PharmaCoNets of Chloroprocaine (SPCN: 17.66 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Chloroprocainehsa00030Pentose phosphate pathway1.09E-022P52209, P37837PGD, TALDO1More
Chloroprocainehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Chloroprocainehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Chloroprocainehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Chloroprocainehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Chloroprocainehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Chloroprocainehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Chloroprocainehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Chloroprocainehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Chloroprocainehsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Chloroprocainehsa04071Sphingolipid signaling pathway2.96E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Chloroprocainehsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Chloroprocainehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Chloroprocainehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Chloroprocainehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Chloroprocainehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Chloroprocainehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Chloroprocainehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Chloroprocainehsa04612Antigen processing and presentation3.21E-026P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Chloroprocainehsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Chloroprocainehsa04664Fc epsilon RI signaling pathway2.18E-022P09917, P20292ALOX5, ALOX5APMore
Chloroprocainehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Chloroprocainehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Chloroprocainehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Chloroprocainehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Chloroprocainehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Chloroprocainehsa04927Cortisol synthesis and secretion8.60E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Chloroprocainehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Chloroprocainehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Chloroprocainehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Chloroprocainehsa04962Vasopressin-regulated water reabsorption2.18E-022P52566, P62491ARHGDIB, RAB11AMore
Chloroprocainehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Chloroprocainehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Chloroprocainehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Chloroprocainehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Chloroprocainehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Chloroprocainehsa05133Pertussis4.94E-021P0C0L4C4AMore
Chloroprocainehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Chloroprocainehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Chloroprocainehsa05202Transcriptional misregulation in cancer1.63E-0315Q15532, Q13315, P14780, P27930, Q15744, Q16548, P11215, O15550, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, UTX, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Chloroprocainehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Chloroprocainehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Chloroprocainehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Chloroprocainehsa05321Inflammatory bowel disease2.29E-024P13765, Q14765, P23771, Q9HBE5HLA-DOB, STAT4, GATA3, IL21RMore
Chloroprocainehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Chloroprocainehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Chloroprocainehsa05332Graft-versus-host disease7.94E-046P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Chloroprocainehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Chloroprocainehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Chloroprocainehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Chloroprocaine (SDC: 2.82)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P52209PGD6Nonephosphogluconate dehydrogenase, decarboxylatingPredicted00.1950.14540.26420.6525
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)