PharmaCoNets of Dexmethylphenidate (SPCN: 50.09 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Dexmethylphenidatehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Dexmethylphenidatehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Dexmethylphenidatehsa00220Arginine biosynthesis4.88E-021P49448GLUD2More
Dexmethylphenidatehsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Dexmethylphenidatehsa00471D-Glutamine and D-glutamate metabolism1.65E-021P49448GLUD2More
Dexmethylphenidatehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Dexmethylphenidatehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Dexmethylphenidatehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Dexmethylphenidatehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Dexmethylphenidatehsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Dexmethylphenidatehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Dexmethylphenidatehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Dexmethylphenidatehsa00910Nitrogen metabolism4.88E-021P49448GLUD2More
Dexmethylphenidatehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Dexmethylphenidatehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Dexmethylphenidatehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Dexmethylphenidatehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Dexmethylphenidatehsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Dexmethylphenidatehsa03060Protein export3.28E-021Q15070OXA1LMore
Dexmethylphenidatehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Dexmethylphenidatehsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Dexmethylphenidatehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Dexmethylphenidatehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Dexmethylphenidatehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Dexmethylphenidatehsa04070Phosphatidylinositol signaling system4.86E-023P0DP23, P42338, P27987CALM1, PIK3CB, ITPKBMore
Dexmethylphenidatehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Dexmethylphenidatehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Dexmethylphenidatehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Dexmethylphenidatehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Dexmethylphenidatehsa04152AMPK signaling pathway2.34E-022Q96EB6, P36956SIRT1, SREBF1More
Dexmethylphenidatehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Dexmethylphenidatehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Dexmethylphenidatehsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Dexmethylphenidatehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Dexmethylphenidatehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Dexmethylphenidatehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Dexmethylphenidatehsa04530Tight junction4.35E-022P63261, Q92974ACTG1, ARHGEF2More
Dexmethylphenidatehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Dexmethylphenidatehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Dexmethylphenidatehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Dexmethylphenidatehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Dexmethylphenidatehsa04650Natural killer cell mediated cytotoxicity1.30E-0411P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3More
Dexmethylphenidatehsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Dexmethylphenidatehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Dexmethylphenidatehsa04659Th17 cell differentiation1.89E-0411Q04759, P19174, P06239, P42224, P14784, P14778, P40189, Q9UL17, P08238, P07766, P20963PRKCQ, PLCG1, LCK, STAT1, IL2RB, IL1R1, IL6ST, TBX21, HSP90AB1, CD3E, CD247More
Dexmethylphenidatehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Dexmethylphenidatehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Dexmethylphenidatehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Dexmethylphenidatehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Dexmethylphenidatehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Dexmethylphenidatehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Dexmethylphenidatehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Dexmethylphenidatehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Dexmethylphenidatehsa04914Progesterone-mediated oocyte maturation2.97E-036Q17RY0, P42338, Q13370, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1More
Dexmethylphenidatehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Dexmethylphenidatehsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Dexmethylphenidatehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Dexmethylphenidatehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Dexmethylphenidatehsa04964Proximal tubule bicarbonate reclamation4.88E-021P49448GLUD2More
Dexmethylphenidatehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Dexmethylphenidatehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Dexmethylphenidatehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Dexmethylphenidatehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Dexmethylphenidatehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Dexmethylphenidatehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Dexmethylphenidatehsa05133Pertussis4.94E-021P0C0L4C4AMore
Dexmethylphenidatehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Dexmethylphenidatehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Dexmethylphenidatehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Dexmethylphenidatehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Dexmethylphenidatehsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Dexmethylphenidatehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Dexmethylphenidatehsa05168Herpes simplex virus 1 infection1.15E-028P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212More
Dexmethylphenidatehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Dexmethylphenidatehsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Dexmethylphenidatehsa05212Pancreatic cancer1.72E-023P42338, P42224, O75293PIK3CB, STAT1, GADD45BMore
Dexmethylphenidatehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Dexmethylphenidatehsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Dexmethylphenidatehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Dexmethylphenidatehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Dexmethylphenidatehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Dexmethylphenidatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Dexmethylphenidatehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Dexmethylphenidatehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Dexmethylphenidatehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Dexmethylphenidatehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Dexmethylphenidatehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Dexmethylphenidatehsa05418Fluid shear stress and atherosclerosis1.40E-0411Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Dexmethylphenidate (SDC: 4.82)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)