PharmaCoNets

PharmaCoNets of Vinorelbine (S_PCN: 36.30 )

Vinorelbine regulated-network (S_DN: 9.73)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Vinorelbine

hsa00010

Glycolysis / Gluconeogenesis

1.18E-02

P60174, P06744

TPI1, GPI

Vinorelbine

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Vinorelbine

hsa00053

Ascorbate and aldarate metabolism

1.80E-02

P51648, Q9UEF7

ALDH3A2, KL

Vinorelbine

hsa00310

Lysine degradation

4.27E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Vinorelbine

hsa00500

Starch and sucrose metabolism

1.36E-03

O43451, P35573, P06737

MGAM, AGL, PYGL

Vinorelbine

hsa00520

Amino sugar and nucleotide sugar metabolism

2.11E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Vinorelbine

hsa00561

Glycerolipid metabolism

4.36E-03

O14494, P51648, P23743

PLPP1, ALDH3A2, DGKA

Vinorelbine

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

8.72E-03

P06865, O75752

HEXA, B3GALNT1

Vinorelbine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.46E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Vinorelbine

hsa00630

Glyoxylate and dicarboxylate metabolism

2.42E-02

P40925, P15104

MDH1, GLUL

Vinorelbine

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Vinorelbine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Vinorelbine

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Vinorelbine

hsa01040

Biosynthesis of unsaturated fatty acids

4.28E-02

P22307

SCP2

Vinorelbine

hsa01200

Carbon metabolism

1.99E-02

P06744, P60174

GPI, TPI1

Vinorelbine

hsa01521

EGFR tyrosine kinase inhibitor resistance

2.90E-02

P17252, P10415, Q9NRA1

PRKCA, BCL2, PDGFC

Vinorelbine

hsa01524

Platinum drug resistance

6.12E-03

Q13315, P10415, Q13489, P78417, P43246, P52701

ATM, BCL2, BIRC3, GSTO1, MSH2, MSH6

Vinorelbine

hsa03040

Spliceosome

1.45E-04

Q14562, O43143, O60508, P26368, P52298, Q13595, Q07955, Q01130, P84103, Q13243, P11142

DHX8, DHX15, CDC40, U2AF2, NCBP2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8

Vinorelbine

hsa04020

Calcium signaling pathway

9.02E-04

P21796, Q16566, P17252, P30679, P25116, P0DP23, P23634, Q9NRA1

VDAC1, CAMK4, PRKCA, GNA15, F2R, CALM1, ATP2B4, PDGFC

Vinorelbine

hsa04064

NF-kappa B signaling pathway

3.04E-03

P10415, Q13489, P25963, P51617, Q13546, Q9UDY8, Q13315, O75293

BCL2, BIRC3, NFKBIA, IRAK1, RIPK1, MALT1, ATM, GADD45B

Vinorelbine

hsa04071

Sphingolipid signaling pathway

1.10E-03

P17252, P21453, Q9H228, P01375, P10415, Q9UQC2, P01042

PRKCA, S1PR1, EDG8, TNF, BCL2, GAB2, KNG1

Vinorelbine

hsa04072

Phospholipase D signaling pathway

1.06E-02

P25116, P17252, O14494, P23743, Q9NRA1

F2R, PRKCA, PLPP1, DGKA, PDGFC

Vinorelbine

hsa04114

Oocyte meiosis

2.05E-02

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Vinorelbine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Vinorelbine

hsa04141

Protein processing in endoplasmic reticulum

2.77E-02

P27824, P30101, P60604, P11142, P08238

CANX, PDIA3, UBE2G2, HSPA8, HSP90AB1

Vinorelbine

hsa04145

Phagosome

2.46E-03

Q15080, P14598, Q13509, P68371, Q13488, P27824

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, CANX

Vinorelbine

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Vinorelbine

hsa04217

Necroptosis

3.16E-06

P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, P10415, O43633

TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A

Vinorelbine

hsa04310

Wnt signaling pathway

5.60E-03

P30279, Q13485, O43318

CCND2, SMAD4, MAP3K7

Vinorelbine

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Vinorelbine

hsa04370

VEGF signaling pathway

1.29E-02

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Vinorelbine

hsa04371

Apelin signaling pathway

1.12E-03

P62873, P63218, P50151, Q13370, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Vinorelbine

hsa04520

Adherens junction

1.09E-03

Q13485, O43318, P84022, O95863, Q15223

SMAD4, MAP3K7, SMAD3, SNAI1, PVRL1

Vinorelbine

hsa04540

Gap junction

5.44E-03

P17252, Q13509, P68371, Q9NRA1

PRKCA, TUBB3, TUBB2C, PDGFC

Vinorelbine

hsa04620

Toll-like receptor signaling pathway

7.24E-03

P51617, Q13546, P01568, P42224, P25963

IRAK1, RIPK1, IFNA21, STAT1, NFKBIA

Vinorelbine

hsa04621

NOD-like receptor signaling pathway

4.54E-02

P08238, P42224, P01568, P25963, Q13489, P10415, Q13546

HSP90AB1, STAT1, IFNA21, NFKBIA, BIRC3, BCL2, RIPK1

Vinorelbine

hsa04623

Cytosolic DNA-sensing pathway

4.52E-05

P01568, Q13546, P25963

IFNA21, RIPK1, NFKBIA

Vinorelbine

hsa04657

IL-17 signaling pathway

3.31E-02

P49841, P14780, P01375

GSK3B, MMP9, TNF

Vinorelbine

hsa04659

Th17 cell differentiation

1.64E-02

P19174, P84022, Q13485, P08238, P07766

PLCG1, SMAD3, SMAD4, HSP90AB1, CD3E

Vinorelbine

hsa04664

Fc epsilon RI signaling pathway

2.35E-02

P07948, P19174, P09917

LYN, PLCG1, ALOX5

Vinorelbine

hsa04666

Fc gamma R-mediated phagocytosis

2.81E-02

P23528, O14494, P14598, P17252

CFL1, PLPP1, NCF1, PRKCA

Vinorelbine

hsa04710

Circadian rhythm

1.79E-02

O15516

CLOCK

Vinorelbine

hsa04720

Long-term potentiation

2.05E-02

P17252, Q16566, P0DP23

PRKCA, CAMK4, CALM1

Vinorelbine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Vinorelbine

hsa04724

Glutamatergic synapse

4.43E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Vinorelbine

hsa04725

Cholinergic synapse

8.04E-03

P17252, P62873, Q16566, P10415

PRKCA, GNB1, CAMK4, BCL2

Vinorelbine

hsa04727

GABAergic synapse

4.43E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Vinorelbine

hsa04744

Phototransduction

8.61E-05

P62873, P0DP23

GNB1, CALM1

Vinorelbine

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Vinorelbine

hsa04914

Progesterone-mediated oocyte maturation

2.66E-02

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Vinorelbine

hsa04916

Melanogenesis

2.90E-02

P0DP23, Q9UJU2, P17252

CALM1, LEF1, PRKCA

Vinorelbine

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Vinorelbine

hsa04925

Aldosterone synthesis and secretion

3.91E-02

P0DP23, P17252, Q16566

CALM1, PRKCA, CAMK4

Vinorelbine

hsa04926

Relaxin signaling pathway

4.94E-02

P63218, P30679

GNG5, GNA15

Vinorelbine

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Vinorelbine

hsa04932

Non-alcoholic fatty liver disease

2.74E-02

P01375, P49841, P48023

TNF, GSK3B, FASLG

Vinorelbine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Vinorelbine

hsa04961

Endocrine and other factor-regulated calcium reabsorption

1.22E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Vinorelbine

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Vinorelbine

hsa05017

Spinocerebellar ataxia

2.16E-02

Q8TB72, P21796

PUM2, VDAC1

Vinorelbine

hsa05032

Morphine addiction

4.43E-02

P63218, P50151, P43250

GNG5, GNG10, GRK6

Vinorelbine

hsa05132

Salmonella infection

1.58E-05

P51617, P25963, P08238, Q9UJU2, Q13546, Q13489, P10415, O75369, Q13561, Q13509, P68371

IRAK1, NFKBIA, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, FLNB, DCTN2, TUBB3, TUBB2C

Vinorelbine

hsa05140

Leishmaniasis

4.05E-03

P14598, P42224, P25963, P29350, P51617, Q15080

NCF1, STAT1, NFKBIA, PTPN6, IRAK1, NCF4

Vinorelbine

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Vinorelbine

hsa05145

Toxoplasmosis

1.95E-02

P51617, P25963, P10415, Q13489, P42224, P11142

IRAK1, NFKBIA, BCL2, BIRC3, STAT1, HSPA8

Vinorelbine

hsa05152

Tuberculosis

6.22E-04

Q13488, P0DP23, P42224, P25208, P10415, P01568, Q9UDY8, P51617

TCIRG1, CALM1, STAT1, NFYB, BCL2, IFNA21, MALT1, IRAK1

Vinorelbine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Vinorelbine

hsa05162

Measles

4.50E-03

P51617, P01568, P25963, P42224, P14784, P10747, P11142, P10415

IRAK1, IFNA21, NFKBIA, STAT1, IL2RB, CD28, HSPA8, BCL2

Vinorelbine

hsa05166

Human T-cell leukemia virus 1 infection

1.77E-02

P27824, P30279, P21796, P84022, Q13485, P07766, Q92830, P06746

CANX, CCND2, VDAC1, SMAD3, SMAD4, CD3E, KAT2A, POLB

Vinorelbine

hsa05168

Herpes simplex virus 1 infection

5.65E-04

P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P51617, Q13398, Q9NR11, P17097, P17038, Q03923, P10415

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, ZNF211, ZNF302, ZNF7, ZNF43, ZNF85, BCL2

Vinorelbine

hsa05170

Human immunodeficiency virus 1 infection

3.95E-05

P62873, P0DP23, P17252, Q13546, P01568, P51617, P25963, Q13315, P23528, P10415, Q9Y6Q5

GNB1, CALM1, PRKCA, RIPK1, IFNA21, IRAK1, NFKBIA, ATM, CFL1, BCL2, AP1M2

Vinorelbine

hsa05200

Pathways in cancer

2.28E-06

P04628, Q13751, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P52701, P14923, P30279, P10415, Q13489, Q12778, P25116, P62873, P63218, P50151, Q14344, P78417, O75293, P0DP23, P01568, P14784, P01042

WNT1, LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, MSH6, JUP, CCND2, BCL2, BIRC3, FOXO1, F2R, GNB1, GNG5, GNG10, GNA13, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13509	TUBB3	Tubulin beta-3 chain	P04628	WNT1	Proto-oncogene Wnt-1	-0.709
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13751	LAMB3	Laminin subunit beta-3	0.748
P68371	TUBB2C	Tubulin beta-4B chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.741
Q13509	TUBB3	Tubulin beta-3 chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.789
Q71U36	TUBA1A	Tubulin alpha-1A chain	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.866
Q13509	TUBB3	Tubulin beta-3 chain	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.733
Q13509	TUBB3	Tubulin beta-3 chain	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.714
Q71U36	TUBA1A	Tubulin alpha-1A chain	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.7
P68371	TUBB2C	Tubulin beta-4B chain	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.714
P68371	TUBB2C	Tubulin beta-4B chain	P17252	PRKCA	Protein kinase C alpha type	-0.842
Q13509	TUBB3	Tubulin beta-3 chain	P17252	PRKCA	Protein kinase C alpha type	-0.756
P68371	TUBB2C	Tubulin beta-4B chain	P43246	MSH2	DNA mismatch repair protein Msh2	0.709
Q13509	TUBB3	Tubulin beta-3 chain	P43246	MSH2	DNA mismatch repair protein Msh2	0.872
Q71U36	TUBA1A	Tubulin alpha-1A chain	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.819
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.794
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.777
Q71U36	TUBA1A	Tubulin alpha-1A chain	P20585	MSH3	DNA mismatch repair protein Msh3	-0.745
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P52701	MSH6	DNA mismatch repair protein Msh6	0.91
P68371	TUBB2C	Tubulin beta-4B chain	P14923	JUP	Junction plakoglobin	-0.781
Q13509	TUBB3	Tubulin beta-3 chain	P14923	JUP	Junction plakoglobin	-0.937
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P30279	CCND2	G1/S-specific cyclin-D2	0.704
Q71U36	TUBA1A	Tubulin alpha-1A chain	P30279	CCND2	G1/S-specific cyclin-D2	-0.721
P68371	TUBB2C	Tubulin beta-4B chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q13509	TUBB3	Tubulin beta-3 chain	P10415	BCL2	Apoptosis regulator Bcl-2	-0.809
P68371	TUBB2C	Tubulin beta-4B chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.892
Q13509	TUBB3	Tubulin beta-3 chain	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P68371	TUBB2C	Tubulin beta-4B chain	Q12778	FOXO1	Forkhead box protein O1	-0.895
P68371	TUBB2C	Tubulin beta-4B chain	P25116	F2R	Proteinase-activated receptor 1	-0.799
P68371	TUBB2C	Tubulin beta-4B chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q13509	TUBB3	Tubulin beta-3 chain	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.816
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.707
Q71U36	TUBA1A	Tubulin alpha-1A chain	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.818
Q71U36	TUBA1A	Tubulin alpha-1A chain	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.827
Q71U36	TUBA1A	Tubulin alpha-1A chain	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.879
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P78417	GSTO1	Glutathione S-transferase omega-1	-0.849
Q13509	TUBB3	Tubulin beta-3 chain	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.826
P68371	TUBB2C	Tubulin beta-4B chain	P0DP23	CALM1	Calmodulin-1	0.742
Q13509	TUBB3	Tubulin beta-3 chain	P0DP23	CALM1	Calmodulin-1	0.892
P68371	TUBB2C	Tubulin beta-4B chain	P01568	IFNA21	Interferon alpha-21	-0.783
Q13509	TUBB3	Tubulin beta-3 chain	P01568	IFNA21	Interferon alpha-21	-0.781
Q13509	TUBB3	Tubulin beta-3 chain	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.709
P68371	TUBB2C	Tubulin beta-4B chain	P01042	KNG1	Kininogen-1	-0.7