q8WZ42, P60709, P63261CACNA2D3, CACNB3, ITGA6, ITGA4, ITGB8, TPM1, TTN, ACTB, ACTG1More
Ferrous-fumaratehsa05412Arrhythmogenic right ventricular cardiomyopathy1.08E-078Q8IZS8, P54284, P15924, P23229, P13612, P26012, P60709, P63261CACNA2D3, CACNB3, DSP, ITGA6, ITGA4, ITGB8, ACTB, ACTG1More
Ferrous-fumaratehsa05414Dilated cardiomyopathy6.73E-0710Q8IZS8, P54284, P23229, P13612, P26012, P09493, Q8WZ42, P26678, P60709, P63261CACNA2D3, CACNB3, ITGA6, ITGA4, ITGB8, TPM1, TTN, PLN, ACTB, ACTG1More

Community members of Ferrous-fumarate (SDC: 1.63)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)