PharmaCoNets of Vigabatrin (SPCN: 17.73 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Vigabatrinhsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Vigabatrinhsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Vigabatrinhsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Vigabatrinhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Vigabatrinhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Vigabatrinhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Vigabatrinhsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Vigabatrinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Vigabatrinhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Vigabatrinhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Vigabatrinhsa04071Sphingolipid signaling pathway4.27E-021Q02156PRKCEMore
Vigabatrinhsa04072Phospholipase D signaling pathway5.37E-038P42338, P61586, P43657, P25024, P25025, P19174, O14986, P63092PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNASMore
Vigabatrinhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Vigabatrinhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Vigabatrinhsa04270Vascular smooth muscle contraction4.59E-021Q02156PRKCEMore
Vigabatrinhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Vigabatrinhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Vigabatrinhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Vigabatrinhsa04610Complement and coagulation cascades1.30E-051P0C0L4C4AMore
Vigabatrinhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Vigabatrinhsa04650Natural killer cell mediated cytotoxicity4.15E-0410P19174, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3BMore
Vigabatrinhsa04658Th1 and Th2 cell differentiation8.66E-0611Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, TBX21, IL2RB, HLA-DOB, RUNX3More
Vigabatrinhsa04659Th17 cell differentiation3.15E-0511Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, CD3E, CD3G, CD247More
Vigabatrinhsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Vigabatrinhsa04666Fc gamma R-mediated phagocytosis4.59E-021Q02156PRKCEMore
Vigabatrinhsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Vigabatrinhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Vigabatrinhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Vigabatrinhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Vigabatrinhsa04750Inflammatory mediator regulation of TRP channels2.25E-036P14778, Q02156, P19174, P42338, P24723, Q04759IL1R1, PRKCE, PLCG1, PIK3CB, PRKCH, PRKCQMore
Vigabatrinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Vigabatrinhsa04925Aldosterone synthesis and secretion3.62E-021Q02156PRKCEMore
Vigabatrinhsa04930Type II diabetes mellitus9.93E-031Q02156PRKCEMore
Vigabatrinhsa04931Insulin resistance2.64E-021Q02156PRKCEMore
Vigabatrinhsa04933AGE-RAGE signaling pathway in diabetic complications2.31E-021Q02156PRKCEMore
Vigabatrinhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Vigabatrinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Vigabatrinhsa04974Protein digestion and absorption9.93E-031Q7Z2H8SLC36A1More
Vigabatrinhsa05032Morphine addiction2.47E-033P62873, P48169, P63092GNB1, GABRA4, GNASMore
Vigabatrinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Vigabatrinhsa05133Pertussis4.94E-021P0C0L4C4AMore
Vigabatrinhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Vigabatrinhsa05144Malaria1.44E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Vigabatrinhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Vigabatrinhsa05150Staphylococcus aureus infection4.36E-022P0C0L4, P13646C4A, KRT13More
Vigabatrinhsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Vigabatrinhsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Vigabatrinhsa05214Glioma4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Vigabatrinhsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Vigabatrinhsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Vigabatrinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.00E-039P42338, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14More

Community members of Vigabatrin (SDC: 2.68)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
Q7Z2H8SLC36A1ProtonNonecoupled amino acid transporter 1Predicted00.20740.034800.1732
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Predicted00.10260.15390.32910.6881
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Predicted00.32530.5650.15791.4506
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)