PharmaCoNets of Warfarin (SPCN: 225.57 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Warfarinhsa00010Glycolysis / Gluconeogenesis4.41E-024P04075, P06733, P04406, P60174ALDOA, ENO1, GAPDH, TPI1More
Warfarinhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Warfarinhsa00051Fructose and mannose metabolism2.08E-034P15121, O14772, P60174, P04075AKR1B1, FPGT, TPI1, ALDOAMore
Warfarinhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Warfarinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Warfarinhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Warfarinhsa00190Oxidative phosphorylation1.94E-023Q16718, P36542, O14521NDUFA5, ATP5C1, SDHDMore
Warfarinhsa00220Arginine biosynthesis7.34E-043P15104, P05089, P49448GLUL, ARG1, GLUD2More
Warfarinhsa00250Alanine, aspartate and glutamate metabolism2.61E-022P49448, P15104GLUD2, GLULMore
Warfarinhsa00310Lysine degradation4.57E-022Q96KQ7, Q02809EHMT2, PLOD1More
Warfarinhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Warfarinhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Warfarinhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Warfarinhsa00500Starch and sucrose metabolism3.94E-083O43451, P46976, P06737MGAM, GYG1, PYGLMore
Warfarinhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Warfarinhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Warfarinhsa00562Inositol phosphate metabolism2.00E-024P27987, P19174, P42338, Q02252ITPKB, PLCG1, PIK3CB, ALDH6A1More
Warfarinhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Warfarinhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Warfarinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Warfarinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Warfarinhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Warfarinhsa00620Pyruvate metabolism3.19E-022P40926, P14550MDH2, AKR1A1More
Warfarinhsa00630Glyoxylate and dicarboxylate metabolism1.67E-022P40925, P15104MDH1, GLULMore
Warfarinhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Warfarinhsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Warfarinhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Warfarinhsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Warfarinhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Warfarinhsa00910Nitrogen metabolism2.61E-022P15104, P49448GLUL, GLUD2More
Warfarinhsa00920Sulfur metabolism3.18E-021Q16762TSTMore
Warfarinhsa00970Aminoacyl-tRNA biosynthesis4.33E-074O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Warfarinhsa00980Metabolism of xenobiotics by cytochrome P4501.05E-055Q16772, P78417, P28332, P09211, P11712GSTA3, GSTO1, ADH6, GSTP1, CYP2C9More
Warfarinhsa00982Drug metabolism - cytochrome P4501.75E-055P11712, Q16772, P09211, P78417, P28332CYP2C9, GSTA3, GSTP1, GSTO1, ADH6More
Warfarinhsa00983Drug metabolism - other enzymes1.28E-045P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Warfarinhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Warfarinhsa01100Metabolic pathways4.14E-0441Q9NR34, P35790, Q9Y259, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, Q13956, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, P49619, O95954, Q9HCC0, P33121, Q02318, Q9UHK6, Q86VZ5, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q9BQB6MAN1C1, CHKA, CHKB, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, PDE6H, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, AMACR, SGMS1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, VKORC1More
Warfarinhsa01200Carbon metabolism5.71E-037P04075, P04406, P60174, P06733, O14521, Q9P2R7, Q02252ALDOA, GAPDH, TPI1, ENO1, SDHD, SUCLA2, ALDH6A1More
Warfarinhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Warfarinhsa01230Biosynthesis of amino acids8.65E-047P60174, P04406, P06733, P04075, P60891, Q99707, P37837TPI1, GAPDH, ENO1, ALDOA, PRPS1, MTR, TALDO1More
Warfarinhsa01522Endocrine resistance4.51E-022P04637, P42773TP53, CDKN2CMore
Warfarinhsa01524Platinum drug resistance4.95E-046O15392, Q16772, P09211, P78417, P11388, P52701BIRC5, GSTA3, GSTP1, GSTO1, TOP2A, MSH6More
Warfarinhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Warfarinhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Warfarinhsa03010Ribosome4.60E-0616P62753, P42677, P25398, P32969, P30050, P40429, P62829, P46776, Q9H0U6, Q07020, P62910, P18077, P36578, P05386, P62249, P23396RPS6, RPS27, RPS12, RPL9, RPL12, RPL13A, RPL23, RPL27A, MRPL18, RPL18, RPL32, RPL35A, RPL4, RPLP1, RPS16, RPS3More
Warfarinhsa03013RNA transport3.66E-1324P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, P47813, Q14152, O75822, P78345, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF3A, EIF3J, RPP38, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1More
Warfarinhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Warfarinhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Warfarinhsa03020RNA polymerase5.68E-096P30876, P24928, P62487, Q9GZM3, P52435, Q9Y535POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J, POLR3HMore
Warfarinhsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Warfarinhsa03040Spliceosome1.28E-0614Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Warfarinhsa03060Protein export1.05E-034Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Warfarinhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Warfarinhsa03410Base excision repair4.17E-022P49005, P29372POLD2, MPGMore
Warfarinhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Warfarinhsa04012ErbB signaling pathway1.30E-045P16333, P17252, P19174, P42338, P01106NCK1, PRKCA, PLCG1, PIK3CB, MYCMore
Warfarinhsa04014Ras signaling pathway9.77E-0512P42338, P20827, P49767, Q13009, P17252, P14921, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, ETS1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Warfarinhsa04015Rap1 signaling pathway1.56E-0516P09603, P20827, P49767, Q9GZP0, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, Q86WV1, P17252, P19174CSF1, EFNA1, VEGFC, PDGFD, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, SKAP1, PRKCA, PLCG1More
Warfarinhsa04020Calcium signaling pathway4.43E-0412P27987, Q08828, P21796, P17252, P30679, O15399, P19174, P0DP23, P05141, P51828, P23634, P49767ITPKB, ADCY1, VDAC1, PRKCA, GNA15, GRIN2D, PLCG1, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Warfarinhsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Warfarinhsa04024cAMP signaling pathway4.64E-039Q08828, P51828, P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1More
Warfarinhsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Warfarinhsa04061Viral protein interaction with cytokine and cytokine receptor1.69E-0510Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Warfarinhsa04062Chemokine signaling pathway7.41E-0721P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5More
Warfarinhsa04064NF-kappa B signaling pathway1.02E-1224P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Warfarinhsa04070Phosphatidylinositol signaling system9.28E-059P19174, P0DP23, P42338, O14986, P23743, Q16760, P48426, P27987, P17252PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKB, PRKCAMore
Warfarinhsa04071Sphingolipid signaling pathway4.45E-089P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Warfarinhsa04072Phospholipase D signaling pathway4.96E-0411P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Warfarinhsa04080Neuroactive ligand-receptor interaction1.28E-0612P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, Q16581, P14416, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, C3AR1, DRD2, ADRB2, ADMMore
Warfarinhsa04110Cell cycle8.91E-0511Q9UBD5, P30260, P06493, O75293, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, GADD45B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Warfarinhsa04114Oocyte meiosis5.20E-049P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Warfarinhsa04115p53 signaling pathway3.32E-035P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Warfarinhsa04122Sulfur relay system3.18E-021Q16762TSTMore
Warfarinhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Warfarinhsa04140Autophagy - animal1.92E-039P31751, Q7L523, O75460, P22694, Q14643, P10415, Q04759, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8More
Warfarinhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Warfarinhsa04145Phagosome2.60E-038Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Warfarinhsa04146Peroxisome2.92E-036O43933, O96011, P56589, Q9UKG9, O75521, P33121PEX1, PEX11B, PEX3, CROT, ECI2, ACSL1More
Warfarinhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Warfarinhsa04151PI3K-Akt signaling pathway2.18E-0523P42338, P43657, P01106, P04637, P09603, P20827, P49767, Q9GZP0, P08238, Q8WYR1, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, P14784, P01568, P17252, Q96BR1, P30281, P56279PIK3CB, P2RY5, MYC, TP53, CSF1, EFNA1, VEGFC, PDGFD, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, IL2RB, IFNA21, PRKCA, SGK3, CCND3, TCL1AMore
Warfarinhsa04210Apoptosis3.34E-0513Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, P24522, Q16548, Q13077, P43234, P18848, Q14643ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1More
Warfarinhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Warfarinhsa04213Longevity regulating pathway - multiple species4.29E-037P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1More
Warfarinhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Warfarinhsa04217Necroptosis1.17E-0516P01568, P23458, Q13489, Q9NQC7, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q13557, Q9H444, O43633, O75351IFNA21, JAK1, BIRC3, CYLD, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, CAMK2D, CHMP4B, CHMP2A, VPS4BMore
Warfarinhsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Warfarinhsa04310Wnt signaling pathway5.60E-033P30279, Q13485, O43318CCND2, SMAD4, MAP3K7More
Warfarinhsa04340Hedgehog signaling pathway2.61E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Warfarinhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Warfarinhsa04360Axon guidance5.10E-048P16333, P20827, O95631, P17252, P42338, P07332, P23528, P19174NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, CFL1, PLCG1More
Warfarinhsa04370VEGF signaling pathway1.04E-046P19174, P16298, P42338, P17252, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1More
Warfarinhsa04371Apelin signaling pathway1.11E-0311P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Warfarinhsa04380Osteoclast differentiation7.25E-0510Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Warfarinhsa04390Hippo signaling pathway2.17E-035P63261, P84022, Q13485, O15105, Q13489ACTG1, SMAD3, SMAD4, SMAD7, BIRC3More
Warfarinhsa04510Focal adhesion7.77E-039P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P49767ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, VEGFCMore
Warfarinhsa04512ECM-receptor interaction3.73E-022P07359, P08514GP1BA, ITGA2BMore
Warfarinhsa04514Cell adhesion molecules8.19E-033P16109, P56750, O00501SELP, CLDN17, CLDN5More
Warfarinhsa04520Adherens junction3.91E-022Q13485, O43318SMAD4, MAP3K7More
Warfarinhsa04530Tight junction3.02E-067Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTNMore
Warfarinhsa04610Complement and coagulation cascades1.29E-043P25116, P09871, P0C0L4F2R, C1S, C4AMore
Warfarinhsa04611Platelet activation5.18E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Warfarinhsa04612Antigen processing and presentation4.88E-0813P04233, P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01889, P10321, Q06323, P01375CD74, HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HLA-B, HLA-C, PSME1, TNFMore
Warfarinhsa04613Neutrophil extracellular trap formation7.03E-0924P17252, P16109, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PRKCA, SELP, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Warfarinhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Warfarinhsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Warfarinhsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Warfarinhsa04623Cytosolic DNA-sensing pathway3.62E-055P01584, P01568, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2More
Warfarinhsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Warfarinhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Warfarinhsa04640Hematopoietic cell lineage1.71E-0612P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P09603ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, CSF1More
Warfarinhsa04650Natural killer cell mediated cytotoxicity4.06E-1116P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Warfarinhsa04657IL-17 signaling pathway3.06E-0710P07900, O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Warfarinhsa04658Th1 and Th2 cell differentiation1.73E-2014Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Warfarinhsa04659Th17 cell differentiation3.83E-1518P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Warfarinhsa04660T cell receptor signaling pathway4.24E-1219P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Warfarinhsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Warfarinhsa04664Fc epsilon RI signaling pathway1.21E-058P01375, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, ALOX5More
Warfarinhsa04666Fc gamma R-mediated phagocytosis8.08E-035P42338, P19174, P23528, P14598, P17252PIK3CB, PLCG1, CFL1, NCF1, PRKCAMore
Warfarinhsa04668TNF signaling pathway1.83E-038P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9More
Warfarinhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Warfarinhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Warfarinhsa04713Circadian entrainment1.43E-037O15399, P0DP23, P17252, P62873, P50151, Q08828, P51828GRIN2D, CALM1, PRKCA, GNB1, GNG10, ADCY1, ADCY7More
Warfarinhsa04720Long-term potentiation1.71E-036P16298, P0DP23, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Warfarinhsa04724Glutamatergic synapse8.08E-035O15399, P17252, P62873, P50151, P15104GRIN2D, PRKCA, GNB1, GNG10, GLULMore
Warfarinhsa04725Cholinergic synapse2.89E-0411Q08828, P51828, P22694, Q14643, P17252, P62873, P50151, P18848, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG10, ATF4, PIK3CB, AKT2, BCL2More
Warfarinhsa04726Serotonergic synapse2.54E-025P17252, P62873, P50151, P33260, P09917PRKCA, GNB1, GNG10, CYP2C18, ALOX5More
Warfarinhsa04727GABAergic synapse1.23E-024P62873, P50151, P15104, P17252GNB1, GNG10, GLUL, PRKCAMore
Warfarinhsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Warfarinhsa04744Phototransduction1.67E-022P62873, P0DP23GNB1, CALM1More
Warfarinhsa04750Inflammatory mediator regulation of TRP channels2.03E-049P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Warfarinhsa04810Regulation of actin cytoskeleton2.58E-023Q15746, P08514, P25116MYLK, ITGA2B, F2RMore
Warfarinhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Warfarinhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Warfarinhsa04912GnRH signaling pathway1.39E-024Q08828, P51828, P18848, P0DP23ADCY1, ADCY7, ATF4, CALM1More
Warfarinhsa04914Progesterone-mediated oocyte maturation1.50E-038Q17RY0, P42338, Q13370, Q9UJX4, P30304, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, ANAPC5, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Warfarinhsa04915Estrogen signaling pathway2.83E-039P14780, P22694, P18848, Q08828, P51828, P31751, Q14643, P0DP23, P10415MMP9, PRKACB, ATF4, ADCY1, ADCY7, AKT2, ITPR1, CALM1, BCL2More
Warfarinhsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Warfarinhsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Warfarinhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Warfarinhsa04920Adipocytokine signaling pathway5.84E-036P25963, P33121, Q9Y478, Q04759, Q96RR4, P01375NFKBIA, ACSL1, PRKAB1, PRKCQ, CAMKK2, TNFMore
Warfarinhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Warfarinhsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Warfarinhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Warfarinhsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Warfarinhsa04926Relaxin signaling pathway2.10E-0412P31751, P25963, P42338, P62873, P63218, P50151, P18848, P49767, Q08828, P51828, P17252, P30679AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7, PRKCA, GNA15More
Warfarinhsa04927Cortisol synthesis and secretion5.17E-045Q14643, P18848, Q08828, P51828, P22694ITPR1, ATF4, ADCY1, ADCY7, PRKACBMore
Warfarinhsa04928Parathyroid hormone synthesis, secretion and action2.33E-035Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Warfarinhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Warfarinhsa04932Non-alcoholic fatty liver disease3.13E-059P31751, O43521, P18848, O75460, P01584, P13073, P12074, O15239, O95298AKT2, BCL2L11, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Warfarinhsa04933AGE-RAGE signaling pathway in diabetic complications2.17E-048P84022, Q13485, P42224, P10415, P42338, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, VEGFC, PRKCA, PLCG1More
Warfarinhsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Warfarinhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Warfarinhsa04964Proximal tubule bicarbonate reclamation2.37E-033P00918, P49448, P40925CA2, GLUD2, MDH1More
Warfarinhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Warfarinhsa04970Salivary secretion2.40E-037Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMPMore
Warfarinhsa04971Gastric acid secretion3.58E-044Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Warfarinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Warfarinhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Warfarinhsa04976Bile secretion1.15E-046O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Warfarinhsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Warfarinhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Warfarinhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Warfarinhsa05016Huntington disease6.73E-0612O15239, O95298, P13073, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460, P28070NDUFA1, NDUFC2, COX4I1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1, PSMB4More
Warfarinhsa05017Spinocerebellar ataxia1.71E-036O75460, Q8TB72, P31751, P28070, P05141, P21796ERN1, PUM2, AKT2, PSMB4, SLC25A5, VDAC1More
Warfarinhsa05020Prion disease9.85E-059P13591, P01584, P11142, O15239, P13073, Q92736, P18848, P05141, O60282NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, RYR2, ATF4, SLC25A5, KIF5CMore
Warfarinhsa05022Pathways of neurodegeneration - multiple diseases1.94E-0312O15239, O95298, P13073, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, Q13557, P28070NDUFA1, NDUFC2, COX4I1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, CAMK2D, PSMB4More
Warfarinhsa05032Morphine addiction4.41E-047P62873, P63218, P50151, Q13370, Q07343, P17252, P43250GNB1, GNG5, GNG10, PDE3B, PDE4B, PRKCA, GRK6More
Warfarinhsa05034Alcoholism8.41E-048Q02930, P50151, Q9BTM1, Q93077, P62807, Q16778, O60814, P68431CREB5, GNG10, H2AFJ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Warfarinhsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Warfarinhsa05110Vibrio cholerae infection3.15E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Warfarinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.39E-056Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Warfarinhsa05130Pathogenic Escherichia coli infection7.39E-034Q14247, P56750, O00501, P25116CTTN, CLDN17, CLDN5, F2RMore
Warfarinhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Warfarinhsa05132Salmonella infection6.12E-0413P51617, P25963, P01375, Q9UJU2, O00471, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509IRAK1, NFKBIA, TNF, LEF1, EXOC5, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3More
Warfarinhsa05133Pertussis1.35E-044P10145, P09871, P0C0L4, Q02556IL8, C1S, C4A, IRF8More
Warfarinhsa05134Legionellosis6.38E-046P01584, P11215, P68104, P11142, P09341, P19875IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Warfarinhsa05140Leishmaniasis1.34E-0410O75015, P14598, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4More
Warfarinhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Warfarinhsa05144Malaria2.84E-047P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Warfarinhsa05145Toxoplasmosis4.33E-0411P51617, P25963, P01375, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2More
Warfarinhsa05146Amoebiasis6.99E-0912P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Warfarinhsa05150Staphylococcus aureus infection2.20E-047P21462, O75015, Q14532, P59665, P59666, P12838, P49913FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Warfarinhsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Warfarinhsa05161Hepatitis B1.61E-0310P17252, P14780, P25963, Q13485, P01375, P10415, P84022, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, SMAD4, TNF, BCL2, SMAD3, IRAK1, TLR2, STAT4More
Warfarinhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Warfarinhsa05163Human cytomegalovirus infection3.01E-0724P31751, P42338, P01375, P25963, P62873, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, PIK3CB, TNF, NFKBIA, GNB1, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Warfarinhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Warfarinhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Warfarinhsa05167Kaposi sarcoma-associated herpesvirus infection2.54E-0413P01568, P42224, P25963, P42338, P40189, P62873, P62879, P50151, P19174, P16298, Q02750, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG10, PLCG1, PPP3CB, MAP2K1, CALM1, UBBMore
Warfarinhsa05168Herpes simplex virus 1 infection1.03E-0317P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Warfarinhsa05169Epstein-Barr virus infection5.99E-0413P13765, P01106, Q13547, O00463, P07948, O00232, P30101, Q13761, P24522, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, PSMD12, PDIA3, RUNX3, GADD45A, OAS2, CD3E, CD3G, CD247More
Warfarinhsa05170Human immunodeficiency virus 1 infection6.98E-0726P42338, Q02750, P62873, P62879, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P10415, Q13619, Q93034, Q9Y6Q5, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Warfarinhsa05171Coronavirus disease - COVID-196.13E-0523P01584, P25963, P42224, P01568, P23396, P62753, P25398, P62249, P42677, P40429, P36578, P32969, P30050, Q07020, P46776, P62910, P18077, P05386, P62829, P40189, P42338, P19174, P17252IL1B, NFKBIA, STAT1, IFNA21, RPS3, RPS6, RPS12, RPS16, RPS27, RPL13A, RPL4, RPL9, RPL12, RPL18, RPL27A, RPL32, RPL35A, RPLP1, RPL23, IL6ST, PIK3CB, PLCG1, PRKCAMore
Warfarinhsa05200Pathways in cancer7.09E-0731Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P84022, Q13485, P52701, Q13547, P10826, P14923, P30279, P30281, Q13489, P49767, P14921, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD3, SMAD4, MSH6, HDAC1, RARB, JUP, CCND2, CCND3, BIRC3, VEGFC, ETS1, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Warfarinhsa05202Transcriptional misregulation in cancer7.88E-0818Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Warfarinhsa05203Viral carcinogenesis7.11E-0514Q12933, Q02930, P42229, P06746, P07948, Q15283, P06396, P12814, P01889, P10321, P06493, P62807, Q16778, O60814TRAF2, CREB5, STAT5A, POLB, LYN, RASA2, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Warfarinhsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Warfarinhsa05210Colorectal cancer2.06E-034P84022, Q13485, P10415, P52701SMAD3, SMAD4, BCL2, MSH6More
Warfarinhsa05212Pancreatic cancer6.72E-058P42338, P31751, Q15311, P23458, P37173, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, TGFBR2, SMAD3, SMAD4, GADD45BMore
Warfarinhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Warfarinhsa05214Glioma2.73E-035P0DP23, P17252, P42338, P19174, O75293CALM1, PRKCA, PIK3CB, PLCG1, GADD45BMore
Warfarinhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Warfarinhsa05220Chronic myeloid leukemia1.44E-036Q13547, Q13485, P25963, P84022, P42338, O75293HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Warfarinhsa05222Small cell lung cancer8.29E-0510P10826, P42338, Q13751, Q13489, P10415, P25963, Q13077, O00463, P24522, O75293RARB, PIK3CB, LAMB3, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45BMore
Warfarinhsa05223Non-small cell lung cancer5.61E-046P17252, P42338, P19174, P10826, Q9HC35, O75293PRKCA, PIK3CB, PLCG1, RARB, EML4, GADD45BMore
Warfarinhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Warfarinhsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Warfarinhsa05231Choline metabolism in cancer4.80E-069P31751, P42338, Q9Y259, P19174, P23743, P49619, Q16760, O14986, P17252AKT2, PIK3CB, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PRKCAMore
Warfarinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.96E-1014P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Warfarinhsa05310Asthma3.88E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Warfarinhsa05321Inflammatory bowel disease4.27E-067O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Warfarinhsa05322Systemic lupus erythematosus2.09E-0412P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Warfarinhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Warfarinhsa05332Graft-versus-host disease3.01E-075P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Warfarinhsa05340Primary immunodeficiency2.18E-044P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Warfarinhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Warfarinhsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Warfarinhsa05418Fluid shear stress and atherosclerosis2.60E-058Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Warfarin (SDC: 8.75)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9BQB6VKORC1Vitamin K epoxide reductase complex subunit 1Reported00.28060.040.16970.39
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Reported10.03150.949301.9143
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
Q16549PCSK7Proprotein convertase subtilisin/kexin type 7Predicted00.27460.027900.1931
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P30304CDC25AMNonephase inducer phosphatase 1Predicted00.17950.23470.42740.9865
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P13612ITGA4Integrin alphaNone4Predicted00.11650.23860.68621.2217
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
Q9GZR1SENP6SentrinNonespecific protease 6Predicted00.38440.078400.349
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P43250GRK6G proteinNonecoupled receptor kinase 6Predicted10.15470.09550.29480.5632
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P14550AKR1A1AldoNoneketo reductase family 1 member A1Predicted10.30560.06210.17370.4508
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P04406GAPDHGlyceraldehydeNone3Nonephosphate dehydrogenasePredicted00.45350.12230.46660.938
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
VKORC1Q9BQB6Ki1.80E+03