PharmaCoNets

PharmaCoNets of Ziprasidone (S_PCN: 191.78 )

Ziprasidone regulated-network (S_DN: 24.52)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Ziprasidone

hsa00020

Citrate cycle (TCA cycle)

3.41E-02

P50213, O14521

IDH3A, SDHD

Ziprasidone

hsa00030

Pentose phosphate pathway

1.08E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Ziprasidone

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Ziprasidone

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Ziprasidone

hsa00130

Ubiquinone and other terpenoid-quinone biosynthesis

1.66E-02

Q9BQB6

VKORC1

Ziprasidone

hsa00190

Oxidative phosphorylation

2.53E-05

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Ziprasidone

hsa00310

Lysine degradation

4.57E-02

Q96KQ7, Q02809

EHMT2, PLOD1

Ziprasidone

hsa00500

Starch and sucrose metabolism

1.91E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Ziprasidone

hsa00513

Various types of N-glycan biosynthesis

4.83E-02

Q9NR34

MAN1C1

Ziprasidone

hsa00562

Inositol phosphate metabolism

2.00E-02

P27987, P19174, P42338, Q02252

ITPKB, PLCG1, PIK3CB, ALDH6A1

Ziprasidone

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Ziprasidone

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Ziprasidone

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Ziprasidone

hsa00600

Sphingolipid metabolism

4.77E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Ziprasidone

hsa00630

Glyoxylate and dicarboxylate metabolism

1.03E-04

P40925, P15104

MDH1, GLUL

Ziprasidone

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Ziprasidone

hsa00730

Thiamine metabolism

1.55E-03

P05186, P24666

ALPL, ACP1

Ziprasidone

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Ziprasidone

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Ziprasidone

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Ziprasidone

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Ziprasidone

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Ziprasidone

hsa00983

Drug metabolism - other enzymes

4.77E-02

P04183, P32320, P05164

TK1, CDA, MPO

Ziprasidone

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Ziprasidone

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Ziprasidone

hsa01230

Biosynthesis of amino acids

2.30E-04

P51854, P60891, Q99707, P50213, P37837

TKTL1, PRPS1, MTR, IDH3A, TALDO1

Ziprasidone

hsa01522

Endocrine resistance

1.69E-02

Q9UM47, P10415, Q13323

NOTCH3, BCL2, BIK

Ziprasidone

hsa01524

Platinum drug resistance

4.78E-02

P31751

AKT2

Ziprasidone

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Ziprasidone

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Ziprasidone

hsa03013

RNA transport

3.73E-08

O14980, P52298, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, EIF4B, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.956
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O14893	GEMIN2	Gem-associated protein 2	0.925
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P61326	MAGOH	Protein mago nashi homolog	0.761
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q7Z3B4	NUP54	Nucleoporin p54	0.854
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.79
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.715
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.793
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P78345	RPP38	Ribonuclease P protein subunit p38	0.819
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.891
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758

Ziprasidone

hsa03020

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Ziprasidone

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Ziprasidone

hsa03040

Spliceosome

1.59E-06

Q14562, O43143, O60508, O14776, P08579, Q15427, O75940, P52298, P38159, P09651, P61978, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, P61326

DHX8, DHX15, CDC40, TCERG1, SNRPB2, SF3B4, SMNDC1, NCBP2, RBMX, HNRNPA1, HNRPK, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, MAGOH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.888
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
P27707	DCK	Deoxycytidine kinase	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.726
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.953
P27707	DCK	Deoxycytidine kinase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.816
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.838
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P27707	DCK	Deoxycytidine kinase	O14776	TCERG1	Transcription elongation regulator 1	0.757
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.788
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P27707	DCK	Deoxycytidine kinase	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.84
P27707	DCK	Deoxycytidine kinase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P27707	DCK	Deoxycytidine kinase	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P27707	DCK	Deoxycytidine kinase	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.824
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
P27707	DCK	Deoxycytidine kinase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.804
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
P27707	DCK	Deoxycytidine kinase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.757
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.746
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P27707	DCK	Deoxycytidine kinase	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	0.797
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761
P27707	DCK	Deoxycytidine kinase	P61326	MAGOH	Protein mago nashi homolog	0.732

Ziprasidone

hsa03060

Protein export

1.20E-03

P37108, Q15005

SRP14, SPCS2

Ziprasidone

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Ziprasidone

hsa03450

Non-homologous end-joining

1.02E-03

P78527, P13010

PRKDC, XRCC5

Ziprasidone

hsa04012

ErbB signaling pathway

1.33E-04

P21860, P16333, P17252, Q13557, P19174, O14944, P42338, P01106

ERBB3, NCK1, PRKCA, CAMK2D, PLCG1, EREG, PIK3CB, MYC

Ziprasidone

hsa04014

Ras signaling pathway

1.48E-04

P31751, P42338, P20827, P49767, Q13009, P17252, P14921, P0DP23, P62873, P50151, P19174

AKT2, PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, ETS1, CALM1, GNB1, GNG10, PLCG1

Ziprasidone

hsa04015

Rap1 signaling pathway

1.52E-03

P20827, P49767, P11215, Q13009, P42338, P31751, P0DP23, P17252, P19174

EFNA1, VEGFC, ITGAM, TIAM1, PIK3CB, AKT2, CALM1, PRKCA, PLCG1

Ziprasidone

hsa04020

Calcium signaling pathway

2.34E-04

P27987, Q96DU7, P45880, Q13557, P17252, P21860, O15399, P19174, P0DP23, P51828, P23634, P49767

ITPKB, ITPKC, VDAC2, CAMK2D, PRKCA, ERBB3, GRIN2D, PLCG1, CALM1, ADCY7, ATP2B4, VEGFC

Ziprasidone

hsa04022

cGMP-PKG signaling pathway

3.48E-03

Q99941, P23634, P31751, P51828, P45880, P0DP23

CREBL1, ATP2B4, AKT2, ADCY7, VDAC2, CALM1

Ziprasidone

hsa04024

cAMP signaling pathway

4.12E-03

P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009

PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1

Ziprasidone

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.31E-03

P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, P14784

CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL2RB

Ziprasidone

hsa04062

Chemokine signaling pathway

7.18E-04

P25024, P25025, P09341, P19875, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963

CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIA

Ziprasidone

hsa04064

NF-kappa B signaling pathway

2.77E-05

P10415, P51617, O00463, P14778, P01584, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, IRAK1, TRAF5, IL1R1, IL1B, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.741
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.801
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Ziprasidone

hsa04070

Phosphatidylinositol signaling system

2.95E-04

P19174, P0DP23, P42338, P23743, Q86XP1, P27987, Q96DU7, P17252

PLCG1, CALM1, PIK3CB, DGKA, DGKH, ITPKB, ITPKC, PRKCA

Ziprasidone

hsa04071

Sphingolipid signaling pathway

2.06E-03

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Ziprasidone

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Ziprasidone

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Ziprasidone

hsa04110

Cell cycle

1.21E-03

Q9UBD5, P06493, P78527, Q14683, P30304, P33981, P01106

ORC3, CDK1, PRKDC, SMC1A, CDC25A, TTK, MYC

Ziprasidone

hsa04114

Oocyte meiosis

6.23E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Ziprasidone

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Ziprasidone

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Ziprasidone

hsa04141

Protein processing in endoplasmic reticulum

3.64E-02

Q99941, O75460, P11142, Q9H3Z4, P07900

CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1

Ziprasidone

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Ziprasidone

hsa04144

Endocytosis

2.99E-04

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, P01889, P10321, P49418, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, HLA-B, HLA-C, AMPH, SNX12

Ziprasidone

hsa04145

Phagosome

1.11E-04

Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765, P01889, P10321

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB, HLA-B, HLA-C

Ziprasidone

hsa04151

PI3K-Akt signaling pathway

1.43E-02

P42338, P20827, P49767, P08238, P62873, P50151, P16144, O15335, Q13751, P14784, P01568, P17252

PIK3CB, EFNA1, VEGFC, HSP90AB1, GNB1, GNG10, ITGB4, CHAD, LAMB3, IL2RB, IFNA21, PRKCA

Ziprasidone

hsa04213

Longevity regulating pathway - multiple species

2.70E-03

P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Ziprasidone

hsa04217

Necroptosis

2.97E-03

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, Q6FI13, Q99878, O43633

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, H2AC18; H2AC19, H2AC14, CHMP2A

Ziprasidone

hsa04218

Cellular senescence

2.86E-04

P31751, P0DP23, P01889, P10321

AKT2, CALM1, HLA-B, HLA-C

Ziprasidone

hsa04261

Adrenergic signaling in cardiomyocytes

3.21E-04

P07550, P51828, P22694, P31751, Q99941, P18848, Q13362, P0DP23, Q13557, P23634

ADRB2, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, ATP2B4

Ziprasidone

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Ziprasidone

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Ziprasidone

hsa04360

Axon guidance

2.13E-03

P16333, P20827, O95631, P17252, P42338, P23528, P19174

NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, PLCG1

Ziprasidone

hsa04370

VEGF signaling pathway

3.67E-05

P19174, P16298, P31751, P42338, P17252, Q05397, Q02750

PLCG1, PPP3CB, AKT2, PIK3CB, PRKCA, PTK2, MAP2K1

Ziprasidone

hsa04371

Apelin signaling pathway

3.23E-03

P31751, P0DP23

AKT2, CALM1

Ziprasidone

hsa04380

Osteoclast differentiation

2.72E-04

Q9NQC7, Q9UQC2, Q16539, P31751, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, AKT2, IL1R1, FCGR3B, TNF, LILRA2

Ziprasidone

hsa04510

Focal adhesion

7.77E-03

P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P49767

ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, VEGFC

Ziprasidone

hsa04514

Cell adhesion molecules

3.29E-02

P01889, P10321

HLA-B, HLA-C

Ziprasidone

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Ziprasidone

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Ziprasidone

hsa04612

Antigen processing and presentation

9.12E-05

Q14953, P26715, P26717, Q13241, P01732, P01889, P10321, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, HLA-B, HLA-C, TNF

Ziprasidone

hsa04613

Neutrophil extracellular trap formation

2.18E-03

P04908, Q93077, P62807, O60814, P68431, O43315, Q16539

H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Ziprasidone

hsa04620

Toll-like receptor signaling pathway

4.78E-02

P31751

AKT2

Ziprasidone

hsa04622

RIG-I-like receptor signaling pathway

1.81E-02

Q9NQC7

CYLD

Ziprasidone

hsa04623

Cytosolic DNA-sensing pathway

1.35E-03

P01584, P01568, P25963, Q8NHW4

IL1B, IFNA21, NFKBIA, CCL4L2

Ziprasidone

hsa04625

C-type lectin receptor signaling pathway

2.27E-04

Q9ULY5, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Ziprasidone

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Ziprasidone

hsa04650

Natural killer cell mediated cytotoxicity

2.49E-09

P16298, P50591, P19174, P01375, P06239, O60880, P20963, Q29983, P10321, P01889, P42338, Q02750, Q13241, P26718, O14931, P26717, Q14953, P26715

PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.774
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.9
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	Q29983	MICA	MHC class I polypeptide-related sequence A	0.774
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.774
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.774
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.799
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Ziprasidone

hsa04657

IL-17 signaling pathway

1.46E-04

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF

Ziprasidone

hsa04658

Th1 and Th2 cell differentiation

1.65E-05

Q04759, P07766, P20963, P19174, P06239, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, PLCG1, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Ziprasidone

hsa04659

Th17 cell differentiation

3.30E-05

P25963, Q04759, P19174, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P08238, P07766, P20963

NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, HSP90AB1, CD3E, CD247

Ziprasidone

hsa04660

T cell receptor signaling pathway

3.37E-03

Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239

PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCK

Ziprasidone

hsa04662

B cell receptor signaling pathway

1.60E-04

P31751, P42338, P60033, P07948, P21854, Q8N149

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2

Ziprasidone

hsa04664

Fc epsilon RI signaling pathway

3.91E-05

P01375, P31751, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P09917

TNF, AKT2, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, ALOX5

Ziprasidone

hsa04666

Fc gamma R-mediated phagocytosis

2.60E-03

P42338, P19174, P23528, P06396, P14598, P49418, P17252

PIK3CB, PLCG1, CFL1, GSN, NCF1, AMPH, PRKCA

Ziprasidone

hsa04668

TNF signaling pathway

2.70E-04

P01375, O00463, Q16539, Q99941, P18848, P19875, P01584, P20749, P14780, O95429

TNF, TRAF5, MAPK14, CREBL1, ATF4, CXCL2, IL1B, BCL3, MMP9, BAG4

Ziprasidone

hsa04713

Circadian entrainment

1.24E-02

O15399, P0DP23, P17252, P62873, P50151

GRIN2D, CALM1, PRKCA, GNB1, GNG10

Ziprasidone

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Ziprasidone

hsa04720

Long-term potentiation

2.85E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Ziprasidone

hsa04721

Synaptic vesicle cycle

1.80E-02

Q13488, P31645

TCIRG1, SLC6A4

Ziprasidone

hsa04722

Neurotrophin signaling pathway

1.61E-04

P31751, P49841, O43524, P48023, P51617, P10415, P0DP23

AKT2, GSK3B, FOXO3, FASLG, IRAK1, BCL2, CALM1

Ziprasidone

hsa04724

Glutamatergic synapse

1.44E-04

O15399, P17252, P62873, P63218, P50151, P15104

GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLUL

Ziprasidone

hsa04725

Cholinergic synapse

4.49E-03

P17252, P62873, P63218, P50151, P42338

PRKCA, GNB1, GNG5, GNG10, PIK3CB

Ziprasidone

hsa04726

Serotonergic synapse

2.54E-02

P17252, P62873, P50151, P33260, P09917

PRKCA, GNB1, GNG10, CYP2C18, ALOX5

Ziprasidone

hsa04727

GABAergic synapse

5.11E-04

P62873, P63218, P50151, P15104, P17252

GNB1, GNG5, GNG10, GLUL, PRKCA

Ziprasidone

hsa04728

Dopaminergic synapse

3.23E-03

P31751, P0DP23

AKT2, CALM1

Ziprasidone

hsa04740

Olfactory transduction

1.36E-04

P62873, Q9H255, P0DP23

GNB1, OR51E2, CALM1

Ziprasidone

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Ziprasidone

hsa04744

Phototransduction

1.34E-06

P62873, P0DP23

GNB1, CALM1

Ziprasidone

hsa04750

Inflammatory mediator regulation of TRP channels

8.97E-05

P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Ziprasidone

hsa04910

Insulin signaling pathway

9.82E-04

P0DP23, P31751

CALM1, AKT2

Ziprasidone

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Ziprasidone

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Ziprasidone

hsa04914

Progesterone-mediated oocyte maturation

5.42E-04

Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1

Ziprasidone

hsa04915

Estrogen signaling pathway

5.15E-04

Q99941, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788

CREBL1, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1

Ziprasidone

hsa04916

Melanogenesis

4.78E-02

P0DP23

CALM1

Ziprasidone

hsa04917

Prolactin signaling pathway

2.41E-02

P31751

AKT2

Ziprasidone

hsa04920

Adipocytokine signaling pathway

4.19E-02

P31751

AKT2

Ziprasidone

hsa04922

Glucagon signaling pathway

1.79E-03

P31751, P0DP23

AKT2, CALM1

Ziprasidone

hsa04923

Regulation of lipolysis in adipocytes

3.88E-03

P07550, P42338, Q9Y4H2, P31751

ADRB2, PIK3CB, IRS2, AKT2

Ziprasidone

hsa04924

Renin secretion

6.02E-03

P22694, P07550, P0DP23

PRKACB, ADRB2, CALM1

Ziprasidone

hsa04925

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Ziprasidone

hsa04926

Relaxin signaling pathway

2.34E-05

P25963, P42338, P62873, P63218, P50151, P18848, P22694, P49767, P14780, P17252, P30679, P49407

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, PRKCA, GNA15, ARRB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.752
P07550	ADRB2	Beta-2 adrenergic receptor	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	-0.704
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P49767	VEGFC	Vascular endothelial growth factor C	0.73
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.8
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P49407	ARRB1	Beta-arrestin-1	-0.709

Ziprasidone

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Ziprasidone

hsa04929

GnRH secretion

3.61E-03

P42338, P31751, P49407

PIK3CB, AKT2, ARRB1

Ziprasidone

hsa04932

Non-alcoholic fatty liver disease

7.01E-05

P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD

Ziprasidone

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.43E-02

P42224, P42338, P49767, P17252, P19174

STAT1, PIK3CB, VEGFC, PRKCA, PLCG1

Ziprasidone

hsa04934

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Ziprasidone

hsa04940

Type I diabetes mellitus

4.29E-04

P48023, P01889, P10321, P01375

FASLG, HLA-B, HLA-C, TNF

Ziprasidone

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.68E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Ziprasidone

hsa04962

Vasopressin-regulated water reabsorption

1.80E-02

P62491, P46459

RAB11A, NSF

Ziprasidone

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Ziprasidone

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Ziprasidone

hsa04970

Salivary secretion

5.38E-04

P07550, Q08828, P51828, P22694, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMP

Ziprasidone

hsa04971

Gastric acid secretion

2.57E-03

P51828, P15311, P0DP23, Q13557

ADCY7, VIL2, CALM1, CAMK2D

Ziprasidone

hsa04972

Pancreatic secretion

2.68E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Ziprasidone

hsa04973

Carbohydrate digestion and absorption

4.61E-03

O43451, P42338, P31751

MGAM, PIK3CB, AKT2

Ziprasidone

hsa04975

Fat digestion and absorption

4.83E-02

O14494

PLPP1

Ziprasidone

hsa04976

Bile secretion

3.14E-03

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Ziprasidone

hsa05010

Alzheimer disease

7.84E-04

Q92542, P05496, P12074, Q00535, O75460, P0DP23, P01584, O15169, P31751, P45880

NCSTN, ATP5G1, COX6A1, CDK5, ERN1, CALM1, IL1B, AXIN1, AKT2, VDAC2

Ziprasidone

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Ziprasidone

hsa05020

Prion disease

1.37E-03

P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539

IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14

Ziprasidone

hsa05022

Pathways of neurodegeneration - multiple diseases

4.25E-03

P49841, Q16718, O14521, Q13561, Q16539, Q00535, Q08752, P0DP23

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, CDK5, PPID, CALM1

Ziprasidone

hsa05030

Cocaine addiction

4.19E-02

Q00535

CDK5

Ziprasidone

hsa05031

Amphetamine addiction

6.98E-03

P0DP23, P22694, P18848, Q13547

CALM1, PRKACB, ATF4, HDAC1

Ziprasidone

hsa05032

Morphine addiction

1.24E-02

P62873, P50151, Q13370, P17252, P43250

GNB1, GNG10, PDE3B, PRKCA, GRK6

Ziprasidone

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Ziprasidone

hsa05110

Vibrio cholerae infection

3.15E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Ziprasidone

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.96E-04

Q16539, P09341, P19875, P19174, P25024, P25025

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Ziprasidone

hsa05132

Salmonella infection

9.26E-07

P51617, P25963, P08238, Q9UJU2, Q13546, Q13489, P10415, P04406, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754

IRAK1, NFKBIA, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	1
P27707	DCK	Deoxycytidine kinase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.89
P27707	DCK	Deoxycytidine kinase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.752
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.825
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.768
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
P27707	DCK	Deoxycytidine kinase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.731
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
P27707	DCK	Deoxycytidine kinase	P10415	BCL2	Apoptosis regulator Bcl-2	0.781
P27707	DCK	Deoxycytidine kinase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.799
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75369	FLNB	Filamin-B	-0.746
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	O75369	FLNB	Filamin-B	-0.713
P27707	DCK	Deoxycytidine kinase	O75369	FLNB	Filamin-B	-0.902
P27707	DCK	Deoxycytidine kinase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	-0.724
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P27707	DCK	Deoxycytidine kinase	O60603	TLR2	Toll-like receptor 2	-0.781
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.924
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.812
P27707	DCK	Deoxycytidine kinase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.713
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13561	DCTN2	Dynactin subunit 2	-0.809
P27707	DCK	Deoxycytidine kinase	Q13561	DCTN2	Dynactin subunit 2	-0.788
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.757
P27707	DCK	Deoxycytidine kinase	Q13509	TUBB3	Tubulin beta-3 chain	-0.851
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783
P27707	DCK	Deoxycytidine kinase	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	-0.813

Ziprasidone

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Ziprasidone

hsa05134

Legionellosis

8.80E-04

P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Ziprasidone

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Ziprasidone

hsa05140

Leishmaniasis

3.44E-05

O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4

Ziprasidone

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Ziprasidone

hsa05144

Malaria

1.44E-03

P69905, P68871, P01375, P35443, P26718

HBA2, HBB, TNF, THBS4, KLRK1

Ziprasidone

hsa05145

Toxoplasmosis

3.45E-02

P25963, Q13489, P42224, P09917, Q13751, P11142

NFKBIA, BIRC3, STAT1, ALOX5, LAMB3, HSPA8

Ziprasidone

hsa05146

Amoebiasis

4.70E-06

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1

Ziprasidone

hsa05152

Tuberculosis

3.82E-06

Q13488, Q15075, P0DP23, P42224, P48382, P25208, O60603, P31751, P10415, P01568, Q9UDY8, P51617

TCIRG1, EEA1, CALM1, STAT1, RFX5, NFYB, TLR2, AKT2, BCL2, IFNA21, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.716
P27707	DCK	Deoxycytidine kinase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.828
P27707	DCK	Deoxycytidine kinase	Q15075	EEA1	Early endosome antigen 1	0.719
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P0DP23	CALM1	Calmodulin-1	-0.703
P27707	DCK	Deoxycytidine kinase	P0DP23	CALM1	Calmodulin-1	-0.759
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P27707	DCK	Deoxycytidine kinase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.7
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P48382	RFX5	DNA-binding protein RFX5	0.797
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P48382	RFX5	DNA-binding protein RFX5	0.727
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P25208	NFYB	Nuclear transcription factor Y subunit beta	0.742
P27707	DCK	Deoxycytidine kinase	P25208	NFYB	Nuclear transcription factor Y subunit beta	0.767
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P27707	DCK	Deoxycytidine kinase	O60603	TLR2	Toll-like receptor 2	-0.781
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
P27707	DCK	Deoxycytidine kinase	P10415	BCL2	Apoptosis regulator Bcl-2	0.781
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
P27707	DCK	Deoxycytidine kinase	P01568	IFNA21	Interferon alpha-21	0.798
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	1
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.741
P27707	DCK	Deoxycytidine kinase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.828
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	1

Ziprasidone

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Ziprasidone

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Ziprasidone

hsa05163

Human cytomegalovirus infection

1.00E-05

P31751, P42338, P01375, P25963, P62873, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, P04637, O00463, P30101, P01568

AKT2, PIK3CB, TNF, NFKBIA, GNB1, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868

Ziprasidone

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.41E-06

P01568, P31751, P42224, P25963, P42338, P40189, P01889, P10321, P62873, P62879, P50151, P19174, P16298, Q02750, Q29983, P0DP23, P0CG47

IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, IL6ST, HLA-B, HLA-C, GNB1, GNB2, GNG10, PLCG1, PPP3CB, MAP2K1, MICA, CALM1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.774
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.774
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.872
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.774
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.799
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	Q29983	MICA	MHC class I polypeptide-related sequence A	0.774
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P0CG47	UBB	Polyubiquitin-B	-0.731

Ziprasidone

hsa05168

Herpes simplex virus 1 infection

2.01E-05

O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, P52738, O75820, Q9UDV6, P10415

TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF140, ZNF189, ZNF212, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P27707	DCK	Deoxycytidine kinase	O60603	TLR2	Toll-like receptor 2	-0.781
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P27707	DCK	Deoxycytidine kinase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.89
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P27707	DCK	Deoxycytidine kinase	P01568	IFNA21	Interferon alpha-21	0.798
P27707	DCK	Deoxycytidine kinase	Q05823	RNASEL	2-5A-dependent ribonuclease	-0.752
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P27707	DCK	Deoxycytidine kinase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.7
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
P27707	DCK	Deoxycytidine kinase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.804
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
P27707	DCK	Deoxycytidine kinase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.757
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
P27707	DCK	Deoxycytidine kinase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.731
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13398	ZNF211	Zinc finger protein 211	0.956
P27707	DCK	Deoxycytidine kinase	Q13398	ZNF211	Zinc finger protein 211	-0.719
P27707	DCK	Deoxycytidine kinase	P51522	ZNF83	Zinc finger protein 83	0.811
P27707	DCK	Deoxycytidine kinase	Q9NR11	ZNF302	Zinc finger protein 302	0.759
P27707	DCK	Deoxycytidine kinase	Q9HCX3	ZNF304	Zinc finger protein 304	0.737
P27707	DCK	Deoxycytidine kinase	P17097	ZNF7	Zinc finger protein 7	0.8
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q03923	ZNF85	Zinc finger protein 85	-0.731
P27707	DCK	Deoxycytidine kinase	Q03923	ZNF85	Zinc finger protein 85	0.731
P27707	DCK	Deoxycytidine kinase	P52738	ZNF140	Zinc finger protein 140	0.789
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75820	ZNF189	Zinc finger protein 189	-0.756
P27707	DCK	Deoxycytidine kinase	O75820	ZNF189	Zinc finger protein 189	0.801
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q9UDV6	ZNF212	Zinc finger protein 212	0.798
P27707	DCK	Deoxycytidine kinase	P10415	BCL2	Apoptosis regulator Bcl-2	0.781

Ziprasidone

hsa05169

Epstein-Barr virus infection

4.67E-03

Q13547, P42338, P07948, P01889, P10321, Q13761, O75293, P07766

HDAC1, PIK3CB, LYN, HLA-B, HLA-C, RUNX3, GADD45B, CD3E

Ziprasidone

hsa05170

Human immunodeficiency virus 1 infection

2.07E-07

P31751, P42338, P01889, P10321, P62873, P50151, P0DP23, P17252, Q13546, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, P19174, P23528, Q9NQU5, P10415, Q9Y6Q5

AKT2, PIK3CB, HLA-B, HLA-C, GNB1, GNG10, CALM1, PRKCA, RIPK1, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, PLCG1, CFL1, PAK6, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.774
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.774
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.701
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.759
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P0DP23	CALM1	Calmodulin-1	-0.703
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P23528	CFL1	Cofilin-1	-0.853
Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	Q9NQU5	PAK6	Serine/threonine-protein kinase PAK 6	0.75
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.946
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.814

Ziprasidone

hsa05171

Coronavirus disease - COVID-19

3.30E-02

P25963, P42224, P01568, P40189, P42338, P19174, P17252

NFKBIA, STAT1, IFNA21, IL6ST, PIK3CB, PLCG1, PRKCA

Ziprasidone

hsa05200

Pathways in cancer

2.31E-06

Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P10826, P14923, P10415, Q13489, Q13077, P49767, P14921, P31751, P62873, P50151, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, RARB, JUP, BCL2, BIRC3, TRAF1, VEGFC, ETS1, AKT2, GNB1, GNG10, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.768
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.925
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P10826	RARB	Retinoic acid receptor beta	0.779
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14923	JUP	Junction plakoglobin	-0.716
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P14923	JUP	Junction plakoglobin	0.766
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.807
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.801
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.759
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	-0.71
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.919
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	P0DP23	CALM1	Calmodulin-1	-0.703
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748

Ziprasidone

hsa05202

Transcriptional misregulation in cancer

1.61E-02

Q12778, Q15532, Q13315, P14780, P14923, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0

FOXO1, SS18, ATM, MMP9, JUP, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B

Ziprasidone

hsa05203

Viral carcinogenesis

8.46E-04

Q15283, P06396, P01889, P10321, P62807, O60814

RASA2, GSN, HLA-B, HLA-C, HIST1H2BC, H2BC12

Ziprasidone

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Ziprasidone

hsa05205

Proteoglycans in cancer

2.92E-04

Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962

TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63

Ziprasidone

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Ziprasidone

hsa05211

Renal cell carcinoma

4.78E-02

P31751

AKT2

Ziprasidone

hsa05212

Pancreatic cancer

4.78E-02

P31751

AKT2

Ziprasidone

hsa05213

Endometrial cancer

3.60E-02

P31751

AKT2

Ziprasidone

hsa05214

Glioma

6.17E-05

P0DP23, P17252, P42338, P31751, P19174, O75293

CALM1, PRKCA, PIK3CB, AKT2, PLCG1, GADD45B

Ziprasidone

hsa05218

Melanoma

3.01E-02

P31751

AKT2

Ziprasidone

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Ziprasidone

hsa05220

Chronic myeloid leukemia

4.19E-02

P31751

AKT2

Ziprasidone

hsa05221

Acute myeloid leukemia

4.19E-02

P31751

AKT2

Ziprasidone

hsa05222

Small cell lung cancer

1.14E-03

P10826, P31751, P42338, Q13751, Q13489, P25963, O75293

RARB, AKT2, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45B

Ziprasidone

hsa05223

Non-small cell lung cancer

2.50E-04

P17252, P31751, P42338, P19174, P10826, O75293

PRKCA, AKT2, PIK3CB, PLCG1, RARB, GADD45B

Ziprasidone

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Ziprasidone

hsa05226

Gastric cancer

3.60E-02

P31751

AKT2

Ziprasidone

hsa05230

Central carbon metabolism in cancer

4.78E-02

P31751

AKT2

Ziprasidone

hsa05231

Choline metabolism in cancer

3.48E-04

P42338, Q9Y259, P19174, P23743, P49619, P17252

PIK3CB, CHKB, PLCG1, DGKA, DGKG, PRKCA

Ziprasidone

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.15E-03

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Ziprasidone

hsa05310

Asthma

2.27E-02

P13765, P12724

HLA-DOB, RNASE3

Ziprasidone

hsa05320

Autoimmune thyroid disease

3.59E-03

P01889, P10321

HLA-B, HLA-C

Ziprasidone

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Ziprasidone

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Ziprasidone

hsa05330

Allograft rejection

4.29E-04

P01889, P10321, P48023, P01375

HLA-B, HLA-C, FASLG, TNF

Ziprasidone

hsa05332

Graft-versus-host disease

2.40E-05

P48023, P01889, P10321, P01375, P26715, Q13241

FASLG, HLA-B, HLA-C, TNF, KLRC1, KLRD1

Ziprasidone

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Ziprasidone

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Ziprasidone

hsa05416

Viral myocarditis

6.58E-03

P01889, P10321

HLA-B, HLA-C

Ziprasidone

hsa05418

Fluid shear stress and atherosclerosis

1.27E-05

Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23

MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1

Community members of Ziprasidone (S_DC: 7.82)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Reported

0.0604

0.4779

2.5081

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P07305

H1None0

Histone H1.0

Predicted

0.054

0.0801

0.1872

P49336

CDK8

CyclinNonedependent kinase 8

Predicted

0.1356

0.647

1.3618

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

P27707

DCK

Deoxycytidine kinase

Predicted

0.0574

0.0614

0.1653

0.3169

Q9P1W9

PIM2

Serine/threonineNoneprotein kinase pimNone2

Predicted

0.1267

0.7674

0.2638

1.8619

Q9GZT9

EGLN1

Egl nine homolog 1

Predicted

0.5804

0.6061

0.2556

1.7581

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

O95271

TNKS

Poly [ADPNoneribose] polymerase tankyraseNone1

Predicted

0.1017

0.2224

0.4957

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q9H4A3

WNK1

Serine/threonineNoneprotein kinase WNK1

Predicted

0.1753

0.0386

0.1648

Q9UDY8

MALT1

MucosaNoneassociated lymphoid tissue lymphoma translocation protein 1

Predicted

0.0516

0.147

0.5592

0.8789

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P51617

IRAK1

InterleukinNone1 receptorNoneassociated kinase 1

Predicted

0.0238

0.3

0.9444

1.5563

P78527

PRKDC

DNANonedependent protein kinase catalytic subunit

Predicted

0.178

0.1944

0.2496

0.7273

Q6PCB7

SLC27A1

LongNonechain fatty acid transport protein 1

Predicted

0.2915

0.0768

0.0992

0.3985

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

Gene name	UniProt_ID	Bioactivity	Value (nM)
DRD2	P14416	IC50	5
DRD2	P14416	Ki	0.8
DRD2	P14416	Ki	1.2
DRD2	P14416	Ki	2.1

PharmaCoNets of Ziprasidone (SPCN: 191.78 )

Ziprasidone regulated-network (SDN: 24.52)

Community members of Ziprasidone (SDC: 7.82)

PharmaCoNets of Ziprasidone (S_PCN: 191.78 )

Ziprasidone regulated-network (S_DN: 24.52)

Community members of Ziprasidone (S_DC: 7.82)