PharmaCoNets of Xanthinol (SPCN: 6.28 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Xanthinolhsa00010Glycolysis / Gluconeogenesis4.41E-024P04075, P06733, P04406, P60174ALDOA, ENO1, GAPDH, TPI1More
Xanthinolhsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Xanthinolhsa00051Fructose and mannose metabolism2.21E-023O14772, P60174, P04075FPGT, TPI1, ALDOAMore
Xanthinolhsa00280Valine, leucine and isoleucine degradation4.55E-022P21953, P51648BCKDHB, ALDH3A2More
Xanthinolhsa00310Lysine degradation5.61E-032Q96KQ7, P51648EHMT2, ALDH3A2More
Xanthinolhsa00533Glycosaminoglycan biosynthesis - keratan sulfate2.92E-021Q9NY97B3GNT2More
Xanthinolhsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Xanthinolhsa01200Carbon metabolism5.71E-037P04075, P04406, P60174, P06733, O14521, Q9P2R7, Q02252ALDOA, GAPDH, TPI1, ENO1, SDHD, SUCLA2, ALDH6A1More
Xanthinolhsa012102-Oxocarboxylic acid metabolism2.92E-021P50213IDH3AMore
Xanthinolhsa01230Biosynthesis of amino acids9.38E-035P60174, P04406, P06733, P04075, Q99707TPI1, GAPDH, ENO1, ALDOA, MTRMore
Xanthinolhsa03010Ribosome1.60E-029P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3More
Xanthinolhsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Xanthinolhsa04020Calcium signaling pathway5.81E-047Q96DU7, Q13557, P21860, P05141, P12236, P26678, P63092ITPKC, CAMK2D, ERBB3, SLC25A5, SLC25A6, PLN, GNASMore
Xanthinolhsa04022cGMP-PKG signaling pathway9.36E-036P61586, P26678, Q99941, P18848, P05141, P12236RHOA, PLN, CREBL1, ATF4, SLC25A5, SLC25A6More
Xanthinolhsa04145Phagosome4.79E-023Q71U36, P27824, P30511TUBA1A, CANX, HLA-FMore
Xanthinolhsa04151PI3K-Akt signaling pathway1.36E-029P21860, P27348, O14944, P07900, Q15831, P22105, Q99941, P18848, O95988ERBB3, YWHAQ, EREG, HSP90AA1, STK11, TNXB, CREBL1, ATF4, TCL1BMore
Xanthinolhsa04261Adrenergic signaling in cardiomyocytes3.12E-025P63092, Q99941, P18848, P26678, Q13557GNAS, CREBL1, ATF4, PLN, CAMK2DMore
Xanthinolhsa04360Axon guidance9.54E-033P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Xanthinolhsa04371Apelin signaling pathway6.44E-034P63218, Q14344, Q13485, Q16566GNG5, GNA13, SMAD4, CAMK4More
Xanthinolhsa04612Antigen processing and presentation4.79E-023P30101, P30511, P27824PDIA3, HLA-F, CANXMore
Xanthinolhsa04662B cell receptor signaling pathway1.70E-023P60033, P07948, Q8N149CD81, LYN, LILRA2More
Xanthinolhsa04720Long-term potentiation4.55E-022Q16566, O15399CAMK4, GRIN2DMore
Xanthinolhsa04730Long-term depression1.09E-022Q14344, P07948GNA13, LYNMore
Xanthinolhsa04911Insulin secretion4.47E-034P63092, Q99941, P18848, Q13557GNAS, CREBL1, ATF4, CAMK2DMore
Xanthinolhsa04920Adipocytokine signaling pathway2.06E-022Q06124, Q9Y478PTPN11, PRKAB1More
Xanthinolhsa04925Aldosterone synthesis and secretion1.68E-024Q99941, P18848, P63092, Q13557CREBL1, ATF4, GNAS, CAMK2DMore
Xanthinolhsa04927Cortisol synthesis and secretion2.40E-023Q99941, P18848, P63092CREBL1, ATF4, GNASMore
Xanthinolhsa04928Parathyroid hormone synthesis, secretion and action2.33E-024P63092, P61586, Q99941, P18848GNAS, RHOA, CREBL1, ATF4More
Xanthinolhsa04934Cushing syndrome1.37E-035Q99941, P18848, P63092, O15169, Q13557CREBL1, ATF4, GNAS, AXIN1, CAMK2DMore
Xanthinolhsa05010Alzheimer disease9.96E-0413Q92542, O15239, P05496, O15399, Q9NZJ5, P18848, Q71U36, O15169, P05141, P12236, P21796, P43686, P62195NCSTN, NDUFA1, ATP5G1, GRIN2D, EIF2AK3, ATF4, TUBA1A, AXIN1, SLC25A5, SLC25A6, VDAC1, PSMC4, PSMC5More
Xanthinolhsa05012Parkinson disease2.88E-039O15239, P05496, P05141, P12236, P63092, P18848, P43686, P62195, Q13557NDUFA1, ATP5G1, SLC25A5, SLC25A6, GNAS, ATF4, PSMC4, PSMC5, CAMK2DMore
Xanthinolhsa05014Amyotrophic lateral sclerosis2.41E-0313O15399, P20333, O15239, P05496, Q9NZJ5, P18848, Q71U36, P43686, P62195, P21796, P51991, P35658, P43243GRIN2D, TNFRSF1B, NDUFA1, ATP5G1, EIF2AK3, ATF4, TUBA1A, PSMC4, PSMC5, VDAC1, HNRPA3, NUP214, MATR3More
Xanthinolhsa05020Prion disease3.57E-0413P46531, O15239, P05496, O15399, Q9NZJ5, P18848, P05141, P12236, P21796, P43686, P62195, Q71U36, Q99941NOTCH1, NDUFA1, ATP5G1, GRIN2D, EIF2AK3, ATF4, SLC25A5, SLC25A6, VDAC1, PSMC4, PSMC5, TUBA1A, CREBL1More
Xanthinolhsa05022Pathways of neurodegeneration - multiple diseases1.57E-0210O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5More
Xanthinolhsa05030Cocaine addiction2.40E-023P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Xanthinolhsa05031Amphetamine addiction4.47E-034Q13557, P63092, Q99941, P18848CAMK2D, GNAS, CREBL1, ATF4More
Xanthinolhsa05144Malaria2.60E-022P69905, O60603HBA2, TLR2More
Xanthinolhsa05163Human cytomegalovirus infection2.77E-024P30511, P63218, Q14344, P30101HLA-F, GNG5, GNA13, PDIA3More
Xanthinolhsa05203Viral carcinogenesis7.09E-036Q99941, P18848, P27348, Q15283, P61586, P61978CREBL1, ATF4, YWHAQ, RASA2, RHOA, HNRPKMore
Xanthinolhsa05205Proteoglycans in cancer4.43E-023P63261, O60603, Q06124ACTG1, TLR2, PTPN11More
Xanthinolhsa05206MicroRNAs in cancer1.54E-026P21860, P61978, P46531, P63279, P22105, P61586ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RHOAMore
Xanthinolhsa05415Diabetic cardiomyopathy1.92E-026P05141, P12236, O15239, P05496, Q13557, P26678SLC25A5, SLC25A6, NDUFA1, ATP5G1, CAMK2D, PLNMore

Community members of Xanthinol (SDC: 1.19)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13423NNTNAD(P) transhydrogenase, mitochondrialReported00.14520.01330.15390.2531
P04406GAPDHGlyceraldehydeNone3Nonephosphate dehydrogenaseReported00.45350.12230.46660.938
P50213IDH3AIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialReported00.12210.01530.28370.3755
P40926MDH2Malate dehydrogenase, mitochondrialReported00.47210.16110.24740.8055
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)