PharmaCoNets of Vilazodone (SPCN: 155.50 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Vilazodonehsa00030Pentose phosphate pathway6.58E-044P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Vilazodonehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Vilazodonehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Vilazodonehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Vilazodonehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Vilazodonehsa00220Arginine biosynthesis6.63E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Vilazodonehsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Vilazodonehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Vilazodonehsa00500Starch and sucrose metabolism1.91E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Vilazodonehsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Vilazodonehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Vilazodonehsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Vilazodonehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Vilazodonehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Vilazodonehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Vilazodonehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Vilazodonehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Vilazodonehsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Vilazodonehsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Vilazodonehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Vilazodonehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Vilazodonehsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Vilazodonehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Vilazodonehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Vilazodonehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Vilazodonehsa00983Drug metabolism - other enzymes1.50E-035P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Vilazodonehsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Vilazodonehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Vilazodonehsa01230Biosynthesis of amino acids2.98E-035P51854, P60891, P05089, P15104, P37837TKTL1, PRPS1, ARG1, GLUL, TALDO1More
Vilazodonehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Vilazodonehsa01523Antifolate resistance1.88E-034P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Vilazodonehsa01524Platinum drug resistance4.94E-022P78417, P52701GSTO1, MSH6More
Vilazodonehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Vilazodonehsa03010Ribosome7.34E-036P62753, P62829, P62888, P61927, P61513, P36578RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4More
Vilazodonehsa03020RNA polymerase2.14E-043P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Vilazodonehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Vilazodonehsa03050Proteasome4.83E-021P55036PSMD4More
Vilazodonehsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Vilazodonehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Vilazodonehsa03430Mismatch repair4.38E-021P20585MSH3More
Vilazodonehsa04012ErbB signaling pathway1.91E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Vilazodonehsa04015Rap1 signaling pathway2.13E-036P06213, P25116, Q8TEU7, O00522, P08514, P17252INSR, F2R, RAPGEF6, KRIT1, ITGA2B, PRKCAMore
Vilazodonehsa04020Calcium signaling pathway8.77E-033P21796, P30679, P23634VDAC1, GNA15, ATP2B4More
Vilazodonehsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Vilazodonehsa04060Cytokine-cytokine receptor interaction1.41E-0313P14784, P27930, P14778, P26842, Q06643, Q13651, P78552, P25024, Q9UBD3, P47992, O75509, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, IL13RA1, CXCR1, XCL2, XCL1, TNFRSF21, CXCL1, CD4More
Vilazodonehsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Vilazodonehsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Vilazodonehsa04064NF-kappa B signaling pathway4.99E-0919P10415, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLDMore
Vilazodonehsa04070Phosphatidylinositol signaling system1.62E-035P19174, P49619, Q86XP1, P27987, Q96DU7PLCG1, DGKG, DGKH, ITPKB, ITPKCMore
Vilazodonehsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Vilazodonehsa04110Cell cycle9.48E-069Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106, Q13547ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Vilazodonehsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Vilazodonehsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Vilazodonehsa04142Lysosome1.46E-0511Q99437, P25774, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2More
Vilazodonehsa04144Endocytosis2.00E-049P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q8WU79, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, SMAP1L, GIT2, SNX12More
Vilazodonehsa04145Phagosome2.59E-029O75015, Q15080, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, NCF4, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Vilazodonehsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Vilazodonehsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Vilazodonehsa04213Longevity regulating pathway - multiple species3.98E-033Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Vilazodonehsa04217Necroptosis2.37E-0611P01375, P48023, Q9NQC7, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q9H444TNF, FASLG, CYLD, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CHMP4BMore
Vilazodonehsa04260Cardiac muscle contraction4.02E-022P09493, P14927TPM1, UQCRBMore
Vilazodonehsa04270Vascular smooth muscle contraction2.36E-046P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Vilazodonehsa04310Wnt signaling pathway5.60E-033P30279, Q13485, O43318CCND2, SMAD4, MAP3K7More
Vilazodonehsa04380Osteoclast differentiation9.58E-0513Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Vilazodonehsa04512ECM-receptor interaction2.93E-022P07359, P08514GP1BA, ITGA2BMore
Vilazodonehsa04520Adherens junction3.91E-022Q13485, O43318SMAD4, MAP3K7More
Vilazodonehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Vilazodonehsa04610Complement and coagulation cascades6.10E-073P09871, P0C0L4, P20023C1S, C4A, CR2More
Vilazodonehsa04611Platelet activation9.37E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Vilazodonehsa04612Antigen processing and presentation1.86E-048P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Vilazodonehsa04613Neutrophil extracellular trap formation1.21E-0526P19174, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q99878, Q93077, P62807, Q16778, O60814, P68431, Q15080, P08311, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC14, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Vilazodonehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Vilazodonehsa04621NOD-like receptor signaling pathway2.12E-0310P01584, P07900, Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838IL1B, HSP90AA1, ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Vilazodonehsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Vilazodonehsa04625C-type lectin receptor signaling pathway9.91E-049Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Vilazodonehsa04630JAK-STAT signaling pathway3.20E-024P01106, P42224, P14784, Q13651MYC, STAT1, IL2RB, IL10RAMore
Vilazodonehsa04640Hematopoietic cell lineage1.02E-0718P13612, P07359, P08514, P14778, P27930, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Vilazodonehsa04650Natural killer cell mediated cytotoxicity6.01E-0711P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O14931, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Vilazodonehsa04657IL-17 signaling pathway1.10E-059P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Vilazodonehsa04658Th1 and Th2 cell differentiation6.50E-1516Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Vilazodonehsa04659Th17 cell differentiation2.15E-1117Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Vilazodonehsa04660T cell receptor signaling pathway2.91E-0914P01375, Q9UDY8, Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Vilazodonehsa04662B cell receptor signaling pathway4.53E-033P20023, Q8WV28, P11912CR2, BLNK, CD79AMore
Vilazodonehsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Vilazodonehsa04668TNF signaling pathway1.56E-038P01375, O00463, Q16539, P18848, P01584, P20749, P14780, P20333TNF, TRAF5, MAPK14, ATF4, IL1B, BCL3, MMP9, TNFRSF1BMore
Vilazodonehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Vilazodonehsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Vilazodonehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Vilazodonehsa04722Neurotrophin signaling pathway1.98E-035Q05655, P49841, O43524, P48023, P52566PRKCD, GSK3B, FOXO3, FASLG, ARHGDIBMore
Vilazodonehsa04730Long-term depression3.52E-021Q14344GNA13More
Vilazodonehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Vilazodonehsa04742Taste transduction1.01E-021P30939HTR1FMore
Vilazodonehsa04750Inflammatory mediator regulation of TRP channels1.32E-0310P14778, P01584, Q08828, P51828, P22694, Q16539, Q14643, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2, CALM1More
Vilazodonehsa04912GnRH signaling pathway5.53E-038Q08828, P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694ADCY1, ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACBMore
Vilazodonehsa04913Ovarian steroidogenesis2.52E-021P06213INSRMore
Vilazodonehsa04915Estrogen signaling pathway4.64E-045Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Vilazodonehsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Vilazodonehsa04919Thyroid hormone signaling pathway1.64E-024P19174, P42224, Q13547, P01106PLCG1, STAT1, HDAC1, MYCMore
Vilazodonehsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Vilazodonehsa04924Renin secretion4.69E-022P07550, P0DP23ADRB2, CALM1More
Vilazodonehsa04926Relaxin signaling pathway4.94E-022P63218, P30679GNG5, GNA15More
Vilazodonehsa04930Type II diabetes mellitus1.48E-032P06213, Q05655INSR, PRKCDMore
Vilazodonehsa04932Non-alcoholic fatty liver disease8.68E-0813P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Vilazodonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Vilazodonehsa04960Aldosterone-regulated sodium reabsorption8.56E-043O00141, P06213, P48048SGK, INSR, KCNJ1More
Vilazodonehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Vilazodonehsa04966Collecting duct acid secretion1.38E-032P02730, P00918SLC4A1, CA2More
Vilazodonehsa04970Salivary secretion2.14E-034P07550, Q08828, P51828, P0DP23ADRB2, ADCY1, ADCY7, CALM1More
Vilazodonehsa04976Bile secretion3.14E-035O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Vilazodonehsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Vilazodonehsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Vilazodonehsa05016Huntington disease3.74E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Vilazodonehsa05017Spinocerebellar ataxia2.16E-022Q8TB72, P21796PUM2, VDAC1More
Vilazodonehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Vilazodonehsa05022Pathways of neurodegeneration - multiple diseases6.94E-0413P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2More
Vilazodonehsa05034Alcoholism5.45E-046Q13547, Q93077, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Vilazodonehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Vilazodonehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Vilazodonehsa05131Shigellosis2.57E-022Q05655, P07737PRKCD, PFN1More
Vilazodonehsa05132Salmonella infection4.88E-022P84095, P07737RHOG, PFN1More
Vilazodonehsa05133Pertussis4.24E-031P0C0L4C4AMore
Vilazodonehsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Vilazodonehsa05140Leishmaniasis2.22E-0410P13612, O75015, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, NCF4More
Vilazodonehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Vilazodonehsa05144Malaria1.43E-048P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Vilazodonehsa05146Amoebiasis3.53E-0710P01584, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311IL1B, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Vilazodonehsa05150Staphylococcus aureus infection4.83E-022P09871, P16109C1S, SELPMore
Vilazodonehsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Vilazodonehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Vilazodonehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Vilazodonehsa05163Human cytomegalovirus infection2.84E-0415P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5More
Vilazodonehsa05169Epstein-Barr virus infection7.68E-0513P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P42224, P01375, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, STAT1, TNF, OAS2, CD3E, CD3G, CD247More
Vilazodonehsa05171Coronavirus disease - COVID-193.18E-037P01584, P62753, P36578, P62888, P61927, P61513, P62829IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23More
Vilazodonehsa05200Pathways in cancer1.44E-025Q13485, P52701, P30279, P63218, P78417SMAD4, MSH6, CCND2, GNG5, GSTO1More
Vilazodonehsa05202Transcriptional misregulation in cancer7.50E-0517Q13315, P17844, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Vilazodonehsa05203Viral carcinogenesis1.29E-037Q13547, Q15283, P12814, P06493, P62807, Q16778, O60814HDAC1, RASA2, ACTN1, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Vilazodonehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Vilazodonehsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Vilazodonehsa05210Colorectal cancer4.94E-022Q13485, P52701SMAD4, MSH6More
Vilazodonehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Vilazodonehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Vilazodonehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Vilazodonehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Vilazodonehsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Vilazodonehsa05231Choline metabolism in cancer2.57E-057Q02750, P09619, Q9GZP0, O15245, Q9Y259, P19174, P49619MAP2K1, PDGFRB, PDGFD, SLC22A1, CHKB, PLCG1, DGKGMore
Vilazodonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.85E-0713O95267, P19174, P07766, P20963, P09693, P06239, P23458, P42224, O60603, Q04759, Q16539, Q9HC35, P01730RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Vilazodonehsa05310Asthma1.25E-054P13765, P29965, P12724, P01375HLA-DOB, CD40LG, RNASE3, TNFMore
Vilazodonehsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Vilazodonehsa05321Inflammatory bowel disease2.41E-088O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Vilazodonehsa05322Systemic lupus erythematosus2.21E-057P09871, Q93077, P62807, Q16778, O60814, P68431, P12814C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Vilazodonehsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Vilazodonehsa05332Graft-versus-host disease5.22E-065P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Vilazodonehsa05340Primary immunodeficiency2.22E-036P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Vilazodonehsa05410Hypertrophic cardiomyopathy1.73E-022P26012, P09493ITGB8, TPM1More
Vilazodonehsa05412Arrhythmogenic right ventricular cardiomyopathy1.08E-058Q8IZS8, P54284, P14923, P15924, P08514, P13612, P26012, Q9UJU2CACNA2D3, CACNB3, JUP, DSP, ITGA2B, ITGA4, ITGB8, LEF1More
Vilazodonehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Vilazodonehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Vilazodonehsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore
Vilazodonehsa05418Fluid shear stress and atherosclerosis1.26E-048Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Vilazodone (SDC: 7.92)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
O75381PEX14Peroxisomal membrane protein PEX14Predicted00.19070.09950.10970.4039
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
SLC6A4P31645IC500.4
SLC6A4P31645Ki0.5