PharmaCoNets

PharmaCoNets of Voxelotor (S_PCN: 80.85 )

Voxelotor regulated-network (S_DN: 17.20)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Voxelotor

hsa00030

Pentose phosphate pathway

2.93E-02

P60891, P37837

PRPS1, TALDO1

Voxelotor

hsa00040

Pentose and glucuronate interconversions

4.00E-02

P15121

AKR1B1

Voxelotor

hsa00052

Galactose metabolism

2.00E-02

P08237, P19367, Q14376

PFKM, HK1, GALE

Voxelotor

hsa00220

Arginine biosynthesis

2.93E-02

P05089, P49448

ARG1, GLUD2

Voxelotor

hsa00380

Tryptophan metabolism

2.05E-05

Q16613, P46952

AANAT, HAAO

Voxelotor

hsa00500

Starch and sucrose metabolism

1.47E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Voxelotor

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Voxelotor

hsa00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

4.51E-05

Q9Y2C2

UST

Voxelotor

hsa00565

Ether lipid metabolism

1.25E-02

Q9Y6K0, Q8N661

CEPT1, TMEM86B

Voxelotor

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Voxelotor

hsa00591

Linoleic acid metabolism

1.48E-03

P11712

CYP2C9

Voxelotor

hsa00630

Glyoxylate and dicarboxylate metabolism

3.93E-06

P40925, P40926, P15104

MDH1, MDH2, GLUL

Voxelotor

hsa00730

Thiamine metabolism

4.07E-02

P05186, P24666

ALPL, ACP1

Voxelotor

hsa00785

Lipoic acid metabolism

1.84E-05

O43766, Q9Y234

LIAS, LIPT1

Voxelotor

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Voxelotor

hsa00830

Retinol metabolism

1.10E-03

P11766, P00352

ADH5, ALDH1A1

Voxelotor

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Voxelotor

hsa00980

Metabolism of xenobiotics by cytochrome P450

6.38E-04

P78417, P09211, P11712

GSTO1, GSTP1, CYP2C9

Voxelotor

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Voxelotor

hsa00983

Drug metabolism - other enzymes

3.59E-02

P04183, P32320, P05164

TK1, CDA, MPO

Voxelotor

hsa01100

Metabolic pathways

2.42E-03

Q9NR34, O43766, Q9Y234, P35790, P05089, Q16772, P30041, P19367, Q14642, P32320, P20839, P00918, P22748, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, Q14376, P48506, P05186, P24666, P08237, O95861, P21399, P07101, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P48651, P57054, Q9UNP4, Q9H4F1, Q9BX95, P32321, P34059, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q969G6, P14927, Q13029

MAN1C1, LIAS, LIPT1, CHKA, ARG1, GSTA3, PRDX6, HK1, INPP5A, CDA, IMPDH1, CA2, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, GALE, GCLC, ALPL, ACP1, PFKM, BPNT1, ACO1, TH, MCCC2, ACSL1, AMACR, SGMS1, PTDSS1, PIGP, ST3GAL5, ST6GALNAC4, SGPP1, DCTD, GALNS, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, RFK, UQCRB, PRDM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P68871	HBB	Hemoglobin subunit beta	O43766	LIAS	Lipoyl synthase, mitochondrial	-0.735
P68871	HBB	Hemoglobin subunit beta	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.835
P68871	HBB	Hemoglobin subunit beta	P35790	CHKA	Choline kinase alpha	-0.808
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P68871	HBB	Hemoglobin subunit beta	Q16772	GSTA3	Glutathione S-transferase A3	-0.757
P68871	HBB	Hemoglobin subunit beta	P30041	PRDX6	Peroxiredoxin-6	0.887
P68871	HBB	Hemoglobin subunit beta	P19367	HK1	Hexokinase-1	0.708
P68871	HBB	Hemoglobin subunit beta	Q14642	INPP5A	Inositol polyphosphate-5-phosphatase A	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
P68871	HBB	Hemoglobin subunit beta	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.835
P68871	HBB	Hemoglobin subunit beta	P00918	CA2	Carbonic anhydrase 2	0.72
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P68871	HBB	Hemoglobin subunit beta	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.812
P68871	HBB	Hemoglobin subunit beta	Q14376	GALE	UDP-glucose 4-epimerase	0.726
P68871	HBB	Hemoglobin subunit beta	P48506	GCLC	Glutamate--cysteine ligase catalytic subunit	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P68871	HBB	Hemoglobin subunit beta	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	0.746
P68871	HBB	Hemoglobin subunit beta	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	-0.705
P68871	HBB	Hemoglobin subunit beta	P21399	ACO1	Cytoplasmic aconitate hydratase	-0.709
P68871	HBB	Hemoglobin subunit beta	P07101	TH	Tyrosine 3-monooxygenase	0.825
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P68871	HBB	Hemoglobin subunit beta	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.727
P68871	HBB	Hemoglobin subunit beta	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.749
P68871	HBB	Hemoglobin subunit beta	P48651	PTDSS1	Phosphatidylserine synthase 1	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
P68871	HBB	Hemoglobin subunit beta	Q9H4F1	ST6GALNAC4	Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase	0.821
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
P68871	HBB	Hemoglobin subunit beta	P34059	GALNS	N-acetylgalactosamine-6-sulfatase	-0.813
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
P68871	HBB	Hemoglobin subunit beta	P35573	AGL	Glycogen debranching enzyme	-0.739
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P68871	HBB	Hemoglobin subunit beta	Q969G6	RFK	Riboflavin kinase	0.817
P68871	HBB	Hemoglobin subunit beta	P14927	UQCRB	Cytochrome b-c1 complex subunit 7	0.765
P68871	HBB	Hemoglobin subunit beta	Q13029	PRDM2	PR domain zinc finger protein 2	0.762

Voxelotor

hsa01200

Carbon metabolism

2.71E-02

P37837, P60891, P11766, P49448

TALDO1, PRPS1, ADH5, GLUD2

Voxelotor

hsa01210

2-Oxocarboxylic acid metabolism

1.51E-02

P21399, P50213

ACO1, IDH3A

Voxelotor

hsa01230

Biosynthesis of amino acids

3.05E-02

P08237, P21399, P50213, P37837

PFKM, ACO1, IDH3A, TALDO1

Voxelotor

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Voxelotor

hsa03008

Ribosome biogenesis in eukaryotes

1.46E-02

Q9NYH9, P78345, Q9BVP2, Q9GZY0

UTP6, RPP38, GNL3, NXF2; NXF2B

Voxelotor

hsa03010

Ribosome

1.12E-04

P40429, P46777, Q07020, Q9UHA3, P27635, P05386, P62249

RPL13A, RPL5, RPL18, RSL24D1, RPL10, RPLP1, RPS16

Voxelotor

hsa03013

RNA transport

1.93E-03

P52298, P61326, Q9GZY0, Q7Z3B4, Q14152, O75822, P78345, Q14240, Q9Y6A5, Q53GS7

NCBP2, MAGOH, NXF2; NXF2B, NUP54, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, GLE1

Voxelotor

hsa03015

mRNA surveillance pathway

9.78E-03

O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7

RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1

Voxelotor

hsa03040

Spliceosome

2.03E-09

Q14562, O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29375	JARID1A	Lysine-specific demethylase 5A	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.781
P29375	JARID1A	Lysine-specific demethylase 5A	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P29375	JARID1A	Lysine-specific demethylase 5A	O60508	CDC40	Pre-mRNA-processing factor 17	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P29375	JARID1A	Lysine-specific demethylase 5A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P29375	JARID1A	Lysine-specific demethylase 5A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P29375	JARID1A	Lysine-specific demethylase 5A	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.732
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Voxelotor

hsa03050

Proteasome

1.79E-03

P55036

PSMD4

Voxelotor

hsa03410

Base excision repair

7.59E-03

P27695

APEX1

Voxelotor

hsa04010

MAPK signaling pathway

1.15E-02

Q02750, Q15283, P09619, Q8IZS8, P54284, Q9H2K8, O43283, Q12933, P51812

MAP2K1, RASA2, PDGFRB, CACNA2D3, CACNB3, TAOK3, MAP3K13, TRAF2, RPS6KA3

Voxelotor

hsa04012

ErbB signaling pathway

3.15E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Voxelotor

hsa04014

Ras signaling pathway

1.98E-03

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Voxelotor

hsa04015

Rap1 signaling pathway

2.49E-03

P09603, P20827, P49767, Q9GZP0, Q96FS4, P11215, Q13009, Q7LDG7, P42338, Q86WV1, P19174

CSF1, EFNA1, VEGFC, PDGFD, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, SKAP1, PLCG1

Voxelotor

hsa04024

cAMP signaling pathway

4.38E-02

P42338, P0DP23, Q13370, Q13009

PIK3CB, CALM1, PDE3B, TIAM1

Voxelotor

hsa04062

Chemokine signaling pathway

9.23E-03

P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Voxelotor

hsa04064

NF-kappa B signaling pathway

1.14E-03

Q13489, O00463, Q13546, P14778, Q9UDY8, Q13077, Q16548, Q8WV28, P24522, P09341, Q9UNE0

BIRC3, TRAF5, RIPK1, IL1R1, MALT1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1, EDAR

Voxelotor

hsa04070

Phosphatidylinositol signaling system

4.86E-02

P0DP23, P42338, P27987

CALM1, PIK3CB, ITPKB

Voxelotor

hsa04071

Sphingolipid signaling pathway

3.31E-03

P17252, Q16537, Q9BX95, Q16539, P04637, P10415

PRKCA, PPP2R5E, SGPP1, MAPK14, TP53, BCL2

Voxelotor

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Voxelotor

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Voxelotor

hsa04141

Protein processing in endoplasmic reticulum

1.91E-03

P18848, Q15437, Q99941, P11142, P07900, Q9NR31

ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1A

Voxelotor

hsa04145

Phagosome

3.27E-04

P63261, Q15080, P14598, Q13509, P68371, P05164, O60603, P35443, P13765

ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4, HLA-DOB

Voxelotor

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Voxelotor

hsa04151

PI3K-Akt signaling pathway

2.70E-06

P62753, P42338, P43657, P01106, P27348, P09603, P20827, P49767, Q9GZP0, P07900, P08238, Q8WYR1, P63218, P50151, P13612, O15335, Q13751, P22105, P14784, Q99941, P18848, O00141, P30281

RPS6, PIK3CB, P2RY5, MYC, YWHAQ, CSF1, EFNA1, VEGFC, PDGFD, HSP90AA1, HSP90AB1, PIK3R5, GNG5, GNG10, ITGA4, CHAD, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P62753	RPS6	40S ribosomal protein S6	0.722
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P43250	GRK6	G protein-coupled receptor kinase 6	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P43250	GRK6	G protein-coupled receptor kinase 6	P01106	MYC	Myc proto-oncogene protein	-0.707
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P27348	YWHAQ	14-3-3 protein theta	0.833
P43250	GRK6	G protein-coupled receptor kinase 6	P09603	CSF1	Macrophage colony-stimulating factor 1	0.73
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P43250	GRK6	G protein-coupled receptor kinase 6	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.7
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P43250	GRK6	G protein-coupled receptor kinase 6	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P43250	GRK6	G protein-coupled receptor kinase 6	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P43250	GRK6	G protein-coupled receptor kinase 6	P13612	ITGA4	Integrin alpha-4	-0.804
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P43250	GRK6	G protein-coupled receptor kinase 6	Q13751	LAMB3	Laminin subunit beta-3	0.867
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P22105	TNXB	Tenascin-X	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P43250	GRK6	G protein-coupled receptor kinase 6	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Voxelotor

hsa04211

Longevity regulating pathway

9.85E-04

Q12778, P51828, Q99941, P18848, Q9UEF7, Q96KQ7

FOXO1, ADCY7, CREBL1, ATF4, KL, EHMT2

Voxelotor

hsa04216

Ferroptosis

1.51E-02

P04637, Q9H1Y0, P33121

TP53, ATG5, ACSL1

Voxelotor

hsa04217

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Voxelotor

hsa04260

Cardiac muscle contraction

1.81E-04

Q8IZS8, P54284, P09493, P14927

CACNA2D3, CACNB3, TPM1, UQCRB

Voxelotor

hsa04261

Adrenergic signaling in cardiomyocytes

1.46E-02

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Voxelotor

hsa04360

Axon guidance

2.47E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1

Voxelotor

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Voxelotor

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Voxelotor

hsa04520

Adherens junction

9.72E-03

Q09472, P19784, P61586, P60709, P63261

EP300, CSNK2A2, RHOA, ACTB, ACTG1

Voxelotor

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Voxelotor

hsa04540

Gap junction

3.53E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Voxelotor

hsa04610

Complement and coagulation cascades

5.02E-03

P00734, P0C0L4

F2, C4A

Voxelotor

hsa04613

Neutrophil extracellular trap formation

2.43E-03

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462, P63261

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, ACTG1

Voxelotor

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Voxelotor

hsa04621

NOD-like receptor signaling pathway

4.72E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Voxelotor

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Voxelotor

hsa04623

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Voxelotor

hsa04640

Hematopoietic cell lineage

5.83E-03

P13612, P11215, P07766, P01730, P06127, P09564, P09603

ITGA4, ITGAM, CD3E, CD4, CD5, CD7, CSF1

Voxelotor

hsa04650

Natural killer cell mediated cytotoxicity

2.94E-02

P16298, P50591, Q02750

PPP3CB, TNFSF10, MAP2K1

Voxelotor

hsa04657

IL-17 signaling pathway

4.55E-02

O00463, Q16539, P49841, P09341, P14780

TRAF5, MAPK14, GSK3B, CXCL1, MMP9

Voxelotor

hsa04658

Th1 and Th2 cell differentiation

9.35E-03

P07766, P19174, P06239, P14784, Q13761

CD3E, PLCG1, LCK, IL2RB, RUNX3

Voxelotor

hsa04659

Th17 cell differentiation

2.19E-03

P19174, P42224, P14784, P14778, P40189, P84022, Q13485, P08238, P07766

PLCG1, STAT1, IL2RB, IL1R1, IL6ST, SMAD3, SMAD4, HSP90AB1, CD3E

Voxelotor

hsa04662

B cell receptor signaling pathway

9.03E-05

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Voxelotor

hsa04664

Fc epsilon RI signaling pathway

1.09E-04

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Voxelotor

hsa04666

Fc gamma R-mediated phagocytosis

8.47E-04

P42338, P23528, P49006, P06396, P14598, P17252

PIK3CB, CFL1, MARCKSL1, GSN, NCF1, PRKCA

Voxelotor

hsa04714

Thermogenesis

3.31E-02

P51828, P62753, P12074, O15239

ADCY7, RPS6, COX6A1, NDUFA1

Voxelotor

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Voxelotor

hsa04724

Glutamatergic synapse

3.24E-02

P43003, P50151, P15104

SLC1A3, GNG10, GLUL

Voxelotor

hsa04725

Cholinergic synapse

2.17E-02

P51828, P18848, Q13557

ADCY7, ATF4, CAMK2D

Voxelotor

hsa04728

Dopaminergic synapse

4.78E-02

Q99941, P18848, Q13557

CREBL1, ATF4, CAMK2D

Voxelotor

hsa04810

Regulation of actin cytoskeleton

2.84E-02

P00734, P61586, Q02750, P23229, P26012, P60709, P63261

F2, RHOA, MAP2K1, ITGA6, ITGB8, ACTB, ACTG1

Voxelotor

hsa04911

Insulin secretion

4.03E-04

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Voxelotor

hsa04912

GnRH signaling pathway

2.17E-02

P51828, P18848, Q13557

ADCY7, ATF4, CAMK2D

Voxelotor

hsa04914

Progesterone-mediated oocyte maturation

2.97E-03

Q17RY0, P42338, Q13370, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1

Voxelotor

hsa04915

Estrogen signaling pathway

2.75E-03

Q99941, P18848, P51828, P07900, P11142

CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8

Voxelotor

hsa04918

Thyroid hormone synthesis

1.69E-03

P51828, Q99941, P18848, P02768

ADCY7, CREBL1, ATF4, ALB

Voxelotor

hsa04919

Thyroid hormone signaling pathway

2.73E-03

Q02750, P26678, P60709, P63261, Q09472, P08237, P01106

MAP2K1, PLN, ACTB, ACTG1, EP300, PFKM, MYC

Voxelotor

hsa04921

Oxytocin signaling pathway

1.22E-02

Q02750, P60660, P60709, P63261, P61586, P54284

MAP2K1, MYL6, ACTB, ACTG1, RHOA, CACNB3

Voxelotor

hsa04924

Renin secretion

3.77E-02

Q13370, P0DP23

PDE3B, CALM1

Voxelotor

hsa04925

Aldosterone synthesis and secretion

1.69E-03

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Voxelotor

hsa04926

Relaxin signaling pathway

3.34E-02

Q99941, P18848, P51828

CREBL1, ATF4, ADCY7

Voxelotor

hsa04927

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, P51828

CREBL1, ATF4, ADCY7

Voxelotor

hsa04928

Parathyroid hormone synthesis, secretion and action

2.17E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Voxelotor

hsa04931

Insulin resistance

3.18E-04

Q9Y4H2, P36956, Q13133

IRS2, SREBF1, NR1H3

Voxelotor

hsa04932

Non-alcoholic fatty liver disease

4.74E-04

Q9Y4H2, P36956, Q13133

IRS2, SREBF1, NR1H3

Voxelotor

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Voxelotor

hsa04934

Cushing syndrome

1.12E-03

Q99941, P18848, P51828, Q13557

CREBL1, ATF4, ADCY7, CAMK2D

Voxelotor

hsa04935

Growth hormone synthesis, secretion and action

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Voxelotor

hsa04966

Collecting duct acid secretion

3.44E-02

P02730, P00918

SLC4A1, CA2

Voxelotor

hsa04972

Pancreatic secretion

1.99E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Voxelotor

hsa04975

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Voxelotor

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Voxelotor

hsa05031

Amphetamine addiction

6.41E-03

Q13557, Q99941, P18848

CAMK2D, CREBL1, ATF4

Voxelotor

hsa05032

Morphine addiction

1.27E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Voxelotor

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Voxelotor

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

8.38E-04

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Voxelotor

hsa05130

Pathogenic Escherichia coli infection

1.31E-02

P61586, P19338, Q13885, P60709, P63261, Q12933, P00734, O95487

RHOA, NCL, TUBB2A, ACTB, ACTG1, TRAF2, F2, SEC24B

Voxelotor

hsa05132

Salmonella infection

1.43E-03

Q9UJU2, P63261, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371

LEF1, ACTG1, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C

Voxelotor

hsa05133

Pertussis

1.96E-02

P10145, P23528, P0C0L4

IL8, CFL1, C4A

Voxelotor

hsa05135

Yersinia infection

9.76E-03

P60709, P63261, P61586, Q16513, P51812, Q12933, Q02750

ACTB, ACTG1, RHOA, PKN2, RPS6KA3, TRAF2, MAP2K1

Voxelotor

hsa05140

Leishmaniasis

2.75E-05

P13612, O75015, P14598, P13765, O60603, P49006, Q16539, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, MARCKSL1, MAPK14, NCF4

Voxelotor

hsa05146

Amoebiasis

4.55E-02

P09341, P14778, P27930, O60603, P05089

CXCL1, IL1R1, IL1R2, TLR2, ARG1

Voxelotor

hsa05161

Hepatitis B

3.34E-02

Q99941, P18848, P27348

CREBL1, ATF4, YWHAQ

Voxelotor

hsa05163

Human cytomegalovirus infection

3.64E-02

Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Voxelotor

hsa05164

Influenza A

8.79E-03

Q09472, P48551, P29728, O15131, Q02750, P60709, P63261, Q9BUJ2

EP300, IFNAR2, OAS2, KPNA5, MAP2K1, ACTB, ACTG1, HNRPUL1

Voxelotor

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Voxelotor

hsa05168

Herpes simplex virus 1 infection

1.15E-02

P42224, Q07955, Q01130, Q13243, P42338, Q13398, Q03923, Q9UDV6

STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF211, ZNF85, ZNF212

Voxelotor

hsa05170

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Voxelotor

hsa05171

Coronavirus disease - COVID-19

3.87E-04

P62249, P40429, P27635, Q07020, P05386

RPS16, RPL13A, RPL10, RPL18, RPLP1

Voxelotor

hsa05200

Pathways in cancer

1.31E-03

Q13751, P42338, P08238, P42224, P19174, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P29375	JARID1A	Lysine-specific demethylase 5A	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P29375	JARID1A	Lysine-specific demethylase 5A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P29375	JARID1A	Lysine-specific demethylase 5A	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.764
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P29375	JARID1A	Lysine-specific demethylase 5A	P43246	MSH2	DNA mismatch repair protein Msh2	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P29375	JARID1A	Lysine-specific demethylase 5A	P14923	JUP	Junction plakoglobin	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P29375	JARID1A	Lysine-specific demethylase 5A	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P29375	JARID1A	Lysine-specific demethylase 5A	P0DP23	CALM1	Calmodulin-1	0.755
P29375	JARID1A	Lysine-specific demethylase 5A	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.768
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P29375	JARID1A	Lysine-specific demethylase 5A	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.83

Voxelotor

hsa05202

Transcriptional misregulation in cancer

6.80E-03

Q12778, Q15532, P41732, P14780, P14923, Q13489, O15550, P04637, P05164, P08246, Q9C0K0, P24522

FOXO1, SS18, TSPAN7, MMP9, JUP, BIRC3, UTX, TP53, MPO, ELA2, BCL11B, GADD45A

Voxelotor

hsa05203

Viral carcinogenesis

3.30E-06

Q99941, P18848, P27348, Q15283, Q12834, P61978, P62807, P33778, Q16778, O60814

CREBL1, ATF4, YWHAQ, RASA2, CDC20, HNRPK, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12

Voxelotor

hsa05204

Chemical carcinogenesis

1.09E-03

P09211, P78417, P11712

GSTP1, GSTO1, CYP2C9

Voxelotor

hsa05205

Proteoglycans in cancer

2.66E-02

Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962

ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63

Voxelotor

hsa05212

Pancreatic cancer

2.14E-03

P42338, P42224, P84022, Q13485, O75293

PIK3CB, STAT1, SMAD3, SMAD4, GADD45B

Voxelotor

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Voxelotor

hsa05214

Glioma

1.72E-02

P0DP23, P42338, O75293

CALM1, PIK3CB, GADD45B

Voxelotor

hsa05216

Thyroid cancer

3.59E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Voxelotor

hsa05217

Basal cell carcinoma

1.46E-02

Q13635, Q9UJU2, P04637, P24522

PTCH1, LEF1, TP53, GADD45A

Voxelotor

hsa05219

Bladder cancer

1.81E-03

P14780, P04637

MMP9, TP53

Voxelotor

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Voxelotor

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Voxelotor

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Voxelotor

hsa05230

Central carbon metabolism in cancer

1.09E-03

P01106, P09619, Q02750, P19367, P08237

MYC, PDGFRB, MAP2K1, HK1, PFKM

Voxelotor

hsa05231

Choline metabolism in cancer

2.71E-02

Q02750, P09619, O15245, P35790

MAP2K1, PDGFRB, SLC22A1, CHKA

Voxelotor

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.55E-02

O95267, P09693, O60603, Q16539, P01730

RASGRP1, CD3G, TLR2, MAPK14, CD4

Voxelotor

hsa05322

Systemic lupus erythematosus

4.71E-07

P09871, Q93077, P62807, P33778, Q16778, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Voxelotor

hsa05323

Rheumatoid arthritis

3.53E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Voxelotor

hsa05410

Hypertrophic cardiomyopathy

1.48E-06

Q8IZS8, P54284, P23229, P13612, P26012, P09493, Q8WZ42, P60709, P63261

CACNA2D3, CACNB3, ITGA6, ITGA4, ITGB8, TPM1, TTN, ACTB, ACTG1

Voxelotor

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

1.08E-07

Q8IZS8, P54284, P15924, P23229, P13612, P26012, P60709, P63261

CACNA2D3, CACNB3, DSP, ITGA6, ITGA4, ITGB8, ACTB, ACTG1

Voxelotor

hsa05414

Dilated cardiomyopathy

6.73E-07

Q8IZS8, P54284, P23229, P13612, P26012, P09493, Q8WZ42, P26678, P60709, P63261

CACNA2D3, CACNB3, ITGA6, ITGA4, ITGB8, TPM1, TTN, PLN, ACTB, ACTG1

Voxelotor

hsa05418

Fluid shear stress and atherosclerosis

3.97E-04

Q16539, P42338, P14598, P10599, P14780, P63261, P04637, P10415, P14778, P27930, P0DP23, P08238, Q92974

MAPK14, PIK3CB, NCF1, TXN, MMP9, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, HSP90AB1, ARHGEF2

Community members of Voxelotor (S_DC: 4.70)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

HBA2

Hemoglobin subunit alpha

Reported

0.3849

0.0667

0.2323

0.5581

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P49281

SLC11A2

Natural resistanceNoneassociated macrophage protein 2

Predicted

0.3325

0.0505

0.2662

0.5334

P09211

GSTP1

Glutathione SNonetransferase P

Predicted

0.3204

0.3523

0.4566

1.3213

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P29375

JARID1A

LysineNonespecific demethylase 5A

Predicted

0.3605

0.7052

1.5906

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P35610

SOAT1

Sterol ONoneacyltransferase 1

Predicted

0.3855

0.2936

0.0165

0.7964

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P27695

APEX1

DNANone(apurinic or apyrimidinic site) endonuclease

Predicted

0.402

0.221

0.1217

0.7647

Q13093

PLA2G7

PlateletNoneactivating factor acetylhydrolase

Predicted

0.0505

0.2096

0.1558

0.6001

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

P43250

GRK6

G proteinNonecoupled receptor kinase 6

Predicted

0.1547

0.0955

0.2948

0.5632

P09105

HBQ1

Hemoglobin subunit thetaNone1

Predicted

0.0718

0.0413

0.1186

P02008

HBZ

Hemoglobin subunit zeta

Predicted

0.4242

0.0399

0.292

P68871

HBB

Hemoglobin subunit beta

Predicted

0.3049

0.0403

0.2323

0.4654

P02042

HBD

Hemoglobin subunit delta

Predicted

0.0669

0.0389

0.1113

P69891

HBG1

Hemoglobin subunit gammaNone1

Predicted

0.0809

0.0339

0.1082

P69892

HBG2

Hemoglobin subunit gammaNone2

Predicted

0.1416

0.034

0.1388

P02100

HBE1

Hemoglobin subunit epsilon

Predicted

0.2962

0.0333

0.2147

PharmaCoNets of Voxelotor (SPCN: 80.85 )

Voxelotor regulated-network (SDN: 17.20)

Community members of Voxelotor (SDC: 4.70)

PharmaCoNets of Voxelotor (S_PCN: 80.85 )

Voxelotor regulated-network (S_DN: 17.20)

Community members of Voxelotor (S_DC: 4.70)