PharmaCoNets of Vildagliptin (SPCN: 4.07 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Vildagliptinhsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Vildagliptinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Vildagliptinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Vildagliptinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Vildagliptinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Vildagliptinhsa04010MAPK signaling pathway4.76E-025Q15283, P21860, Q12933, P01584, O14944RASA2, ERBB3, TRAF2, IL1B, EREGMore
Vildagliptinhsa04020Calcium signaling pathway3.61E-024Q96DU7, Q08828, Q13557, P21860ITPKC, ADCY1, CAMK2D, ERBB3More
Vildagliptinhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Vildagliptinhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Vildagliptinhsa04668TNF signaling pathway1.26E-024Q12933, Q99941, P01584, O95429TRAF2, CREBL1, IL1B, BAG4More
Vildagliptinhsa04713Circadian entrainment4.25E-023Q13557, Q02153, Q08828CAMK2D, GUCY1B3, ADCY1More
Vildagliptinhsa04750Inflammatory mediator regulation of TRP channels4.25E-023P01584, Q08828, Q13557IL1B, ADCY1, CAMK2DMore
Vildagliptinhsa04911Insulin secretion2.23E-023Q08828, Q99941, Q13557ADCY1, CREBL1, CAMK2DMore
Vildagliptinhsa04932Non-alcoholic fatty liver disease4.44E-024Q12933, P01584, P12074, O15239TRAF2, IL1B, COX6A1, NDUFA1More
Vildagliptinhsa04934Cushing syndrome6.07E-034Q99941, Q08828, O15169, Q13557CREBL1, ADCY1, AXIN1, CAMK2DMore
Vildagliptinhsa05010Alzheimer disease1.23E-028Q92542, O15239, P05496, P12074, P01584, Q12933, O15169, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, IL1B, TRAF2, AXIN1, PSMC4More
Vildagliptinhsa05012Parkinson disease3.53E-026P62987, O15239, P12074, P05496, P43686, Q13557UBA52, NDUFA1, COX6A1, ATP5G1, PSMC4, CAMK2DMore
Vildagliptinhsa05014Amyotrophic lateral sclerosis2.99E-027O15239, P12074, P05496, Q12933, P43686, P37198, P35658NDUFA1, COX6A1, ATP5G1, TRAF2, PSMC4, NUP62, NUP214More
Vildagliptinhsa05020Prion disease2.99E-027P01584, P46531, O15239, P05496, P12074, P43686, Q99941IL1B, NOTCH1, NDUFA1, ATP5G1, COX6A1, PSMC4, CREBL1More
Vildagliptinhsa05022Pathways of neurodegeneration - multiple diseases9.10E-039O15239, P12074, P05496, Q12933, O15169, P01584, Q13557, P62987, P43686NDUFA1, COX6A1, ATP5G1, TRAF2, AXIN1, IL1B, CAMK2D, UBA52, PSMC4More
Vildagliptinhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Vildagliptinhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Vildagliptinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Vildagliptinhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More

Community members of Vildagliptin (SDC: 1.56)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)