PharmaCoNets of Zopiclone (SPCN: 3.78 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Eszopiclonehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Eszopiclonehsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Eszopiclonehsa00730Thiamine metabolism1.15E-032Q9Y6K8, P24666AK5, ACP1More
Eszopiclonehsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Eszopiclonehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Eszopiclonehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Eszopiclonehsa03050Proteasome1.40E-021P55036PSMD4More
Eszopiclonehsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Eszopiclonehsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Eszopiclonehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Eszopiclonehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Eszopiclonehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Eszopiclonehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Eszopiclonehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Eszopiclonehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Eszopiclonehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Eszopiclonehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Eszopiclonehsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Eszopiclonehsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Eszopiclonehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Eszopiclonehsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Eszopiclonehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Eszopiclonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Eszopiclonehsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Eszopiclonehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Eszopiclonehsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Eszopiclonehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Eszopiclonehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Eszopiclonehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Eszopiclonehsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Eszopiclonehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Eszopiclonehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Eszopiclonehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Eszopiclonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Eszopiclonehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Eszopiclonehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Eszopiclonehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Zopiclonehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Zopiclonehsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Zopiclonehsa00730Thiamine metabolism1.15E-032Q9Y6K8, P24666AK5, ACP1More
Zopiclonehsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Zopiclonehsa01523Antifolate resistance3.80E-022Q92820, P04818GGH, TYMSMore
Zopiclonehsa03050Proteasome1.40E-021P55036PSMD4More
Zopiclonehsa04110Cell cycle6.80E-036P06493, O75293, P30304, P33981, P42773, P01106CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Zopiclonehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Zopiclonehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Zopiclonehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Zopiclonehsa04640Hematopoietic cell lineage3.69E-024P21926, P07766, P01730, P09564CD9, CD3E, CD4, CD7More
Zopiclonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Zopiclonehsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Zopiclonehsa05032Morphine addiction1.09E-022P78334, P32298GABRE, GRK4More
Zopiclonehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Zopiclonehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Zopiclonehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Zopiclonehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Zopiclonehsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Zopiclonehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Zopiclonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-024P07766, P06239, Q9HC35, P01730CD3E, LCK, EML4, CD4More
Zopiclonehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Zopiclonehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Zopiclonehsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore

Community members of Zopiclone (SDC: 1.37)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonPredicted00.13940.40970.15791.0469
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Predicted00.15590.43870.16951.1248
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)