PharmaCoNets

PharmaCoNets of Varenicline (S_PCN: 192.59 )

Varenicline regulated-network (S_DN: 22.71)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Varenicline

hsa00030

Pentose phosphate pathway

1.08E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Varenicline

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Varenicline

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Varenicline

hsa00190

Oxidative phosphorylation

4.38E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Varenicline

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Varenicline

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Varenicline

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Varenicline

hsa00350

Tyrosine metabolism

3.40E-02

P28332

ADH6

Varenicline

hsa00500

Starch and sucrose metabolism

6.17E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Varenicline

hsa00565

Ether lipid metabolism

3.00E-03

Q8N661

TMEM86B

Varenicline

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Varenicline

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Varenicline

hsa00600

Sphingolipid metabolism

2.44E-02

Q9BX95, Q06136

SGPP1, FVT1

Varenicline

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Varenicline

hsa00670

One carbon pool by folate

1.32E-02

P00374

DHFR

Varenicline

hsa00730

Thiamine metabolism

2.27E-02

P05186, P24666

ALPL, ACP1

Varenicline

hsa00740

Riboflavin metabolism

4.77E-02

P30043

BLVRB

Varenicline

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Varenicline

hsa00785

Lipoic acid metabolism

4.32E-02

Q9Y234

LIPT1

Varenicline

hsa00790

Folate biosynthesis

1.32E-02

P00374

DHFR

Varenicline

hsa00830

Retinol metabolism

2.51E-03

P00325, P00352, Q9BPW9, O75911

ADH1B, ALDH1A1, DHRS9, DHRS3

Varenicline

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Varenicline

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Varenicline

hsa00980

Metabolism of xenobiotics by cytochrome P450

8.40E-04

P78417, P28332, P11712

GSTO1, ADH6, CYP2C9

Varenicline

hsa00982

Drug metabolism - cytochrome P450

8.40E-04

P11712, P78417, P28332

CYP2C9, GSTO1, ADH6

Varenicline

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Varenicline

hsa01230

Biosynthesis of amino acids

2.22E-03

P51854, P60891, Q99707, P37837

TKTL1, PRPS1, MTR, TALDO1

Varenicline

hsa01523

Antifolate resistance

2.64E-03

Q92820, P04818, P00374

GGH, TYMS, DHFR

Varenicline

hsa01524

Platinum drug resistance

4.57E-02

P20585

MSH3

Varenicline

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Varenicline

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Varenicline

hsa03013

RNA transport

4.13E-07

O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787

XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, UPF3B, EIF4B, TACC3, FMR1

Varenicline

hsa03015

mRNA surveillance pathway

1.93E-03

Q9BZI7, Q13362, Q14738, O94913, Q9UBU9

UPF3B, PPP2R5C, PPP2R5D, PCF11, NXF1

Varenicline

hsa03020

RNA polymerase

9.82E-08

P30876, P24928, P62487, Q9GZM3, P52435

POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J

Varenicline

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Varenicline

hsa03060

Protein export

2.58E-03

P37108, Q15005

SRP14, SPCS2

Varenicline

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Varenicline

hsa03410

Base excision repair

7.59E-03

P27695

APEX1

Varenicline

hsa03430

Mismatch repair

3.93E-02

P20585

MSH3

Varenicline

hsa03450

Non-homologous end-joining

3.17E-03

Q9NP87, P13010

POLM, XRCC5

Varenicline

hsa04010

MAPK signaling pathway

1.53E-02

Q9H2K8, Q12933

TAOK3, TRAF2

Varenicline

hsa04020

Calcium signaling pathway

8.47E-03

Q13557, P61073, P0DP24, P05141, P51828, P63092

CAMK2D, CXCR4, CALM2, SLC25A5, ADCY7, GNAS

Varenicline

hsa04022

cGMP-PKG signaling pathway

2.55E-02

P18848, Q8WYR1, P05141, P0DP24

ATF4, PIK3R5, SLC25A5, CALM2

Varenicline

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Varenicline

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.70E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Varenicline

hsa04062

Chemokine signaling pathway

4.01E-04

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK

Varenicline

hsa04064

NF-kappa B signaling pathway

6.52E-06

P10415, Q13489, O00463, P14778, P01584, P29965, P19174, Q04759, Q9UDY8, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, BIRC3, TRAF5, IL1R1, IL1B, CD40LG, PLCG1, PRKCQ, MALT1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825

Varenicline

hsa04070

Phosphatidylinositol signaling system

2.98E-03

P0DP23, Q14643, P23743, Q86XP1, Q96DU7, P17252

CALM1, ITPR1, DGKA, DGKH, ITPKC, PRKCA

Varenicline

hsa04071

Sphingolipid signaling pathway

1.65E-04

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q12933, Q02156

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCE

Varenicline

hsa04072

Phospholipase D signaling pathway

5.38E-03

P42338, Q9UQC2, P43657, P25024, P25025, P19174, Q8WYR1, P63092, P51828, Q16760

PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIK3R5, GNAS, ADCY7, DGKD

Varenicline

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Varenicline

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Varenicline

hsa04114

Oocyte meiosis

5.93E-06

Q9Y6D9, P51812, Q02750, Q13557, P0DP23, P0DP24, P16298, Q17RY0, P51828, P27348, Q13362, Q14738

MAD1L1, RPS6KA3, MAP2K1, CAMK2D, CALM1, CALM2, PPP3CB, CPEB4, ADCY7, YWHAQ, PPP2R5C, PPP2R5D

Varenicline

hsa04120

Ubiquitin mediated proteolysis

7.75E-05

Q9UBT2, Q14145, Q13042, P62837, Q15751, O95071, Q14669, P0CG47

SAE2, KEAP1, CDC16, UBE2D2, HERC1, UBR5, TRIP12, UBB

Varenicline

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Varenicline

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Varenicline

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Varenicline

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Varenicline

hsa04145

Phagosome

1.59E-03

Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB

Varenicline

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Varenicline

hsa04151

PI3K-Akt signaling pathway

1.65E-03

P62753, P25116, O43521, P27348, P49767, Q13362, Q8WYR1, P62873, P16144, O60603, P01568, P18848, P10415, P17252, O00141, Q6ZUJ8

RPS6, F2R, BCL2L11, YWHAQ, VEGFC, PPP2R5C, PIK3R5, GNB1, ITGB4, TLR2, IFNA21, ATF4, BCL2, PRKCA, SGK, PIK3AP1

Varenicline

hsa04152

AMPK signaling pathway

1.83E-02

Q96RR4, Q13362, Q14738

CAMKK2, PPP2R5C, PPP2R5D

Varenicline

hsa04210

Apoptosis

3.63E-02

O75460, O43521, P18848

ERN1, BCL2L11, ATF4

Varenicline

hsa04213

Longevity regulating pathway - multiple species

2.70E-03

P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Varenicline

hsa04217

Necroptosis

6.15E-09

P01375, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, O75351, Q08752

TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, VPS4B, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	P01568	IFNA21	Interferon alpha-21	-0.813
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.785
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.788
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.743
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	1
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P61073	CXCR4	C-X-C chemokine receptor type 4	P15104	GLUL	Glutamine synthetase	0.754
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P05141	SLC25A5	ADP/ATP translocase 2	0.813
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P01584	IL1B	Interleukin-1 beta	0.816
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P0C0S5	H2AFZ	Histone H2A.Z	0.772
P61073	CXCR4	C-X-C chemokine receptor type 4	P0C0S5	H2AFZ	Histone H2A.Z	0.732
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.751
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.705
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.78
P61073	CXCR4	C-X-C chemokine receptor type 4	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.731
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.706
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725

Varenicline

hsa04218

Cellular senescence

4.79E-02

P01106, O75293, P30304, P06493

MYC, GADD45B, CDC25A, CDK1

Varenicline

hsa04261

Adrenergic signaling in cardiomyocytes

4.24E-06

P09493, P07550, P63092, P51828, P22694, Q8WYR1, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415

TPM1, ADRB2, GNAS, ADCY7, PRKACB, PIK3R5, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.718
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P51828	ADCY7	Adenylate cyclase type 7	0.789
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.797
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.795
P07550	ADRB2	Beta-2 adrenergic receptor	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	-0.704
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
Q9Y2I1	NISCH	Nischarin	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.719
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.767
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
Q9Y2I1	NISCH	Nischarin	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.729
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q9Y2I1	NISCH	Nischarin	P0DP23	CALM1	Calmodulin-1	0.747
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P0DP24	CALM2	Calmodulin-2	0.749
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.705
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844

Varenicline

hsa04270

Vascular smooth muscle contraction

4.17E-04

P0DP24, P0DP23, Q08828, P51828, P63092, P35579, P35749, P35318

CALM2, CALM1, ADCY1, ADCY7, GNAS, MYH9, MYH11, ADM

Varenicline

hsa04370

VEGF signaling pathway

1.79E-05

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Varenicline

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Varenicline

hsa04390

Hippo signaling pathway

5.79E-03

P04628, Q9UJU2, O43623, Q13489

WNT1, LEF1, SNAI2, BIRC3

Varenicline

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Varenicline

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Varenicline

hsa04550

Signaling pathways regulating pluripotency of stem cells

4.73E-02

Q13873, Q02750, Q86SE9

BMPR2, MAP2K1, PCGF5

Varenicline

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Varenicline

hsa04612

Antigen processing and presentation

9.02E-05

P13765, P01730, Q14953, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Varenicline

hsa04613

Neutrophil extracellular trap formation

3.41E-04

P17252, O60603, P08246, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462, O43315, Q16539

PRKCA, TLR2, ELA2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14

Varenicline

hsa04622

RIG-I-like receptor signaling pathway

2.47E-02

Q12933

TRAF2

Varenicline

hsa04623

Cytosolic DNA-sensing pathway

1.53E-04

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Varenicline

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Varenicline

hsa04640

Hematopoietic cell lineage

1.47E-06

P13612, P21926, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, CD9, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Varenicline

hsa04650

Natural killer cell mediated cytotoxicity

3.31E-10

P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, Q14953, P26715

PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Varenicline

hsa04657

IL-17 signaling pathway

8.98E-04

O00463, Q16539, P49841, P19875, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL2, MMP9, LCN2, TNF

Varenicline

hsa04658

Th1 and Th2 cell differentiation

2.82E-10

Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Varenicline

hsa04659

Th17 cell differentiation

2.90E-08

Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Varenicline

hsa04660

T cell receptor signaling pathway

1.03E-05

Q04759, P42338, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

PRKCQ, PIK3CB, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Varenicline

hsa04664

Fc epsilon RI signaling pathway

3.98E-02

P01375, Q16539, Q9UQC2

TNF, MAPK14, GAB2

Varenicline

hsa04668

TNF signaling pathway

1.71E-04

P01375, O00463, Q16539, P18848, P19875, P01584, P20749, P14780, P20333

TNF, TRAF5, MAPK14, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1B

Varenicline

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Varenicline

hsa04713

Circadian entrainment

1.31E-03

P0DP23, P0DP24, Q13557, P17252, P62873, Q14643, P51828, P63092

CALM1, CALM2, CAMK2D, PRKCA, GNB1, ITPR1, ADCY7, GNAS

Varenicline

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Varenicline

hsa04720

Long-term potentiation

1.56E-04

P17252, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Varenicline

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Varenicline

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Varenicline

hsa04725

Cholinergic synapse

1.83E-03

P51828, Q14643, P17252, P62873, P18848, Q13557, P10415, Q8WYR1

ADCY7, ITPR1, PRKCA, GNB1, ATF4, CAMK2D, BCL2, PIK3R5

Varenicline

hsa04728

Dopaminergic synapse

2.78E-04

P63092, Q14643, P17252, P62873, P18848, Q13557, Q13362, Q14738, P0DP23, P0DP24

GNAS, ITPR1, PRKCA, GNB1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1, CALM2

Varenicline

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Varenicline

hsa04750

Inflammatory mediator regulation of TRP channels

1.21E-05

P14778, P01584, P63092, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP24, P0DP23

IL1R1, IL1B, GNAS, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2, CALM1

Varenicline

hsa04911

Insulin secretion

7.99E-03

P51828, P63092, P18848, Q13557

ADCY7, GNAS, ATF4, CAMK2D

Varenicline

hsa04912

GnRH signaling pathway

6.24E-04

P17252, P51828, P18848, Q13557, Q14643, P0DP23, P0DP24, P63092

PRKCA, ADCY7, ATF4, CAMK2D, ITPR1, CALM1, CALM2, GNAS

Varenicline

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Varenicline

hsa04914

Progesterone-mediated oocyte maturation

7.22E-04

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Varenicline

hsa04915

Estrogen signaling pathway

3.17E-02

Q08828, P51828, P0DMV8, P0DP23, Q15788

ADCY1, ADCY7, HSPA1A, CALM1, NCOA1

Varenicline

hsa04916

Melanogenesis

7.99E-03

Q13557, P0DP24, P63092, P51828

CAMK2D, CALM2, GNAS, ADCY7

Varenicline

hsa04918

Thyroid hormone synthesis

4.75E-03

P63092, P51828, P18848, P02768, P05543

GNAS, ADCY7, ATF4, ALB, SERPINA7

Varenicline

hsa04921

Oxytocin signaling pathway

3.70E-03

P0DP23, P0DP24, P51828, P63092, Q13557, Q96RR4, Q13469, Q8WYR1

CALM1, CALM2, ADCY7, GNAS, CAMK2D, CAMKK2, NFATC2, PIK3R5

Varenicline

hsa04922

Glucagon signaling pathway

3.34E-03

P63092, P18848, Q12778, Q13370, P0DP23, P0DP24, Q13557, Q14643

GNAS, ATF4, FOXO1, PDE3B, CALM1, CALM2, CAMK2D, ITPR1

Varenicline

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Varenicline

hsa04924

Renin secretion

7.38E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Varenicline

hsa04925

Aldosterone synthesis and secretion

4.75E-03

P18848, P51828, P0DP24, P63092, Q13557

ATF4, ADCY7, CALM2, GNAS, CAMK2D

Varenicline

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Varenicline

hsa04927

Cortisol synthesis and secretion

1.61E-03

P18848, P51828, P63092, P22694

ATF4, ADCY7, GNAS, PRKACB

Varenicline

hsa04930

Type II diabetes mellitus

2.47E-02

Q02156

PRKCE

Varenicline

hsa04932

Non-alcoholic fatty liver disease

3.35E-09

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O43521	BCL2L11	Bcl-2-like protein 11	0.813
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.795
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.785
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P01584	IL1B	Interleukin-1 beta	0.816
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.777
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Varenicline

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.27E-02

P42224, P10415, Q12778, P49767, P17252

STAT1, BCL2, FOXO1, VEGFC, PRKCA

Varenicline

hsa04934

Cushing syndrome

2.00E-02

P18848, P51828, P63092, Q13557

ATF4, ADCY7, GNAS, CAMK2D

Varenicline

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Varenicline

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Varenicline

hsa04966

Collecting duct acid secretion

2.07E-03

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Varenicline

hsa04970

Salivary secretion

2.25E-04

P07550, P63092, Q08828, P51828, P22694, P0DP24, P0DP23, P49913

ADRB2, GNAS, ADCY1, ADCY7, PRKACB, CALM2, CALM1, CAMP

Varenicline

hsa04971

Gastric acid secretion

7.63E-04

P51828, P63092, P15311, P0DP24, Q13557

ADCY7, GNAS, VIL2, CALM2, CAMK2D

Varenicline

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Varenicline

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Varenicline

hsa04976

Bile secretion

3.14E-03

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Varenicline

hsa04979

Cholesterol metabolism

1.61E-02

P38571, P61916

LIPA, NPC2

Varenicline

hsa05010

Alzheimer disease

1.83E-04

O15239, Q16718, O14521, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P0DP24, P01584, P18848, Q13509, P68371, P05141, Q08752, P28070

NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, CALM2, IL1B, ATF4, TUBB3, TUBB2C, SLC25A5, PPID, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.777
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.796
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.74
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.739
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.785
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P0DP24	CALM2	Calmodulin-2	0.749
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P01584	IL1B	Interleukin-1 beta	0.816
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.795
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P05141	SLC25A5	ADP/ATP translocase 2	0.813
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P28070	PSMB4	Proteasome subunit beta type-4	0.749

Varenicline

hsa05012

Parkinson disease

3.18E-05

O15239, Q16718, O14521, P13073, P12074, P05141, P63092, O75460, P18848, P28070, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371

NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, SLC25A5, GNAS, ERN1, ATF4, PSMB4, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.777
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.796
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.74
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P05141	SLC25A5	ADP/ATP translocase 2	0.813
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.718
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.785
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.795
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P28070	PSMB4	Proteasome subunit beta type-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P0DP24	CALM2	Calmodulin-2	0.749
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.705
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842

Varenicline

hsa05016

Huntington disease

9.21E-07

O15239, O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460, P28070, O00232

NDUFA1, NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.777
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.74
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.751
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
P61073	CXCR4	C-X-C chemokine receptor type 4	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.714
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.832
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
P61073	CXCR4	C-X-C chemokine receptor type 4	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.756
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	P52435	POLR2J	DNA-directed RNA polymerase II subunit RPB11-a	0.76
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P05141	SLC25A5	ADP/ATP translocase 2	0.813
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9NYC9	DNAH9	Dynein axonemal heavy chain 9	0.785
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.785
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P28070	PSMB4	Proteasome subunit beta type-4	0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703

Varenicline

hsa05020

Prion disease

2.20E-04

Q16718, O14521, Q92736, Q14643, O60282, Q13509, P68371, P49841, P14598, Q15080, Q16539

NDUFA5, SDHD, RYR2, ITPR1, KIF5C, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14

Varenicline

hsa05022

Pathways of neurodegeneration - multiple diseases

9.93E-07

Q14643, Q13509, P68371, P49841, P10415, O15239, Q16718, O14521, P13073, P12074, O75460, P18848, Q13561, P05141, P17252, P20333, Q16539, Q00535, P01584, Q08752, P0DP23, P0DP24, Q13557, P28070

ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, CDK5, IL1B, PPID, CALM1, CALM2, CAMK2D, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.777
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.796
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.74
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.785
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.795
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P05141	SLC25A5	ADP/ATP translocase 2	0.813
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P61073	CXCR4	C-X-C chemokine receptor type 4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.706
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.739
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P01584	IL1B	Interleukin-1 beta	0.816
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P0DP24	CALM2	Calmodulin-2	0.749
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.705
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P28070	PSMB4	Proteasome subunit beta type-4	0.749

Varenicline

hsa05030

Cocaine addiction

3.67E-02

P63092, Q00535, P18848

GNAS, CDK5, ATF4

Varenicline

hsa05031

Amphetamine addiction

1.16E-03

P0DP24, Q13557, P22694, P63092, P18848, Q13547

CALM2, CAMK2D, PRKACB, GNAS, ATF4, HDAC1

Varenicline

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Varenicline

hsa05100

Bacterial invasion of epithelial cells

1.82E-03

Q14141, Q05397, Q92529, Q96JJ3

SEPT6, PTK2, SHC3, ELMO2

Varenicline

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Varenicline

hsa05131

Shigellosis

3.33E-03

Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Varenicline

hsa05132

Salmonella infection

2.14E-05

Q9UJU2, O00471, Q13546, Q13489, P10415, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371

LEF1, EXOC5, RIPK1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C

Varenicline

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Varenicline

hsa05134

Legionellosis

8.80E-04

P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Varenicline

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Varenicline

hsa05140

Leishmaniasis

2.17E-03

P14598, P42224, P13765, O60603, P29350, Q15080

NCF1, STAT1, HLA-DOB, TLR2, PTPN6, NCF4

Varenicline

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Varenicline

hsa05144

Malaria

1.44E-03

P69905, P68871, P01375, P35443, P26718

HBA2, HBB, TNF, THBS4, KLRK1

Varenicline

hsa05145

Toxoplasmosis

1.11E-02

P10415, Q13489, P42224, P13765, O60603, P29965

BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Varenicline

hsa05146

Amoebiasis

7.67E-07

P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSG

Varenicline

hsa05150

Staphylococcus aureus infection

1.91E-02

Q14532, P59665, P59666, P49913

KRT32, DEFA1; DEFA1B, DEFA3, CAMP

Varenicline

hsa05152

Tuberculosis

7.93E-04

Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Varenicline

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Varenicline

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Varenicline

hsa05163

Human cytomegalovirus infection

1.37E-04

P01375, P0DP24, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P18848, P63092, O00463, P61769

TNF, CALM2, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TRAF5, B2M

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P0DP24	CALM2	Calmodulin-2	0.749
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P51828	ADCY7	Adenylate cyclase type 7	0.789
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P23458	JAK1	Tyrosine-protein kinase JAK1	0.785
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P01584	IL1B	Interleukin-1 beta	0.816
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P61073	CXCR4	C-X-C chemokine receptor type 4	0.792
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.795
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	0.718
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
Q9UBB5	MBD2	Methyl-CpG-binding domain protein 2	P61769	B2M	Beta-2-microglobulin	0.741

Varenicline

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Varenicline

hsa05167

Kaposi sarcoma-associated herpesvirus infection

4.23E-04

P01568, P42224, P23458, P62873, P62879, Q13469, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2

IFNA21, STAT1, JAK1, GNB1, GNB2, NFATC2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1

Varenicline

hsa05168

Herpes simplex virus 1 infection

4.79E-02

P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820

NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189

Varenicline

hsa05169

Epstein-Barr virus infection

4.84E-03

P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Varenicline

hsa05170

Human immunodeficiency virus 1 infection

8.44E-05

Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333

MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1B

Varenicline

hsa05200

Pathways in cancer

9.44E-03

P17301, P42224, Q9UJU2, P17252, P20585, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568

ITGA2, STAT1, LEF1, PRKCA, MSH3, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21

Varenicline

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Varenicline

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Varenicline

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Varenicline

hsa05212

Pancreatic cancer

4.16E-02

Q15311, P23458

RALBP1, JAK1

Varenicline

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Varenicline

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Varenicline

hsa05217

Basal cell carcinoma

4.31E-02

P04628, Q9UJU2

WNT1, LEF1

Varenicline

hsa05223

Non-small cell lung cancer

1.39E-02

P10826, Q9HC35, O75293

RARB, EML4, GADD45B

Varenicline

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Varenicline

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

9.97E-06

P42338, P19174, P07766, P20963, P09693, P06239, Q04759, Q9HC35, P01730

PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, EML4, CD4

Varenicline

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Varenicline

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Varenicline

hsa05322

Systemic lupus erythematosus

4.80E-06

P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Varenicline

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Varenicline

hsa05330

Allograft rejection

1.04E-03

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Varenicline

hsa05332

Graft-versus-host disease

9.47E-05

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Varenicline

hsa05340

Primary immunodeficiency

1.31E-04

P01730, P01732, P11912, P07766, P06239

CD4, CD8A, CD79A, CD3E, LCK

Varenicline

hsa05410

Hypertrophic cardiomyopathy

2.63E-02

P17301

ITGA2

Varenicline

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

3.44E-03

P54284, P17301

CACNB3, ITGA2

Varenicline

hsa05415

Diabetic cardiomyopathy

1.58E-03

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B

Varenicline

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Varenicline

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Varenicline (S_DC: 8.48)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

PIM2

Serine/threonineNoneprotein kinase pimNone2

Predicted

0.1267

0.7674

0.2638

1.8619

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P27695

APEX1

DNANone(apurinic or apyrimidinic site) endonuclease

Predicted

0.402

0.221

0.1217

0.7647

P49759

CLK1

Dual specificity protein kinase CLK1

Predicted

0.2968

0.4546

0.1587

1.2163

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

Q13627

DYRK1A

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 1A

Predicted

0.015

0.7082

1.4239

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

Q9Y2I1

NISCH

Nischarin

Predicted

0.6082

0.2251

0.7543

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P51608

MECP2

MethylNoneCpGNonebinding protein 2

Predicted

0.0407

0.0165

0.0534

Q9UBB5

MBD2

MethylNoneCpGNonebinding domain protein 2

Predicted

0.5064

0.0054

0.264

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

Q02156

PRKCE

Protein kinase C epsilon type

Predicted

0.1175

0.5287

0.5377

1.6539

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

Q9UGN5

PARP2

Poly [ADPNoneribose] polymerase 2

Predicted

0.0435

0.2635

0.2461

0.7947

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

Q05397

PTK2

Focal adhesion kinase 1

Predicted

0.2153

0.5864

0.9713

2.2518

Q13546

RIPK1

ReceptorNoneinteracting serine/threonineNoneprotein kinase 1

Predicted

0.5199

0.4183

0.843

1.9396

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P17301

ITGA2

Integrin alphaNone2

Predicted

0.5221

0.0447

0.6839

1.0343

PharmaCoNets of Varenicline (SPCN: 192.59 )

Varenicline regulated-network (SDN: 22.71)

Community members of Varenicline (SDC: 8.48)

PharmaCoNets of Varenicline (S_PCN: 192.59 )

Varenicline regulated-network (S_DN: 22.71)

Community members of Varenicline (S_DC: 8.48)