PharmaCoNets of Vorapaxar (SPCN: 16.13 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Vorapaxarhsa00220Arginine biosynthesis2.86E-022P15104, P05089GLUL, ARG1More
Vorapaxarhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Vorapaxarhsa00310Lysine degradation7.78E-052Q96KQ7, P51648EHMT2, ALDH3A2More
Vorapaxarhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Vorapaxarhsa00515Mannose type O-glycan biosynthesis2.43E-031O75072FCMDMore
Vorapaxarhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Vorapaxarhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Vorapaxarhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Vorapaxarhsa00620Pyruvate metabolism9.34E-042P40925, P51648MDH1, ALDH3A2More
Vorapaxarhsa00630Glyoxylate and dicarboxylate metabolism5.60E-062P40925, P15104MDH1, GLULMore
Vorapaxarhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Vorapaxarhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Vorapaxarhsa03040Spliceosome5.98E-066O60508, P26368, Q01130, Q13243, P11142, O43447CDC40, U2AF2, SFRS2, SFRS5, HSPA8, PPIHMore
Vorapaxarhsa03450Non-homologous end-joining2.43E-031Q9NP87POLMMore
Vorapaxarhsa04015Rap1 signaling pathway3.07E-024P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Vorapaxarhsa04060Cytokine-cytokine receptor interaction1.71E-029P27930, P14778, P26842, Q13651, P25024, P09341, P18510, P09603, P01730IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCL1, IL1RN, CSF1, CD4More
Vorapaxarhsa04064NF-kappa B signaling pathway4.09E-038P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Vorapaxarhsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Vorapaxarhsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Vorapaxarhsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Vorapaxarhsa04141Protein processing in endoplasmic reticulum5.37E-044P30101, P60604, P11142, P08238PDIA3, UBE2G2, HSPA8, HSP90AB1More
Vorapaxarhsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Vorapaxarhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Vorapaxarhsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Vorapaxarhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Vorapaxarhsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Vorapaxarhsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Vorapaxarhsa04613Neutrophil extracellular trap formation3.77E-0312O60603, P05164, P08246, Q9UM07, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1More
Vorapaxarhsa04640Hematopoietic cell lineage7.16E-037P13612, P14778, P27930, P07766, P01730, P09564, P09603ITGA4, IL1R1, IL1R2, CD3E, CD4, CD7, CSF1More
Vorapaxarhsa04650Natural killer cell mediated cytotoxicity2.96E-026O60880, P20963, Q13241, P26718, P26717, P26715SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Vorapaxarhsa04658Th1 and Th2 cell differentiation1.51E-0511Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3More
Vorapaxarhsa04659Th17 cell differentiation7.88E-0410Q04759, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Vorapaxarhsa04660T cell receptor signaling pathway1.00E-027Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8AMore
Vorapaxarhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Vorapaxarhsa04724Glutamatergic synapse2.72E-035P48058, P43003, P63218, P50151, P15104GRIA4, SLC1A3, GNG5, GNG10, GLULMore
Vorapaxarhsa04727GABAergic synapse3.89E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Vorapaxarhsa04730Long-term depression3.36E-042Q14344, P07948GNA13, LYNMore
Vorapaxarhsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Vorapaxarhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Vorapaxarhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Vorapaxarhsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Vorapaxarhsa05012Parkinson disease1.43E-034P21796, P60604, Q71U36, Q13509VDAC1, UBE2G2, TUBA1A, TUBB3More
Vorapaxarhsa05020Prion disease3.23E-034P11142, P21796, Q71U36, Q13509HSPA8, VDAC1, TUBA1A, TUBB3More
Vorapaxarhsa05022Pathways of neurodegeneration - multiple diseases4.84E-035Q71U36, Q13509, P21796, P04628, P60604TUBA1A, TUBB3, VDAC1, WNT1, UBE2G2More
Vorapaxarhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Vorapaxarhsa05146Amoebiasis4.54E-036Q13751, P09341, P14778, P27930, P05089, P12814LAMB3, CXCL1, IL1R1, IL1R2, ARG1, ACTN1More
Vorapaxarhsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Vorapaxarhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Vorapaxarhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Vorapaxarhsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Vorapaxarhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Vorapaxarhsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Vorapaxarhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Vorapaxarhsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Vorapaxarhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Vorapaxarhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Vorapaxarhsa05330Allograft rejection3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Vorapaxarhsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Vorapaxarhsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Vorapaxarhsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Vorapaxar (SDC: 2.07)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P25116F2RProteinaseNoneactivated receptor 1Reported10.20380.31960.51361.2547
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P43657P2RY5Lysophosphatidic acid receptor 6Predicted00.75390.04480.37080.8373
O14843FFAR3Free fatty acid receptor 3Predicted00.01270.006500.0193
O15529GPR42GNoneprotein coupled receptor 42Predicted10.01270.016200.0388
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)