PharmaCoNets of Zonisamide (SPCN: 20.76 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Zonisamidehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Zonisamidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Zonisamidehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Zonisamidehsa00520Amino sugar and nucleotide sugar metabolism3.76E-021Q13231CHIT1More
Zonisamidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Zonisamidehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Zonisamidehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Zonisamidehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Zonisamidehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Zonisamidehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Zonisamidehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Zonisamidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Zonisamidehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Zonisamidehsa03040Spliceosome6.29E-037Q14562, O43143, O75940, O75494, Q07955, Q13243, O75643DHX8, DHX15, SMNDC1, FUSIP1, SFRS1, SFRS5, ASCC3L1More
Zonisamidehsa04012ErbB signaling pathway3.69E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Zonisamidehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Zonisamidehsa04070Phosphatidylinositol signaling system2.11E-024P19174, P0DP23, P49619, P27987PLCG1, CALM1, DGKG, ITPKBMore
Zonisamidehsa04071Sphingolipid signaling pathway1.53E-037Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Zonisamidehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Zonisamidehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Zonisamidehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Zonisamidehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Zonisamidehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Zonisamidehsa04360Axon guidance4.39E-024P16333, P20827, O95631, P19174NCK1, EFNA1, NTN1, PLCG1More
Zonisamidehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Zonisamidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Zonisamidehsa04613Neutrophil extracellular trap formation1.07E-0420P19174, P11215, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PLCG1, ITGAM, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Zonisamidehsa04614Renin-angiotensin system2.52E-021P50052AGTR2More
Zonisamidehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Zonisamidehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Zonisamidehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Zonisamidehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Zonisamidehsa04657IL-17 signaling pathway6.64E-037O00463, Q16539, P49841, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, MMP9, ANAPC5, LCN2, TNFMore
Zonisamidehsa04744Phototransduction7.59E-032P62873, P0DP23GNB1, CALM1More
Zonisamidehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Zonisamidehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Zonisamidehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Zonisamidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Zonisamidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Zonisamidehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Zonisamidehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Zonisamidehsa05034Alcoholism2.90E-046P0DP23, P62873, Q93077, P62807, O60814, P68431CALM1, GNB1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Zonisamidehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Zonisamidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Zonisamidehsa05140Leishmaniasis3.52E-024P14598, P11215, P42224, P29350NCF1, ITGAM, STAT1, PTPN6More
Zonisamidehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Zonisamidehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Zonisamidehsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Zonisamidehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Zonisamidehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Zonisamidehsa05214Glioma3.69E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Zonisamidehsa05231Choline metabolism in cancer4.95E-023Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Zonisamidehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Zonisamidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Zonisamide (SDC: 3.81)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O60939SCN2BSodium channel subunit betaNone2Reported00.22050.046700.2036
P00918CA2Carbonic anhydrase 2Reported10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Reported00.00560.82670.16091.8171
O75493CA11Carbonic anhydraseNonerelated protein 11Reported00.07450.061200.1597
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CA2P00918Ki10.3
CA2P00918Ki35
CA2P00918Ki35.2
CA2P00918Kd47.6
CA4P22748Ki8590
CA4P22748Ki38400
CA4P22748Ki38450