PharmaCoNets of Vismodegib (SPCN: 162.91 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Vismodegibhsa00030Pentose phosphate pathway2.27E-022P60891, P37837PRPS1, TALDO1More
Vismodegibhsa00071Fatty acid degradation3.65E-034O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Vismodegibhsa00190Oxidative phosphorylation2.35E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Vismodegibhsa00220Arginine biosynthesis4.88E-021P49448GLUD2More
Vismodegibhsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Vismodegibhsa00471D-Glutamine and D-glutamate metabolism1.65E-021P49448GLUD2More
Vismodegibhsa00500Starch and sucrose metabolism5.94E-074O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Vismodegibhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Vismodegibhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Vismodegibhsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Vismodegibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Vismodegibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Vismodegibhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Vismodegibhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Vismodegibhsa00730Thiamine metabolism2.68E-063Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Vismodegibhsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Vismodegibhsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Vismodegibhsa00770Pantothenate and CoA biosynthesis1.94E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Vismodegibhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Vismodegibhsa00910Nitrogen metabolism4.88E-021P49448GLUD2More
Vismodegibhsa00920Sulfur metabolism1.78E-021Q16762TSTMore
Vismodegibhsa00970Aminoacyl-tRNA biosynthesis1.17E-023O95363, P14868, Q15046FARS2, DARS, KARSMore
Vismodegibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Vismodegibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Vismodegibhsa00983Drug metabolism - other enzymes2.99E-023P04183, P32320, P05164TK1, CDA, MPOMore
Vismodegibhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Vismodegibhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Vismodegibhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Vismodegibhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Vismodegibhsa01522Endocrine resistance1.69E-024P22694, P08069, P10415, Q13323PRKACB, IGF1R, BCL2, BIKMore
Vismodegibhsa01523Antifolate resistance2.04E-022P04818, P18054TYMS, ALOX12More
Vismodegibhsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Vismodegibhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Vismodegibhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Vismodegibhsa03013RNA transport3.99E-0517P52298, Q09161, O14893, P38919, Q15287, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q9Y6A5NCBP2, NCBP1, GEMIN2, EIF4A3, RNPS1, NXF1, NUP62, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, TACC3More
Vismodegibhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Vismodegibhsa03020RNA polymerase2.61E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Vismodegibhsa03022Basal transcription factors2.68E-043O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Vismodegibhsa03040Spliceosome4.52E-039Q14562, O60508, P08579, Q15427, P38159, P61978, Q01130, P11142, O43447DHX8, CDC40, SNRPB2, SF3B4, RBMX, HNRPK, SFRS2, HSPA8, PPIHMore
Vismodegibhsa03050Proteasome4.83E-021P55036PSMD4More
Vismodegibhsa03060Protein export3.46E-064Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Vismodegibhsa03320PPAR signaling pathway4.55E-022O00767, Q02318SCD, CYP27A1More
Vismodegibhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Vismodegibhsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Vismodegibhsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Vismodegibhsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Vismodegibhsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Vismodegibhsa04020Calcium signaling pathway6.50E-046Q96DU7, P45880, Q13557, P21860, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4More
Vismodegibhsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Vismodegibhsa04060Cytokine-cytokine receptor interaction7.61E-0312P27930, P08476, P78552, P25024, P25025, Q9UBD3, P47992, O75509, P01375, P09341, P18510, Q93038IL1R2, INHBA, IL13RA1, CXCR1, CXCR2, XCL2, XCL1, TNFRSF21, TNF, CXCL1, IL1RN, TNFRSF25More
Vismodegibhsa04061Viral protein interaction with cytokine and cytokine receptor2.84E-0410P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Vismodegibhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Vismodegibhsa04064NF-kappa B signaling pathway7.70E-0822P10415, Q13489, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Vismodegibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Vismodegibhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Vismodegibhsa04071Sphingolipid signaling pathway2.06E-027Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Vismodegibhsa04072Phospholipase D signaling pathway5.17E-037P42338, Q92529, P43657, P25024, P25025, P19174, Q14344PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, GNA13More
Vismodegibhsa04080Neuroactive ligand-receptor interaction5.83E-0510P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADMMore
Vismodegibhsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Vismodegibhsa04122Sulfur relay system1.78E-021Q16762TSTMore
Vismodegibhsa04136Autophagy - other3.53E-021O94817ATG12More
Vismodegibhsa04140Autophagy - animal2.81E-024P08069, P22694, Q14643, P10415IGF1R, PRKACB, ITPR1, BCL2More
Vismodegibhsa04141Protein processing in endoplasmic reticulum4.76E-037P18848, O60337, Q99941, O75460, P11142, Q9H3Z4, P07900ATF4, MARH6, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Vismodegibhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Vismodegibhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Vismodegibhsa04145Phagosome1.66E-039Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Vismodegibhsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Vismodegibhsa04152AMPK signaling pathway2.07E-033P08069, Q96EB6, P36956IGF1R, SIRT1, SREBF1More
Vismodegibhsa04211Longevity regulating pathway1.34E-034Q12778, P08069, Q9UEF7, Q96KQ7FOXO1, IGF1R, KL, EHMT2More
Vismodegibhsa04213Longevity regulating pathway - multiple species9.82E-048P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Vismodegibhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Vismodegibhsa04217Necroptosis4.29E-059P01568, Q13489, Q13546, P07900, P15104, P05141, P01584, P0C0S5, Q13557IFNA21, BIRC3, RIPK1, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Vismodegibhsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Vismodegibhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Vismodegibhsa04330Notch signaling pathway2.46E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Vismodegibhsa04340Hedgehog signaling pathway4.70E-044P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Vismodegibhsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Vismodegibhsa04390Hippo signaling pathway2.17E-035P63261, P84022, Q13485, O15105, Q13489ACTG1, SMAD3, SMAD4, SMAD7, BIRC3More
Vismodegibhsa04510Focal adhesion3.48E-021P08069IGF1RMore
Vismodegibhsa04514Cell adhesion molecules2.37E-022P16109, O00501SELP, CLDN5More
Vismodegibhsa04520Adherens junction8.29E-031P08069IGF1RMore
Vismodegibhsa04530Tight junction3.34E-058Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247, P24844RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9More
Vismodegibhsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Vismodegibhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Vismodegibhsa04610Complement and coagulation cascades1.47E-052P00734, P0C0L4F2, C4AMore
Vismodegibhsa04612Antigen processing and presentation7.94E-058P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Vismodegibhsa04613Neutrophil extracellular trap formation1.41E-0622O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Vismodegibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Vismodegibhsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Vismodegibhsa04621NOD-like receptor signaling pathway7.00E-0313Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P01375, P09341, P12838MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, TNF, CXCL1, DEFA4More
Vismodegibhsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Vismodegibhsa04623Cytosolic DNA-sensing pathway9.06E-054P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Vismodegibhsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Vismodegibhsa04640Hematopoietic cell lineage1.89E-0415P13612, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1BMore
Vismodegibhsa04650Natural killer cell mediated cytotoxicity5.03E-1013P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Vismodegibhsa04657IL-17 signaling pathway1.06E-059P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Vismodegibhsa04658Th1 and Th2 cell differentiation1.20E-1115Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P42226, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Vismodegibhsa04659Th17 cell differentiation9.37E-0918P25963, Q04759, Q16539, P19174, P06239, P42226, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, CD3E, CD3G, CD247, JAK1More
Vismodegibhsa04660T cell receptor signaling pathway1.46E-0914P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Vismodegibhsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Vismodegibhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Vismodegibhsa04666Fc gamma R-mediated phagocytosis2.42E-025P23528, P06396, O14494, P14598, P17252CFL1, GSN, PLPP1, NCF1, PRKCAMore
Vismodegibhsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Vismodegibhsa04672Intestinal immune network for IgA production1.37E-034P29965, P10747, P13765, P13612CD40LG, CD28, HLA-DOB, ITGA4More
Vismodegibhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Vismodegibhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Vismodegibhsa04725Cholinergic synapse3.62E-036P22694, Q14643, P63218, P50151, P42338, P10415PRKACB, ITPR1, GNG5, GNG10, PIK3CB, BCL2More
Vismodegibhsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Vismodegibhsa04730Long-term depression1.55E-032Q14344, P08069GNA13, IGF1RMore
Vismodegibhsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Vismodegibhsa04750Inflammatory mediator regulation of TRP channels4.82E-0614P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Vismodegibhsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Vismodegibhsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Vismodegibhsa04913Ovarian steroidogenesis8.54E-033P42330, P22694, P08069AKR1C3, PRKACB, IGF1RMore
Vismodegibhsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Vismodegibhsa04915Estrogen signaling pathway4.19E-038Q99941, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, Q15788CREBL1, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Vismodegibhsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Vismodegibhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Vismodegibhsa04924Renin secretion3.09E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Vismodegibhsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Vismodegibhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Vismodegibhsa04927Cortisol synthesis and secretion2.72E-022Q14643, P22694ITPR1, PRKACBMore
Vismodegibhsa04928Parathyroid hormone synthesis, secretion and action1.02E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Vismodegibhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Vismodegibhsa04932Non-alcoholic fatty liver disease3.84E-0511P49841, O43521, P18848, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521GSK3B, BCL2L11, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Vismodegibhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Vismodegibhsa04934Cushing syndrome5.32E-047Q14643, Q99941, P51828, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1More
Vismodegibhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Vismodegibhsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Vismodegibhsa04964Proximal tubule bicarbonate reclamation4.88E-021P49448GLUD2More
Vismodegibhsa04970Salivary secretion2.62E-036P07550, Q08828, P51828, P22694, Q14643, P0DP23ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1More
Vismodegibhsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Vismodegibhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Vismodegibhsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Vismodegibhsa04976Bile secretion3.14E-035O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Vismodegibhsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Vismodegibhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Vismodegibhsa05016Huntington disease2.72E-0311O15239, O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFA1, NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Vismodegibhsa05020Prion disease2.03E-0516P13591, P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P12074, P18848, P05141, P45880, P49841, Q99941, Q16539NCAM1, IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, VDAC2, GSK3B, CREBL1, MAPK14More
Vismodegibhsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Vismodegibhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Vismodegibhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Vismodegibhsa05132Salmonella infection2.41E-0413P51617, P25963, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Vismodegibhsa05133Pertussis2.95E-032P0DP23, P0C0L4CALM1, C4AMore
Vismodegibhsa05134Legionellosis4.93E-058P01584, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Vismodegibhsa05140Leishmaniasis1.93E-0310P13612, O75015, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, NCF4More
Vismodegibhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Vismodegibhsa05144Malaria1.03E-046P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Vismodegibhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Vismodegibhsa05146Amoebiasis1.06E-0613P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Vismodegibhsa05150Staphylococcus aureus infection2.45E-037P21730, P21462, O75015, P13765, Q16581, P12838, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4, CAMPMore
Vismodegibhsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Vismodegibhsa05160Hepatitis C3.71E-037P52630, P60033, O00501, P29728, Q9NZJ5, P49841, P01106STAT2, CD81, CLDN5, OAS2, EIF2AK3, GSK3B, MYCMore
Vismodegibhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Vismodegibhsa05162Measles3.74E-035P23458, P0DMV8, P11142, P01584, Q9NP90JAK1, HSPA1A, HSPA8, IL1B, RAB9BMore
Vismodegibhsa05163Human cytomegalovirus infection3.41E-0314Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5More
Vismodegibhsa05169Epstein-Barr virus infection1.03E-0419P20023, P13765, Q13547, Q92769, O00463, P16070, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, Q8WV28, P01375, O60603, P07766, P09693, P20963CR2, HLA-DOB, HDAC1, HDAC2, TRAF5, CD44, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, BLNK, TNF, TLR2, CD3E, CD3G, CD247More
Vismodegibhsa05170Human immunodeficiency virus 1 infection5.94E-0312P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Vismodegibhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Vismodegibhsa05202Transcriptional misregulation in cancer4.21E-0823Q12778, Q15532, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, Q15652, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Vismodegibhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Vismodegibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Vismodegibhsa05205Proteoglycans in cancer4.93E-0311Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P08069, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63More
Vismodegibhsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Vismodegibhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Vismodegibhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Vismodegibhsa05214Glioma9.95E-031P08069IGF1RMore
Vismodegibhsa05215Prostate cancer1.33E-021P08069IGF1RMore
Vismodegibhsa05217Basal cell carcinoma1.34E-044Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Vismodegibhsa05218Melanoma6.63E-031P08069IGF1RMore
Vismodegibhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Vismodegibhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Vismodegibhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Vismodegibhsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Vismodegibhsa05225Hepatocellular carcinoma6.30E-043Q92529, P08069, P51531SHC3, IGF1R, SMARCA2More
Vismodegibhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Vismodegibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.89E-0512P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, CD4More
Vismodegibhsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Vismodegibhsa05321Inflammatory bowel disease2.30E-078O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL1BMore
Vismodegibhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Vismodegibhsa05332Graft-versus-host disease2.15E-034P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Vismodegibhsa05415Diabetic cardiomyopathy1.02E-038P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2DMore
Vismodegibhsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Vismodegib (SDC: 7.79)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P10619CTSALysosomal protective proteinPredicted00.12260.15310.19010.5575
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P07195LDHBLNonelactate dehydrogenase B chainPredicted00.01670.17490.2310.5892
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
Q9H228EDG8Sphingosine 1Nonephosphate receptor 5Predicted00.09250.05520.10030.2569
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P13612ITGA4Integrin alphaNone4Predicted00.11650.23860.68621.2217
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)