PharmaCoNets of Zaleplon (SPCN: 279.70 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Zaleplonhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Zaleplonhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Zaleplonhsa00030Pentose phosphate pathway1.80E-094P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Zaleplonhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Zaleplonhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Zaleplonhsa00052Galactose metabolism4.25E-056P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Zaleplonhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Zaleplonhsa00071Fatty acid degradation2.44E-045P11310, O75521, P00325, P11766, P33121ACADM, ECI2, ADH1B, ADH5, ACSL1More
Zaleplonhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Zaleplonhsa00190Oxidative phosphorylation3.98E-064Q16718, Q13488, P36542, O14521NDUFA5, TCIRG1, ATP5C1, SDHDMore
Zaleplonhsa00220Arginine biosynthesis4.50E-083P15104, P05089, P49448GLUL, ARG1, GLUD2More
Zaleplonhsa00230Purine metabolism2.92E-034Q7LG56, P31350, P51828, P21589RRM2B, RRM2, ADCY7, NT5EMore
Zaleplonhsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Zaleplonhsa00250Alanine, aspartate and glutamate metabolism3.77E-063Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Zaleplonhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Zaleplonhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Zaleplonhsa00310Lysine degradation1.30E-067Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Zaleplonhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Zaleplonhsa00380Tryptophan metabolism2.01E-031Q16613AANATMore
Zaleplonhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Zaleplonhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Zaleplonhsa00500Starch and sucrose metabolism1.38E-104O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Zaleplonhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Zaleplonhsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Zaleplonhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Zaleplonhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Zaleplonhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Zaleplonhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Zaleplonhsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Zaleplonhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Zaleplonhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Zaleplonhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Zaleplonhsa00590Arachidonic acid metabolism2.48E-033P11712, P09917, P09960CYP2C9, ALOX5, LTA4HMore
Zaleplonhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Zaleplonhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Zaleplonhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Zaleplonhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Zaleplonhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Zaleplonhsa00630Glyoxylate and dicarboxylate metabolism5.92E-124P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Zaleplonhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Zaleplonhsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Zaleplonhsa00730Thiamine metabolism1.51E-063Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Zaleplonhsa00740Riboflavin metabolism2.80E-032P30043, P24666BLVRB, ACP1More
Zaleplonhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Zaleplonhsa00770Pantothenate and CoA biosynthesis1.65E-054O95498, O95497, Q6ZQY3, Q9NRN7VNN2, VNN1, GADL1, AASDHPPTMore
Zaleplonhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Zaleplonhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Zaleplonhsa00830Retinol metabolism3.48E-055P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Zaleplonhsa00860Porphyrin and chlorophyll metabolism2.26E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Zaleplonhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Zaleplonhsa00910Nitrogen metabolism1.75E-042P15104, P49448GLUL, GLUD2More
Zaleplonhsa00920Sulfur metabolism1.78E-021Q16762TSTMore
Zaleplonhsa00970Aminoacyl-tRNA biosynthesis8.29E-094O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Zaleplonhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Zaleplonhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Zaleplonhsa00983Drug metabolism - other enzymes1.07E-065P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Zaleplonhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Zaleplonhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Zaleplonhsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Zaleplonhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Zaleplonhsa01230Biosynthesis of amino acids2.13E-057P51854, P60891, Q99707, P50213, P05089, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1More
Zaleplonhsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Zaleplonhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Zaleplonhsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Zaleplonhsa01523Antifolate resistance5.68E-064P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Zaleplonhsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Zaleplonhsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Zaleplonhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Zaleplonhsa03010Ribosome7.89E-1321P26373, P62753, P42677, P25398, P32969, P62917, P62829, P46776, Q9H0U6, Q07020, P62888, P62899, P62910, P18077, P61927, P61513, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL23, RPL27A, MRPL18, RPL18, RPL30, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL6, RPL4, RPL10, RPLP1, RPS3More
Zaleplonhsa03013RNA transport2.94E-2329P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Zaleplonhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Zaleplonhsa03020RNA polymerase5.44E-094P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Zaleplonhsa03022Basal transcription factors4.32E-044P20226, O00268, Q5H9L4, Q15544TBP, TAF4, TAF7L, TAF11More
Zaleplonhsa03040Spliceosome1.03E-1018Q14562, O43143, O60508, P08579, Q15427, P26368, O75940, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, SMNDC1, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Zaleplonhsa03050Proteasome9.50E-041P55036PSMD4More
Zaleplonhsa03060Protein export1.16E-104Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Zaleplonhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Zaleplonhsa03430Mismatch repair4.38E-021P20585MSH3More
Zaleplonhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Zaleplonhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Zaleplonhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Zaleplonhsa04012ErbB signaling pathway3.54E-0610P21860, Q13153, P16333, Q13191, Q13557, P19174, O14944, P42338, P01106, P04049ERBB3, PAK1, NCK1, CBLB, CAMK2D, PLCG1, EREG, PIK3CB, MYC, RAF1More
Zaleplonhsa04014Ras signaling pathway1.07E-0410P04049, P31751, Q9NRA1, P08069, Q13009, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PDGFC, IGF1R, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Zaleplonhsa04015Rap1 signaling pathway3.20E-076P04049, P08069, P06213, O00522, P31751, P0DP23RAF1, IGF1R, INSR, KRIT1, AKT2, CALM1More
Zaleplonhsa04020Calcium signaling pathway1.12E-0812Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P0DP24, P0DP23, P05141, P51828, P23634ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4More
Zaleplonhsa04022cGMP-PKG signaling pathway2.03E-0812Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Zaleplonhsa04024cAMP signaling pathway1.71E-0612P63092, Q08828, P51828, P42338, P31751, P26678, P0DP23, P04049, P61586, Q13370, Q13009, Q13153GNAS, ADCY1, ADCY7, PIK3CB, AKT2, PLN, CALM1, RAF1, RHOA, PDE3B, TIAM1, PAK1More
Zaleplonhsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Zaleplonhsa04061Viral protein interaction with cytokine and cytokine receptor1.84E-0610Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Zaleplonhsa04062Chemokine signaling pathway4.74E-1021P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963, P49841CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIA, GSK3BMore
Zaleplonhsa04064NF-kappa B signaling pathway5.91E-2227P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Zaleplonhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Zaleplonhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Zaleplonhsa04070Phosphatidylinositol signaling system1.12E-0713P19174, P0DP23, Q14643, P42338, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Zaleplonhsa04071Sphingolipid signaling pathway2.24E-0712P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, Q16539, P10415, Q12933, Q02156RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, MAPK14, BCL2, TRAF2, PRKCEMore
Zaleplonhsa04072Phospholipase D signaling pathway1.23E-0615P04049, P31751, P42338, Q9UQC2, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, GAB2, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKDMore
Zaleplonhsa04080Neuroactive ligand-receptor interaction3.76E-0713P08311, P78334, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P30939, P14416, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, HTR1F, DRD2, ADRB2, ADMMore
Zaleplonhsa04110Cell cycle1.56E-0812Q9UBD5, P30260, P06493, O60566, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Zaleplonhsa04114Oocyte meiosis5.73E-1011Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Zaleplonhsa04115p53 signaling pathway4.58E-048P24522, O15151, Q13315, P31350, Q53FA7, P06493, O95067, P10415GADD45A, MDM4, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2More
Zaleplonhsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Zaleplonhsa04122Sulfur relay system1.78E-021Q16762TSTMore
Zaleplonhsa04136Autophagy - other5.45E-042O94817, Q9H1Y0ATG12, ATG5More
Zaleplonhsa04137Mitophagy - animal9.04E-054P19784, P67870, P19532, P18848CSNK2A2, CSNK2B, TFE3, ATF4More
Zaleplonhsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Zaleplonhsa04141Protein processing in endoplasmic reticulum6.17E-0714P18848, Q12933, P30101, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Zaleplonhsa04142Lysosome1.89E-0613Q99437, P25774, O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900ATP6V0B, CTSS, TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Zaleplonhsa04144Endocytosis1.37E-0822Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, Q9NZZ3, P62491, P42566, P25024, P61073, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, RAB11A, EPS15, CXCR1, CXCR4, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Zaleplonhsa04145Phagosome8.81E-0915O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Zaleplonhsa04146Peroxisome1.95E-036O00623, O96011, P56589, Q9UKG9, O75521, P33121PEX12, PEX11B, PEX3, CROT, ECI2, ACSL1More
Zaleplonhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Zaleplonhsa04151PI3K-Akt signaling pathway2.54E-0727P62753, P21860, P25116, O43521, P04637, P27348, P49767, Q13362, P07900, P62873, P61952, P16144, P02452, P24821, Q16363, P22105, O60603, P23458, P01568, Q99941, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, ERBB3, F2R, BCL2L11, TP53, YWHAQ, VEGFC, PPP2R5C, HSP90AA1, GNB1, GNG11, ITGB4, COL1A1, TNC, LAMA4, TNXB, TLR2, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, TCL1AMore
Zaleplonhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Zaleplonhsa04210Apoptosis4.57E-0413Q13315, P10415, Q13489, P25963, Q14790, P01375, P48023, P24522, Q16548, Q13077, Q14643, P42575, P04049ATM, BCL2, BIRC3, NFKBIA, CASP8, TNF, FASLG, GADD45A, BCL2A1, TRAF1, ITPR1, CASP2, RAF1More
Zaleplonhsa04211Longevity regulating pathway1.55E-059Q12778, P31751, P08069, Q08828, P51828, P18848, Q9UEF7, Q96RR4, Q96KQ7FOXO1, AKT2, IGF1R, ADCY1, ADCY7, ATF4, KL, CAMKK2, EHMT2More
Zaleplonhsa04213Longevity regulating pathway - multiple species2.19E-099P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Zaleplonhsa04217Necroptosis3.33E-1521Q12933, P01568, P23458, Q13489, Q9NQC7, Q13546, P42224, P07900, P15104, P05141, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351, P45880, Q08752TRAF2, IFNA21, JAK1, BIRC3, CYLD, RIPK1, STAT1, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B, VDAC2, PPIDMore
Zaleplonhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Zaleplonhsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Zaleplonhsa04261Adrenergic signaling in cardiomyocytes9.78E-1015P09493, P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Zaleplonhsa04270Vascular smooth muscle contraction1.62E-0712P24723, Q04759, Q14643, P0DP23, P0DP24, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, CALM2, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Zaleplonhsa04310Wnt signaling pathway4.24E-067P61586, P30279, Q13485, O43318, P17612, P19784, P67870RHOA, CCND2, SMAD4, MAP3K7, PRKACA, CSNK2A2, CSNK2BMore
Zaleplonhsa04330Notch signaling pathway4.48E-054Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Zaleplonhsa04340Hedgehog signaling pathway2.00E-045P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Zaleplonhsa04360Axon guidance2.95E-0510P16298, Q05397, P20827, O95631, Q13873, P42338, P23528, P04049, O14639, P24844PPP3CB, PTK2, EFNA1, NTN1, BMPR2, PIK3CB, CFL1, RAF1, ABLIM1, MYL9More
Zaleplonhsa04370VEGF signaling pathway6.18E-137P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Zaleplonhsa04371Apelin signaling pathway6.52E-0714P62873, P63218, P50151, P61952, P31751, P04049, Q08828, P51828, Q13370, Q14344, P84022, P62753, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, AKT2, RAF1, ADCY1, ADCY7, PDE3B, GNA13, SMAD3, RPS6, CALM1, CALM2More
Zaleplonhsa04380Osteoclast differentiation2.23E-0914Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Zaleplonhsa04390Hippo signaling pathway3.37E-055O95835, P04628, Q9UJU2, O43623, Q13489LATS1, WNT1, LEF1, SNAI2, BIRC3More
Zaleplonhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Zaleplonhsa04510Focal adhesion2.36E-048Q15942, O14986, P61586, Q16363, P51636, P30281, P04049, P08069ZYX, PIP5K1B, RHOA, LAMA4, CAV2, CCND3, RAF1, IGF1RMore
Zaleplonhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Zaleplonhsa04514Cell adhesion molecules2.37E-022P16109, O00501SELP, CLDN5More
Zaleplonhsa04520Adherens junction7.51E-066Q13485, O43318, P08069, P19784, P67870, P61586SMAD4, MAP3K7, IGF1R, CSNK2A2, CSNK2B, RHOAMore
Zaleplonhsa04530Tight junction3.27E-035P16989, P56750, O00501, Q14247, P24844CSDA, CLDN17, CLDN5, CTTN, MYL9More
Zaleplonhsa04540Gap junction2.36E-067P17252, Q13509, P68371, Q71U36, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, TUBA1A, RAF1, PDGFC, ITPR1More
Zaleplonhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Zaleplonhsa04610Complement and coagulation cascades1.51E-104P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Zaleplonhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Zaleplonhsa04612Antigen processing and presentation5.55E-1312P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, HSPA8, TNFMore
Zaleplonhsa04613Neutrophil extracellular trap formation3.27E-1231P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q99878, Q93077, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Zaleplonhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Zaleplonhsa04620Toll-like receptor signaling pathway3.00E-065Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Zaleplonhsa04621NOD-like receptor signaling pathway1.35E-0923P01584, P07900, Q16539, Q14643, P23458, P01568, P45880, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838IL1B, HSP90AA1, MAPK14, ITPR1, JAK1, IFNA21, VDAC2, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Zaleplonhsa04622RIG-I-like receptor signaling pathway1.16E-085P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Zaleplonhsa04623Cytosolic DNA-sensing pathway8.50E-146P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Zaleplonhsa04625C-type lectin receptor signaling pathway4.35E-0913Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Zaleplonhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Zaleplonhsa04640Hematopoietic cell lineage1.79E-1119P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Zaleplonhsa04650Natural killer cell mediated cytotoxicity1.54E-2619P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Zaleplonhsa04657IL-17 signaling pathway2.57E-1014P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, S100A9, IL1BMore
Zaleplonhsa04658Th1 and Th2 cell differentiation1.56E-3318P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, P23458, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, JAK1, RUNX3More
Zaleplonhsa04659Th17 cell differentiation3.29E-2622P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Zaleplonhsa04660T cell receptor signaling pathway9.43E-2720P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Zaleplonhsa04662B cell receptor signaling pathway3.04E-1213P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Zaleplonhsa04664Fc epsilon RI signaling pathway4.09E-0810P01375, P31751, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Zaleplonhsa04666Fc gamma R-mediated phagocytosis1.02E-037P08637, O75015, P42338, P04049, P23528, P06396, P14598FCGR3A, FCGR3B, PIK3CB, RAF1, CFL1, GSN, NCF1More
Zaleplonhsa04668TNF signaling pathway7.88E-0714P01375, Q12933, O00463, Q13489, Q16539, P25963, Q99941, P18848, P01584, P20749, Q13077, P14780, P20333, O95429TNF, TRAF2, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, ATF4, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B, BAG4More
Zaleplonhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Zaleplonhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Zaleplonhsa04710Circadian rhythm2.11E-031O15516CLOCKMore
Zaleplonhsa04713Circadian entrainment1.98E-0913P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P63218, P50151, P61952, Q14643, Q08828, P51828, P63092CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG5, GNG10, GNG11, ITPR1, ADCY1, ADCY7, GNASMore
Zaleplonhsa04714Thermogenesis4.42E-024Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Zaleplonhsa04720Long-term potentiation9.48E-1112P17252, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Zaleplonhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Zaleplonhsa04722Neurotrophin signaling pathway9.79E-067Q05655, P31751, P04049, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, ARHGDIB, IRAK1, BCL2, CALM1More
Zaleplonhsa04723Retrograde endocannabinoid signaling2.51E-048Q14643, P17252, P48169, P62873, P61952, Q08828, O15239, Q16718ITPR1, PRKCA, GABRA4, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5More
Zaleplonhsa04724Glutamatergic synapse1.46E-078O15399, Q08828, P63092, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNAS, GNB1, GNG5, GNG10, GNG11, GLULMore
Zaleplonhsa04725Cholinergic synapse3.22E-0713Q08828, P51828, Q14643, P17252, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Zaleplonhsa04726Serotonergic synapse4.42E-046P63092, P62873, P63218, P50151, P09917, P04049GNAS, GNB1, GNG5, GNG10, ALOX5, RAF1More
Zaleplonhsa04727GABAergic synapse1.20E-099Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1More
Zaleplonhsa04728Dopaminergic synapse1.69E-1020Q14643, P17252, P14416, P62873, P63218, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCK, GRIA4More
Zaleplonhsa04730Long-term depression4.37E-034Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Zaleplonhsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Zaleplonhsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Zaleplonhsa04744Phototransduction1.58E-103P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Zaleplonhsa04750Inflammatory mediator regulation of TRP channels1.95E-1214P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Zaleplonhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Zaleplonhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Zaleplonhsa04911Insulin secretion4.38E-085Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Zaleplonhsa04912GnRH signaling pathway5.96E-0712P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049, P45985PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1, MAP2K4More
Zaleplonhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Zaleplonhsa04914Progesterone-mediated oocyte maturation2.17E-099P08069, Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Zaleplonhsa04915Estrogen signaling pathway9.41E-1212P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Zaleplonhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Zaleplonhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Zaleplonhsa04918Thyroid hormone synthesis2.47E-045Q08828, Q99941, P18848, P02768, P05543ADCY1, CREBL1, ATF4, ALB, SERPINA7More
Zaleplonhsa04919Thyroid hormone signaling pathway1.21E-047P19174, P04049, P42224, P60709, Q13547, Q9UM47, P01106PLCG1, RAF1, STAT1, ACTB, HDAC1, NOTCH3, MYCMore
Zaleplonhsa04920Adipocytokine signaling pathway1.22E-025P25963, P33121, Q04759, P31751, P01375NFKBIA, ACSL1, PRKCQ, AKT2, TNFMore
Zaleplonhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Zaleplonhsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Zaleplonhsa04923Regulation of lipolysis in adipocytes4.29E-077Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Zaleplonhsa04924Renin secretion7.68E-085P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Zaleplonhsa04925Aldosterone synthesis and secretion3.39E-108Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Zaleplonhsa04926Relaxin signaling pathway1.62E-0714P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Zaleplonhsa04927Cortisol synthesis and secretion2.32E-054Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Zaleplonhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Zaleplonhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Zaleplonhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Zaleplonhsa04932Non-alcoholic fatty liver disease4.37E-1212P31751, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298, P19404AKT2, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Zaleplonhsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Zaleplonhsa04934Cushing syndrome6.22E-096Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Zaleplonhsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Zaleplonhsa04940Type I diabetes mellitus7.38E-044P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Zaleplonhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Zaleplonhsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Zaleplonhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Zaleplonhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Zaleplonhsa04970Salivary secretion4.02E-1011P07550, Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CALM1, GUCY1B3, CAMPMore
Zaleplonhsa04971Gastric acid secretion1.49E-086Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Zaleplonhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Zaleplonhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Zaleplonhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Zaleplonhsa04975Fat digestion and absorption1.43E-031O14494PLPP1More
Zaleplonhsa04976Bile secretion2.26E-056O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Zaleplonhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Zaleplonhsa05010Alzheimer disease1.31E-1027P49768, Q92542, O15239, Q16718, O95298, P19404, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, Q12933, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, P45880, Q08752, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, VDAC2, PPID, PSMB4, PSMC4More
Zaleplonhsa05012Parkinson disease3.20E-0622O15239, Q16718, O95298, O14521, P13073, P12074, P05496, P05141, P12236, P60604, O75460, P18848, P28070, P43686, Q14643, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, UBE2G2, ERN1, ATF4, PSMB4, PSMC4, ITPR1, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Zaleplonhsa05014Amyotrophic lateral sclerosis6.58E-0315P01375, Q16718, P19404, O14521, P12074, P36542, O75460, P28070, Q8TEV9, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, NDUFV2, SDHD, COX6A1, ATP5C1, ERN1, PSMB4, SMCR8, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Zaleplonhsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Zaleplonhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Zaleplonhsa05020Prion disease7.78E-0824P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, P12236, P45880, P28070, P43686, Q13509, P68371, P67870, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, SLC25A6, VDAC2, PSMB4, PSMC4, TUBB3, TUBB2C, CSNK2B, CREBL1, NCF1, NCF4More
Zaleplonhsa05022Pathways of neurodegeneration - multiple diseases7.23E-1035Q14643, Q13509, P68371, P67870, P10415, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P05141, P45880, P17252, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, CSNK2B, BCL2, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, VDAC2, PRKCA, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4More
Zaleplonhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Zaleplonhsa05031Amphetamine addiction4.45E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Zaleplonhsa05032Morphine addiction7.04E-078P62873, P63218, P50151, Q13370, P48169, P78334, P63092, P32298GNB1, GNG5, GNG10, PDE3B, GABRA4, GABRE, GNAS, GRK4More
Zaleplonhsa05033Nicotine addiction4.01E-021P78334GABREMore
Zaleplonhsa05034Alcoholism8.53E-0715Q99941, P18848, Q13547, P0DP24, Q96RR4, P62873, P61952, P04049, P0C0S5, Q93077, P62807, Q16778, O60814, P84243, P68431CREBL1, ATF4, HDAC1, CALM2, CAMKK2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Zaleplonhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Zaleplonhsa05110Vibrio cholerae infection1.86E-042Q99437, P17612ATP6V0B, PRKACAMore
Zaleplonhsa05120Epithelial cell signaling in Helicobacter pylori infection1.37E-1513Q16539, P25963, Q13488, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240, P07948MAPK14, NFKBIA, TCIRG1, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Zaleplonhsa05130Pathogenic Escherichia coli infection3.26E-0412Q71U36, P16333, Q13509, P68371, P60709, Q14344, P25963, P04406, P29350, Q15438, P35579, P55061TUBA1A, NCK1, TUBB3, TUBB2C, ACTB, GNA13, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Zaleplonhsa05131Shigellosis9.80E-0724P01375, P25963, Q12933, O00463, Q13546, P68431, Q05655, Q02156, Q04759, Q9UDY8, Q9NQL2, Q9H1Y0, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32, P07737TNF, NFKBIA, TRAF2, TRAF5, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, PRKCQ, MALT1, RRAGD, ATG5, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPF, PFN1More
Zaleplonhsa05132Salmonella infection3.40E-1224P51617, P25963, P01375, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q13546, Q13489, P10415, P04406, O75369, P07737, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, TNF, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Zaleplonhsa05133Pertussis1.55E-063P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Zaleplonhsa05134Legionellosis2.20E-119P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Zaleplonhsa05135Yersinia infection4.96E-0512Q05397, P51812, P13612, P06239, P19174, Q16539, Q02750, P01375, P42338, P49841, Q96JJ3, P01732PTK2, RPS6KA3, ITGA4, LCK, PLCG1, MAPK14, MAP2K1, TNF, PIK3CB, GSK3B, ELMO2, CD8AMore
Zaleplonhsa05140Leishmaniasis2.39E-1316P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Zaleplonhsa05142Chagas disease1.64E-034P01375, P30679, P48023, Q14790TNF, GNA15, FASLG, CASP8More
Zaleplonhsa05143African trypanosomiasis5.79E-064P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Zaleplonhsa05144Malaria6.89E-1110P60033, P69905, P68871, O60603, P01375, P05107, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL1B, IL8, KLRK1More
Zaleplonhsa05145Toxoplasmosis1.19E-039P51617, P25963, P01375, P10415, Q13489, P42224, P13765, O60603, P29965IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Zaleplonhsa05146Amoebiasis1.17E-2013P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Zaleplonhsa05150Staphylococcus aureus infection3.85E-1315P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Zaleplonhsa05152Tuberculosis2.18E-0716P04049, Q13488, Q99437, P0DP23, P42224, P48382, O60603, P01375, P31751, P10415, P13765, P25774, P01568, P49913, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, CALM1, STAT1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, IRAK1More
Zaleplonhsa05160Hepatitis C4.90E-047Q13546, P01568, P52630, P60033, Q9NZJ5, P04049, P49841RIPK1, IFNA21, STAT2, CD81, EIF2AK3, RAF1, GSK3BMore
Zaleplonhsa05161Hepatitis B4.54E-0412P17252, P04049, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765PRKCA, RAF1, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4More
Zaleplonhsa05162Measles4.77E-056P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Zaleplonhsa05163Human cytomegalovirus infection2.37E-1431P31751, P04049, P01375, P25963, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P63092, P04637, O00463, P30101, P61769, P01568AKT2, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, GNAS, TP53, TRAF5, PDIA3, B2M, IFNA21More
Zaleplonhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Zaleplonhsa05165Human papillomavirus infection7.06E-0517P16144, P02452, P24821, Q16363, Q05086, P30281, Q9UM47, P01568, P42224, P01889, P10321, Q13488, Q99437, Q13362, Q12778, P04628, Q13315ITGB4, COL1A1, TNC, LAMA4, UBE3A, CCND3, NOTCH3, IFNA21, STAT1, HLA-B, HLA-C, TCIRG1, ATP6V0B, PPP2R5C, FOXO1, WNT1, ATMMore
Zaleplonhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Zaleplonhsa05167Kaposi sarcoma-associated herpesvirus infection5.19E-0815P01568, P31751, P42224, P25963, P62873, P63218, P50151, P19174, Q14643, P04049, P07948, P01106, P04141, P0DP23, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, ITPR1, RAF1, LYN, MYC, CSF2, CALM1, LEF1More
Zaleplonhsa05168Herpes simplex virus 1 infection3.14E-0523O00463, O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q16629, P30101, P42338, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Zaleplonhsa05169Epstein-Barr virus infection1.72E-0617P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Zaleplonhsa05170Human immunodeficiency virus 1 infection1.30E-1126P31751, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P10415, Q13619, Q93034, Q9Y6Q5AKT2, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, BCL2, CUL4A, CUL5, AP1M2More
Zaleplonhsa05171Coronavirus disease - COVID-194.03E-1323P01584, P23396, P62753, P25398, P42677, Q9UHA3, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P62888, P46776, P62899, P62910, P18077, P61927, P61513, P05386, P62829, O14786IL1B, RPS3, RPS6, RPS12, RPS27, RSL24D1, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL30, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPLP1, RPL23, NRP1More
Zaleplonhsa05200Pathways in cancer1.41E-0935P42338, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P52701, P14923, P30279, P10415, Q13489, Q13077, P49767, P14921, Q12778, P31751, P25116, P62873, P63218, P50151, Q14344, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, MSH6, JUP, CCND2, BCL2, BIRC3, TRAF1, VEGFC, ETS1, FOXO1, AKT2, F2R, GNB1, GNG5, GNG10, GNA13, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1More
Zaleplonhsa05202Transcriptional misregulation in cancer3.71E-1324Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Zaleplonhsa05203Viral carcinogenesis8.79E-0615Q12933, Q99941, P18848, P30281, P27348, Q13547, Q15283, P06396, P12814, P01889, P10321, P06493, P62807, Q16778, O60814TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Zaleplonhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Zaleplonhsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Zaleplonhsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Zaleplonhsa05210Colorectal cancer1.47E-049Q9UKG1, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Zaleplonhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Zaleplonhsa05212Pancreatic cancer6.56E-068P42338, P31751, P04049, Q15311, P23458, P42224, P84022, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, GADD45BMore
Zaleplonhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Zaleplonhsa05214Glioma1.10E-077P08069, P0DP23, P04049, P42338, P31751, P19174, O75293IGF1R, CALM1, RAF1, PIK3CB, AKT2, PLCG1, GADD45BMore
Zaleplonhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Zaleplonhsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Zaleplonhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Zaleplonhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Zaleplonhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Zaleplonhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Zaleplonhsa05222Small cell lung cancer5.10E-037P31751, Q13489, P10415, P25963, Q13077, O00463, P24522AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Zaleplonhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Zaleplonhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Zaleplonhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Zaleplonhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Zaleplonhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Zaleplonhsa05231Choline metabolism in cancer2.51E-069P04049, P31751, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494RAF1, AKT2, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1More
Zaleplonhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer7.16E-1618P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P23458, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, JAK1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Zaleplonhsa05310Asthma1.58E-093P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Zaleplonhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Zaleplonhsa05321Inflammatory bowel disease1.25E-178O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Zaleplonhsa05322Systemic lupus erythematosus6.76E-1018P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P14678, P12814, P05455FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1, SSBMore
Zaleplonhsa05323Rheumatoid arthritis7.52E-068P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Zaleplonhsa05330Allograft rejection7.88E-055P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Zaleplonhsa05332Graft-versus-host disease3.65E-146P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Zaleplonhsa05340Primary immunodeficiency2.96E-046P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Zaleplonhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Zaleplonhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Zaleplonhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Zaleplonhsa05415Diabetic cardiomyopathy4.77E-049P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P14780, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2More
Zaleplonhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Zaleplonhsa05418Fluid shear stress and atherosclerosis6.20E-0813Q16539, P31751, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, AKT2, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Zaleplon (SDC: 12.63)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Predicted00.32530.5650.15791.4506
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
Q13510ASAH1Acid ceramidasePredicted00.40640.04230.28020.568
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P10619CTSALysosomal protective proteinPredicted00.12260.15310.19010.5575
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonPredicted00.13940.40970.15791.0469
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Predicted00.15590.43870.16951.1248
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)