PharmaCoNets of Vinblastine (SPCN: 27.61 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Vinblastinehsa00010Glycolysis / Gluconeogenesis1.18E-022P60174, P06744TPI1, GPIMore
Vinblastinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Vinblastinehsa00053Ascorbate and aldarate metabolism1.80E-022P51648, Q9UEF7ALDH3A2, KLMore
Vinblastinehsa00310Lysine degradation4.27E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Vinblastinehsa00500Starch and sucrose metabolism1.36E-033O43451, P35573, P06737MGAM, AGL, PYGLMore
Vinblastinehsa00561Glycerolipid metabolism4.36E-033O14494, P51648, P23743PLPP1, ALDH3A2, DGKAMore
Vinblastinehsa00564Glycerophospholipid metabolism1.43E-033Q9Y259, P49619, Q3LIE5CHKB, DGKG, ADPRMMore
Vinblastinehsa00630Glyoxylate and dicarboxylate metabolism2.42E-022P40925, P15104MDH1, GLULMore
Vinblastinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Vinblastinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Vinblastinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Vinblastinehsa01200Carbon metabolism1.99E-022P06744, P60174GPI, TPI1More
Vinblastinehsa01521EGFR tyrosine kinase inhibitor resistance2.90E-023P17252, P10415, Q9NRA1PRKCA, BCL2, PDGFCMore
Vinblastinehsa01524Platinum drug resistance4.02E-024Q13315, P10415, Q13489, P43246ATM, BCL2, BIRC3, MSH2More
Vinblastinehsa03040Spliceosome1.45E-0411Q14562, O43143, O60508, P26368, P52298, Q13595, Q07955, Q01130, P84103, Q13243, P11142DHX8, DHX15, CDC40, U2AF2, NCBP2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8More
Vinblastinehsa04020Calcium signaling pathway2.09E-025Q16566, P17252, P25116, P0DP23, Q9NRA1CAMK4, PRKCA, F2R, CALM1, PDGFCMore
Vinblastinehsa04064NF-kappa B signaling pathway3.04E-038P10415, Q13489, P25963, P51617, Q13546, Q9UDY8, Q13315, O75293BCL2, BIRC3, NFKBIA, IRAK1, RIPK1, MALT1, ATM, GADD45BMore
Vinblastinehsa04071Sphingolipid signaling pathway1.10E-037P17252, P21453, Q9H228, P01375, P10415, Q9UQC2, P01042PRKCA, S1PR1, EDG8, TNF, BCL2, GAB2, KNG1More
Vinblastinehsa04072Phospholipase D signaling pathway1.06E-025P25116, P17252, O14494, P23743, Q9NRA1F2R, PRKCA, PLPP1, DGKA, PDGFCMore
Vinblastinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Vinblastinehsa04141Protein processing in endoplasmic reticulum2.77E-025P27824, P30101, P60604, P11142, P08238CANX, PDIA3, UBE2G2, HSPA8, HSP90AB1More
Vinblastinehsa04145Phagosome2.46E-036Q15080, P14598, Q13509, P68371, Q13488, P27824NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, CANXMore
Vinblastinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Vinblastinehsa04217Necroptosis3.16E-0612P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, P10415, O43633TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, BCL2, CHMP2AMore
Vinblastinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Vinblastinehsa04371Apelin signaling pathway1.12E-039P62873, P63218, P50151, Q13370, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Vinblastinehsa04520Adherens junction8.77E-034Q13485, P84022, O95863, Q15223SMAD4, SMAD3, SNAI1, PVRL1More
Vinblastinehsa04540Gap junction5.44E-034P17252, Q13509, P68371, Q9NRA1PRKCA, TUBB3, TUBB2C, PDGFCMore
Vinblastinehsa04620Toll-like receptor signaling pathway7.24E-035P51617, Q13546, P01568, P42224, P25963IRAK1, RIPK1, IFNA21, STAT1, NFKBIAMore
Vinblastinehsa04621NOD-like receptor signaling pathway4.54E-027P08238, P42224, P01568, P25963, Q13489, P10415, Q13546HSP90AB1, STAT1, IFNA21, NFKBIA, BIRC3, BCL2, RIPK1More
Vinblastinehsa04623Cytosolic DNA-sensing pathway4.52E-053P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Vinblastinehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Vinblastinehsa04659Th17 cell differentiation1.64E-025P19174, P84022, Q13485, P08238, P07766PLCG1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Vinblastinehsa04664Fc epsilon RI signaling pathway2.35E-023P07948, P19174, P09917LYN, PLCG1, ALOX5More
Vinblastinehsa04666Fc gamma R-mediated phagocytosis2.81E-024P23528, O14494, P14598, P17252CFL1, PLPP1, NCF1, PRKCAMore
Vinblastinehsa04710Circadian rhythm1.79E-021O15516CLOCKMore
Vinblastinehsa04720Long-term potentiation2.05E-023P17252, Q16566, P0DP23PRKCA, CAMK4, CALM1More
Vinblastinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Vinblastinehsa04724Glutamatergic synapse4.43E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Vinblastinehsa04725Cholinergic synapse8.04E-034P17252, P62873, Q16566, P10415PRKCA, GNB1, CAMK4, BCL2More
Vinblastinehsa04727GABAergic synapse4.43E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Vinblastinehsa04744Phototransduction8.61E-052P62873, P0DP23GNB1, CALM1More
Vinblastinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Vinblastinehsa04916Melanogenesis2.90E-023P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Vinblastinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Vinblastinehsa04925Aldosterone synthesis and secretion3.91E-023P0DP23, P17252, Q16566CALM1, PRKCA, CAMK4More
Vinblastinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Vinblastinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Vinblastinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Vinblastinehsa04961Endocrine and other factor-regulated calcium reabsorption1.22E-023P20020, Q9UEF7, P17252ATP2B1, KL, PRKCAMore
Vinblastinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Vinblastinehsa05032Morphine addiction4.43E-023P63218, P50151, P43250GNG5, GNG10, GRK6More
Vinblastinehsa05132Salmonella infection1.58E-0511P51617, P25963, P08238, Q9UJU2, Q13546, Q13489, P10415, O75369, Q13561, Q13509, P68371IRAK1, NFKBIA, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, FLNB, DCTN2, TUBB3, TUBB2CMore
Vinblastinehsa05140Leishmaniasis4.05E-036P14598, P42224, P25963, P29350, P51617, Q15080NCF1, STAT1, NFKBIA, PTPN6, IRAK1, NCF4More
Vinblastinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Vinblastinehsa05145Toxoplasmosis1.95E-026P51617, P25963, P10415, Q13489, P42224, P11142IRAK1, NFKBIA, BCL2, BIRC3, STAT1, HSPA8More
Vinblastinehsa05152Tuberculosis6.22E-048Q13488, P0DP23, P42224, P25208, P10415, P01568, Q9UDY8, P51617TCIRG1, CALM1, STAT1, NFYB, BCL2, IFNA21, MALT1, IRAK1More
Vinblastinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Vinblastinehsa05162Measles4.50E-038P51617, P01568, P25963, P42224, P14784, P10747, P11142, P10415IRAK1, IFNA21, NFKBIA, STAT1, IL2RB, CD28, HSPA8, BCL2More
Vinblastinehsa05166Human T-cell leukemia virus 1 infection1.77E-028P27824, P30279, P21796, P84022, Q13485, P07766, Q92830, P06746CANX, CCND2, VDAC1, SMAD3, SMAD4, CD3E, KAT2A, POLBMore
Vinblastinehsa05168Herpes simplex virus 1 infection5.65E-0414P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P51617, Q13398, Q9NR11, P17097, P17038, Q03923, P10415NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, ZNF211, ZNF302, ZNF7, ZNF43, ZNF85, BCL2More
Vinblastinehsa05170Human immunodeficiency virus 1 infection3.95E-0511P62873, P0DP23, P17252, Q13546, P01568, P51617, P25963, Q13315, P23528, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, RIPK1, IFNA21, IRAK1, NFKBIA, ATM, CFL1, BCL2, AP1M2More
Vinblastinehsa05200Pathways in cancer2.19E-0527P04628, Q13751, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P14923, P30279, P10415, Q13489, Q12778, P25116, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P01042WNT1, LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, JUP, CCND2, BCL2, BIRC3, FOXO1, F2R, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Vinblastinehsa05203Viral carcinogenesis1.90E-026P06746, Q92830, P07948, P30279, P29083, Q93079POLB, KAT2A, LYN, CCND2, GTF2E1, H2BC9More
Vinblastinehsa05214Glioma2.90E-023P0DP23, Q16566, P17252CALM1, CAMK4, PRKCAMore
Vinblastinehsa05215Prostate cancer6.15E-035P10415, Q9UJU2, Q12778, Q9NRA1, P08238BCL2, LEF1, FOXO1, PDGFC, HSP90AB1More
Vinblastinehsa05223Non-small cell lung cancer4.91E-022P10826, Q9HC35RARB, EML4More
Vinblastinehsa05231Choline metabolism in cancer6.75E-046Q9NRA1, Q9Y259, P23743, P49619, O14494, P17252PDGFC, CHKB, DGKA, DGKG, PLPP1, PRKCAMore
Vinblastinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Vinblastinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Vinblastine (SDC: 3.13)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q71U36TUBA1ATubulin alphaNone1A chainReported00.58880.07010.70941.1439
Q9UJT1TUBD1Tubulin delta chainReported00.32760.006700.1771
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
Q13885TUBB2ATubulin betaNone2A chainPredicted00.03980.09630.64840.8609
P68371TUBB2CTubulin betaNone4B chainPredicted00.28660.0970.64840.9857
Q13509TUBB3Tubulin betaNone3 chainPredicted00.09040.09610.64840.8858
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)