PharmaCoNets

PharmaCoNets of Econazole (S_PCN: 195.26 )

Econazole regulated-network (S_DN: 25.62)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Econazole

hsa00052

Galactose metabolism

1.06E-03

P06280, O43451

GLA, MGAM

Econazole

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Econazole

hsa00190

Oxidative phosphorylation

8.71E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Econazole

hsa00220

Arginine biosynthesis

7.34E-05

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Econazole

hsa00250

Alanine, aspartate and glutamate metabolism

1.97E-02

P49448, P15104

GLUD2, GLUL

Econazole

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Econazole

hsa00500

Starch and sucrose metabolism

3.07E-07

O43451, P46976, P06737

MGAM, GYG1, PYGL

Econazole

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Econazole

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Econazole

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Econazole

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Econazole

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Econazole

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Econazole

hsa00630

Glyoxylate and dicarboxylate metabolism

1.23E-04

P40925, P15104

MDH1, GLUL

Econazole

hsa00730

Thiamine metabolism

1.87E-06

P05186, P24666

ALPL, ACP1

Econazole

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Econazole

hsa00910

Nitrogen metabolism

1.97E-02

P15104, P49448

GLUL, GLUD2

Econazole

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Econazole

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Econazole

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Econazole

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Econazole

hsa01240

Biosynthesis of cofactors

2.95E-02

P13716, P14618

ALAD, PKM2

Econazole

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Econazole

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Econazole

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Econazole

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Econazole

hsa03010

Ribosome

7.34E-03

P62753, P62829, P62888, P61927, P61513, P36578

RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4

Econazole

hsa03013

RNA transport

8.19E-04

Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042

RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2

Econazole

hsa03020

RNA polymerase

2.51E-02

P24928, P62487

POLR2A, POLR2G

Econazole

hsa03030

DNA replication

5.00E-02

P27694

RPA1

Econazole

hsa03040

Spliceosome

1.87E-06

Q14562, O43143, O60508, P08579, Q15427, P38159, P61978, Q07955, Q01130, Q13243, P11142, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, SF3B4, RBMX, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.803
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.869
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O60508	CDC40	Pre-mRNA-processing factor 17	0.827
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.778
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.928
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.786
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	0.78

Econazole

hsa03060

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Econazole

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Econazole

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Econazole

hsa04012

ErbB signaling pathway

1.66E-03

P21860, P16333, Q13557, P19174, O14944, P42338, P01106

ERBB3, NCK1, CAMK2D, PLCG1, EREG, PIK3CB, MYC

Econazole

hsa04014

Ras signaling pathway

6.17E-06

P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869

Econazole

hsa04015

Rap1 signaling pathway

1.44E-04

P20827, Q9NRA1, P49767, P08069, P06213, P11215, Q13009, O00522, P42338, P0DP23, P19174

EFNA1, PDGFC, VEGFC, IGF1R, INSR, ITGAM, TIAM1, KRIT1, PIK3CB, CALM1, PLCG1

Econazole

hsa04020

Calcium signaling pathway

1.09E-04

P27987, Q96DU7, P21796, P45880, Q13557, P21860, P19174, P0DP23, P51828, P23634, Q9NRA1, P49767

ITPKB, ITPKC, VDAC1, VDAC2, CAMK2D, ERBB3, PLCG1, CALM1, ADCY7, ATP2B4, PDGFC, VEGFC

Econazole

hsa04022

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Econazole

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Econazole

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.32E-02

P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Econazole

hsa04062

Chemokine signaling pathway

5.96E-08

P25024, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963

CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818

Econazole

hsa04064

NF-kappa B signaling pathway

9.31E-05

P10415, Q13489, O00463, P14778, P29965, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, Q06643

BCL2, BIRC3, TRAF5, IL1R1, CD40LG, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, LTB

Econazole

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Econazole

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Econazole

hsa04070

Phosphatidylinositol signaling system

8.82E-05

P19174, P0DP23, Q14643, P42338, P23743, P27987, P17252

PLCG1, CALM1, ITPR1, PIK3CB, DGKA, ITPKB, PRKCA

Econazole

hsa04071

Sphingolipid signaling pathway

2.87E-03

P17252, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2

PRKCA, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2

Econazole

hsa04072

Phospholipase D signaling pathway

4.67E-02

P42338, P19174, Q14344, P23743, Q9NRA1

PIK3CB, PLCG1, GNA13, DGKA, PDGFC

Econazole

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Econazole

hsa04114

Oocyte meiosis

3.19E-03

P51812, Q02750, P16298, Q17RY0, P08069

RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Econazole

hsa04120

Ubiquitin mediated proteolysis

4.61E-02

Q13042, Q15751

CDC16, HERC1

Econazole

hsa04140

Autophagy - animal

2.82E-02

P08069

IGF1R

Econazole

hsa04141

Protein processing in endoplasmic reticulum

1.33E-03

P30101, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9H173, Q9UNL2

PDIA3, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SIL1, SSR3

Econazole

hsa04145

Phagosome

3.28E-05

P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, O60603, P13765

ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB

Econazole

hsa04150

mTOR signaling pathway

7.74E-03

P08069, Q02750, Q9NQL2, P51812

IGF1R, MAP2K1, RRAGD, RPS6KA3

Econazole

hsa04151

PI3K-Akt signaling pathway

1.26E-04

P42338, P43657, P25116, P01106, P09603, P20827, Q9NRA1, P49767, Q9GZP0, Q13362, P08238, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252

PIK3CB, P2RY5, F2R, MYC, CSF1, EFNA1, PDGFC, VEGFC, PDGFD, PPP2R5C, HSP90AB1, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.702
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.736
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P13612	ITGA4	Integrin alpha-4	0.77
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15335	CHAD	Chondroadherin	-0.729
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O15335	CHAD	Chondroadherin	-0.704
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13751	LAMB3	Laminin subunit beta-3	-0.794
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1

Econazole

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Econazole

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Econazole

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Econazole

hsa04213

Longevity regulating pathway - multiple species

1.66E-02

P08069

IGF1R

Econazole

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Econazole

hsa04217

Necroptosis

8.11E-05

P01568, Q13489, Q9NQC7, P42224, P07900, P15104, P01584, Q6FI13, P10415, Q9H444, O43633, Q08752

IFNA21, BIRC3, CYLD, STAT1, HSP90AA1, GLUL, IL1B, H2AC18; H2AC19, BCL2, CHMP4B, CHMP2A, PPID

Econazole

hsa04261

Adrenergic signaling in cardiomyocytes

3.49E-03

P09493, P51828, Q99941, Q13362, P0DP23, Q13557, P17252, P10415, P23634

TPM1, ADCY7, CREBL1, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4

Econazole

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Econazole

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Econazole

hsa04360

Axon guidance

2.87E-02

P16333, P20827, O95631, P42338, P19174

NCK1, EFNA1, NTN1, PIK3CB, PLCG1

Econazole

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Econazole

hsa04371

Apelin signaling pathway

6.35E-06

P62873, P63218, P50151, Q13370, Q14814, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, SMAD3, CALM1

Econazole

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Econazole

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Econazole

hsa04392

Hippo signaling pathway - multiple species

3.01E-02

Q6V0I7

FAT4

Econazole

hsa04510

Focal adhesion

3.48E-02

P08069

IGF1R

Econazole

hsa04512

ECM-receptor interaction

3.11E-03

Q13751, P13612, P26012, O15335, P16070

LAMB3, ITGA4, ITGB8, CHAD, CD44

Econazole

hsa04514

Cell adhesion molecules

1.22E-02

P23229, P30511

ITGA6, HLA-F

Econazole

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Econazole

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Econazole

hsa04540

Gap junction

3.48E-04

P17252, Q13509, P68371, Q71U36, Q9NRA1, Q14643

PRKCA, TUBB3, TUBB2C, TUBA1A, PDGFC, ITPR1

Econazole

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Econazole

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Econazole

hsa04612

Antigen processing and presentation

1.75E-02

P13765, P01730, P26715, P26717, Q13241, P01732

HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8A

Econazole

hsa04613

Neutrophil extracellular trap formation

2.60E-04

P42338, P19174, P17252, P11215, O60603, P08246, Q13547, Q6FI13, Q93077, P62807, Q93079, O60814, P68431, P21796, P14598, Q15080, P21462

PIK3CB, PLCG1, PRKCA, ITGAM, TLR2, ELA2, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, FPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731

Econazole

hsa04620

Toll-like receptor signaling pathway

4.00E-02

P01568, P42224, P25963, P42338

IFNA21, STAT1, NFKBIA, PIK3CB

Econazole

hsa04621

NOD-like receptor signaling pathway

2.92E-02

P01584, P07900, P43490

IL1B, HSP90AA1, PBEF1

Econazole

hsa04623

Cytosolic DNA-sensing pathway

1.55E-03

P01568, P25963

IFNA21, NFKBIA

Econazole

hsa04625

C-type lectin receptor signaling pathway

2.21E-03

Q9ULY5, P42224, P20749, P25963, P01375, P42338, P0DP23, Q16539

CLEC4E, STAT1, BCL3, NFKBIA, TNF, PIK3CB, CALM1, MAPK14

Econazole

hsa04640

Hematopoietic cell lineage

3.30E-05

P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765

ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB

Econazole

hsa04650

Natural killer cell mediated cytotoxicity

3.04E-05

P16298, P50591, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Econazole

hsa04657

IL-17 signaling pathway

1.64E-05

P07900, O00463, Q16539, P49841, P09341, P14780, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF, IL1B

Econazole

hsa04658

Th1 and Th2 cell differentiation

1.54E-09

P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, P23771, Q9UL17, P14784, P13765, Q13761

NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85

Econazole

hsa04659

Th17 cell differentiation

2.55E-10

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P14778	IL1R1	Interleukin-1 receptor type 1	0.909
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q9UL17	TBX21	T-box transcription factor TBX21	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703

Econazole

hsa04660

T cell receptor signaling pathway

8.91E-04

Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Econazole

hsa04662

B cell receptor signaling pathway

1.12E-02

P25963, P42338, P07948, P21854, Q8N149

NFKBIA, PIK3CB, LYN, CD72, LILRA2

Econazole

hsa04664

Fc epsilon RI signaling pathway

2.63E-05

P01375, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Econazole

hsa04666

Fc gamma R-mediated phagocytosis

2.92E-02

P07948, P42338, P19174, P14598

LYN, PIK3CB, PLCG1, NCF1

Econazole

hsa04668

TNF signaling pathway

2.47E-03

P01375, O00463, Q16539, Q99941, P01584, P20749, P14780, O95429

TNF, TRAF5, MAPK14, CREBL1, IL1B, BCL3, MMP9, BAG4

Econazole

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Econazole

hsa04710

Circadian rhythm

1.44E-03

O15516, Q16526, Q9Y478

CLOCK, CRY1, PRKAB1

Econazole

hsa04713

Circadian entrainment

1.66E-04

P0DP23, P17252, P62873, P63218, P50151, Q14643

CALM1, PRKCA, GNB1, GNG5, GNG10, ITPR1

Econazole

hsa04720

Long-term potentiation

1.95E-03

P17252, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Econazole

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Econazole

hsa04724

Glutamatergic synapse

3.48E-05

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Econazole

hsa04725

Cholinergic synapse

1.38E-03

Q14643, P17252, P62873, P63218, P50151, P42338, P10415

ITPR1, PRKCA, GNB1, GNG5, GNG10, PIK3CB, BCL2

Econazole

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Econazole

hsa04727

GABAergic synapse

5.37E-06

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Econazole

hsa04728

Dopaminergic synapse

3.55E-02

Q14643, P17252, P62873, Q13362, P0DP23

ITPR1, PRKCA, GNB1, PPP2R5C, CALM1

Econazole

hsa04730

Long-term depression

2.66E-04

Q14344, P08069, P07948

GNA13, IGF1R, LYN

Econazole

hsa04744

Phototransduction

1.24E-06

P62873, P0DP23

GNB1, CALM1

Econazole

hsa04750

Inflammatory mediator regulation of TRP channels

4.11E-03

P01584, P51828, Q13557, P19174, P42338, P24723, P0DP23

IL1B, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, CALM1

Econazole

hsa04810

Regulation of actin cytoskeleton

4.14E-03

P12814, Q13009, P42338, P23229, P11215, Q14344, Q9NRA1

ACTN1, TIAM1, PIK3CB, ITGA6, ITGAM, GNA13, PDGFC

Econazole

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Econazole

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Econazole

hsa04912

GnRH signaling pathway

3.89E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Econazole

hsa04913

Ovarian steroidogenesis

8.40E-04

P06213, P08069

INSR, IGF1R

Econazole

hsa04914

Progesterone-mediated oocyte maturation

1.85E-03

P08069, Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750

IGF1R, CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1

Econazole

hsa04915

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Econazole

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Econazole

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Econazole

hsa04922

Glucagon signaling pathway

5.91E-03

P14618, P06737, Q12778, Q13370, P0DP23, Q14643

PKM2, PYGL, FOXO1, PDE3B, CALM1, ITPR1

Econazole

hsa04923

Regulation of lipolysis in adipocytes

3.76E-02

P06213

INSR

Econazole

hsa04924

Renin secretion

8.71E-03

Q14643, Q13370, P0DP23

ITPR1, PDE3B, CALM1

Econazole

hsa04925

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Econazole

hsa04926

Relaxin signaling pathway

8.74E-03

P25963, P42338, P62873, P63218, P50151, P49767

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC

Econazole

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Econazole

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Econazole

hsa04932

Non-alcoholic fatty liver disease

3.44E-02

P01584, P12074, O15239

IL1B, COX6A1, NDUFA1

Econazole

hsa04933

AGE-RAGE signaling pathway in diabetic complications

5.84E-04

P84022, Q13485, P42224, P10415, Q12778, P49767, P17252

SMAD3, SMAD4, STAT1, BCL2, FOXO1, VEGFC, PRKCA

Econazole

hsa04934

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Econazole

hsa04960

Aldosterone-regulated sodium reabsorption

7.59E-03

O00141, P06213

SGK, INSR

Econazole

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Econazole

hsa04966

Collecting duct acid secretion

2.07E-03

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Econazole

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Econazole

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Econazole

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Econazole

hsa05010

Alzheimer disease

4.42E-04

Q92542, Q16718, O14521, P05496, P12074, Q14643, O15399, Q9NZJ5, O75460, P0DP23, Q13564, P01584, Q71U36, Q13509, P68371, O15169, P09603, P21796, P45880, Q08752

NCSTN, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, GRIN2D, EIF2AK3, ERN1, CALM1, APPBP1, IL1B, TUBA1A, TUBB3, TUBB2C, AXIN1, CSF1, VDAC1, VDAC2, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.707
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.728
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.873
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.85
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.88
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725

Econazole

hsa05012

Parkinson disease

1.54E-04

Q16718, O14521, P21796, P60604, Q14643, P19174, P0DP23, Q71U36, Q13509, P68371

NDUFA5, SDHD, VDAC1, UBE2G2, ITPR1, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Econazole

hsa05020

Prion disease

1.17E-03

P01584, P46531, P11142, Q16718, O14521, P05496, P12074, Q14643, P45880, Q13509, P68371, Q99941, P14598, Q15080

IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, VDAC2, TUBB3, TUBB2C, CREBL1, NCF1, NCF4

Econazole

hsa05022

Pathways of neurodegeneration - multiple diseases

4.00E-03

Q14643, Q13509, P68371, P10415, Q16718, O14521, Q06055, Q13561, P17252, Q08752, O15020, P0DP23

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, ATP5G2, DCTN2, PRKCA, PPID, SPTBN2, CALM1

Econazole

hsa05032

Morphine addiction

1.77E-05

P62873, P63218, P50151, Q13370, Q07343, P43250

GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6

Econazole

hsa05034

Alcoholism

9.92E-05

Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431

HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Econazole

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

6.88E-04

Q16539, P25963, Q13488, P09341, P19174, P25024, P25025, P07948

MAPK14, NFKBIA, TCIRG1, CXCL1, PLCG1, CXCR1, CXCR2, LYN

Econazole

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Econazole

hsa05131

Shigellosis

2.27E-02

P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Econazole

hsa05132

Salmonella infection

8.06E-06

P25963, P08238, Q9UJU2, P01106, P42338, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

NFKBIA, HSP90AB1, LEF1, MYC, PIK3CB, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75369	FLNB	Filamin-B	0.706
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.728

Econazole

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Econazole

hsa05134

Legionellosis

4.75E-02

P25963, P11215, P11142

NFKBIA, ITGAM, HSPA8

Econazole

hsa05140

Leishmaniasis

3.18E-05

O75015, P14598, P11215, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4

Econazole

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Econazole

hsa05144

Malaria

1.44E-03

P60033, P69905, P68871, O60603, P35443, P26718

CD81, HBA2, HBB, TLR2, THBS4, KLRK1

Econazole

hsa05145

Toxoplasmosis

1.02E-03

P25963, P10415, Q13489, P42224, P13765, O60603, P29965

NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Econazole

hsa05146

Amoebiasis

1.32E-03

P09341, P14778, P27930, O60603, P05089, P12814, P08311

CXCL1, IL1R1, IL1R2, TLR2, ARG1, ACTN1, CTSG

Econazole

hsa05152

Tuberculosis

7.93E-04

Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Econazole

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Econazole

hsa05162

Measles

1.84E-02

P01568, P25963, P42224, P14784, P07766, P42338, P11142

IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8

Econazole

hsa05163

Human cytomegalovirus infection

2.26E-08

P42338, P01375, P30511, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, P49841, P01106, P14778, P25025, Q16539, P04637, O00463, P30101, P01568

PIK3CB, TNF, HLA-F, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, GSK3B, MYC, IL1R1, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P27694	RPA1	Replication protein A 70 kDa DNA-binding subunit	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.898
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P27694	RPA1	Replication protein A 70 kDa DNA-binding subunit	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.727
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733

Econazole

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Econazole

hsa05167

Kaposi sarcoma-associated herpesvirus infection

6.63E-10

P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q14643, Q02750, P07948, P01106, P04141, P0DP23, P0CG47, Q9UJU2

IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, ITPR1, MAP2K1, LYN, MYC, CSF2, CALM1, UBB, LEF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881

Econazole

hsa05168

Herpes simplex virus 1 infection

5.29E-03

P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189

Econazole

hsa05169

Epstein-Barr virus infection

4.19E-06

P13765, P01106, Q13547, O00463, P25963, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, O60603, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, TLR2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q13547	HDAC1	Histone deacetylase 1	-0.727
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60603	TLR2	Toll-like receptor 2	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703

Econazole

hsa05170

Human immunodeficiency virus 1 infection

5.01E-08

P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, P30101, Q14643, P01568, P25963, O60603, Q13315, P19174, P07766, P10415, Q9Y6Q5, P20333

PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, ITPR1, IFNA21, NFKBIA, TLR2, ATM, PLCG1, CD3E, BCL2, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Econazole

hsa05171

Coronavirus disease - COVID-19

3.18E-03

P01584, P62753, P36578, P62888, P61927, P61513, P62829

IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23

Econazole

hsa05200

Pathways in cancer

3.99E-06

P42338, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, P84022, P20585, Q13547, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD3, MSH3, HDAC1, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43246	MSH2	DNA mismatch repair protein Msh2	0.887
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.735
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717

Econazole

hsa05202

Transcriptional misregulation in cancer

2.82E-02

P08069

IGF1R

Econazole

hsa05203

Viral carcinogenesis

6.72E-04

P42338, P06746, P07948, P29083, Q13547, Q15283, P12814, P25963, P62807, Q93079, O60814

PIK3CB, POLB, LYN, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, HIST1H2BC, H2BC9, H2BC12

Econazole

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Econazole

hsa05205

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Econazole

hsa05206

MicroRNAs in cancer

4.00E-04

P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P20827, P19174

CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, EFNA1, PLCG1

Econazole

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Econazole

hsa05212

Pancreatic cancer

4.70E-03

P42224, P84022, Q13485, O75293

STAT1, SMAD3, SMAD4, GADD45B

Econazole

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Econazole

hsa05214

Glioma

2.68E-04

P08069, P0DP23, P42338, P19174, O75293

IGF1R, CALM1, PIK3CB, PLCG1, GADD45B

Econazole

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Econazole

hsa05218

Melanoma

2.77E-03

P08069, Q9NRA1, P42338, O75293

IGF1R, PDGFC, PIK3CB, GADD45B

Econazole

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Econazole

hsa05220

Chronic myeloid leukemia

1.14E-03

Q13547, P01106, Q13485, P25963, P84022, P42338, O75293

HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Econazole

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Econazole

hsa05224

Breast cancer

1.24E-02

P08069, P49841, Q92837, P04637, P24522

IGF1R, GSK3B, FRAT1, TP53, GADD45A

Econazole

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Econazole

hsa05226

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Econazole

hsa05231

Choline metabolism in cancer

2.92E-03

P42338, Q9NRA1, Q9Y259, P19174, P23743

PIK3CB, PDGFC, CHKB, PLCG1, DGKA

Econazole

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.90E-05

P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, Q04759, Q16539, P01730

NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.703
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P06239	LCK	Tyrosine-protein kinase Lck	-0.709
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	O60603	TLR2	Toll-like receptor 2	0.72
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746

Econazole

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Econazole

hsa05322

Systemic lupus erythematosus

4.80E-06

P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Econazole

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Econazole

hsa05330

Allograft rejection

1.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Econazole

hsa05332

Graft-versus-host disease

3.93E-02

P13765, P26715, Q13241

HLA-DOB, KLRC1, KLRD1

Econazole

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Econazole

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Econazole

hsa05415

Diabetic cardiomyopathy

3.55E-02

P17252, P14598, Q15080, Q16718, O14521

PRKCA, NCF1, NCF4, NDUFA5, SDHD

Econazole

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Econazole

hsa05418

Fluid shear stress and atherosclerosis

1.26E-04

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Econazole (S_DC: 7.62)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

NR1I2

Nuclear receptor subfamily 1 group I member 2

Reported

0.0315

0.9493

1.9143

P61088

UBE2N

UbiquitinNoneconjugating enzyme E2 N

Predicted

0.1102

0.3825

0.3736

1.1937

P40925

MDH1

Malate dehydrogenase, cytoplasmic

Predicted

0.3566

0.2746

0.2426

0.97

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P05186

ALPL

Alkaline phosphatase, tissueNonenonspecific isozyme

Predicted

0.3064

0.4143

0.1992

1.181

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P27694

RPA1

Replication protein A 70 kDa DNANonebinding subunit

Predicted

0.2273

0.1756

0.2746

0.7395

P06213

INSR

Insulin receptor

Predicted

0.2794

0.7813

0.7209

2.4232

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P07947

YES1

TyrosineNoneprotein kinase Yes

Predicted

0.1212

0.4345

0.165

1.0947

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P30530

AXL

TyrosineNoneprotein kinase receptor UFO

Predicted

0.3797

0.5365

0.1637

1.4264

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

O00141

SGK

Serine/threonineNoneprotein kinase Sgk1

Predicted

0.2413

0.3037

0.3059

1.034

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

PharmaCoNets of Econazole (SPCN: 195.26 )

Econazole regulated-network (SDN: 25.62)

Community members of Econazole (SDC: 7.62)

PharmaCoNets of Econazole (S_PCN: 195.26 )

Econazole regulated-network (S_DN: 25.62)

Community members of Econazole (S_DC: 7.62)