PharmaCoNets of Ertapenem (SPCN: 3.90 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ertapenemhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Ertapenemhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Ertapenemhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Ertapenemhsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Ertapenemhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Ertapenemhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Ertapenemhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Ertapenemhsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Ertapenemhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Ertapenemhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Ertapenemhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Ertapenemhsa04530Tight junction9.34E-056Q8TEU7, P63261, O00501, Q92974, Q14247, P24844RAPGEF6, ACTG1, CLDN5, ARHGEF2, CTTN, MYL9More
Ertapenemhsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Ertapenemhsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Ertapenemhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Ertapenemhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Ertapenemhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Ertapenemhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore

Community members of Ertapenem (SDC: 1.79)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)