PharmaCoNets

PharmaCoNets of Zanubrutinib (S_PCN: 229.71 )

Zanubrutinib regulated-network (S_DN: 24.28)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Zanubrutinib

hsa00030

Pentose phosphate pathway

5.43E-06

P60891, P51854, P52209, P37837

PRPS1, TKTL1, PGD, TALDO1

Zanubrutinib

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Zanubrutinib

hsa00071

Fatty acid degradation

3.50E-02

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Zanubrutinib

hsa00190

Oxidative phosphorylation

1.00E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Zanubrutinib

hsa00220

Arginine biosynthesis

6.43E-05

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Zanubrutinib

hsa00250

Alanine, aspartate and glutamate metabolism

4.81E-04

Q96RQ9, P15104

IL4I1, GLUL

Zanubrutinib

hsa00270

Cysteine and methionine metabolism

2.39E-02

Q96RQ9, P40926

IL4I1, MDH2

Zanubrutinib

hsa00280

Valine, leucine and isoleucine degradation

8.48E-03

Q96RQ9, P05166

IL4I1, PCCB

Zanubrutinib

hsa00310

Lysine degradation

1.48E-04

Q9NVH6, Q96KQ7, O15047, Q02809, P51648

TMLHE, EHMT2, SETD1A, PLOD1, ALDH3A2

Zanubrutinib

hsa00410

beta-Alanine metabolism

3.98E-02

Q6ZQY3

GADL1

Zanubrutinib

hsa00471

D-Glutamine and D-glutamate metabolism

3.98E-02

Q7Z3D6

C14orf159

Zanubrutinib

hsa00500

Starch and sucrose metabolism

3.98E-06

O43451, P46976, P06737

MGAM, GYG1, PYGL

Zanubrutinib

hsa00510

N-Glycan biosynthesis

3.15E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Zanubrutinib

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

2.03E-02

P35557

GCK

Zanubrutinib

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Zanubrutinib

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Zanubrutinib

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Zanubrutinib

hsa00630

Glyoxylate and dicarboxylate metabolism

2.04E-07

P40925, P40926, P05166, P15104

MDH1, MDH2, PCCB, GLUL

Zanubrutinib

hsa00670

One carbon pool by folate

2.15E-02

O95954, Q99707

FTCD, MTR

Zanubrutinib

hsa00730

Thiamine metabolism

1.38E-05

Q9Y6K8, P05186, P24666

AK5, ALPL, ACP1

Zanubrutinib

hsa00740

Riboflavin metabolism

4.03E-02

P24666

ACP1

Zanubrutinib

hsa00750

Vitamin B6 metabolism

4.45E-02

O00764

PDXK

Zanubrutinib

hsa00770

Pantothenate and CoA biosynthesis

1.19E-03

O95498, Q6ZQY3, Q9NRN7

VNN2, GADL1, AASDHPPT

Zanubrutinib

hsa00830

Retinol metabolism

2.27E-03

P00325, P11766, P00352, Q9BPW9, O75911

ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3

Zanubrutinib

hsa00860

Porphyrin and chlorophyll metabolism

5.86E-04

P36551, P30043

CPOX, BLVRB

Zanubrutinib

hsa00910

Nitrogen metabolism

2.42E-02

P15104

GLUL

Zanubrutinib

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Zanubrutinib

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Zanubrutinib

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Zanubrutinib

hsa00983

Drug metabolism - other enzymes

2.45E-02

P20839, P32320, P05164

IMPDH1, CDA, MPO

Zanubrutinib

hsa01100

Metabolic pathways

3.18E-03

Q9NR34, P05089, Q9UJ14, P15104, Q96DU7, P32320, Q08828, Q02153, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q86XP1, Q96RQ9, Q9HCC0, P33121, Q9UHK6, P57054, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, P05166, P12074, P05496, O15239, O15047, Q9NVH6

MAN1C1, ARG1, GGTL3, GLUL, ITPKC, CDA, ADCY1, GUCY1B3, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKH, IL4I1, MCCC2, ACSL1, AMACR, PIGP, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, PCCB, COX6A1, ATP5G1, NDUFA1, SETD1A, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q9UJ14	GGTL3	Glutathione hydrolase 7	-0.717
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P15104	GLUL	Glutamine synthetase	-0.718
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	0.879
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q08828	ADCY1	Adenylate cyclase type 1	-0.748
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q02153	GUCY1B3	Guanylate cyclase soluble subunit beta-1	0.847
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P40926	MDH2	Malate dehydrogenase, mitochondrial	-0.731
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q86XP1	DGKH	Diacylglycerol kinase eta	0.804
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q96RQ9	IL4I1	L-amino-acid oxidase	0.761
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	0.839
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q9H4F1	ST6GALNAC4	Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase	-0.785
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q9BRR6	ADPGK	ADP-dependent glucokinase	-0.71
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P05166	PCCB	Propionyl-CoA carboxylase beta chain, mitochondrial	-0.714
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	-0.715
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	-0.815
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	-0.834
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	O15047	SETD1A	Histone-lysine N-methyltransferase SETD1A	-0.831
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	0.74

Zanubrutinib

hsa01230

Biosynthesis of amino acids

1.69E-04

P51854, P60891, Q99707, P05089, P15104, P37837

TKTL1, PRPS1, MTR, ARG1, GLUL, TALDO1

Zanubrutinib

hsa01240

Biosynthesis of cofactors

2.95E-02

P13716, P14618

ALAD, PKM2

Zanubrutinib

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Zanubrutinib

hsa01522

Endocrine resistance

1.69E-02

P22694, P08069, P10415, Q13323

PRKACB, IGF1R, BCL2, BIK

Zanubrutinib

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Zanubrutinib

hsa02010

ABC transporters

4.48E-02

Q8IZY2

ABCA7

Zanubrutinib

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Zanubrutinib

hsa03013

RNA transport

4.20E-08

O14980, P52298, O14893, P61326, Q9H307, Q7Z3B4, P35658, O14602, Q14152, P78345, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787, P51114

XPO1, NCBP2, GEMIN2, MAGOH, PNN, NUP54, NUP214, EIF1AY, EIF3A, RPP38, EIF4A2, UPF3B, EIF4B, TACC3, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9P289	STK26	Serine/threonine-protein kinase 26	O14980	XPO1	Exportin-1	0.781
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q07912	TNK2	Activated CDC42 kinase 1	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.701
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q07912	TNK2	Activated CDC42 kinase 1	O14893	GEMIN2	Gem-associated protein 2	-0.752
Q9P289	STK26	Serine/threonine-protein kinase 26	O14893	GEMIN2	Gem-associated protein 2	0.765
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q9P289	STK26	Serine/threonine-protein kinase 26	Q9H307	PNN	Pinin	0.716
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q9P289	STK26	Serine/threonine-protein kinase 26	P35658	NUP214	Nuclear pore complex protein Nup214	-0.713
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q07912	TNK2	Activated CDC42 kinase 1	O14602	EIF1AY	Eukaryotic translation initiation factor 1A, Y-chromosomal	-0.826
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q07912	TNK2	Activated CDC42 kinase 1	P78345	RPP38	Ribonuclease P protein subunit p38	-0.717
Q9P289	STK26	Serine/threonine-protein kinase 26	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.703
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q9P289	STK26	Serine/threonine-protein kinase 26	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.732
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q9P289	STK26	Serine/threonine-protein kinase 26	Q06787	FMR1	Synaptic functional regulator FMR1	0.796
Q9P289	STK26	Serine/threonine-protein kinase 26	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.803

Zanubrutinib

hsa03020

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Zanubrutinib

hsa03022

Basal transcription factors

3.52E-03

O00268, Q5H9L4, Q15544

TAF4, TAF7L, TAF11

Zanubrutinib

hsa03040

Spliceosome

4.11E-07

Q14562, O43143, O60508, P17844, P08579, P26368, P52298, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, NCBP2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.75
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.841
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P07948	LYN	Tyrosine-protein kinase Lyn	O60508	CDC40	Pre-mRNA-processing factor 17	-0.814
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P07948	LYN	Tyrosine-protein kinase Lyn	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.739
P07948	LYN	Tyrosine-protein kinase Lyn	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.775
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.72
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
P07948	LYN	Tyrosine-protein kinase Lyn	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.742
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.722
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.757
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
P07948	LYN	Tyrosine-protein kinase Lyn	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.716
P07948	LYN	Tyrosine-protein kinase Lyn	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.79
P07948	LYN	Tyrosine-protein kinase Lyn	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.781
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.71
P07948	LYN	Tyrosine-protein kinase Lyn	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.732
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P07948	LYN	Tyrosine-protein kinase Lyn	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.734
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761
P07948	LYN	Tyrosine-protein kinase Lyn	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.742

Zanubrutinib

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Zanubrutinib

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Zanubrutinib

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Zanubrutinib

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Zanubrutinib

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Zanubrutinib

hsa03460

Fanconi anemia pathway

1.75E-02

P40692, O60673, Q9UNA4

MLH1, REV3L, POLI

Zanubrutinib

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Zanubrutinib

hsa04014

Ras signaling pathway

3.65E-02

P08069

IGF1R

Zanubrutinib

hsa04015

Rap1 signaling pathway

1.05E-04

P08069, P06213, P25116, Q8TEU7, O00522, P08514

IGF1R, INSR, F2R, RAPGEF6, KRIT1, ITGA2B

Zanubrutinib

hsa04022

cGMP-PKG signaling pathway

1.05E-02

P24844, Q8WYR1, Q15746

MYL9, PIK3R5, MYLK

Zanubrutinib

hsa04024

cAMP signaling pathway

1.40E-02

P48058, P25116, P24844

GRIA4, F2R, MYL9

Zanubrutinib

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Zanubrutinib

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.70E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Zanubrutinib

hsa04062

Chemokine signaling pathway

4.01E-04

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK

Zanubrutinib

hsa04064

NF-kappa B signaling pathway

2.30E-12

P10415, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
P42681	TXK	Tyrosine-protein kinase TXK	P10415	BCL2	Apoptosis regulator Bcl-2	0.716
Q07912	TNK2	Activated CDC42 kinase 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O00463	TRAF5	TNF receptor-associated factor 5	0.945
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	O00463	TRAF5	TNF receptor-associated factor 5	-0.735
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42681	TXK	Tyrosine-protein kinase TXK	O00463	TRAF5	TNF receptor-associated factor 5	0.827
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q07912	TNK2	Activated CDC42 kinase 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.702
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
Q07912	TNK2	Activated CDC42 kinase 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.801
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16548	BCL2A1	Bcl-2-related protein A1	0.742
P42681	TXK	Tyrosine-protein kinase TXK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
Q07912	TNK2	Activated CDC42 kinase 1	Q13315	ATM	Serine-protein kinase ATM	-0.755
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.758
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42681	TXK	Tyrosine-protein kinase TXK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P09341	CXCL1	Growth-regulated alpha protein	0.78
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42681	TXK	Tyrosine-protein kinase TXK	P09341	CXCL1	Growth-regulated alpha protein	-0.881
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Zanubrutinib

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Zanubrutinib

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Zanubrutinib

hsa04070

Phosphatidylinositol signaling system

2.98E-03

P0DP23, Q14643, P23743, Q86XP1, Q96DU7, P17252

CALM1, ITPR1, DGKA, DGKH, ITPKC, PRKCA

Zanubrutinib

hsa04071

Sphingolipid signaling pathway

4.49E-02

P17252, P21453, Q9BX95, P10415

PRKCA, S1PR1, SGPP1, BCL2

Zanubrutinib

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Zanubrutinib

hsa04080

Neuroactive ligand-receptor interaction

4.92E-04

P08311, Q15722, P21453, Q9H228, O00398, P25116, P21462, Q16581, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, F2R, FPR1, C3AR1, ADRB2

Zanubrutinib

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Zanubrutinib

hsa04114

Oocyte meiosis

1.43E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Zanubrutinib

hsa04115

p53 signaling pathway

2.54E-02

O15151, Q13315, P10415

MDM4, ATM, BCL2

Zanubrutinib

hsa04120

Ubiquitin mediated proteolysis

4.82E-03

Q9UBT2, Q14669

SAE2, TRIP12

Zanubrutinib

hsa04136

Autophagy - other

4.46E-05

O94817, Q9H1Y0

ATG12, ATG5

Zanubrutinib

hsa04140

Autophagy - animal

1.32E-03

P08069, P22694, Q14643, P10415, Q9H1Y0, Q04759

IGF1R, PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Zanubrutinib

hsa04141

Protein processing in endoplasmic reticulum

1.91E-03

P18848, Q15437, Q99941, P11142, P07900, Q9NR31

ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1A

Zanubrutinib

hsa04142

Lysosome

2.45E-03

Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Zanubrutinib

hsa04144

Endocytosis

1.13E-03

Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3

CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5

Zanubrutinib

hsa04145

Phagosome

1.37E-04

O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774

FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSS

Zanubrutinib

hsa04150

mTOR signaling pathway

2.32E-02

P08069

IGF1R

Zanubrutinib

hsa04151

PI3K-Akt signaling pathway

3.91E-03

P62753, P27348, P07900, P22105, Q99941, P18848, O00141

RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGK

Zanubrutinib

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Zanubrutinib

hsa04211

Longevity regulating pathway

5.33E-03

P08069, P51828, Q99941, P18848

IGF1R, ADCY7, CREBL1, ATF4

Zanubrutinib

hsa04213

Longevity regulating pathway - multiple species

9.82E-04

P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Zanubrutinib

hsa04217

Necroptosis

3.36E-04

P01568, Q13489, Q13546, P42224, P08238, Q6FI13, Q93077, P10415, O43633, Q08752

IFNA21, BIRC3, RIPK1, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, BCL2, CHMP2A, PPID

Zanubrutinib

hsa04261

Adrenergic signaling in cardiomyocytes

1.46E-02

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Zanubrutinib

hsa04270

Vascular smooth muscle contraction

6.60E-04

Q15746, P24844, P0DP23, Q08828, P51828, P35579, P35749, P35318

MYLK, MYL9, CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Zanubrutinib

hsa04330

Notch signaling pathway

6.65E-03

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Zanubrutinib

hsa04340

Hedgehog signaling pathway

1.03E-03

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Zanubrutinib

hsa04370

VEGF signaling pathway

3.06E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Zanubrutinib

hsa04380

Osteoclast differentiation

9.58E-05

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Zanubrutinib

hsa04510

Focal adhesion

8.31E-04

P08514, Q15746, P24844, Q15942, P51636, P30281, P08069

ITGA2B, MYLK, MYL9, ZYX, CAV2, CCND3, IGF1R

Zanubrutinib

hsa04512

ECM-receptor interaction

9.97E-04

P07359, P26012, P08514, P16070

GP1BA, ITGB8, ITGA2B, CD44

Zanubrutinib

hsa04514

Cell adhesion molecules

4.65E-02

P16109, O00501

SELP, CLDN5

Zanubrutinib

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Zanubrutinib

hsa04530

Tight junction

1.14E-04

Q8TEU7, P16989, P56750, O00501, Q14247, P24844

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9

Zanubrutinib

hsa04540

Gap junction

2.58E-05

P17252, P22694, Q13509, P68371, Q9NRA1, Q14643

PRKCA, PRKACB, TUBB3, TUBB2C, PDGFC, ITPR1

Zanubrutinib

hsa04550

Signaling pathways regulating pluripotency of stem cells

9.61E-03

Q13873, Q02750, P08069, Q86SE9

BMPR2, MAP2K1, IGF1R, PCGF5

Zanubrutinib

hsa04610

Complement and coagulation cascades

5.51E-04

P25116, P0C0L4, P10909

F2R, C4A, CLU

Zanubrutinib

hsa04611

Platelet activation

1.59E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Zanubrutinib

hsa04612

Antigen processing and presentation

2.02E-03

P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNF

Zanubrutinib

hsa04613

Neutrophil extracellular trap formation

5.20E-04

P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P17252	PRKCA	Protein kinase C alpha type	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	O60603	TLR2	Toll-like receptor 2	-0.729
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P08246	ELA2	Neutrophil elastase	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.843
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.703
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P14598	NCF1	Neutrophil cytosol factor 1	-0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P21462	FPR1	fMet-Leu-Phe receptor	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Zanubrutinib

hsa04614

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Zanubrutinib

hsa04623

Cytosolic DNA-sensing pathway

4.28E-05

P01584, P01568, Q13546, P25963, Q8NHW4

IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2

Zanubrutinib

hsa04625

C-type lectin receptor signaling pathway

9.91E-04

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Zanubrutinib

hsa04640

Hematopoietic cell lineage

2.95E-07

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P15144	ANPEP	Aminopeptidase N	-0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P25063	CD24	Signal transducer CD24	-0.839
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Zanubrutinib

hsa04650

Natural killer cell mediated cytotoxicity

1.26E-09

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.862
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P42681	TXK	Tyrosine-protein kinase TXK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.881
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P42681	TXK	Tyrosine-protein kinase TXK	Q13241	KLRD1	Natural killer cells antigen CD94	0.888
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.922
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P42681	TXK	Tyrosine-protein kinase TXK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P42681	TXK	Tyrosine-protein kinase TXK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.901
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P42681	TXK	Tyrosine-protein kinase TXK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.901
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846

Zanubrutinib

hsa04657

IL-17 signaling pathway

1.41E-04

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Zanubrutinib

hsa04658

Th1 and Th2 cell differentiation

2.79E-17

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
P42681	TXK	Tyrosine-protein kinase TXK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42681	TXK	Tyrosine-protein kinase TXK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.856
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42681	TXK	Tyrosine-protein kinase TXK	Q9UL17	TBX21	T-box transcription factor TBX21	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42681	TXK	Tyrosine-protein kinase TXK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.89
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Zanubrutinib

hsa04659

Th17 cell differentiation

1.13E-14

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P01584, P08238, P07766, P09693, P20963, P23458

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42681	TXK	Tyrosine-protein kinase TXK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.89
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P42681	TXK	Tyrosine-protein kinase TXK	Q9UL17	TBX21	T-box transcription factor TBX21	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P42681	TXK	Tyrosine-protein kinase TXK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.856
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Zanubrutinib

hsa04660

T cell receptor signaling pathway

3.27E-12

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42681	TXK	Tyrosine-protein kinase TXK	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.776
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P42681	TXK	Tyrosine-protein kinase TXK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.857
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	1
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P42681	TXK	Tyrosine-protein kinase TXK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.847
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P42681	TXK	Tyrosine-protein kinase TXK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.9
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.811
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P42681	TXK	Tyrosine-protein kinase TXK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Zanubrutinib

hsa04662

B cell receptor signaling pathway

2.54E-04

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Zanubrutinib

hsa04664

Fc epsilon RI signaling pathway

2.20E-03

P01375, Q16539, P42338, Q9UQC2, P07948, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5

Zanubrutinib

hsa04666

Fc gamma R-mediated phagocytosis

1.88E-02

P23528, O14494, P14598, P17252

CFL1, PLPP1, NCF1, PRKCA

Zanubrutinib

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Zanubrutinib

hsa04713

Circadian entrainment

6.70E-04

P0DP23, Q13557, Q02153, P17252, P62873, P61952, Q14643, Q08828

CALM1, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG11, ITPR1, ADCY1

Zanubrutinib

hsa04714

Thermogenesis

3.31E-02

P51828, P62753, P12074, O15239

ADCY7, RPS6, COX6A1, NDUFA1

Zanubrutinib

hsa04720

Long-term potentiation

5.00E-04

P17252, Q16566, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Zanubrutinib

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Zanubrutinib

hsa04724

Glutamatergic synapse

4.09E-05

P48058, O15399, P63218, P50151, P15104, Q9NSB8

GRIA4, GRIN2D, GNG5, GNG10, GLUL, HOMER2

Zanubrutinib

hsa04725

Cholinergic synapse

2.80E-06

P51828, P22694, Q14643, P17252, P62873, P63218, P50151, P18848, Q16566, Q13557, P42338, P10415

ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK4, CAMK2D, PIK3CB, BCL2

Zanubrutinib

hsa04726

Serotonergic synapse

4.49E-02

Q14643, P17252, P62873, P33260

ITPR1, PRKCA, GNB1, CYP2C18

Zanubrutinib

hsa04727

GABAergic synapse

6.58E-05

Q08828, P63218, P50151, P61952, P15104, Q15111

ADCY1, GNG5, GNG10, GNG11, GLUL, PLCL1

Zanubrutinib

hsa04728

Dopaminergic synapse

5.30E-03

P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P48058

GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, GRIA4

Zanubrutinib

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Zanubrutinib

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Zanubrutinib

hsa04750

Inflammatory mediator regulation of TRP channels

3.66E-05

P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1

Zanubrutinib

hsa04810

Regulation of actin cytoskeleton

1.38E-03

P24844, Q15746, P08514, P25116

MYL9, MYLK, ITGA2B, F2R

Zanubrutinib

hsa04911

Insulin secretion

5.41E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Zanubrutinib

hsa04912

GnRH signaling pathway

7.11E-04

P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694

PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB

Zanubrutinib

hsa04913

Ovarian steroidogenesis

6.44E-04

P42330, P22694, P06213, P08069

AKR1C3, PRKACB, INSR, IGF1R

Zanubrutinib

hsa04914

Progesterone-mediated oocyte maturation

1.91E-03

P08069, Q17RY0, Q9Y6D9, P51812, Q02750

IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1

Zanubrutinib

hsa04915

Estrogen signaling pathway

4.95E-04

Q99941, P18848, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, Q15788

CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1

Zanubrutinib

hsa04918

Thyroid hormone synthesis

1.69E-03

P51828, Q99941, P18848, P02768

ADCY7, CREBL1, ATF4, ALB

Zanubrutinib

hsa04921

Oxytocin signaling pathway

6.37E-03

Q15746, P24844, Q8WYR1

MYLK, MYL9, PIK3R5

Zanubrutinib

hsa04922

Glucagon signaling pathway

4.18E-02

P14618, P06737

PKM2, PYGL

Zanubrutinib

hsa04923

Regulation of lipolysis in adipocytes

4.24E-03

P07550, P06213, P42338, Q9Y4H2

ADRB2, INSR, PIK3CB, IRS2

Zanubrutinib

hsa04924

Renin secretion

3.09E-03

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Zanubrutinib

hsa04925

Aldosterone synthesis and secretion

1.07E-04

Q14643, Q99941, P18848, P51828, P0DP23, P17252, Q16566, Q13557

ITPR1, CREBL1, ATF4, ADCY7, CALM1, PRKCA, CAMK4, CAMK2D

Zanubrutinib

hsa04926

Relaxin signaling pathway

5.00E-04

P42338, P63218, P50151, Q99941, P18848, P49767, P51828, P49407

PIK3CB, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY7, ARRB1

Zanubrutinib

hsa04927

Cortisol synthesis and secretion

3.03E-04

Q14643, Q99941, P18848, P51828, P22694

ITPR1, CREBL1, ATF4, ADCY7, PRKACB

Zanubrutinib

hsa04928

Parathyroid hormone synthesis, secretion and action

5.87E-04

Q14643, P51828, P22694, P23771, Q99941, P18848, P10415

ITPR1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2

Zanubrutinib

hsa04929

GnRH secretion

4.62E-02

P42338, P49407

PIK3CB, ARRB1

Zanubrutinib

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Zanubrutinib

hsa04932

Non-alcoholic fatty liver disease

1.39E-02

O43521, O75460, P01584, P13073, P12074, O95298

BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2

Zanubrutinib

hsa04934

Cushing syndrome

6.22E-06

Q14643, Q99941, P18848, Q08828, P51828, P22694, O15169, Q13557, P04628

ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1

Zanubrutinib

hsa04935

Growth hormone synthesis, secretion and action

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Zanubrutinib

hsa04950

Maturity onset diabetes of the young

2.03E-02

P35557

GCK

Zanubrutinib

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P06213

INSR

Zanubrutinib

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Zanubrutinib

hsa04966

Collecting duct acid secretion

1.95E-03

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Zanubrutinib

hsa04970

Salivary secretion

2.62E-03

P07550, Q08828, P51828, P22694, Q14643, P0DP23

ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1

Zanubrutinib

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Zanubrutinib

hsa04976

Bile secretion

4.78E-02

Q08828, P51828, Q14032

ADCY1, ADCY7, BAAT

Zanubrutinib

hsa05010

Alzheimer disease

2.41E-02

P49768, Q92542, O15239, P05496, P12074, Q12933, O15169, P43686

PSEN1, NCSTN, NDUFA1, ATP5G1, COX6A1, TRAF2, AXIN1, PSMC4

Zanubrutinib

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Zanubrutinib

hsa05017

Spinocerebellar ataxia

2.22E-02

Q92915, O15399, P42338, P21796

FGF14, GRIN2D, PIK3CB, VDAC1

Zanubrutinib

hsa05020

Prion disease

3.99E-02

O14521, Q14643, Q13509, P68371, P14598, Q15080

SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4

Zanubrutinib

hsa05022

Pathways of neurodegeneration - multiple diseases

1.02E-03

Q14643, Q13509, P68371, P10415, O15239, O14521, P12074, P05496, Q12933, Q13561, P17252, O15169, P49768, O15020, P0DP23, Q13557, P62987, P43686

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA1, SDHD, COX6A1, ATP5G1, TRAF2, DCTN2, PRKCA, AXIN1, PSEN1, SPTBN2, CALM1, CAMK2D, UBA52, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.701
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q13509	TUBB3	Tubulin beta-3 chain	-0.716
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P68371	TUBB2C	Tubulin beta-4B chain	-0.892
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P10415	BCL2	Apoptosis regulator Bcl-2	0.848
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	-0.834
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.728
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	-0.715
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	-0.815
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q12933	TRAF2	TNF receptor-associated factor 2	-0.771
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q13561	DCTN2	Dynactin subunit 2	-0.862
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P17252	PRKCA	Protein kinase C alpha type	0.849
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	O15169	AXIN1	Axin-1	-0.74
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P49768	PSEN1	Presenilin-1	-0.732
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	-0.718
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P0DP23	CALM1	Calmodulin-1	-0.8
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	-0.85
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P62987	UBA52	Ubiquitin-60S ribosomal protein L40	0.772
P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	P43686	PSMC4	26S proteasome regulatory subunit 6B	-0.729

Zanubrutinib

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Zanubrutinib

hsa05031

Amphetamine addiction

6.41E-03

Q13557, Q99941, P18848

CAMK2D, CREBL1, ATF4

Zanubrutinib

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Zanubrutinib

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Zanubrutinib

hsa05110

Vibrio cholerae infection

4.78E-02

Q99437

ATP6V0B

Zanubrutinib

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.40E-08

Q16539, Q99437, P09341, P19875, P19174, P25024, P25025, P41240

MAPK14, ATP6V0B, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, CSK

Zanubrutinib

hsa05130

Pathogenic Escherichia coli infection

2.51E-02

Q14247, O00501, P25116

CTTN, CLDN5, F2R

Zanubrutinib

hsa05131

Shigellosis

1.80E-02

Q13546, Q9UDY8, Q12778, Q13315, P10415

RIPK1, MALT1, FOXO1, ATM, BCL2

Zanubrutinib

hsa05132

Salmonella infection

1.65E-03

Q9UJU2, Q13546, Q13489, P10415, O60603, Q13561, Q13509, P68371

LEF1, RIPK1, BIRC3, BCL2, TLR2, DCTN2, TUBB3, TUBB2C

Zanubrutinib

hsa05133

Pertussis

4.95E-03

P0DP23, P23528, P09871, P0C0L4

CALM1, CFL1, C1S, C4A

Zanubrutinib

hsa05134

Legionellosis

8.80E-04

P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Zanubrutinib

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Zanubrutinib

hsa05140

Leishmaniasis

1.34E-05

P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080

ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15080	NCF4	Neutrophil cytosol factor 4	-0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758

Zanubrutinib

hsa05144

Malaria

8.73E-04

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Zanubrutinib

hsa05146

Amoebiasis

1.89E-10

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P09341	CXCL1	Growth-regulated alpha protein	0.78
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P42681	TXK	Tyrosine-protein kinase TXK	P09341	CXCL1	Growth-regulated alpha protein	-0.881
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P27930	IL1R2	Interleukin-1 receptor type 2	0.824
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P42681	TXK	Tyrosine-protein kinase TXK	O60603	TLR2	Toll-like receptor 2	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05089	ARG1	Arginase-1	-0.868
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P05089	ARG1	Arginase-1	0.875
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P42681	TXK	Tyrosine-protein kinase TXK	P05089	ARG1	Arginase-1	-0.739
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.873
P42681	TXK	Tyrosine-protein kinase TXK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.878
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P12814	ACTN1	Alpha-actinin-1	0.794
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08311	CTSG	Cathepsin G	-0.866
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P08311	CTSG	Cathepsin G	0.768
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P42681	TXK	Tyrosine-protein kinase TXK	P08311	CTSG	Cathepsin G	-0.83
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744

Zanubrutinib

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Zanubrutinib

hsa05152

Tuberculosis

2.40E-03

Q13488, Q99437, P0DP23, P48382, O60603, P10415, P25774, P01568, Q9UDY8

TCIRG1, ATP6V0B, CALM1, RFX5, TLR2, BCL2, CTSS, IFNA21, MALT1

Zanubrutinib

hsa05160

Hepatitis C

3.16E-02

P52630, P60033, Q9NZJ5, P49841

STAT2, CD81, EIF2AK3, GSK3B

Zanubrutinib

hsa05161

Hepatitis B

3.34E-02

Q99941, P18848, P27348

CREBL1, ATF4, YWHAQ

Zanubrutinib

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Zanubrutinib

hsa05163

Human cytomegalovirus infection

2.63E-06

P01375, P62873, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, P04637, Q13546, O00463, P01568

TNF, GNB1, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, TP53, RIPK1, TRAF5, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.795
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.701
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P0DP23	CALM1	Calmodulin-1	-0.8
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P17252	PRKCA	Protein kinase C alpha type	0.849
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.797
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P25025	CXCR2	C-X-C chemokine receptor type 2	0.774
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.788
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	O00463	TRAF5	TNF receptor-associated factor 5	-0.735
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	P01568	IFNA21	Interferon alpha-21	0.898

Zanubrutinib

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Zanubrutinib

hsa05169

Epstein-Barr virus infection

1.01E-04

P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, O60603, P29728, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TLR2, OAS2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P42681	TXK	Tyrosine-protein kinase TXK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.89
P06239	LCK	Tyrosine-protein kinase Lck	P01106	MYC	Myc proto-oncogene protein	0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q13547	HDAC1	Histone deacetylase 1	0.811
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13547	HDAC1	Histone deacetylase 1	-0.774
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P42681	TXK	Tyrosine-protein kinase TXK	O00463	TRAF5	TNF receptor-associated factor 5	0.827
P42681	TXK	Tyrosine-protein kinase TXK	P10415	BCL2	Apoptosis regulator Bcl-2	0.716
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13761	RUNX3	Runt-related transcription factor 3	-0.708
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P42681	TXK	Tyrosine-protein kinase TXK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.79
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.768
P42681	TXK	Tyrosine-protein kinase TXK	O60603	TLR2	Toll-like receptor 2	-0.714
P42681	TXK	Tyrosine-protein kinase TXK	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.831
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811

Zanubrutinib

hsa05170

Human immunodeficiency virus 1 infection

1.16E-03

P62873, P0DP23, P17252, Q13546, Q14643, P01568, O60603, P23528, P10415, Q9Y6Q5

GNB1, CALM1, PRKCA, RIPK1, ITPR1, IFNA21, TLR2, CFL1, BCL2, AP1M2

Zanubrutinib

hsa05202

Transcriptional misregulation in cancer

9.99E-06

Q13315, P41732, P17844, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

ATM, TSPAN7, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P41732	TSPAN7	Tetraspanin-7	-0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P14780	MMP9	Matrix metalloproteinase-9	-0.855
P42681	TXK	Tyrosine-protein kinase TXK	P14780	MMP9	Matrix metalloproteinase-9	-0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.833
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P42681	TXK	Tyrosine-protein kinase TXK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P42681	TXK	Tyrosine-protein kinase TXK	O15550	UTX	Lysine-specific demethylase 6A	-0.731
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P42681	TXK	Tyrosine-protein kinase TXK	P05164	MPO	Myeloperoxidase	-0.829
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P12838	DEFA4	Neutrophil defensin 4	-0.86
P42681	TXK	Tyrosine-protein kinase TXK	P12838	DEFA4	Neutrophil defensin 4	-0.707
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08246	ELA2	Neutrophil elastase	-0.782
P42681	TXK	Tyrosine-protein kinase TXK	P08246	ELA2	Neutrophil elastase	-0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.9
P42681	TXK	Tyrosine-protein kinase TXK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.874
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P42681	TXK	Tyrosine-protein kinase TXK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Zanubrutinib

hsa05203

Viral carcinogenesis

2.63E-03

Q99941, P18848, P27348, Q15283, P61978, P62807, O60814

CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12

Zanubrutinib

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Zanubrutinib

hsa05205

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Zanubrutinib

hsa05214

Glioma

9.95E-03

P08069

IGF1R

Zanubrutinib

hsa05215

Prostate cancer

2.79E-03

P10415, Q12778, P08069, Q9NRA1

BCL2, FOXO1, IGF1R, PDGFC

Zanubrutinib

hsa05217

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Zanubrutinib

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Zanubrutinib

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Zanubrutinib

hsa05224

Breast cancer

1.24E-02

P08069, P49841, Q92837, P04637, P24522

IGF1R, GSK3B, FRAT1, TP53, GADD45A

Zanubrutinib

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Zanubrutinib

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.20E-09

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P42681	TXK	Tyrosine-protein kinase TXK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.857
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P42681	TXK	Tyrosine-protein kinase TXK	O60603	TLR2	Toll-like receptor 2	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42681	TXK	Tyrosine-protein kinase TXK	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.776
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707

Zanubrutinib

hsa05310

Asthma

1.92E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Zanubrutinib

hsa05321

Inflammatory bowel disease

1.10E-07

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R

Zanubrutinib

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Zanubrutinib

hsa05323

Rheumatoid arthritis

2.19E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Zanubrutinib

hsa05332

Graft-versus-host disease

2.87E-05

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Zanubrutinib

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Zanubrutinib

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Zanubrutinib

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Zanubrutinib

hsa05415

Diabetic cardiomyopathy

1.07E-02

P17252, P14598, Q15080, Q16718, O14521, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH

Zanubrutinib

hsa05418

Fluid shear stress and atherosclerosis

1.26E-04

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Zanubrutinib (S_DC: 9.46)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

ITK

TyrosineNoneprotein kinase ITK/TSK

Reported

0.1635

0.5545

0.422

1.6127

P51813

BMX

Cytoplasmic tyrosineNoneprotein kinase BMX

Reported

0.0597

0.3263

0.6825

P09769

FGR

TyrosineNoneprotein kinase Fgr

Reported

0.0622

0.3244

0.225

0.9049

P06239

LCK

TyrosineNoneprotein kinase Lck

Reported

0.0576

0.7287

2.7575

P42681

TXK

TyrosineNoneprotein kinase TXK

Reported

0.2804

0.3026

0.1913

0.9367

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

P07948

LYN

TyrosineNoneprotein kinase Lyn

Predicted

0.091

0.5319

0.606

1.7154

P06213

INSR

Insulin receptor

Predicted

0.2794

0.7813

0.7209

2.4232

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

Q9NZJ5

EIF2AK3

Eukaryotic translation initiation factor 2Nonealpha kinase 3

Predicted

0.0939

0.1574

0.6398

1.0015

Q9P1W9

PIM2

Serine/threonineNoneprotein kinase pimNone2

Predicted

0.1267

0.7674

0.2638

1.8619

Q9P289

STK26

Serine/threonineNoneprotein kinase 26

Predicted

0.0285

0.2628

0.5399

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

Q07912

TNK2

Activated CDC42 kinase 1

Predicted

0.009

0.3472

0.6988

Q05397

PTK2

Focal adhesion kinase 1

Predicted

0.2153

0.5864

0.9713

2.2518

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P21453

S1PR1

Sphingosine 1Nonephosphate receptor 1

Predicted

0.1434

0.3847

0.221

1.0621

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P08514

ITGA2B

Integrin alphaNoneIIb

Predicted

0.0782

0.3248

0.779

1.4677

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

P07947

YES1

TyrosineNoneprotein kinase Yes

Predicted

0.1212

0.4345

0.165

1.0947

P41240

CSK

TyrosineNoneprotein kinase CSK

Predicted

0.6986

0.3626

0.1023

1.1768

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

Q13822

ENPP2

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Predicted

0.113

0.305

0.0063

0.6729

Q13489

BIRC3

Baculoviral IAP repeatNonecontaining protein 3

Predicted

0.3362

0.0493

0.8472

1.114

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P21860

ERBB3

Receptor tyrosineNoneprotein kinase erbBNone3

Predicted

0.126

0.2729

0.4788

1.0876

P07947

YES1

TyrosineNoneprotein kinase Yes

Predicted

0.1212

0.4345

0.165

1.0947

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P07948

LYN

TyrosineNoneprotein kinase Lyn

Predicted

0.091

0.5319

0.606

1.7154

P41240

CSK

TyrosineNoneprotein kinase CSK

Predicted

0.6986

0.3626

0.1023

1.1768

Q13239

SLA

SrcNonelikeNoneadapter

Predicted

0.1605

0.0098

0.0999

PharmaCoNets of Zanubrutinib (SPCN: 229.71 )

Zanubrutinib regulated-network (SDN: 24.28)

Community members of Zanubrutinib (SDC: 9.46)

PharmaCoNets of Zanubrutinib (S_PCN: 229.71 )

Zanubrutinib regulated-network (S_DN: 24.28)

Community members of Zanubrutinib (S_DC: 9.46)