PharmaCoNets of Zidovudine (SPCN: 63.00 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Zidovudinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Zidovudinehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Zidovudinehsa00240Pyrimidine metabolism8.44E-044P31350, P21589, P32320, P04183RRM2, NT5E, CDA, TK1More
Zidovudinehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Zidovudinehsa00561Glycerolipid metabolism2.51E-022P51648, P23743ALDH3A2, DGKAMore
Zidovudinehsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Zidovudinehsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Zidovudinehsa00630Glyoxylate and dicarboxylate metabolism2.78E-032P40925, P15104MDH1, GLULMore
Zidovudinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Zidovudinehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Zidovudinehsa00983Drug metabolism - other enzymes3.83E-044P04183, P32320, P31350, P05164TK1, CDA, RRM2, MPOMore
Zidovudinehsa01100Metabolic pathways4.12E-0212P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P23743, P43034, P09917, Q53FZ2GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, DGKA, PAFAH1B1, ALOX5, ACSM3More
Zidovudinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Zidovudinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Zidovudinehsa01521EGFR tyrosine kinase inhibitor resistance7.30E-044Q92529, P19174, P42338, Q9NRA1SHC3, PLCG1, PIK3CB, PDGFCMore
Zidovudinehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Zidovudinehsa03020RNA polymerase3.22E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Zidovudinehsa04010MAPK signaling pathway1.53E-022Q9H2K8, Q12933TAOK3, TRAF2More
Zidovudinehsa04012ErbB signaling pathway9.49E-033Q92529, P19174, P42338SHC3, PLCG1, PIK3CBMore
Zidovudinehsa04014Ras signaling pathway2.29E-047P42338, Q92529, Q9NRA1, P49767, P63218, P50151, P19174PIK3CB, SHC3, PDGFC, VEGFC, GNG5, GNG10, PLCG1More
Zidovudinehsa04015Rap1 signaling pathway3.91E-024Q9NRA1, P49767, P42338, P19174PDGFC, VEGFC, PIK3CB, PLCG1More
Zidovudinehsa04020Calcium signaling pathway2.16E-024P27987, P19174, Q9NRA1, P49767ITPKB, PLCG1, PDGFC, VEGFCMore
Zidovudinehsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Zidovudinehsa04062Chemokine signaling pathway4.35E-036P07948, P42338, P19174, Q92529, P63218, P50151LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10More
Zidovudinehsa04064NF-kappa B signaling pathway1.98E-037P10415, P51617, Q04759, Q9UDY8, Q13315, P24522, P09341BCL2, IRAK1, PRKCQ, MALT1, ATM, GADD45A, CXCL1More
Zidovudinehsa04070Phosphatidylinositol signaling system3.19E-045P19174, P42338, P23743, Q96PE3, P27987PLCG1, PIK3CB, DGKA, INPP4A, ITPKBMore
Zidovudinehsa04071Sphingolipid signaling pathway6.68E-046P21453, Q9H228, P01375, Q13362, Q12933, Q02156S1PR1, EDG8, TNF, PPP2R5C, TRAF2, PRKCEMore
Zidovudinehsa04072Phospholipase D signaling pathway1.85E-046P42338, Q92529, P19174, Q14344, P23743, Q9NRA1PIK3CB, SHC3, PLCG1, GNA13, DGKA, PDGFCMore
Zidovudinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Zidovudinehsa04115p53 signaling pathway3.35E-035P24522, Q13315, P31350, O95067, P10415GADD45A, ATM, RRM2, CCNB2, BCL2More
Zidovudinehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Zidovudinehsa04145Phagosome1.73E-036Q15080, P68371, P05164, P78380, P35443, P13765NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOBMore
Zidovudinehsa04151PI3K-Akt signaling pathway6.21E-0515P62753, P42338, O43521, P27348, Q9NRA1, P49767, P08238, Q8WYR1, P63218, P50151, O15335, P14784, P18848, O00141, Q6ZUJ8RPS6, PIK3CB, BCL2L11, YWHAQ, PDGFC, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, IL2RB, ATF4, SGK, PIK3AP1More
Zidovudinehsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Zidovudinehsa04217Necroptosis8.73E-067P07900, P15104, P05141, P01584, P0C0S5, Q13557, Q9H444HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Zidovudinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Zidovudinehsa04370VEGF signaling pathway1.56E-022P19174, P42338PLCG1, PIK3CBMore
Zidovudinehsa04371Apelin signaling pathway1.24E-024P63218, P50151, Q13370, Q14344GNG5, GNG10, PDE3B, GNA13More
Zidovudinehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Zidovudinehsa04510Focal adhesion1.55E-025P42338, O15335, Q9NRA1, P49767, Q92529PIK3CB, CHAD, PDGFC, VEGFC, SHC3More
Zidovudinehsa04611Platelet activation4.11E-023P42338, Q14344, P07948PIK3CB, GNA13, LYNMore
Zidovudinehsa04612Antigen processing and presentation2.08E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Zidovudinehsa04622RIG-I-like receptor signaling pathway2.47E-021Q12933TRAF2More
Zidovudinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Zidovudinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Zidovudinehsa04657IL-17 signaling pathway8.71E-059P07900, O00463, Q16539, P49841, P19875, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL2, MMP9, LCN2, TNF, IL1BMore
Zidovudinehsa04658Th1 and Th2 cell differentiation1.01E-024P07766, P19174, P14784, Q13761CD3E, PLCG1, IL2RB, RUNX3More
Zidovudinehsa04659Th17 cell differentiation2.16E-024P19174, P14784, P08238, P07766PLCG1, IL2RB, HSP90AB1, CD3EMore
Zidovudinehsa04662B cell receptor signaling pathway2.78E-023P42338, P07948, Q8N149PIK3CB, LYN, LILRA2More
Zidovudinehsa04664Fc epsilon RI signaling pathway1.34E-047P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Zidovudinehsa04666Fc gamma R-mediated phagocytosis1.73E-023P07948, P42338, P19174LYN, PIK3CB, PLCG1More
Zidovudinehsa04668TNF signaling pathway1.71E-049P01375, O00463, Q16539, P18848, P19875, P01584, P20749, P14780, P20333TNF, TRAF5, MAPK14, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1BMore
Zidovudinehsa04722Neurotrophin signaling pathway4.87E-023P42338, P19174, Q92529PIK3CB, PLCG1, SHC3More
Zidovudinehsa04724Glutamatergic synapse1.73E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Zidovudinehsa04725Cholinergic synapse1.73E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Zidovudinehsa04726Serotonergic synapse3.41E-023P63218, P50151, P09917GNG5, GNG10, ALOX5More
Zidovudinehsa04727GABAergic synapse6.57E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Zidovudinehsa04730Long-term depression1.56E-022Q14344, P07948GNA13, LYNMore
Zidovudinehsa04910Insulin signaling pathway4.11E-023Q92529, Q13370, P42338SHC3, PDE3B, PIK3CBMore
Zidovudinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Zidovudinehsa04914Progesterone-mediated oocyte maturation2.22E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Zidovudinehsa04915Estrogen signaling pathway4.76E-034P42338, Q92529, P08238, P11142PIK3CB, SHC3, HSP90AB1, HSPA8More
Zidovudinehsa04923Regulation of lipolysis in adipocytes3.64E-022Q13370, P42338PDE3B, PIK3CBMore
Zidovudinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Zidovudinehsa04926Relaxin signaling pathway1.18E-049P42338, P63218, P50151, P18848, P22694, P49767, P14780, Q92529, P30679PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, SHC3, GNA15More
Zidovudinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Zidovudinehsa04930Type II diabetes mellitus2.47E-021Q02156PRKCEMore
Zidovudinehsa04932Non-alcoholic fatty liver disease5.73E-056O43521, P18848, O75460, P01584, P13073, O15239BCL2L11, ATF4, ERN1, IL1B, COX4I1, NDUFA1More
Zidovudinehsa04933AGE-RAGE signaling pathway in diabetic complications4.11E-023P42338, P49767, P19174PIK3CB, VEGFC, PLCG1More
Zidovudinehsa04935Growth hormone synthesis, secretion and action2.78E-023P19174, P42338, Q92529PLCG1, PIK3CB, SHC3More
Zidovudinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Zidovudinehsa04974Protein digestion and absorption2.47E-021Q7Z2H8SLC36A1More
Zidovudinehsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Zidovudinehsa05012Parkinson disease2.77E-037O15239, P13073, P05141, O75460, P18848, P0DP24, Q13557NDUFA1, COX4I1, SLC25A5, ERN1, ATF4, CALM2, CAMK2DMore
Zidovudinehsa05016Huntington disease4.33E-037O15239, P13073, P24928, P30876, P62487, P05141, O75460NDUFA1, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1More
Zidovudinehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Zidovudinehsa05022Pathways of neurodegeneration - multiple diseases2.20E-039O15239, P13073, O75460, P18848, P05141, P20333, P01584, P0DP24, Q13557NDUFA1, COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2, CAMK2DMore
Zidovudinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Zidovudinehsa05032Morphine addiction2.22E-023P63218, P50151, Q13370GNG5, GNG10, PDE3BMore
Zidovudinehsa05100Bacterial invasion of epithelial cells3.64E-022P42338, Q92529PIK3CB, SHC3More
Zidovudinehsa05131Shigellosis1.65E-022Q12933, Q02156TRAF2, PRKCEMore
Zidovudinehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Zidovudinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Zidovudinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Zidovudinehsa05150Staphylococcus aureus infection1.91E-024Q14532, P59665, P59666, P49913KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Zidovudinehsa05152Tuberculosis1.95E-025P48382, P10415, P13765, Q9UDY8, P51617RFX5, BCL2, HLA-DOB, MALT1, IRAK1More
Zidovudinehsa05162Measles4.15E-036P14784, P07766, P42338, P11142, P01584, Q9NP90IL2RB, CD3E, PIK3CB, HSPA8, IL1B, RAB9BMore
Zidovudinehsa05163Human cytomegalovirus infection1.10E-0311P42338, P01375, P63218, P50151, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101PIK3CB, TNF, GNG5, GNG10, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3More
Zidovudinehsa05167Kaposi sarcoma-associated herpesvirus infection1.14E-025P42338, P63218, P50151, P19174, P07948PIK3CB, GNG5, GNG10, PLCG1, LYNMore
Zidovudinehsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Zidovudinehsa05169Epstein-Barr virus infection3.34E-025P42338, P07948, P30101, Q13761, P07766PIK3CB, LYN, PDIA3, RUNX3, CD3EMore
Zidovudinehsa05170Human immunodeficiency virus 1 infection7.03E-036P42338, P63218, P50151, P30101, P19174, P07766PIK3CB, GNG5, GNG10, PDIA3, PLCG1, CD3EMore
Zidovudinehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Zidovudinehsa05200Pathways in cancer3.05E-028P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RBMore
Zidovudinehsa05202Transcriptional misregulation in cancer3.11E-027Q13315, P14923, Q15744, P05164, P08246, Q9C0K0, P24522ATM, JUP, CEBPE, MPO, ELA2, BCL11B, GADD45AMore
Zidovudinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Zidovudinehsa05214Glioma9.49E-033Q92529, P42338, P19174SHC3, PIK3CB, PLCG1More
Zidovudinehsa05215Prostate cancer4.87E-023Q9NRA1, P08238, P42338PDGFC, HSP90AB1, PIK3CBMore
Zidovudinehsa05218Melanoma3.64E-022Q9NRA1, P42338PDGFC, PIK3CBMore
Zidovudinehsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Zidovudinehsa05231Choline metabolism in cancer1.17E-034P42338, Q9NRA1, P19174, P23743PIK3CB, PDGFC, PLCG1, DGKAMore
Zidovudinehsa05310Asthma3.01E-022P13765, P12724HLA-DOB, RNASE3More
Zidovudinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Zidovudinehsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More
Zidovudinehsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Zidovudinehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Zidovudine (SDC: 4.05)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P04183TK1Thymidine kinase, cytosolicPredicted00.27170.16370.16530.6286
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P06746POLBDNA polymerase betaPredicted00.45730.18680.48561.0878
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)