PharmaCoNets of Apixaban (SPCN: 67.81 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Apixabanhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Apixabanhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Apixabanhsa00380Tryptophan metabolism1.33E-022P46952, P51648HAAO, ALDH3A2More
Apixabanhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Apixabanhsa00562Inositol phosphate metabolism1.91E-023P27987, Q13572, Q96PE3ITPKB, ITPK1, INPP4AMore
Apixabanhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Apixabanhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Apixabanhsa00600Sphingolipid metabolism2.44E-022Q9BX95, Q06136SGPP1, FVT1More
Apixabanhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Apixabanhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Apixabanhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Apixabanhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Apixabanhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Apixabanhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Apixabanhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Apixabanhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Apixabanhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Apixabanhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Apixabanhsa03040Spliceosome1.87E-0310Q14562, O60508, P17844, P08579, P51991, P61978, Q15365, Q01130, P11142, O43447DHX8, CDC40, DDX5, SNRPB2, HNRPA3, HNRPK, PCBP1, SFRS2, HSPA8, PPIHMore
Apixabanhsa03050Proteasome4.83E-021P55036PSMD4More
Apixabanhsa03060Protein export3.37E-022P37108, Q15005SRP14, SPCS2More
Apixabanhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Apixabanhsa04020Calcium signaling pathway1.92E-036P27987, Q16566, P30679, O15399, P23634, P49767ITPKB, CAMK4, GNA15, GRIN2D, ATP2B4, VEGFCMore
Apixabanhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Apixabanhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Apixabanhsa04064NF-kappa B signaling pathway7.84E-0415O00463, P14778, P01584, P01375, P19174, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, P19875, Q06643, Q9NQC7TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTB, CYLDMore
Apixabanhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Apixabanhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Apixabanhsa04141Protein processing in endoplasmic reticulum6.04E-038P18848, Q15437, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31ATF4, SEC23B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Apixabanhsa04151PI3K-Akt signaling pathway9.80E-0310O43521, P27348, Q13362, P07900, P22105, P23458, Q99941, P18848, O00141, Q6ZUJ8BCL2L11, YWHAQ, PPP2R5C, HSP90AA1, TNXB, JAK1, CREBL1, ATF4, SGK, PIK3AP1More
Apixabanhsa04211Longevity regulating pathway4.57E-024P51828, Q99941, P18848, Q96RR4ADCY7, CREBL1, ATF4, CAMKK2More
Apixabanhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Apixabanhsa04217Necroptosis3.22E-0411P01568, P23458, Q13489, Q9NQC7, Q13546, P07900, P05141, P01584, Q6FI13, Q9H444, O75351IFNA21, JAK1, BIRC3, CYLD, RIPK1, HSP90AA1, SLC25A5, IL1B, H2AC18; H2AC19, CHMP4B, VPS4BMore
Apixabanhsa04261Adrenergic signaling in cardiomyocytes1.26E-026P67936, P51828, Q99941, P18848, Q13362, P23634TPM4, ADCY7, CREBL1, ATF4, PPP2R5C, ATP2B4More
Apixabanhsa04371Apelin signaling pathway2.95E-024P63218, Q14344, Q13485, Q16566GNG5, GNA13, SMAD4, CAMK4More
Apixabanhsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Apixabanhsa04390Hippo signaling pathway5.79E-034P04628, Q9UJU2, O43623, Q13489WNT1, LEF1, SNAI2, BIRC3More
Apixabanhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Apixabanhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Apixabanhsa04612Antigen processing and presentation4.78E-026P48382, P26715, P26717, Q13241, O43908, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, TNFMore
Apixabanhsa04613Neutrophil extracellular trap formation4.05E-0318O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Apixabanhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Apixabanhsa04621NOD-like receptor signaling pathway1.38E-0313P01584, P07900, P23458, Q9H3M7, Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838IL1B, HSP90AA1, JAK1, TXNIP, ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Apixabanhsa04623Cytosolic DNA-sensing pathway5.29E-032P01568, Q13546IFNA21, RIPK1More
Apixabanhsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Apixabanhsa04640Hematopoietic cell lineage2.62E-0314P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1BMore
Apixabanhsa04650Natural killer cell mediated cytotoxicity2.11E-0513P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Apixabanhsa04657IL-17 signaling pathway1.56E-028O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Apixabanhsa04658Th1 and Th2 cell differentiation2.95E-0514Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Apixabanhsa04659Th17 cell differentiation1.17E-0414Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Apixabanhsa04660T cell receptor signaling pathway1.96E-0414P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Apixabanhsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Apixabanhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Apixabanhsa04724Glutamatergic synapse5.34E-045O15399, P63218, P50151, P15104, Q9NSB8GRIN2D, GNG5, GNG10, GLUL, HOMER2More
Apixabanhsa04725Cholinergic synapse4.10E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Apixabanhsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Apixabanhsa04730Long-term depression2.54E-022Q14344, P07948GNA13, LYNMore
Apixabanhsa04750Inflammatory mediator regulation of TRP channels3.14E-0411P14778, P01584, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Apixabanhsa04911Insulin secretion4.85E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Apixabanhsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Apixabanhsa04915Estrogen signaling pathway1.65E-026Q99941, P18848, P51828, P07900, P11142, Q15788CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, NCOA1More
Apixabanhsa04918Thyroid hormone synthesis2.50E-024P51828, Q99941, P18848, P05543ADCY7, CREBL1, ATF4, SERPINA7More
Apixabanhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Apixabanhsa04925Aldosterone synthesis and secretion2.50E-024Q99941, P18848, P51828, P23634CREBL1, ATF4, ADCY7, ATP2B4More
Apixabanhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Apixabanhsa04927Cortisol synthesis and secretion3.29E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Apixabanhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Apixabanhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Apixabanhsa05033Nicotine addiction2.54E-022P28472, O15399GABRB3, GRIN2DMore
Apixabanhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Apixabanhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Apixabanhsa05132Salmonella infection1.67E-036Q9UJU2, Q13546, Q13489, Q13561, Q13509, P68371LEF1, RIPK1, BIRC3, DCTN2, TUBB3, TUBB2CMore
Apixabanhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Apixabanhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Apixabanhsa05140Leishmaniasis2.29E-029P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4More
Apixabanhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Apixabanhsa05144Malaria2.04E-036P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Apixabanhsa05146Amoebiasis1.54E-0413P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Apixabanhsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Apixabanhsa05163Human cytomegalovirus infection4.52E-027P51828, P23458, P01584, P61073, Q13651, Q99941, P18848ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4More
Apixabanhsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Apixabanhsa05202Transcriptional misregulation in cancer6.59E-0315P17844, P14780, P27930, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522DDX5, MMP9, IL1R2, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Apixabanhsa05203Viral carcinogenesis4.22E-039Q99941, P18848, P23458, P27348, Q7KZF4, Q15283, P61978, P62807, O60814CREBL1, ATF4, JAK1, YWHAQ, SND1, RASA2, HNRPK, HIST1H2BC, H2BC12More
Apixabanhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Apixabanhsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Apixabanhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.58E-0311P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14More
Apixabanhsa05321Inflammatory bowel disease1.21E-027O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Apixabanhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More

Community members of Apixaban (SDC: 5.97)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O15294OGTUDPNoneNNoneacetylglucosamineNoneNonepeptide NNoneacetylglucosaminyltransferase 110 kDa subunitPredicted00.27390.06020.10210.3594
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P22891PROZVitamin KNonedependent protein ZPredicted00.79810.016800.4327
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)