PharmaCoNets of Zalcitabine (SPCN: 16.10 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Zalcitabinehsa00190Oxidative phosphorylation3.20E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Zalcitabinehsa00240Pyrimidine metabolism8.44E-044P31350, P21589, P32320, P04183RRM2, NT5E, CDA, TK1More
Zalcitabinehsa00983Drug metabolism - other enzymes3.83E-044P04183, P32320, P31350, P05164TK1, CDA, RRM2, MPOMore
Zalcitabinehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Zalcitabinehsa03020RNA polymerase3.22E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Zalcitabinehsa03040Spliceosome1.64E-0311Q14562, O43143, O14776, O75940, P52298, P09651, O75494, Q07955, Q13243, O95777, P61326DHX8, DHX15, TCERG1, SMNDC1, NCBP2, HNRNPA1, FUSIP1, SFRS1, SFRS5, LSM8, MAGOHMore
Zalcitabinehsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Zalcitabinehsa04061Viral protein interaction with cytokine and cytokine receptor4.28E-027P51684, P09341, P25024, P25025, P47992, Q9UBD3, P01375CCR6, CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Zalcitabinehsa04064NF-kappa B signaling pathway2.37E-0411P10415, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341BCL2, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1More
Zalcitabinehsa04071Sphingolipid signaling pathway9.29E-037P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Zalcitabinehsa04115p53 signaling pathway3.35E-035P24522, Q13315, P31350, O95067, P10415GADD45A, ATM, RRM2, CCNB2, BCL2More
Zalcitabinehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Zalcitabinehsa04145Phagosome1.73E-036Q15080, P68371, P05164, P78380, P35443, P13765NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOBMore
Zalcitabinehsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Zalcitabinehsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Zalcitabinehsa04217Necroptosis8.73E-067P07900, P15104, P05141, P01584, P0C0S5, Q13557, Q9H444HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Zalcitabinehsa04612Antigen processing and presentation4.72E-024P13765, P48382, P26715, P26717HLA-DOB, RFX5, KLRC1, KLRC2More
Zalcitabinehsa04613Neutrophil extracellular trap formation1.02E-0214O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Zalcitabinehsa04621NOD-like receptor signaling pathway4.83E-0210Q16539, Q14643, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P49913, P12838MAPK14, ITPR1, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, CAMP, DEFA4More
Zalcitabinehsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Zalcitabinehsa04658Th1 and Th2 cell differentiation8.47E-038Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Zalcitabinehsa04660T cell receptor signaling pathway2.57E-0311P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14More
Zalcitabinehsa04668TNF signaling pathway2.91E-023P18848, P01584, P20333ATF4, IL1B, TNFRSF1BMore
Zalcitabinehsa04744Phototransduction2.59E-022P62873, P0DP23GNB1, CALM1More
Zalcitabinehsa04932Non-alcoholic fatty liver disease5.73E-056O43521, P18848, O75460, P01584, P13073, O15239BCL2L11, ATF4, ERN1, IL1B, COX4I1, NDUFA1More
Zalcitabinehsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Zalcitabinehsa05012Parkinson disease2.77E-037O15239, P13073, P05141, O75460, P18848, P0DP24, Q13557NDUFA1, COX4I1, SLC25A5, ERN1, ATF4, CALM2, CAMK2DMore
Zalcitabinehsa05016Huntington disease4.33E-037O15239, P13073, P24928, P30876, P62487, P05141, O75460NDUFA1, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1More
Zalcitabinehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Zalcitabinehsa05022Pathways of neurodegeneration - multiple diseases2.20E-039O15239, P13073, O75460, P18848, P05141, P20333, P01584, P0DP24, Q13557NDUFA1, COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2, CAMK2DMore
Zalcitabinehsa05132Salmonella infection2.35E-0312P25963, P08238, Q13489, P10415, P04406, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P49754NFKBIA, HSP90AB1, BIRC3, BCL2, GAPDH, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, VPS41More
Zalcitabinehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Zalcitabinehsa05140Leishmaniasis2.25E-026P14598, P42224, O60603, P25963, P29350, Q15080NCF1, STAT1, TLR2, NFKBIA, PTPN6, NCF4More
Zalcitabinehsa05146Amoebiasis3.11E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Zalcitabinehsa05150Staphylococcus aureus infection2.53E-026P21730, P21462, O75015, P13765, P12838, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMPMore
Zalcitabinehsa05152Tuberculosis1.88E-0516Q13488, Q15075, P0DP23, O75015, P42224, P48382, P25208, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, Q16539, P51617TCIRG1, EEA1, CALM1, FCGR3B, STAT1, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14, IRAK1More
Zalcitabinehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Zalcitabinehsa05168Herpes simplex virus 1 infection7.93E-0417O60603, P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, P52738, O75820, P10415TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF140, ZNF189, BCL2More
Zalcitabinehsa05170Human immunodeficiency virus 1 infection4.82E-0211P01375, O00463, Q14643, Q16539, O60603, Q13315, P09693, P20963, P10415, Q93034, Q9Y6Q5TNF, TRAF5, ITPR1, MAPK14, TLR2, ATM, CD3G, CD247, BCL2, CUL5, AP1M2More
Zalcitabinehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Zalcitabinehsa05202Transcriptional misregulation in cancer1.01E-0315Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Zalcitabinehsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Zalcitabinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.11E-027O95267, P20963, P09693, O60603, P10747, Q04759, Q16539RASGRP1, CD247, CD3G, TLR2, CD28, PRKCQ, MAPK14More
Zalcitabinehsa05310Asthma1.68E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Zalcitabinehsa05321Inflammatory bowel disease2.47E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Zalcitabinehsa05322Systemic lupus erythematosus4.61E-028O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Zalcitabinehsa05323Rheumatoid arthritis2.84E-025P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Zalcitabinehsa05332Graft-versus-host disease3.93E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Zalcitabinehsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore

Community members of Zalcitabine (SDC: 1.82)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P27707DCKDeoxycytidine kinasePredicted00.05740.06140.16530.3169
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P32320CDACytidine deaminasePredicted00.05160.05690.16530.3049
P04183TK1Thymidine kinase, cytosolicPredicted00.27170.16370.16530.6286
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)