PharmaCoNets of Vernakalant (SPCN: 66.06 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Vernakalanthsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Vernakalanthsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Vernakalanthsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Vernakalanthsa00190Oxidative phosphorylation4.07E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Vernakalanthsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Vernakalanthsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Vernakalanthsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Vernakalanthsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Vernakalanthsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Vernakalanthsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Vernakalanthsa00620Pyruvate metabolism4.20E-022P40926, P14550MDH2, AKR1A1More
Vernakalanthsa00630Glyoxylate and dicarboxylate metabolism9.21E-032P40925, P15104MDH1, GLULMore
Vernakalanthsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Vernakalanthsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Vernakalanthsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Vernakalanthsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Vernakalanthsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Vernakalanthsa01100Metabolic pathways4.56E-0211P15144, P32320, P06280, P24666, P33121, P42330, Q13093, Q9NY28, Q9BX95, P09960, Q16718ANPEP, CDA, GLA, ACP1, ACSL1, AKR1C3, PLA2G7, GALNT8, SGPP1, LTA4H, NDUFA5More
Vernakalanthsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Vernakalanthsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Vernakalanthsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Vernakalanthsa03010Ribosome3.56E-0614P62753, P42677, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P62910, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL32, RPL6, RPL4, RPLP1, RPS16, RPS3More
Vernakalanthsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Vernakalanthsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Vernakalanthsa03040Spliceosome1.08E-027Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8More
Vernakalanthsa03050Proteasome4.83E-021P55036PSMD4More
Vernakalanthsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Vernakalanthsa04024cAMP signaling pathway1.53E-024P49019, P22694, P20020, P48058HCAR3, PRKACB, ATP2B1, GRIA4More
Vernakalanthsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Vernakalanthsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Vernakalanthsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Vernakalanthsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Vernakalanthsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Vernakalanthsa04141Protein processing in endoplasmic reticulum8.60E-036P30101, P60604, P11142, P08238, Q9H173, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3More
Vernakalanthsa04145Phagosome5.17E-047P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Vernakalanthsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Vernakalanthsa04217Necroptosis1.27E-0512P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Vernakalanthsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Vernakalanthsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Vernakalanthsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Vernakalanthsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Vernakalanthsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Vernakalanthsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Vernakalanthsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Vernakalanthsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Vernakalanthsa04623Cytosolic DNA-sensing pathway1.31E-032P01568, P25963IFNA21, NFKBIAMore
Vernakalanthsa04650Natural killer cell mediated cytotoxicity3.65E-059P01375, P17252, O60880, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, PRKCA, SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Vernakalanthsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Vernakalanthsa04659Th17 cell differentiation1.11E-026P25963, P19174, P42224, P14784, P84022, P08238NFKBIA, PLCG1, STAT1, IL2RB, SMAD3, HSP90AB1More
Vernakalanthsa04664Fc epsilon RI signaling pathway6.97E-034P04141, P07948, P19174, P09917CSF2, LYN, PLCG1, ALOX5More
Vernakalanthsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Vernakalanthsa04713Circadian entrainment1.07E-037P0DP23, P17252, P62873, P63218, P50151, P48058, P22694CALM1, PRKCA, GNB1, GNG5, GNG10, GRIA4, PRKACBMore
Vernakalanthsa04714Thermogenesis4.53E-045P22694, Q16539, P33121, Q16718, O14521PRKACB, MAPK14, ACSL1, NDUFA5, SDHDMore
Vernakalanthsa04721Synaptic vesicle cycle6.59E-042Q13488, P31645TCIRG1, SLC6A4More
Vernakalanthsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Vernakalanthsa04723Retrograde endocannabinoid signaling1.20E-034P17252, P48058, P22694, Q16718PRKCA, GRIA4, PRKACB, NDUFA5More
Vernakalanthsa04724Glutamatergic synapse5.96E-047P48058, P22694, P17252, P62873, P63218, P50151, P15104GRIA4, PRKACB, PRKCA, GNB1, GNG5, GNG10, GLULMore
Vernakalanthsa04726Serotonergic synapse2.87E-037P22694, P17252, P31645, P62873, P63218, P50151, P09917PRKACB, PRKCA, SLC6A4, GNB1, GNG5, GNG10, ALOX5More
Vernakalanthsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Vernakalanthsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Vernakalanthsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Vernakalanthsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Vernakalanthsa04911Insulin secretion3.01E-022P22694, P17252PRKACB, PRKCAMore
Vernakalanthsa04913Ovarian steroidogenesis6.39E-042P42330, P22694AKR1C3, PRKACBMore
Vernakalanthsa04918Thyroid hormone synthesis3.01E-022P22694, P17252PRKACB, PRKCAMore
Vernakalanthsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Vernakalanthsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Vernakalanthsa04925Aldosterone synthesis and secretion9.86E-033P17252, P22694, P20020PRKCA, PRKACB, ATP2B1More
Vernakalanthsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Vernakalanthsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Vernakalanthsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Vernakalanthsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Vernakalanthsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Vernakalanthsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Vernakalanthsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Vernakalanthsa04970Salivary secretion3.56E-045P07550, P22694, P20020, P17252, P49913ADRB2, PRKACB, ATP2B1, PRKCA, CAMPMore
Vernakalanthsa04972Pancreatic secretion1.48E-032P20020, P17252ATP2B1, PRKCAMore
Vernakalanthsa04976Bile secretion1.16E-043O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Vernakalanthsa05010Alzheimer disease7.11E-039O15239, P13073, P18848, O15169, P67870, P05141, P12236, P28070, P43686NDUFA1, COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4More
Vernakalanthsa05012Parkinson disease1.29E-0313O15239, P13073, P05141, P12236, P60604, P18848, P28070, P43686, P19174, P0DP23, Q71U36, Q13509, P68371NDUFA1, COX4I1, SLC25A5, SLC25A6, UBE2G2, ATF4, PSMB4, PSMC4, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Vernakalanthsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Vernakalanthsa05017Spinocerebellar ataxia4.66E-024P28070, P43686, P05141, P12236PSMB4, PSMC4, SLC25A5, SLC25A6More
Vernakalanthsa05020Prion disease7.85E-0514P46531, O15239, Q16718, O14521, P13073, P18848, P05141, P12236, P28070, P43686, P49841, P67870, P51636, Q16539NOTCH1, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, GSK3B, CSNK2B, CAV2, MAPK14More
Vernakalanthsa05022Pathways of neurodegeneration - multiple diseases9.54E-0620P49841, P67870, O15239, Q16718, O14521, P13073, Q06055, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, Q16539, O15169, Q08752, O15020, P28070, P43686GSK3B, CSNK2B, NDUFA1, NDUFA5, SDHD, COX4I1, ATP5G2, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, MAPK14, AXIN1, PPID, SPTBN2, PSMB4, PSMC4More
Vernakalanthsa05031Amphetamine addiction1.94E-035P48058, P22694, P18848, P17252, Q13547GRIA4, PRKACB, ATF4, PRKCA, HDAC1More
Vernakalanthsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Vernakalanthsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Vernakalanthsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Vernakalanthsa05110Vibrio cholerae infection3.01E-022P17252, P22694PRKCA, PRKACBMore
Vernakalanthsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Vernakalanthsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Vernakalanthsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Vernakalanthsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Vernakalanthsa05140Leishmaniasis2.02E-036P14598, P11215, P42224, P25963, P29350, Q15080NCF1, ITGAM, STAT1, NFKBIA, PTPN6, NCF4More
Vernakalanthsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Vernakalanthsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Vernakalanthsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Vernakalanthsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Vernakalanthsa05163Human cytomegalovirus infection2.56E-038P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Vernakalanthsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Vernakalanthsa05168Herpes simplex virus 1 infection4.84E-0414P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Vernakalanthsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Vernakalanthsa05171Coronavirus disease - COVID-191.08E-0413P23396, P62753, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P05386RPS3, RPS6, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPLP1More
Vernakalanthsa05200Pathways in cancer1.99E-0315P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Vernakalanthsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Vernakalanthsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Vernakalanthsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Vernakalanthsa05212Pancreatic cancer4.75E-023P42224, P84022, O75293STAT1, SMAD3, GADD45BMore
Vernakalanthsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Vernakalanthsa05224Breast cancer3.88E-023P46531, Q9UM47, O15169NOTCH1, NOTCH3, AXIN1More
Vernakalanthsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Vernakalanthsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Vernakalanthsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Vernakalanthsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Vernakalanthsa05415Diabetic cardiomyopathy3.85E-058P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Vernakalant (SDC: 4.51)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Predicted00.01310.083500.1736
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Predicted00.28270.078500.2984
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)