PharmaCoNets of Vitamin-a (SPCN: 15.87 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Vitamin-Ahsa00040Pentose and glucuronate interconversions2.31E-022Q9UEF7, O60701KL, UGDHMore
Vitamin-Ahsa00140Steroid hormone biosynthesis3.95E-021P11511CYP19A1More
Vitamin-Ahsa00190Oxidative phosphorylation2.74E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Vitamin-Ahsa00220Arginine biosynthesis4.82E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Vitamin-Ahsa00250Alanine, aspartate and glutamate metabolism5.84E-033P51649, P49448, P15104ALDH5A1, GLUD2, GLULMore
Vitamin-Ahsa00280Valine, leucine and isoleucine degradation2.20E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Vitamin-Ahsa00500Starch and sucrose metabolism1.60E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Vitamin-Ahsa00531Glycosaminoglycan degradation3.03E-021P15586GNSMore
Vitamin-Ahsa00730Thiamine metabolism7.82E-042P05186, P24666ALPL, ACP1More
Vitamin-Ahsa00830Retinol metabolism4.71E-022Q9BPW9, O75911DHRS9, DHRS3More
Vitamin-Ahsa00910Nitrogen metabolism4.32E-022P15104, P49448GLUL, GLUD2More
Vitamin-Ahsa01522Endocrine resistance4.74E-023P22694, P10415, Q13323PRKACB, BCL2, BIKMore
Vitamin-Ahsa01524Platinum drug resistance1.01E-034P04637, O15392, P48023, P11388TP53, BIRC5, FASLG, TOP2AMore
Vitamin-Ahsa03013RNA transport3.02E-029O14980, Q09161, Q9H307, P35658, Q14152, O75822, Q14240, Q9Y6A5, Q06787XPO1, NCBP1, PNN, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FMR1More
Vitamin-Ahsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Vitamin-Ahsa03020RNA polymerase8.13E-043P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Vitamin-Ahsa03410Base excision repair1.39E-022P49005, P29372POLD2, MPGMore
Vitamin-Ahsa04020Calcium signaling pathway2.31E-035Q13557, P61073, P0DP24, P05141, P51828CAMK2D, CXCR4, CALM2, SLC25A5, ADCY7More
Vitamin-Ahsa04062Chemokine signaling pathway3.13E-028P25024, P25025, P07948, P42338, P63218, P50151, P49407, P49841CXCR1, CXCR2, LYN, PIK3CB, GNG5, GNG10, ARRB1, GSK3BMore
Vitamin-Ahsa04064NF-kappa B signaling pathway8.74E-035O00463, Q13077, Q16548, P06239, Q8WV28TRAF5, TRAF1, BCL2A1, LCK, BLNKMore
Vitamin-Ahsa04068FoxO signaling pathway6.45E-032P48023, Q96BR1FASLG, SGK3More
Vitamin-Ahsa04080Neuroactive ligand-receptor interaction4.90E-036P08311, Q15722, P21453, Q9H228, O00398, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, ADRB2More
Vitamin-Ahsa04114Oocyte meiosis3.68E-035Q13557, P0DP24, P51828, P27348, Q13362CAMK2D, CALM2, ADCY7, YWHAQ, PPP2R5CMore
Vitamin-Ahsa04137Mitophagy - animal2.60E-024Q96CV9, Q9H1Y0, P18848, O43524OPTN, ATG5, ATF4, FOXO3More
Vitamin-Ahsa04140Autophagy - animal4.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Vitamin-Ahsa04141Protein processing in endoplasmic reticulum1.24E-036P18848, Q86TM6, P0DMV8, P51668, Q9H3Z4, Q9NR31ATF4, SYVN1, HSPA1A, UBE2D1, DNAJC5, SAR1AMore
Vitamin-Ahsa04150mTOR signaling pathway2.72E-024P42338, Q9NQL2, Q13322, P49841PIK3CB, RRAGD, GRB10, GSK3BMore
Vitamin-Ahsa04151PI3K-Akt signaling pathway4.21E-033P48023, P04637, Q96BR1FASLG, TP53, SGK3More
Vitamin-Ahsa04217Necroptosis6.56E-057P23458, Q9NQC7, P15104, P05141, P01584, P0C0S5, Q13557JAK1, CYLD, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Vitamin-Ahsa04261Adrenergic signaling in cardiomyocytes5.64E-035P51828, P18848, Q13362, P0DP24, Q13557ADCY7, ATF4, PPP2R5C, CALM2, CAMK2DMore
Vitamin-Ahsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Vitamin-Ahsa04380Osteoclast differentiation6.63E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8N149CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, LILRA2More
Vitamin-Ahsa04390Hippo signaling pathway1.46E-024P63261, Q13485, O15105, O43623ACTG1, SMAD4, SMAD7, SNAI2More
Vitamin-Ahsa04510Focal adhesion1.01E-024O14986, P02751, Q16363, Q02750PIP5K1B, FN1, LAMA4, MAP2K1More
Vitamin-Ahsa04512ECM-receptor interaction3.62E-022Q16363, P02751LAMA4, FN1More
Vitamin-Ahsa04520Adherens junction4.63E-023Q13485, O43623, P63261SMAD4, SNAI2, ACTG1More
Vitamin-Ahsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Vitamin-Ahsa04612Antigen processing and presentation7.14E-049P25208, P48382, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375NFYB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Vitamin-Ahsa04613Neutrophil extracellular trap formation3.45E-0211O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P49913, O75015, P21730, P21462TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1More
Vitamin-Ahsa04621NOD-like receptor signaling pathway3.74E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Vitamin-Ahsa04622RIG-I-like receptor signaling pathway3.49E-024P01568, P25963, Q9H1Y0, Q13546IFNA21, NFKBIA, ATG5, RIPK1More
Vitamin-Ahsa04623Cytosolic DNA-sensing pathway3.47E-033P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Vitamin-Ahsa04650Natural killer cell mediated cytotoxicity1.37E-0510P06239, P20963, P48023, Q13241, P26718, O14931, P26717, Q07444, Q14953, P26715LCK, CD247, FASLG, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KIR2DS5, KLRC1More
Vitamin-Ahsa04658Th1 and Th2 cell differentiation1.11E-0610Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21, RUNX3More
Vitamin-Ahsa04659Th17 cell differentiation1.01E-0410Q04759, Q16539, P01730, P06239, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Vitamin-Ahsa04660T cell receptor signaling pathway1.12E-0412Q04759, P42338, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, P06239, Q16539, P49841PRKCQ, PIK3CB, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, LCK, MAPK14, GSK3BMore
Vitamin-Ahsa04662B cell receptor signaling pathway2.80E-036P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Vitamin-Ahsa04664Fc epsilon RI signaling pathway1.80E-024Q16539, P42338, P07948, P09917MAPK14, PIK3CB, LYN, ALOX5More
Vitamin-Ahsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Vitamin-Ahsa04722Neurotrophin signaling pathway2.27E-022P48023, P04637FASLG, TP53More
Vitamin-Ahsa04723Retrograde endocannabinoid signaling3.86E-024P63218, P50151, P48058, Q16539GNG5, GNG10, GRIA4, MAPK14More
Vitamin-Ahsa04724Glutamatergic synapse7.09E-035P48058, P43003, P63218, P50151, P15104GRIA4, SLC1A3, GNG5, GNG10, GLULMore
Vitamin-Ahsa04725Cholinergic synapse3.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Vitamin-Ahsa04728Dopaminergic synapse2.35E-026P63218, P50151, P49841, Q16539, P49407, P48058GNG5, GNG10, GSK3B, MAPK14, ARRB1, GRIA4More
Vitamin-Ahsa04744Phototransduction2.31E-022P62873, P0DP23GNB1, CALM1More
Vitamin-Ahsa04750Inflammatory mediator regulation of TRP channels1.41E-034P01584, P51828, Q13557, P0DP24IL1B, ADCY7, CAMK2D, CALM2More
Vitamin-Ahsa04911Insulin secretion4.85E-033P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Vitamin-Ahsa04912GnRH signaling pathway2.68E-034P51828, P18848, Q13557, P0DP24ADCY7, ATF4, CAMK2D, CALM2More
Vitamin-Ahsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Vitamin-Ahsa04915Estrogen signaling pathway6.84E-045P18848, P51828, P0DMV8, P0DP24, Q15788ATF4, ADCY7, HSPA1A, CALM2, NCOA1More
Vitamin-Ahsa04916Melanogenesis4.74E-047Q13557, P0DP24, P0DP23, Q9UJU2, P51828, P17252, P04628CAMK2D, CALM2, CALM1, LEF1, ADCY7, PRKCA, WNT1More
Vitamin-Ahsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Vitamin-Ahsa04924Renin secretion3.09E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Vitamin-Ahsa04925Aldosterone synthesis and secretion1.41E-034P18848, P51828, P0DP24, Q13557ATF4, ADCY7, CALM2, CAMK2DMore
Vitamin-Ahsa04927Cortisol synthesis and secretion2.72E-022Q14643, P22694ITPR1, PRKACBMore
Vitamin-Ahsa04928Parathyroid hormone synthesis, secretion and action1.02E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Vitamin-Ahsa04934Cushing syndrome4.74E-023Q14643, P22694, P04628ITPR1, PRKACB, WNT1More
Vitamin-Ahsa04970Salivary secretion2.11E-023P07550, P22694, Q14643ADRB2, PRKACB, ITPR1More
Vitamin-Ahsa04971Gastric acid secretion4.85E-033P51828, P0DP24, Q13557ADCY7, CALM2, CAMK2DMore
Vitamin-Ahsa04973Carbohydrate digestion and absorption1.57E-022O43451, P42338MGAM, PIK3CBMore
Vitamin-Ahsa05031Amphetamine addiction4.85E-033P0DP24, Q13557, P18848CALM2, CAMK2D, ATF4More
Vitamin-Ahsa05034Alcoholism7.79E-045P18848, P0DP24, Q96RR4, P0C0S5, P84243ATF4, CALM2, CAMKK2, H2AFZ, H3F3AMore
Vitamin-Ahsa05120Epithelial cell signaling in Helicobacter pylori infection1.09E-034Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Vitamin-Ahsa05132Salmonella infection3.43E-0413P25963, Q9UJU2, Q13546, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P49754NFKBIA, LEF1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, VPS41More
Vitamin-Ahsa05134Legionellosis6.74E-043P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Vitamin-Ahsa05135Yersinia infection5.93E-0410P02751, O14986, P51812, P13612, P06239, Q16539, Q02750, P42338, P49841, P01730FN1, PIP5K1B, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, PIK3CB, GSK3B, CD4More
Vitamin-Ahsa05140Leishmaniasis3.86E-023P13765, P49006, Q16539HLA-DOB, MARCKSL1, MAPK14More
Vitamin-Ahsa05144Malaria4.12E-024O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Vitamin-Ahsa05146Amoebiasis2.25E-037P02751, Q16363, P09341, P15812, P05089, P12814, P08311FN1, LAMA4, CXCL1, CD1E, ARG1, ACTN1, CTSGMore
Vitamin-Ahsa05150Staphylococcus aureus infection1.70E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Vitamin-Ahsa05152Tuberculosis1.70E-0312Q13488, Q15075, P0DP23, O75015, P48382, P25208, O60603, P01375, P10415, P01568, P49913, Q9UDY8TCIRG1, EEA1, CALM1, FCGR3B, RFX5, NFYB, TLR2, TNF, BCL2, IFNA21, CAMP, MALT1More
Vitamin-Ahsa05160Hepatitis C3.81E-022P04637, P48023TP53, FASLGMore
Vitamin-Ahsa05162Measles2.82E-055P23458, P0DMV8, P01584, Q9NP90, P30281JAK1, HSPA1A, IL1B, RAB9B, CCND3More
Vitamin-Ahsa05163Human cytomegalovirus infection1.01E-0416P42338, P63218, P50151, P0DP24, P51828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P18848, O00463, P61769PIK3CB, GNG5, GNG10, CALM2, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, ATF4, TRAF5, B2MMore
Vitamin-Ahsa05164Influenza A3.07E-048P01584, P23458, P05141, Q9UBU9, Q9GZY0, P48023, P62491, P30281IL1B, JAK1, SLC25A5, NXF1, NXF2; NXF2B, FASLG, RAB11A, CCND3More
Vitamin-Ahsa05168Herpes simplex virus 1 infection2.26E-0317O60603, P25963, P01568, P04637, Q9GZY0, Q07955, P48023, Q13489, Q13398, P51522, Q9NR11, Q9HCX3, P17097, Q03923, O75820, P98182, P10415TLR2, NFKBIA, IFNA21, TP53, NXF2; NXF2B, SFRS1, FASLG, BIRC3, ZNF211, ZNF83, ZNF302, ZNF304, ZNF7, ZNF85, ZNF189, ZNF200, BCL2More
Vitamin-Ahsa05169Epstein-Barr virus infection2.32E-029Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247More
Vitamin-Ahsa05170Human immunodeficiency virus 1 infection2.38E-0210P62873, P0DP23, P17252, Q13546, P01568, P25963, O60603, P10415, Q13619, Q9Y6Q5GNB1, CALM1, PRKCA, RIPK1, IFNA21, NFKBIA, TLR2, BCL2, CUL4A, AP1M2More
Vitamin-Ahsa05219Bladder cancer4.51E-021P04637TP53More
Vitamin-Ahsa05222Small cell lung cancer1.61E-038P10826, P02751, Q16363, Q13489, P10415, P25963, Q13077, O75293RARB, FN1, LAMA4, BIRC3, BCL2, NFKBIA, TRAF1, GADD45BMore
Vitamin-Ahsa05231Choline metabolism in cancer4.55E-022Q02750, O14986MAP2K1, PIP5K1BMore
Vitamin-Ahsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.29E-049P42338, O95267, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4More
Vitamin-Ahsa05321Inflammatory bowel disease4.12E-024O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Vitamin-Ahsa05322Systemic lupus erythematosus1.57E-024P08311, P62807, Q16778, P12814CTSG, HIST1H2BC, HIST2H2BE, ACTN1More
Vitamin-Ahsa05332Graft-versus-host disease1.48E-024P10747, P01375, P26715, Q13241CD28, TNF, KLRC1, KLRD1More

Community members of Vitamin-a (SDC: 1.24)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)