| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Abemaciclib | hsa00030 | Pentose phosphate pathway | 2.25E-03 | 3 | P60891, P51854, P37837 | PRPS1, TKTL1, TALDO1 | More | | | Abemaciclib | hsa00040 | Pentose and glucuronate interconversions | 3.53E-02 | 1 | O60701 | UGDH | More | | | Abemaciclib | hsa00052 | Galactose metabolism | 4.27E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Abemaciclib | hsa00220 | Arginine biosynthesis | 1.48E-03 | 2 | P05089, P49448 | ARG1, GLUD2 | More | | | Abemaciclib | hsa00310 | Lysine degradation | 3.15E-02 | 2 | Q96KQ7, P51648 | EHMT2, ALDH3A2 | More | | | Abemaciclib | hsa00500 | Starch and sucrose metabolism | 1.91E-04 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Abemaciclib | hsa00562 | Inositol phosphate metabolism | 3.69E-02 | 3 | P27987, P19174, P42338 | ITPKB, PLCG1, PIK3CB | More | | | Abemaciclib | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Abemaciclib | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Abemaciclib | hsa00630 | Glyoxylate and dicarboxylate metabolism | 1.13E-02 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Abemaciclib | hsa00670 | One carbon pool by folate | 1.33E-02 | 2 | P04818, Q99707 | TYMS, MTR | More | | | Abemaciclib | hsa00730 | Thiamine metabolism | 1.55E-03 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Abemaciclib | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Abemaciclib | hsa00830 | Retinol metabolism | 3.93E-02 | 3 | P00352, Q9BPW9, O75911 | ALDH1A1, DHRS9, DHRS3 | More | | | Abemaciclib | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Abemaciclib | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Abemaciclib | hsa00983 | Drug metabolism - other enzymes | 3.32E-02 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Abemaciclib | hsa01100 | Metabolic pathways | 4.43E-02 | 23 | Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737 | MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL | More | | | Abemaciclib | hsa01230 | Biosynthesis of amino acids | 3.21E-02 | 4 | P51854, P60891, P05089, P37837 | TKTL1, PRPS1, ARG1, TALDO1 | More | | | Abemaciclib | hsa01240 | Biosynthesis of cofactors | 2.17E-03 | 4 | P13716, P36551, O60701, P14618 | ALAD, CPOX, UGDH, PKM2 | More | | | Abemaciclib | hsa01523 | Antifolate resistance | 1.88E-03 | 4 | P41440, Q92820, P04818, P01375 | SLC19A1, GGH, TYMS, TNF | More | | | Abemaciclib | hsa03013 | RNA transport | 3.89E-03 | 9 | P62826, P38919, Q9UBU9, P37198, P35658, P63279, P68104, P55884, Q14232 | RAN, EIF4A3, NXF1, NUP62, NUP214, UBE2I, EEF1A1, EIF3B, EIF2B1 | More | | | Abemaciclib | hsa03020 | RNA polymerase | 7.98E-06 | 4 | P30876, P24928, P62487, Q9Y535 | POLR2B, POLR2A, POLR2G, POLR3H | More | | | Abemaciclib | hsa03040 | Spliceosome | 2.10E-04 | 10 | O60508, P08579, P26368, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643 | CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1 | More | | | Abemaciclib | hsa03050 | Proteasome | 4.83E-02 | 1 | P55036 | PSMD4 | More | | | Abemaciclib | hsa03060 | Protein export | 4.42E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Abemaciclib | hsa04010 | MAPK signaling pathway | 1.53E-02 | 2 | Q9H2K8, Q12933 | TAOK3, TRAF2 | More | | | Abemaciclib | hsa04012 | ErbB signaling pathway | 1.71E-03 | 5 | P16333, Q13191, P19174, P42338, P01106 | NCK1, CBLB, PLCG1, PIK3CB, MYC | More | | | Abemaciclib | hsa04020 | Calcium signaling pathway | 4.83E-02 | 4 | Q08828, P0DP23, P05141, P51828 | ADCY1, CALM1, SLC25A5, ADCY7 | More | | | Abemaciclib | hsa04022 | cGMP-PKG signaling pathway | 3.26E-04 | 8 | P18848, Q8WYR1, P31751, Q08828, P51828, P05141, P0DP24, P0DP23 | ATF4, PIK3R5, AKT2, ADCY1, ADCY7, SLC25A5, CALM2, CALM1 | More | | | Abemaciclib | hsa04024 | cAMP signaling pathway | 3.94E-02 | 4 | Q08828, P51828, P31751, P0DP23 | ADCY1, ADCY7, AKT2, CALM1 | More | | | Abemaciclib | hsa04060 | Cytokine-cytokine receptor interaction | 2.18E-06 | 17 | P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038 | IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25 | More | | | Abemaciclib | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 1.17E-05 | 9 | Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784 | CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB | More | | | Abemaciclib | hsa04062 | Chemokine signaling pathway | 7.61E-06 | 14 | P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881 | CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK | More | | | Abemaciclib | hsa04064 | NF-kappa B signaling pathway | 4.17E-10 | 18 | O00463, P14778, P01584, P01375, P19174, Q04759, Q13077, Q16548, P07948, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7 | TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, TRAF1, BCL2A1, LYN, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q04759 | PRKCQ | Protein kinase C theta type | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.81 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P06239 | LCK | Tyrosine-protein kinase Lck | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | | P24723 | PRKCH | Protein kinase C eta type | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.705 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | Q04759 | PRKCQ | Protein kinase C theta type | P01375 | TNF | Tumor necrosis factor | -0.725 | | P24723 | PRKCH | Protein kinase C eta type | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.767 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P24723 | PRKCH | Protein kinase C eta type | Q04759 | PRKCQ | Protein kinase C theta type | 0.791 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | | Q04759 | PRKCQ | Protein kinase C theta type | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.76 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P24723 | PRKCH | Protein kinase C eta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.912 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | | Q04759 | PRKCQ | Protein kinase C theta type | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.846 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | | P06239 | LCK | Tyrosine-protein kinase Lck | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.724 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | Q04759 | PRKCQ | Protein kinase C theta type | P09341 | CXCL1 | Growth-regulated alpha protein | -0.885 | | P24723 | PRKCH | Protein kinase C eta type | P09341 | CXCL1 | Growth-regulated alpha protein | -0.707 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | P24723 | PRKCH | Protein kinase C eta type | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.853 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | P24723 | PRKCH | Protein kinase C eta type | Q06643 | LTB | Lymphotoxin-beta | 0.763 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q06643 | LTB | Lymphotoxin-beta | 0.846 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q06643 | LTB | Lymphotoxin-beta | 0.74 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 |
| | Abemaciclib | hsa04070 | Phosphatidylinositol signaling system | 5.86E-04 | 6 | P0DP23, O14986, Q86XP1, Q16760, P48426, Q96DU7 | CALM1, PIP5K1B, DGKH, DGKD, PIP4K2A, ITPKC | More | | | Abemaciclib | hsa04071 | Sphingolipid signaling pathway | 4.14E-03 | 2 | Q12933, Q02156 | TRAF2, PRKCE | More | | | Abemaciclib | hsa04072 | Phospholipase D signaling pathway | 4.96E-04 | 11 | P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760 | AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD | More | | | Abemaciclib | hsa04110 | Cell cycle | 8.83E-05 | 8 | Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106 | ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYC | More | | | Abemaciclib | hsa04114 | Oocyte meiosis | 1.35E-02 | 5 | P0DP23, Q08828, P51828, Q13362, Q14738 | CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5D | More | | | Abemaciclib | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Abemaciclib | hsa04140 | Autophagy - animal | 7.93E-04 | 9 | Q9Y4H2, P42338, P31751, Q7L523, Q9NQL2, O75460, Q04759, Q96GC9, Q8TEV9 | IRS2, PIK3CB, AKT2, RRAGA, RRAGD, ERN1, PRKCQ, TMEM49, SMCR8 | More | | | Abemaciclib | hsa04142 | Lysosome | 1.46E-02 | 7 | P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916 | HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2 | More | | | Abemaciclib | hsa04144 | Endocytosis | 1.13E-03 | 14 | Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3 | CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5 | More | | | Abemaciclib | hsa04151 | PI3K-Akt signaling pathway | 7.39E-03 | 7 | P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8 | RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1 | More | | | Abemaciclib | hsa04210 | Apoptosis | 3.63E-02 | 3 | O75460, O43521, P18848 | ERN1, BCL2L11, ATF4 | More | | | Abemaciclib | hsa04211 | Longevity regulating pathway | 1.88E-02 | 4 | P31751, Q08828, P51828, P18848 | AKT2, ADCY1, ADCY7, ATF4 | More | | | Abemaciclib | hsa04213 | Longevity regulating pathway - multiple species | 1.65E-05 | 8 | P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547 | AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1 | More | | | Abemaciclib | hsa04217 | Necroptosis | 3.89E-04 | 9 | P01375, P48023, Q14765, P15104, P05141, P01584, P0C0S5, Q99878, Q9H444 | TNF, FASLG, STAT4, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CHMP4B | More | | | Abemaciclib | hsa04261 | Adrenergic signaling in cardiomyocytes | 4.98E-04 | 7 | Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23 | ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1 | More | | | Abemaciclib | hsa04270 | Vascular smooth muscle contraction | 6.96E-03 | 6 | P0DP23, Q08828, P51828, P35579, P35749, P35318 | CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | | Abemaciclib | hsa04330 | Notch signaling pathway | 2.77E-02 | 2 | Q92542, P49768 | NCSTN, PSEN1 | More | | | Abemaciclib | hsa04370 | VEGF signaling pathway | 4.05E-02 | 2 | P19174, P42338 | PLCG1, PIK3CB | More | | | Abemaciclib | hsa04371 | Apelin signaling pathway | 3.94E-02 | 4 | P31751, Q08828, P51828, P0DP23 | AKT2, ADCY1, ADCY7, CALM1 | More | | | Abemaciclib | hsa04380 | Osteoclast differentiation | 5.27E-04 | 10 | Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149 | CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2 | More | | | Abemaciclib | hsa04390 | Hippo signaling pathway | 3.73E-02 | 2 | P35240, Q92796 | NF2, DLG3 | More | | | Abemaciclib | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Abemaciclib | hsa04612 | Antigen processing and presentation | 9.71E-05 | 10 | P13765, P01730, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375 | HLA-DOB, CD4, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNF | More | | | Abemaciclib | hsa04613 | Neutrophil extracellular trap formation | 1.73E-02 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Abemaciclib | hsa04620 | Toll-like receptor signaling pathway | 2.54E-03 | 3 | P01584, P31751, Q8NHW4 | IL1B, AKT2, CCL4L2 | More | | | Abemaciclib | hsa04621 | NOD-like receptor signaling pathway | 3.40E-02 | 8 | Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838 | ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4 | More | | | Abemaciclib | hsa04622 | RIG-I-like receptor signaling pathway | 2.47E-02 | 1 | Q12933 | TRAF2 | More | | | Abemaciclib | hsa04623 | Cytosolic DNA-sensing pathway | 1.21E-05 | 3 | P01584, Q9Y535, Q8NHW4 | IL1B, POLR3H, CCL4L2 | More | | | Abemaciclib | hsa04625 | C-type lectin receptor signaling pathway | 1.14E-03 | 8 | Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539 | CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14 | More | | | Abemaciclib | hsa04630 | JAK-STAT signaling pathway | 4.54E-02 | 3 | P31751, P23458, Q13651 | AKT2, JAK1, IL10RA | More | | | Abemaciclib | hsa04640 | Hematopoietic cell lineage | 9.52E-10 | 13 | P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375 | ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06239 | LCK | Tyrosine-protein kinase Lck | P13612 | ITGA4 | Integrin alpha-4 | 0.732 | | P24723 | PRKCH | Protein kinase C eta type | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.705 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.746 | | Q04759 | PRKCQ | Protein kinase C theta type | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.733 | | P06239 | LCK | Tyrosine-protein kinase Lck | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.771 | | P24723 | PRKCH | Protein kinase C eta type | P11215 | ITGAM | Integrin alpha-M | -0.7 | | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | | Q04759 | PRKCQ | Protein kinase C theta type | P25063 | CD24 | Signal transducer CD24 | -0.903 | | P24723 | PRKCH | Protein kinase C eta type | P25063 | CD24 | Signal transducer CD24 | -0.838 | | P06239 | LCK | Tyrosine-protein kinase Lck | P25063 | CD24 | Signal transducer CD24 | -0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25063 | CD24 | Signal transducer CD24 | -0.706 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P25063 | CD24 | Signal transducer CD24 | -0.787 | | Q04759 | PRKCQ | Protein kinase C theta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.713 | | P24723 | PRKCH | Protein kinase C eta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.887 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.855 | | Q04759 | PRKCQ | Protein kinase C theta type | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.756 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q04759 | PRKCQ | Protein kinase C theta type | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.861 | | P24723 | PRKCH | Protein kinase C eta type | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.838 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.744 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P06493 | CDK1 | Cyclin-dependent kinase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.732 | | P06493 | CDK1 | Cyclin-dependent kinase 1 | P06127 | CD5 | T-cell surface glycoprotein CD5 | -0.739 | | P24723 | PRKCH | Protein kinase C eta type | P09564 | CD7 | T-cell antigen CD7 | 0.865 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09564 | CD7 | T-cell antigen CD7 | 0.84 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09564 | CD7 | T-cell antigen CD7 | 0.738 | | P06493 | CDK1 | Cyclin-dependent kinase 1 | P09564 | CD7 | T-cell antigen CD7 | -0.735 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P09564 | CD7 | T-cell antigen CD7 | 0.723 | | Q04759 | PRKCQ | Protein kinase C theta type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.82 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | Q04759 | PRKCQ | Protein kinase C theta type | P01375 | TNF | Tumor necrosis factor | -0.725 |
| | Abemaciclib | hsa04650 | Natural killer cell mediated cytotoxicity | 2.82E-10 | 12 | P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q07444, P26715 | PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P24723 | PRKCH | Protein kinase C eta type | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.767 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q04759 | PRKCQ | Protein kinase C theta type | P01375 | TNF | Tumor necrosis factor | -0.725 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P24723 | PRKCH | Protein kinase C eta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.912 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | Q04759 | PRKCQ | Protein kinase C theta type | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.855 | | P24723 | PRKCH | Protein kinase C eta type | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.835 | | P06239 | LCK | Tyrosine-protein kinase Lck | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.906 | | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P24723 | PRKCH | Protein kinase C eta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.939 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P24723 | PRKCH | Protein kinase C eta type | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | Q04759 | PRKCQ | Protein kinase C theta type | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.849 | | P24723 | PRKCH | Protein kinase C eta type | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.768 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.758 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | | Q04759 | PRKCQ | Protein kinase C theta type | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.918 | | P24723 | PRKCH | Protein kinase C eta type | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.822 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.886 | | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | | P24723 | PRKCH | Protein kinase C eta type | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.828 | | P06239 | LCK | Tyrosine-protein kinase Lck | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | | Q04759 | PRKCQ | Protein kinase C theta type | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.803 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.756 | | P24723 | PRKCH | Protein kinase C eta type | Q07444 | KLRC3 | NKG2-E type II integral membrane protein | 0.723 | | Q04759 | PRKCQ | Protein kinase C theta type | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.803 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.756 |
| | Abemaciclib | hsa04657 | IL-17 signaling pathway | 1.88E-03 | 6 | O00463, Q16539, P49841, P09341, P14780, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF | More | | | Abemaciclib | hsa04658 | Th1 and Th2 cell differentiation | 8.29E-21 | 13 | Q04759, P07766, P20963, P09693, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P24723 | PRKCH | Protein kinase C eta type | Q04759 | PRKCQ | Protein kinase C theta type | 0.791 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q04759 | PRKCQ | Protein kinase C theta type | 0.79 | | Q04759 | PRKCQ | Protein kinase C theta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.713 | | P24723 | PRKCH | Protein kinase C eta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.887 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.824 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.855 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P24723 | PRKCH | Protein kinase C eta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.939 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.895 | | Q04759 | PRKCQ | Protein kinase C theta type | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.756 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P24723 | PRKCH | Protein kinase C eta type | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.767 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P24723 | PRKCH | Protein kinase C eta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.912 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P06239 | LCK | Tyrosine-protein kinase Lck | -0.701 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.867 | | Q04759 | PRKCQ | Protein kinase C theta type | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.746 | | Q04759 | PRKCQ | Protein kinase C theta type | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.867 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | Q04759 | PRKCQ | Protein kinase C theta type | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.843 | | P24723 | PRKCH | Protein kinase C eta type | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.856 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.79 | | P24723 | PRKCH | Protein kinase C eta type | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.876 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.771 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.753 | | Q04759 | PRKCQ | Protein kinase C theta type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.82 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P24723 | PRKCH | Protein kinase C eta type | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.915 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.855 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.82 |
| | Abemaciclib | hsa04659 | Th17 cell differentiation | 2.80E-19 | 15 | Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963 | PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P24723 | PRKCH | Protein kinase C eta type | Q04759 | PRKCQ | Protein kinase C theta type | 0.791 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q04759 | PRKCQ | Protein kinase C theta type | 0.79 | | P24723 | PRKCH | Protein kinase C eta type | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.767 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P24723 | PRKCH | Protein kinase C eta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.912 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P06239 | LCK | Tyrosine-protein kinase Lck | -0.701 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.867 | | P24723 | PRKCH | Protein kinase C eta type | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.876 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.771 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.753 | | Q04759 | PRKCQ | Protein kinase C theta type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.82 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P24723 | PRKCH | Protein kinase C eta type | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.705 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.714 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.746 | | Q04759 | PRKCQ | Protein kinase C theta type | Q9HBE5 | IL21R | Interleukin-21 receptor | 0.8 | | P24723 | PRKCH | Protein kinase C eta type | Q9HBE5 | IL21R | Interleukin-21 receptor | 0.776 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q9HBE5 | IL21R | Interleukin-21 receptor | 0.841 | | Q04759 | PRKCQ | Protein kinase C theta type | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.843 | | P24723 | PRKCH | Protein kinase C eta type | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.856 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.79 | | Q04759 | PRKCQ | Protein kinase C theta type | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.867 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.729 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.782 | | Q04759 | PRKCQ | Protein kinase C theta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.713 | | P24723 | PRKCH | Protein kinase C eta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.887 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.824 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.855 | | Q04759 | PRKCQ | Protein kinase C theta type | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.756 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P24723 | PRKCH | Protein kinase C eta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.939 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.895 |
| | Abemaciclib | hsa04660 | T cell receptor signaling pathway | 7.45E-13 | 13 | P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239 | TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q04759 | PRKCQ | Protein kinase C theta type | P01375 | TNF | Tumor necrosis factor | -0.725 | | Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P24723 | PRKCH | Protein kinase C eta type | Q04759 | PRKCQ | Protein kinase C theta type | 0.791 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q04759 | PRKCQ | Protein kinase C theta type | 0.79 | | P24723 | PRKCH | Protein kinase C eta type | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.791 | | Q04759 | PRKCQ | Protein kinase C theta type | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.733 | | Q04759 | PRKCQ | Protein kinase C theta type | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.803 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | P24723 | PRKCH | Protein kinase C eta type | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.767 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q04759 | PRKCQ | Protein kinase C theta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.713 | | P24723 | PRKCH | Protein kinase C eta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.887 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.855 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P24723 | PRKCH | Protein kinase C eta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.939 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.895 | | Q04759 | PRKCQ | Protein kinase C theta type | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.756 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | Q04759 | PRKCQ | Protein kinase C theta type | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.861 | | P24723 | PRKCH | Protein kinase C eta type | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.838 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.744 | | Q04759 | PRKCQ | Protein kinase C theta type | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.767 | | P24723 | PRKCH | Protein kinase C eta type | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.779 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.714 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.738 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P24723 | PRKCH | Protein kinase C eta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.912 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.867 |
| | Abemaciclib | hsa04662 | B cell receptor signaling pathway | 3.25E-05 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Abemaciclib | hsa04664 | Fc epsilon RI signaling pathway | 3.98E-02 | 3 | P01375, Q16539, Q9UQC2 | TNF, MAPK14, GAB2 | More | | | Abemaciclib | hsa04668 | TNF signaling pathway | 1.56E-03 | 8 | P01375, O00463, Q16539, P18848, P01584, P20749, P14780, P20333 | TNF, TRAF5, MAPK14, ATF4, IL1B, BCL3, MMP9, TNFRSF1B | More | | | Abemaciclib | hsa04713 | Circadian entrainment | 4.54E-02 | 3 | P0DP23, Q08828, P51828 | CALM1, ADCY1, ADCY7 | More | | | Abemaciclib | hsa04720 | Long-term potentiation | 4.54E-02 | 3 | P0DP23, P18848, Q08828 | CALM1, ATF4, ADCY1 | More | | | Abemaciclib | hsa04722 | Neurotrophin signaling pathway | 1.98E-03 | 5 | Q05655, P49841, O43524, P48023, P52566 | PRKCD, GSK3B, FOXO3, FASLG, ARHGDIB | More | | | Abemaciclib | hsa04724 | Glutamatergic synapse | 2.22E-02 | 4 | O15399, P63218, P50151, P15104 | GRIN2D, GNG5, GNG10, GLUL | More | | | Abemaciclib | hsa04725 | Cholinergic synapse | 1.39E-02 | 4 | Q08828, P51828, P18848, P31751 | ADCY1, ADCY7, ATF4, AKT2 | More | | | Abemaciclib | hsa04727 | GABAergic synapse | 4.42E-02 | 3 | P63218, P50151, P15104 | GNG5, GNG10, GLUL | More | | | Abemaciclib | hsa04728 | Dopaminergic synapse | 7.83E-03 | 5 | P31751, P18848, Q13362, Q14738, P0DP23 | AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1 | More | | | Abemaciclib | hsa04740 | Olfactory transduction | 2.52E-02 | 1 | Q9H255 | OR51E2 | More | | | Abemaciclib | hsa04742 | Taste transduction | 1.01E-02 | 1 | P30939 | HTR1F | More | | | Abemaciclib | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.21E-08 | 9 | P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23 | IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1 | More | | | Abemaciclib | hsa04911 | Insulin secretion | 2.40E-02 | 3 | Q08828, P51828, P18848 | ADCY1, ADCY7, ATF4 | More | | | Abemaciclib | hsa04912 | GnRH signaling pathway | 1.39E-02 | 4 | Q08828, P51828, P18848, P0DP23 | ADCY1, ADCY7, ATF4, CALM1 | More | | | Abemaciclib | hsa04915 | Estrogen signaling pathway | 2.01E-03 | 7 | P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788 | ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1 | More | | | Abemaciclib | hsa04916 | Melanogenesis | 2.40E-02 | 3 | P0DP23, Q08828, P51828 | CALM1, ADCY1, ADCY7 | More | | | Abemaciclib | hsa04923 | Regulation of lipolysis in adipocytes | 2.89E-04 | 6 | Q08828, P51828, P07550, P42338, Q9Y4H2, P31751 | ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2 | More | | | Abemaciclib | hsa04925 | Aldosterone synthesis and secretion | 9.86E-03 | 4 | P18848, Q08828, P51828, P0DP23 | ATF4, ADCY1, ADCY7, CALM1 | More | | | Abemaciclib | hsa04926 | Relaxin signaling pathway | 2.46E-02 | 4 | P31751, P18848, Q08828, P51828 | AKT2, ATF4, ADCY1, ADCY7 | More | | | Abemaciclib | hsa04927 | Cortisol synthesis and secretion | 1.59E-02 | 3 | P18848, Q08828, P51828 | ATF4, ADCY1, ADCY7 | More | | | Abemaciclib | hsa04930 | Type II diabetes mellitus | 9.83E-04 | 2 | Q05655, Q02156 | PRKCD, PRKCE | More | | | Abemaciclib | hsa04932 | Non-alcoholic fatty liver disease | 2.50E-07 | 11 | P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O95298 | AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFC2 | More | | | Abemaciclib | hsa04934 | Cushing syndrome | 4.54E-02 | 3 | P18848, Q08828, P51828 | ATF4, ADCY1, ADCY7 | More | | | Abemaciclib | hsa04935 | Growth hormone synthesis, secretion and action | 1.88E-02 | 4 | Q08828, P51828, P18848, P31751 | ADCY1, ADCY7, ATF4, AKT2 | More | | | Abemaciclib | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Abemaciclib | hsa04970 | Salivary secretion | 1.89E-03 | 3 | Q08828, P51828, P0DP23 | ADCY1, ADCY7, CALM1 | More | | | Abemaciclib | hsa04971 | Gastric acid secretion | 2.54E-03 | 4 | Q08828, P51828, P15311, P0DP23 | ADCY1, ADCY7, VIL2, CALM1 | More | | | Abemaciclib | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Abemaciclib | hsa04974 | Protein digestion and absorption | 2.47E-02 | 1 | Q7Z2H8 | SLC36A1 | More | | | Abemaciclib | hsa04976 | Bile secretion | 1.89E-03 | 3 | Q08828, P51828, Q14032 | ADCY1, ADCY7, BAAT | More | | | Abemaciclib | hsa05010 | Alzheimer disease | 4.40E-04 | 11 | O95298, P13073, Q00535, O75460, P0DP24, P0DP23, P01584, P18848, P31751, P05141, P28070 | NDUFC2, COX4I1, CDK5, ERN1, CALM2, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4 | More | | | Abemaciclib | hsa05012 | Parkinson disease | 3.89E-02 | 5 | P13073, P05141, O75460, P18848, P0DP24 | COX4I1, SLC25A5, ERN1, ATF4, CALM2 | More | | | Abemaciclib | hsa05016 | Huntington disease | 2.84E-04 | 10 | O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12 | More | | | Abemaciclib | hsa05017 | Spinocerebellar ataxia | 2.86E-03 | 8 | Q92915, O75460, O15399, P42338, P31751, P28070, P05141, P21796 | FGF14, ERN1, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1 | More | | | Abemaciclib | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.06E-03 | 12 | O95298, P13073, Q8TEV9, O75460, P18848, P05141, P20333, Q00535, P01584, P0DP24, P0DP23, P28070 | NDUFC2, COX4I1, SMCR8, ERN1, ATF4, SLC25A5, TNFRSF1B, CDK5, IL1B, CALM2, CALM1, PSMB4 | More | | | Abemaciclib | hsa05034 | Alcoholism | 2.89E-03 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Abemaciclib | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.84E-05 | 6 | Q16539, P09341, P19875, P19174, P25024, P25025 | MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | | Abemaciclib | hsa05131 | Shigellosis | 8.54E-04 | 4 | Q12933, Q05655, Q02156, P07737 | TRAF2, PRKCD, PRKCE, PFN1 | More | | | Abemaciclib | hsa05132 | Salmonella infection | 4.88E-02 | 2 | P84095, P07737 | RHOG, PFN1 | More | | | Abemaciclib | hsa05134 | Legionellosis | 1.31E-05 | 7 | P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875 | IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2 | More | | | Abemaciclib | hsa05135 | Yersinia infection | 4.39E-02 | 4 | P06239, P19174, P42338, P01732 | LCK, PLCG1, PIK3CB, CD8A | More | | | Abemaciclib | hsa05140 | Leishmaniasis | 2.69E-02 | 5 | O75015, P13765, O60603, P49006, Q16539 | FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14 | More | | | Abemaciclib | hsa05143 | African trypanosomiasis | 2.72E-02 | 2 | P01375, P48023 | TNF, FASLG | More | | | Abemaciclib | hsa05146 | Amoebiasis | 8.23E-14 | 12 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q04759 | PRKCQ | Protein kinase C theta type | P09341 | CXCL1 | Growth-regulated alpha protein | -0.885 | | P24723 | PRKCH | Protein kinase C eta type | P09341 | CXCL1 | Growth-regulated alpha protein | -0.707 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | P24723 | PRKCH | Protein kinase C eta type | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.853 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | P24723 | PRKCH | Protein kinase C eta type | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.705 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.746 | | Q04759 | PRKCQ | Protein kinase C theta type | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.733 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | | P06239 | LCK | Tyrosine-protein kinase Lck | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.771 | | Q04759 | PRKCQ | Protein kinase C theta type | P01375 | TNF | Tumor necrosis factor | -0.725 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | | P24723 | PRKCH | Protein kinase C eta type | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.791 | | P24723 | PRKCH | Protein kinase C eta type | P11215 | ITGAM | Integrin alpha-M | -0.7 | | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | | Q04759 | PRKCQ | Protein kinase C theta type | P05089 | ARG1 | Arginase-1 | -0.899 | | P24723 | PRKCH | Protein kinase C eta type | P05089 | ARG1 | Arginase-1 | -0.749 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | | P06239 | LCK | Tyrosine-protein kinase Lck | P05089 | ARG1 | Arginase-1 | -0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | P05089 | ARG1 | Arginase-1 | -0.769 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P05089 | ARG1 | Arginase-1 | -0.79 | | Q04759 | PRKCQ | Protein kinase C theta type | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | 0.755 | | Q04759 | PRKCQ | Protein kinase C theta type | P12814 | ACTN1 | Alpha-actinin-1 | -0.821 | | P24723 | PRKCH | Protein kinase C eta type | P12814 | ACTN1 | Alpha-actinin-1 | -0.869 | | P06239 | LCK | Tyrosine-protein kinase Lck | P12814 | ACTN1 | Alpha-actinin-1 | -0.867 | | Q13547 | HDAC1 | Histone deacetylase 1 | P12814 | ACTN1 | Alpha-actinin-1 | -0.887 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P12814 | ACTN1 | Alpha-actinin-1 | -0.819 | | Q04759 | PRKCQ | Protein kinase C theta type | P08311 | CTSG | Cathepsin G | -0.913 | | P24723 | PRKCH | Protein kinase C eta type | P08311 | CTSG | Cathepsin G | -0.744 | | P06239 | LCK | Tyrosine-protein kinase Lck | P08311 | CTSG | Cathepsin G | -0.816 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P08311 | CTSG | Cathepsin G | -0.734 |
| | Abemaciclib | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Abemaciclib | hsa05162 | Measles | 3.18E-02 | 4 | P23458, P0DMV8, P01584, Q9NP90 | JAK1, HSPA1A, IL1B, RAB9B | More | | | Abemaciclib | hsa05163 | Human cytomegalovirus infection | 5.04E-07 | 17 | P31751, P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463 | AKT2, TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.786 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.861 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 |
| | Abemaciclib | hsa05164 | Influenza A | 4.49E-02 | 5 | P31751, P01584, P23458, P05141, Q9UBU9 | AKT2, IL1B, JAK1, SLC25A5, NXF1 | More | | | Abemaciclib | hsa05166 | Human T-cell leukemia virus 1 infection | 3.90E-02 | 7 | P23458, P05141, P62826, Q08828, P51828, P18848, P31751 | JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2 | More | | | Abemaciclib | hsa05169 | Epstein-Barr virus infection | 5.59E-04 | 12 | P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P01375, P29728, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, TNF, OAS2, CD3E, CD3G, CD247 | More | | | Abemaciclib | hsa05202 | Transcriptional misregulation in cancer | 3.92E-02 | 10 | P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, Q13547, P24522 | MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, HDAC1, GADD45A | More | | | Abemaciclib | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | | | Abemaciclib | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Abemaciclib | hsa05210 | Colorectal cancer | 3.43E-02 | 2 | Q9UKG1, P37173 | APPL1, TGFBR2 | More | | | Abemaciclib | hsa05212 | Pancreatic cancer | 2.40E-02 | 3 | P31751, Q15311, P23458 | AKT2, RALBP1, JAK1 | More | | | Abemaciclib | hsa05219 | Bladder cancer | 4.07E-02 | 2 | P14780, P04637 | MMP9, TP53 | More | | | Abemaciclib | hsa05221 | Acute myeloid leukemia | 4.95E-02 | 3 | P42338, Q15744, P11215 | PIK3CB, CEBPE, ITGAM | More | | | Abemaciclib | hsa05224 | Breast cancer | 4.75E-02 | 4 | P49841, Q92837, P04637, P24522 | GSK3B, FRAT1, TP53, GADD45A | More | | | Abemaciclib | hsa05231 | Choline metabolism in cancer | 2.02E-03 | 6 | P31751, Q9Y259, P19174, P49619, Q16760, O14986 | AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1B | More | | | Abemaciclib | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1.14E-09 | 11 | P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730 | PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P24723 | PRKCH | Protein kinase C eta type | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.791 | | Q04759 | PRKCQ | Protein kinase C theta type | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.733 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | | P24723 | PRKCH | Protein kinase C eta type | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.767 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | Q04759 | PRKCQ | Protein kinase C theta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.713 | | P24723 | PRKCH | Protein kinase C eta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.887 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.855 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P24723 | PRKCH | Protein kinase C eta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.939 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.895 | | Q04759 | PRKCQ | Protein kinase C theta type | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.756 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.744 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P24723 | PRKCH | Protein kinase C eta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.912 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.867 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | | Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P24723 | PRKCH | Protein kinase C eta type | Q04759 | PRKCQ | Protein kinase C theta type | 0.791 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | Q15131 | CDK10 | Cyclin-dependent kinase 10 | Q04759 | PRKCQ | Protein kinase C theta type | 0.79 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.707 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 |
| | Abemaciclib | hsa05310 | Asthma | 8.13E-03 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Abemaciclib | hsa05321 | Inflammatory bowel disease | 2.80E-04 | 6 | P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | | Abemaciclib | hsa05322 | Systemic lupus erythematosus | 1.31E-04 | 5 | P09871, Q93077, P62807, O60814, P68431 | C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Abemaciclib | hsa05323 | Rheumatoid arthritis | 4.95E-02 | 3 | Q06643, P09341, P19875 | LTB, CXCL1, CXCL2 | More | | | Abemaciclib | hsa05330 | Allograft rejection | 2.72E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Abemaciclib | hsa05332 | Graft-versus-host disease | 7.76E-05 | 5 | P13765, P48023, P01375, P26715, Q13241 | HLA-DOB, FASLG, TNF, KLRC1, KLRD1 | More | | | Abemaciclib | hsa05340 | Primary immunodeficiency | 2.62E-03 | 4 | P01730, P01732, P07766, P06239 | CD4, CD8A, CD3E, LCK | More | | | Abemaciclib | hsa05415 | Diabetic cardiomyopathy | 4.23E-02 | 2 | P30405, P37173 | PPIF, TGFBR2 | More | | | Abemaciclib | hsa05418 | Fluid shear stress and atherosclerosis | 1.26E-04 | 8 | Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930 | MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2 | More | |
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