PharmaCoNets

PharmaCoNets of Vardenafil (S_PCN: 135.65 )

Vardenafil regulated-network (S_DN: 18.02)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Vardenafil

hsa00020

Citrate cycle (TCA cycle)

3.41E-02

P50213, O14521

IDH3A, SDHD

Vardenafil

hsa00030

Pentose phosphate pathway

1.69E-02

P60891, P37837

PRPS1, TALDO1

Vardenafil

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Vardenafil

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Vardenafil

hsa00190

Oxidative phosphorylation

5.76E-06

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Vardenafil

hsa00220

Arginine biosynthesis

1.43E-02

P05089, P49448

ARG1, GLUD2

Vardenafil

hsa00500

Starch and sucrose metabolism

1.91E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Vardenafil

hsa00520

Amino sugar and nucleotide sugar metabolism

2.11E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Vardenafil

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Vardenafil

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Vardenafil

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Vardenafil

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

8.72E-03

P06865, O75752

HEXA, B3GALNT1

Vardenafil

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.46E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Vardenafil

hsa00630

Glyoxylate and dicarboxylate metabolism

5.34E-03

P40925, P15104

MDH1, GLUL

Vardenafil

hsa00670

One carbon pool by folate

1.14E-02

O95954, Q99707

FTCD, MTR

Vardenafil

hsa00730

Thiamine metabolism

1.55E-03

P05186, P24666

ALPL, ACP1

Vardenafil

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Vardenafil

hsa00860

Porphyrin and chlorophyll metabolism

3.15E-04

P36551, P30043

CPOX, BLVRB

Vardenafil

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Vardenafil

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Vardenafil

hsa01040

Biosynthesis of unsaturated fatty acids

4.28E-02

P22307

SCP2

Vardenafil

hsa01100

Metabolic pathways

5.54E-03

Q9NR34, P05089, Q99707, P11310, P27707, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P30043, P05186, P24666, O14772, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UNP4, O15466, P36551, Q9BX95, P32321, Q9P2R7, Q9BPW9, O75911, Q9UHY7, P43490, Q9Y2B2, P46976, P35573, P06737, Q16718

MAN1C1, ARG1, MTR, ACADM, DCK, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRB, ALPL, ACP1, FPGT, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, ST3GAL5, ST8SIA5, CPOX, SGPP1, DCTD, SUCLA2, DHRS9, DHRS3, ENOPH1, PBEF1, PIGL, GYG1, AGL, PYGL, NDUFA5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Q99707	MTR	Methionine synthase	0.869
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	0.736
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	P27707	DCK	Deoxycytidine kinase	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	P30043	BLVRB	Flavin reductase	-0.864
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	O14772	FPGT	Fucose-1-phosphate guanylyltransferase	0.742
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	O95954	FTCD	Formimidoyltransferase-cyclodeaminase	-0.774
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	-0.708
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	O15466	ST8SIA5	Alpha-2,8-sialyltransferase 8E	-0.766
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	P36551	CPOX	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	0.719
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Q9P2R7	SUCLA2	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0.722
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Q9Y2B2	PIGL	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase	0.8
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	P35573	AGL	Glycogen debranching enzyme	0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
Q13956	PDE6H	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.766

Vardenafil

hsa01230

Biosynthesis of amino acids

3.27E-03

P51854, P60891, Q99707, P50213, P37837

TKTL1, PRPS1, MTR, IDH3A, TALDO1

Vardenafil

hsa01524

Platinum drug resistance

2.24E-03

O15392, P78417, P11388, P52701

BIRC5, GSTO1, TOP2A, MSH6

Vardenafil

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Vardenafil

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Vardenafil

hsa03013

RNA transport

1.21E-07

O14980, P52298, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, P23588, Q9Y6A5

XPO1, NCBP2, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, EIF4B, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912

Vardenafil

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Vardenafil

hsa03020

RNA polymerase

3.00E-02

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Vardenafil

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Vardenafil

hsa03040

Spliceosome

2.91E-04

Q14562, O43143, O60508, P08579, Q15427, O75940, P38159, P61978, O75494, Q07955, Q01130, Q13243, P11142, O43447

DHX8, DHX15, CDC40, SNRPB2, SF3B4, SMNDC1, RBMX, HNRPK, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, PPIH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.853
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.818
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.786
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.73
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.776
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.758
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.87
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761

Vardenafil

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Vardenafil

hsa03060

Protein export

1.20E-03

P37108, Q15005

SRP14, SPCS2

Vardenafil

hsa04012

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Vardenafil

hsa04014

Ras signaling pathway

1.70E-02

P20827, Q9NRA1, P49767, P17252, P0DP23, P62873, P19174

EFNA1, PDGFC, VEGFC, PRKCA, CALM1, GNB1, PLCG1

Vardenafil

hsa04015

Rap1 signaling pathway

4.58E-02

P20827, Q9NRA1, P49767, P0DP23, P17252, P19174

EFNA1, PDGFC, VEGFC, CALM1, PRKCA, PLCG1

Vardenafil

hsa04020

Calcium signaling pathway

3.88E-06

Q96DU7, P21796, P45880, Q13557, P17252, P21860, P30679, P19174, P0DP23, P51828, P20020, P23634, Q9NRA1, P49767

ITPKC, VDAC1, VDAC2, CAMK2D, PRKCA, ERBB3, GNA15, PLCG1, CALM1, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFC

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.758
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P20020	ATP2B1	Plasma membrane calcium-transporting ATPase 1	0.763
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.796
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9NRA1	PDGFC	Platelet-derived growth factor C	0.766
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49767	VEGFC	Vascular endothelial growth factor C	0.761

Vardenafil

hsa04022

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Vardenafil

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Vardenafil

hsa04062

Chemokine signaling pathway

1.83E-02

P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151

CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10

Vardenafil

hsa04064

NF-kappa B signaling pathway

1.69E-04

O00463, P14778, P01584, P19174, Q04759, Q13077, Q16548, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

TRAF5, IL1R1, IL1B, PLCG1, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Vardenafil

hsa04070

Phosphatidylinositol signaling system

4.40E-02

P19174, P0DP23, P23743, P17252

PLCG1, CALM1, DGKA, PRKCA

Vardenafil

hsa04071

Sphingolipid signaling pathway

1.87E-02

Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Vardenafil

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Vardenafil

hsa04114

Oocyte meiosis

2.05E-02

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Vardenafil

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Vardenafil

hsa04130

SNARE interactions in vesicular transport

1.27E-02

O15155

BET1

Vardenafil

hsa04136

Autophagy - other

2.35E-05

O94817, Q9H1Y0

ATG12, ATG5

Vardenafil

hsa04141

Protein processing in endoplasmic reticulum

3.64E-02

Q99941, O75460, P11142, Q9H3Z4, P07900

CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1

Vardenafil

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Vardenafil

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Vardenafil

hsa04145

Phagosome

4.68E-02

Q15080, P14598, Q13509, P68371, Q13488

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1

Vardenafil

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Vardenafil

hsa04213

Longevity regulating pathway - multiple species

2.70E-03

P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Vardenafil

hsa04217

Necroptosis

1.07E-03

P01375, P01568, P48023, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Vardenafil

hsa04261

Adrenergic signaling in cardiomyocytes

3.98E-02

P51828, Q99941, Q13557, P23634

ADCY7, CREBL1, CAMK2D, ATP2B4

Vardenafil

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Vardenafil

hsa04310

Wnt signaling pathway

5.60E-03

P30279, Q13485, O43318

CCND2, SMAD4, MAP3K7

Vardenafil

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Vardenafil

hsa04360

Axon guidance

2.29E-02

P16333, P20827, O95631, P17252, P19174

NCK1, EFNA1, NTN1, PRKCA, PLCG1

Vardenafil

hsa04370

VEGF signaling pathway

1.29E-02

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Vardenafil

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Vardenafil

hsa04520

Adherens junction

3.91E-02

Q13485, O43318

SMAD4, MAP3K7

Vardenafil

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Vardenafil

hsa04540

Gap junction

1.67E-02

P17252, Q13509, P68371, Q9NRA1

PRKCA, TUBB3, TUBB2C, PDGFC

Vardenafil

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Vardenafil

hsa04612

Antigen processing and presentation

8.21E-03

P26715, P26717, Q07444, Q13241, P01732

KLRC1, KLRC2, KLRC3, KLRD1, CD8A

Vardenafil

hsa04613

Neutrophil extracellular trap formation

9.88E-05

O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Vardenafil

hsa04623

Cytosolic DNA-sensing pathway

8.84E-04

P01584, P01568, P25963, Q8NHW4

IL1B, IFNA21, NFKBIA, CCL4L2

Vardenafil

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Vardenafil

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Vardenafil

hsa04650

Natural killer cell mediated cytotoxicity

1.17E-06

P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q07444, P26715

PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1

Vardenafil

hsa04657

IL-17 signaling pathway

3.11E-05

P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, Q9UJX4, P04141, P80188, P01375, P06702

NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, CSF2, LCN2, TNF, S100A9

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.776
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	0.757
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P06702	S100A9	Protein S100-A9	-0.71

Vardenafil

hsa04658

Th1 and Th2 cell differentiation

6.40E-08

Q04759, P07766, P20963, P09693, P19174, P06239, P23771, Q9UL17, P14784, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, GATA3, TBX21, IL2RB, RUNX3

Vardenafil

hsa04659

Th17 cell differentiation

1.02E-05

Q04759, P19174, P06239, P14784, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Vardenafil

hsa04660

T cell receptor signaling pathway

2.28E-06

P04141, P25963, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01732, Q13191, P06239, P29350

CSF2, NFKBIA, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, PTPN6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	0.757
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.758
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.752
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P16333	NCK1	Cytoplasmic protein NCK1	-0.703
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.763
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.797

Vardenafil

hsa04662

B cell receptor signaling pathway

1.49E-03

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Vardenafil

hsa04664

Fc epsilon RI signaling pathway

2.20E-03

P01375, Q16539, P42338, Q9UQC2, P07948, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5

Vardenafil

hsa04668

TNF signaling pathway

2.47E-03

P01375, O00463, Q16539, Q99941, P01584, P20749, P14780, O95429

TNF, TRAF5, MAPK14, CREBL1, IL1B, BCL3, MMP9, BAG4

Vardenafil

hsa04713

Circadian entrainment

3.32E-02

P0DP23, P17252, P62873, O15055

CALM1, PRKCA, GNB1, PER2

Vardenafil

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Vardenafil

hsa04721

Synaptic vesicle cycle

1.80E-02

Q13488, P31645

TCIRG1, SLC6A4

Vardenafil

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Vardenafil

hsa04724

Glutamatergic synapse

5.94E-03

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Vardenafil

hsa04725

Cholinergic synapse

4.10E-02

P63218, P50151, P42338

GNG5, GNG10, PIK3CB

Vardenafil

hsa04727

GABAergic synapse

1.63E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Vardenafil

hsa04744

Phototransduction

1.18E-02

P62873, P0DP23

GNB1, CALM1

Vardenafil

hsa04750

Inflammatory mediator regulation of TRP channels

8.97E-05

P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Vardenafil

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Vardenafil

hsa04914

Progesterone-mediated oocyte maturation

2.66E-02

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Vardenafil

hsa04915

Estrogen signaling pathway

4.19E-03

Q99941, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, Q15788

CREBL1, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1

Vardenafil

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Vardenafil

hsa04925

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Vardenafil

hsa04926

Relaxin signaling pathway

8.02E-04

P42338, P63218, P50151, P49767, P30679, P49407

PIK3CB, GNG5, GNG10, VEGFC, GNA15, ARRB1

Vardenafil

hsa04929

GnRH secretion

4.62E-02

P42338, P49407

PIK3CB, ARRB1

Vardenafil

hsa04932

Non-alcoholic fatty liver disease

7.01E-05

P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521

TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD

Vardenafil

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.72E-02

P42224, Q12778, P49767, P17252, P19174

STAT1, FOXO1, VEGFC, PRKCA, PLCG1

Vardenafil

hsa04934

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Vardenafil

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Vardenafil

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Vardenafil

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Vardenafil

hsa04970

Salivary secretion

4.78E-02

Q08828, P51828, P0DP23

ADCY1, ADCY7, CALM1

Vardenafil

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Vardenafil

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Vardenafil

hsa04976

Bile secretion

3.14E-03

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Vardenafil

hsa05010

Alzheimer disease

2.07E-02

Q92542, P05496, P12074, O75460, P01584, O15169, P45880

NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2

Vardenafil

hsa05012

Parkinson disease

3.12E-02

Q16718, O14521, P19174, P0DP23, Q13509, P68371

NDUFA5, SDHD, PLCG1, CALM1, TUBB3, TUBB2C

Vardenafil

hsa05016

Huntington disease

2.46E-02

O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12

Vardenafil

hsa05017

Spinocerebellar ataxia

2.16E-02

Q8TB72, P21796

PUM2, VDAC1

Vardenafil

hsa05020

Prion disease

1.37E-03

P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539

IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14

Vardenafil

hsa05022

Pathways of neurodegeneration - multiple diseases

1.14E-03

Q13509, P68371, P49841, Q16718, O14521, Q13561, P19174, P17252, Q16539, Q08752, P0DP23

TUBB3, TUBB2C, GSK3B, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, MAPK14, PPID, CALM1

Vardenafil

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Vardenafil

hsa05110

Vibrio cholerae infection

1.98E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Vardenafil

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.96E-04

Q16539, P09341, P19875, P19174, P25024, P25025

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Vardenafil

hsa05132

Salmonella infection

1.70E-02

P25963, P08238, P04406, O75369, Q13561, Q13509, P68371, P49754

NFKBIA, HSP90AB1, GAPDH, FLNB, DCTN2, TUBB3, TUBB2C, VPS41

Vardenafil

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Vardenafil

hsa05134

Legionellosis

8.80E-04

P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Vardenafil

hsa05140

Leishmaniasis

2.25E-05

O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4

Vardenafil

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Vardenafil

hsa05144

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Vardenafil

hsa05146

Amoebiasis

5.28E-06

P09341, P19875, P14778, P27930, O60603, P42338, P11215, P05089, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TLR2, PIK3CB, ITGAM, ARG1, ACTN1, CTSG

Vardenafil

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Vardenafil

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Vardenafil

hsa05163

Human cytomegalovirus infection

2.84E-04

P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463

TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5

Vardenafil

hsa05167

Kaposi sarcoma-associated herpesvirus infection

5.71E-03

P01568, P42224, P25963, P40189, P62873, P19174, P04141, P0DP23

IFNA21, STAT1, NFKBIA, IL6ST, GNB1, PLCG1, CSF2, CALM1

Vardenafil

hsa05168

Herpes simplex virus 1 infection

4.15E-03

P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13398, Q03923, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, ZNF211, ZNF85, ZNF140, ZNF189, ZNF212

Vardenafil

hsa05169

Epstein-Barr virus infection

3.72E-02

Q13547, P42338, P07948, Q13761, O75293, P07766

HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3E

Vardenafil

hsa05171

Coronavirus disease - COVID-19

1.36E-02

P25963, P42224, P01568, P40189, P04141, P19174, P17252

NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCA

Vardenafil

hsa05200

Pathways in cancer

1.67E-03

P08238, P42224, P25963, P19174, P17252, P43246, Q13485, P52701, P14923, P30279, P49767, Q12778, P62873, P63218, P78417, O75293, P0DP23, P01568, P40189

HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD4, MSH6, JUP, CCND2, VEGFC, FOXO1, GNB1, GNG5, GSTO1, GADD45B, CALM1, IFNA21, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P43246	MSH2	DNA mismatch repair protein Msh2	-0.768
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	0.794
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P52701	MSH6	DNA mismatch repair protein Msh6	0.91
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P14923	JUP	Junction plakoglobin	0.735
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P30279	CCND2	G1/S-specific cyclin-D2	0.704
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49767	VEGFC	Vascular endothelial growth factor C	0.761
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q12778	FOXO1	Forkhead box protein O1	0.753
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.833
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.707
O43318	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	P78417	GSTO1	Glutathione S-transferase omega-1	-0.849
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.713
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P40189	IL6ST	Interleukin-6 receptor subunit beta	-0.746

Vardenafil

hsa05202

Transcriptional misregulation in cancer

1.45E-02

Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522

SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45A

Vardenafil

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Vardenafil

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Vardenafil

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Vardenafil

hsa05210

Colorectal cancer

4.94E-02

Q13485, P52701

SMAD4, MSH6

Vardenafil

hsa05214

Glioma

1.09E-02

P0DP23, P17252, P19174, O75293

CALM1, PRKCA, PLCG1, GADD45B

Vardenafil

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Vardenafil

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Vardenafil

hsa05231

Choline metabolism in cancer

2.25E-03

Q9NRA1, Q9Y259, P19174, P23743, P17252

PDGFC, CHKB, PLCG1, DGKA, PRKCA

Vardenafil

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

2.41E-06

P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P42224, O60603, P10747, Q04759, Q16539, P01730

NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, STAT1, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.737
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.797
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.812
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	P06239	LCK	Tyrosine-protein kinase Lck	0.771
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.797
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.758
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	Q04759	PRKCQ	Protein kinase C theta type	0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707

Vardenafil

hsa05322

Systemic lupus erythematosus

1.49E-05

P08311, P09871, Q93077, P62807, Q16778, O60814, P68431, P12814

CTSG, C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1

Vardenafil

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Vardenafil

hsa05332

Graft-versus-host disease

3.70E-02

P48023, P01375

FASLG, TNF

Vardenafil

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Vardenafil

hsa05415

Diabetic cardiomyopathy

5.17E-04

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Vardenafil

hsa05418

Fluid shear stress and atherosclerosis

1.26E-04

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Vardenafil (S_DC: 7.53)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

PDE6H

Retinal cone rhodopsinNonesensitive cGMP 3',5'Nonecyclic phosphodiesterase subunit gamma

Reported

0.0604

0.0133

0.1653

0.2222

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P00352

ALDH1A1

Aldehyde dehydrogenase 1A1

Predicted

0.3208

0.2925

0.1543

0.8998

P49336

CDK8

CyclinNonedependent kinase 8

Predicted

0.1356

0.647

1.3618

O43318

MAP3K7

MitogenNoneactivated protein kinase kinase kinase 7

Predicted

0.0059

0.3649

1.7327

Q02750

MAP2K1

Dual specificity mitogenNoneactivated protein kinase kinase 1

Predicted

0.312

0.5129

2.1819

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

Q86W56

PARG

Poly(ADPNoneribose) glycohydrolase

Predicted

0.0358

0.0441

0.106

Q13370

PDE3B

cGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase B

Predicted

0.0906

0.1614

0.3558

0.7239

PharmaCoNets of Vardenafil (SPCN: 135.65 )

Vardenafil regulated-network (SDN: 18.02)

Community members of Vardenafil (SDC: 7.53)

PharmaCoNets of Vardenafil (S_PCN: 135.65 )

Vardenafil regulated-network (S_DN: 18.02)

Community members of Vardenafil (S_DC: 7.53)